TR 399 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TITANOCENE DICHLORIDE
NTP Experiment-Test: 05047-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/06/94
Route: GAVAGE Time: 21:43:31
Facility: TSI Mason Research
Chemical CAS #: 1271-19-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 80 80 80
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 19 25 21
Dead 4 5 7
Accident 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 36 30 31
Moribund 1
Aborted 10 9 10
Animals Examined Microscopically 60 61 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (59) (57) (56)
Leiomyosarcoma 1 (2%)
Liver (60) (61) (60)
Hepatocellular Adenoma 2 (3%)
Neoplastic Nodule 1 (2%)
Mesentery (3) (9) (10)
Pancreas (60) (61) (59)
Acinus, Adenoma 1 (2%) 1 (2%) 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (60) (61) (60)
Stomach, Forestomach (60) (60) (60)
Squamous Cell Papilloma 1 (2%) 2 (3%)
Stomach, Glandular (60) (60) (60)
Tooth (1)
Pulp, Fibroma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (61) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (61) (60)
Adrenal Gland, Medulla (58) (60) (59)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 6 (10%) 6 (10%) 4 (7%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (3%)
Islets, Pancreatic (59) (61) (59)
Adenoma 2 (3%)
Adenoma, Multiple 1 (2%)
Pituitary Gland (59) (59) (60)
Pars Distalis, Adenoma 26 (44%) 22 (37%) 16 (27%)
Pars Distalis, Adenoma, Multiple 3 (5%) 1 (2%)
Thyroid Gland (60) (57) (59)
Bilateral, C-Cell, Adenoma 1 (2%)
Bilateral, C-Cell, Carcinoma 2 (4%)
C-Cell, Adenoma 9 (15%) 7 (12%) 7 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma, Multiple 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (56) (55) (56)
Adenoma 9 (16%) 8 (15%) 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Bilateral, Adenoma 3 (5%)
Ovary (58) (61) (60)
Uterus (60) (61) (60)
Adenoma 1 (2%)
Polyp Stromal 11 (18%) 10 (16%) 14 (23%)
Bilateral, Polyp Stromal 2 (3%)
Cervix, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Bone Marrow (59) (61) (59)
Lymph Node (60) (61) (60)
Lymph Node, Mandibular (56) (59) (60)
Page 3
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mesenteric (60) (61) (60)
Spleen (60) (60) (60)
Sarcoma 1 (2%) 1 (2%)
Thymus (55) (56) (58)
Epithelial Cell, Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (56) (56) (49)
Adenocarcinoma 2 (4%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 1 (2%) 1 (2%)
Fibroadenoma 17 (30%) 17 (30%) 15 (31%)
Fibroadenoma, Multiple 9 (16%) 7 (13%) 3 (6%)
Skin (60) (61) (58)
Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (61) (60)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (61) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Pleura, Alveolar/Bronchiolar Carcinoma,
Page 4
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (11) (18)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (61) (60)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (60) (58) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(61) *(60)
Leukemia Mononuclear 21 (35%) 20 (33%) 15 (25%)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 55 53 46
Total Primary Neoplasms 135 115 96
Total Animals with Benign Neoplasms 46 50 40
Total Benign Neoplasms 102 88 75
Total Animals with Malignant Neoplasms 29 25 18
Total Malignant Neoplasms 33 27 21
Total Animals with Metastatic Neoplasms 4 1 1
Total Metastatic Neoplasm 5 1 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 80 80 80
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 11 15 17
Moribund 8 14 17
Accident 1 2
Survivors
Terminal Sacrifice 41 30 24
Aborted 10 10 10
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (56) (54) (57)
Intestine Small, Ileum (55) (52) (57)
Liver (60) (59) (60)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 4 (7%) 2 (3%) 6 (10%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%)
Mesentery (6) (4) (5)
Pancreas (59) (56) (59)
Acinus, Adenoma 4 (7%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (57) (59) (59)
Basosquamous Tumor Benign 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 4 (7%) 1 (2%)
Stomach, Glandular (58) (59) (58)
Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60)
Adenoma 1 (2%)
Adrenal Gland, Medulla (60) (60) (59)
Pheochromocytoma Malignant 3 (5%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 15 (25%) 13 (22%) 8 (14%)
Bilateral, Pheochromocytoma Benign 5 (8%) 8 (13%) 9 (15%)
Islets, Pancreatic (58) (56) (59)
Adenoma 5 (9%) 5 (9%) 1 (2%)
Parathyroid Gland (56) (54) (51)
Adenoma 1 (2%)
Pituitary Gland (56) (59) (56)
Pars Distalis, Adenoma 23 (41%) 18 (31%) 13 (23%)
Pars Distalis, Adenoma, Multiple 2 (3%) 1 (2%)
Thyroid Gland (60) (55) (58)
C-Cell, Adenoma 12 (20%) 9 (16%) 9 (16%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (58) (60)
Preputial Gland (56) (59) (56)
Adenoma 3 (5%) 1 (2%) 3 (5%)
Carcinoma 1 (2%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Testes (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 40 (67%) 41 (68%) 44 (73%)
Interstitial Cell, Adenoma 11 (18%) 9 (15%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (58) (60)
Lymph Node (60) (59) (60)
Lymph Node, Mandibular (58) (56) (56)
Lymph Node, Mesenteric (59) (54) (58)
Spleen (58) (56) (59)
Thymus (55) (50) (52)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (36) (41)
Fibroadenoma 4 (10%) 5 (14%) 2 (5%)
Fibroadenoma, Multiple 1 (3%)
Skin (58) (60) (59)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Keratoacanthoma 2 (3%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (9%) 2 (3%) 3 (5%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (3%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60)
Granular Cell Tumor Benign 1 (2%)
Neoplasm NOS 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Alveolar/Bronchiolar Adenoma 3 (5%) 2 (3%) 5 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Carcinoma Adenosquamous 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (59) (60) (56)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (3) (1)
Fibrosarcoma 1 (100%)
Zymbal's Gland (3) (2) (1)
Carcinoma 3 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (60) (55) (56)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 15 (25%) 12 (20%) 11 (18%)
Mesothelioma Malignant 3 (5%) 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:43:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 56 48
Total Primary Neoplasms 168 156 134
Total Animals with Benign Neoplasms 59 55 48
Total Benign Neoplasms 137 134 112
Total Animals with Malignant Neoplasms 24 19 19
Total Malignant Neoplasms 31 21 22
Total Animals with Metastatic Neoplasms 3 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 63525-63525/63525
--multipart-boundary--