TR 399 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason TITANOCENE DICHLORIDE DATE: 09/06/94
EXPERIMENT: 05047 TEST: 01 TIME: 22:02:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES9561904 ROUTE: GAVAGE NTP C#: 04502
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 1271-19-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason TITANOCENE DICHLORIDE DATE: 09/06/94
EXPERIMENT: 05047 TEST: 01 TIME: 22:02:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561904 ROUTE: GAVAGE NTP C#: 04502
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 1271-19-8
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason TITANOCENE DICHLORIDE DATE: 09/06/94
EXPERIMENT: 05047 TEST: 01 TIME: 22:02:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561904 ROUTE: GAVAGE NTP C#: 04502
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 1271-19-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TITANOCENE DICHLORIDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Testes Adenoma
All Organs Mesothelioma Benign, Malignant, NOS
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Carcinoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/60 (33%) 21/60 (35%) 17/59 (29%) | 6/58 (10%) 7/60 (12%) 6/59 (10%) |
|ADJUSTED (b) | 46.3% 65.1% 58.3% | 16.0% 21.9% 18.2% |
|TERMINAL (d) | 18/41 (44%) 19/30 (63%) 12/24 (50%) | 5/36 (14%) 5/30 (17%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | 670 536 662 | 702 721 674 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.078 P=0.089 P=0.123 | P=0.414 P=0.368 P=0.475 |
|INCIDENTAL TUMOR | P=0.132 P=0.119 P=0.195 | P=0.436 P=0.439 P=0.503 |
|LOGISTIC REGRESSION | P=0.152 P=0.126 P=0.198 | P=0.416 P=0.393 P=0.487 |
|COCHRAN-ARMITAGE | P=0.335N | P=0.547N |
|FISHER EXACT | P=0.500 P=0.369N | P=0.526 P=0.607N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 1/59 (2%) | 1/58 (2%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 6.5% 2.3% 2.8% | 2.8% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 0/30 (0%) 0/24 (0%) | 1/36 (3%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 647 603 620 | 743 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.407N P=0.482N | P=0.298N P=0.536N P=0.536N |
|INCIDENTAL TUMOR | P=0.211N P=0.315N P=0.338N | P=0.298N P=0.536N P=0.536N |
|LOGISTIC REGRESSION | P=0.222N P=0.305N P=0.361N | P=0.298N P=0.536N P=0.536N |
|COCHRAN-ARMITAGE | P=0.206N | P=0.266N |
|FISHER EXACT | P=0.309N P=0.316N | P=0.492N P=0.496N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/60 (37%) 22/60 (37%) 18/59 (31%) | 7/58 (12%) 7/60 (12%) 6/59 (10%) |
|ADJUSTED (b) | 49.6% 65.9% 59.4% | 18.7% 21.9% 18.2% |
|TERMINAL (d) | 19/41 (46%) 19/30 (63%) 12/24 (50%) | 6/36 (17%) 5/30 (17%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | 647 536 620 | 702 721 674 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.103 P=0.122 P=0.149 | P=0.523 P=0.473 P=0.583 |
|INCIDENTAL TUMOR | P=0.189 P=0.177 P=0.256 | P=0.548 P=0.545 P=0.610 |
|LOGISTIC REGRESSION | P=0.220 P=0.188 P=0.273 | P=0.528 P=0.502 P=0.595 |
|COCHRAN-ARMITAGE | P=0.272N | P=0.429N |
|FISHER EXACT | P=0.575N P=0.303N | P=0.585N P=0.487N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/56 (7%) 1/59 (2%) 3/56 (5%) | 12/56 (21%) 8/55 (15%) 2/56 (4%) |
|ADJUSTED (b) | 10.8% 2.0% 11.1% | 31.9% 20.7% 5.2% |
|TERMINAL (d) | 4/37 (11%) 0/30 (0%) 2/24 (8%) | 10/34 (29%) 4/30 (13%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 537 662 | 384 510 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.574 P=0.245N P=0.585 | P=0.009N** P=0.323N P=0.009N** |
|INCIDENTAL TUMOR | P=0.534N P=0.164N P=0.614 | P=0.003N** P=0.212N P=0.003N** |
|LOGISTIC REGRESSION | P=0.518N P=0.191N P=0.640 | P=0.005N** P=0.259N P=0.007N** |
|COCHRAN-ARMITAGE | P=0.411N | P=0.004N** |
|FISHER EXACT | P=0.166N P=0.500N | P=0.244N P=0.004N** |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/56 (9%) 1/59 (2%) 4/56 (7%) | 13/56 (23%) 9/55 (16%) 2/56 (4%) |
|ADJUSTED (b) | 12.8% 2.0% 14.0% | 34.8% 23.8% 5.2% |
|TERMINAL (d) | 4/37 (11%) 0/30 (0%) 2/24 (8%) | 11/34 (32%) 5/30 (17%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 716 537 662 | 384 510 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.516 P=0.163N P=0.510 | P=0.006N** P=0.338N P=0.005N** |
|INCIDENTAL TUMOR | P=0.531N P=0.099N P=0.601 | P=0.002N** P=0.228N P=0.002N** |
|LOGISTIC REGRESSION | P=0.541N P=0.115N P=0.597 | P=0.003N** P=0.277N P=0.004N** |
|COCHRAN-ARMITAGE | P=0.420N | P=0.002N** |
|FISHER EXACT | P=0.092N P=0.500N | P=0.253N P=0.002N** |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/58 (9%) 5/56 (9%) 1/59 (2%) | 2/59 (3%) 1/61 (2%) 0/59 (0%) |
|ADJUSTED (b) | 10.8% 16.7% 4.3% | 5.6% 3.3% 0.0% |
|TERMINAL (d) | 2/39 (5%) 5/30 (17%) 1/23 (4%) | 2/36 (6%) 1/30 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 577 738 (T) 738 (T) | 743 (T) 743 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.257N P=0.459 P=0.246N | P=0.172N P=0.564N P=0.272N |
|INCIDENTAL TUMOR | P=0.199N P=0.501 P=0.158N | P=0.172N P=0.564N P=0.272N |
|LOGISTIC REGRESSION | P=0.186N P=0.519 P=0.156N | P=0.172N P=0.564N P=0.272N |
|COCHRAN-ARMITAGE | P=0.088N | P=0.141N |
|FISHER EXACT | P=0.606 P=0.099N | P=0.487N P=0.248N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/59 (5%) 7/60 (12%) | 0/60 (0%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 9.8% 10.0% 26.3% | 0.0% 3.3% 6.5% |
|TERMINAL (d) | 4/41 (10%) 3/30 (10%) 5/24 (21%) | 0/37 (0%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 738 (T) 708 | --- 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042 * P=0.643 P=0.057 | P=0.119 P=0.458 P=0.200 |
|INCIDENTAL TUMOR | P=0.053 P=0.643 P=0.076 | P=0.119 P=0.458 P=0.200 |
|LOGISTIC REGRESSION | P=0.052 P=0.643 P=0.072 | P=0.119 P=0.458 P=0.200 |
|COCHRAN-ARMITAGE | P=0.198 | P=0.142 |
|FISHER EXACT | P=0.509N P=0.264 | P=0.504 P=0.248 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/59 (5%) 8/60 (13%) | 0/60 (0%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 9.8% 10.0% 28.1% | 0.0% 3.3% 6.5% |
|TERMINAL (d) | 4/41 (10%) 3/30 (10%) 5/24 (21%) | 0/37 (0%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 738 (T) 612 | --- 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.022 * P=0.643 P=0.032 * | P=0.119 P=0.458 P=0.200 |
|INCIDENTAL TUMOR | P=0.031 * P=0.643 P=0.051 | P=0.119 P=0.458 P=0.200 |
|LOGISTIC REGRESSION | P=0.032 * P=0.643 P=0.050 * | P=0.119 P=0.458 P=0.200 |
|COCHRAN-ARMITAGE | P=0.124 | P=0.142 |
|FISHER EXACT | P=0.509N P=0.181 | P=0.504 P=0.248 |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/59 (5%) 8/60 (13%) | 0/60 (0%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 9.8% 10.0% 28.1% | 0.0% 3.3% 6.5% |
|TERMINAL (d) | 4/41 (10%) 3/30 (10%) 5/24 (21%) | 0/37 (0%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 738 (T) 612 | --- 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.022 * P=0.643 P=0.032 * | P=0.119 P=0.458 P=0.200 |
|INCIDENTAL TUMOR | P=0.031 * P=0.643 P=0.051 | P=0.119 P=0.458 P=0.200 |
|LOGISTIC REGRESSION | P=0.032 * P=0.643 P=0.050 * | P=0.119 P=0.458 P=0.200 |
|COCHRAN-ARMITAGE | P=0.124 | P=0.142 |
|FISHER EXACT | P=0.509N P=0.181 | P=0.504 P=0.248 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 5/60 (8%) | 1/60 (2%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 6.6% 6.7% 20.8% | 2.7% 3.3% 6.5% |
|TERMINAL (d) | 1/41 (2%) 2/30 (7%) 5/24 (21%) | 1/37 (3%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 681 738 (T) 738 (T) | 743 (T) 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098 P=0.633N P=0.132 | P=0.324 P=0.715 P=0.438 |
|INCIDENTAL TUMOR | P=0.119 P=0.603N P=0.167 | P=0.324 P=0.715 P=0.438 |
|LOGISTIC REGRESSION | P=0.122 P=0.592N P=0.169 | P=0.324 P=0.715 P=0.438 |
|COCHRAN-ARMITAGE | P=0.275 | P=0.378 |
|FISHER EXACT | P=0.500N P=0.359 | P=0.748N P=0.500 |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 2/60 (3%) 5/60 (8%) | 2/60 (3%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 8.4% 6.7% 20.8% | 5.4% 3.3% 6.5% |
|TERMINAL (d) | 1/41 (2%) 2/30 (7%) 5/24 (21%) | 2/37 (5%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 605 738 (T) 738 (T) | 743 (T) 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190 P=0.475N P=0.230 | P=0.542 P=0.573N P=0.630 |
|INCIDENTAL TUMOR | P=0.239 P=0.396N P=0.307 | P=0.542 P=0.573N P=0.630 |
|LOGISTIC REGRESSION | P=0.246 P=0.390N P=0.310 | P=0.542 P=0.573N P=0.630 |
|COCHRAN-ARMITAGE | P=0.424 | P=0.610 |
|FISHER EXACT | P=0.340N P=0.500 | P=0.494N P=0.691N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) | 3/60 (5%) 1/61 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.0% 1.7% 0.0% |
|TERMINAL (d) | 0/41 (0%) 0/30 (0%) 0/24 (0%) | 2/37 (5%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 342 350 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.077N P=0.341N P=0.149N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.018N* P=0.331N P=0.072N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.023N* P=0.227N P=0.084N |
|COCHRAN-ARMITAGE | (e) | P=0.060N |
|FISHER EXACT | (e) (e) | P=0.303N P=0.122N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) | 4/60 (7%) 2/61 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 9.7% 3.6% 0.0% |
|TERMINAL (d) | 0/41 (0%) 0/30 (0%) 0/24 (0%) | 3/37 (8%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 342 350 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.055N P=0.389N P=0.085N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.017N* P=0.355N P=0.041N* |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.015N* P=0.261N P=0.051N |
|COCHRAN-ARMITAGE | (e) | P=0.037N* |
|FISHER EXACT | (e) (e) | P=0.332N P=0.059N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) 2/60 (3%) | 26/60 (43%) 24/61 (39%) 18/60 (30%) |
|ADJUSTED (b) | 9.8% 19.2% 8.3% | 61.3% 56.8% 50.5% |
|TERMINAL (d) | 4/41 (10%) 5/30 (17%) 2/24 (8%) | 21/37 (57%) 13/30 (43%) 14/31 (45%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 717 738 (T) | 639 504 496 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.196 P=0.599N | P=0.283N P=0.387 P=0.285N |
|INCIDENTAL TUMOR | P=0.570N P=0.204 P=0.599N | P=0.224N P=0.544N P=0.250N |
|LOGISTIC REGRESSION | P=0.567N P=0.200 P=0.599N | P=0.238N P=0.571N P=0.280N |
|COCHRAN-ARMITAGE | P=0.292N | P=0.079N |
|FISHER EXACT | P=0.372 P=0.340N | P=0.397N P=0.092N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) 2/60 (3%) | 26/60 (43%) 25/61 (41%) 18/60 (30%) |
|ADJUSTED (b) | 9.8% 19.2% 8.3% | 61.3% 57.6% 50.5% |
|TERMINAL (d) | 4/41 (10%) 5/30 (17%) 2/24 (8%) | 21/37 (57%) 13/30 (43%) 14/31 (45%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 717 738 (T) | 639 504 496 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.196 P=0.599N | P=0.289N P=0.323 P=0.285N |
|INCIDENTAL TUMOR | P=0.570N P=0.204 P=0.599N | P=0.236N P=0.544 P=0.250N |
|LOGISTIC REGRESSION | P=0.567N P=0.200 P=0.599N | P=0.234N P=0.523 P=0.280N |
|COCHRAN-ARMITAGE | P=0.292N | P=0.079N |
|FISHER EXACT | P=0.372 P=0.340N | P=0.469N P=0.092N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) 2/60 (3%) | 27/60 (45%) 26/61 (43%) 18/60 (30%) |
|ADJUSTED (b) | 9.8% 19.2% 8.3% | 62.0% 58.3% 50.5% |
|TERMINAL (d) | 4/41 (10%) 5/30 (17%) 2/24 (8%) | 21/37 (57%) 13/30 (43%) 14/31 (45%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 717 738 (T) | 342 350 496 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.553 P=0.196 P=0.599N | P=0.239N P=0.329 P=0.228N |
|INCIDENTAL TUMOR | P=0.570N P=0.204 P=0.599N | P=0.141N P=0.543 P=0.164N |
|LOGISTIC REGRESSION | P=0.567N P=0.200 P=0.599N | P=0.151N P=0.552N P=0.198N |
|COCHRAN-ARMITAGE | P=0.292N | P=0.056N |
|FISHER EXACT | P=0.372 P=0.340N | P=0.468N P=0.066N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 4/56 (7%) 0/59 (0%) | 1/60 (2%) 1/61 (2%) 1/59 (2%) |
|ADJUSTED (b) | 0.0% 12.1% 0.0% | 2.7% 3.3% 3.2% |
|TERMINAL (d) | 0/40 (0%) 3/30 (10%) 0/23 (0%) | 1/37 (3%) 1/30 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- 611 --- | 743 (T) 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.468 P=0.036 * (e) | P=0.588 P=0.715 P=0.722 |
|INCIDENTAL TUMOR | P=0.511 P=0.047 * (e) | P=0.588 P=0.715 P=0.722 |
|LOGISTIC REGRESSION | P=0.525 P=0.043 * (e) | P=0.588 P=0.715 P=0.722 |
|COCHRAN-ARMITAGE | P=0.621 | P=0.635 |
|FISHER EXACT | P=0.053 (e) | P=0.748N P=0.748 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/56 (41%) 20/59 (34%) 14/56 (25%) | 29/59 (49%) 23/59 (39%) 16/60 (27%) |
|ADJUSTED (b) | 50.1% 52.2% 39.7% | 62.3% 58.0% 42.3% |
|TERMINAL (d) | 17/39 (44%) 13/30 (43%) 6/24 (25%) | 20/37 (54%) 15/30 (50%) 10/31 (32%) |
|FIRST INCIDENCE (DAYS) | 579 400 465 | 549 574 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.481N P=0.402 P=0.493N | P=0.079N P=0.481N P=0.089N |
|INCIDENTAL TUMOR | P=0.189N P=0.517N P=0.194N | P=0.072N P=0.276N P=0.083N |
|LOGISTIC REGRESSION | P=0.159N P=0.478N P=0.171N | P=0.032N* P=0.267N P=0.041N* |
|COCHRAN-ARMITAGE | P=0.044N* | P=0.008N** |
|FISHER EXACT | P=0.274N P=0.054N | P=0.177N P=0.009N** |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 0/61 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.9% 0.0% 4.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/41 (5%) 0/30 (0%) 1/24 (4%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 738 (T) --- 738 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.511N P=0.309N P=0.683N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.511N P=0.309N P=0.683N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.511N P=0.309N P=0.683N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.361N | (e) |
|FISHER EXACT | P=0.248N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 1/60 (2%) | 1/60 (2%) 0/61 (0%) 0/60 (0%) |
|ADJUSTED (b) | 7.3% 0.0% 4.2% | 2.7% 0.0% 0.0% |
|TERMINAL (d) | 3/41 (7%) 0/30 (0%) 1/24 (4%) | 1/37 (3%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 738 (T) --- 738 (T) | 743 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311N P=0.181N P=0.510N | P=0.299N P=0.542N P=0.535N |
|INCIDENTAL TUMOR | P=0.311N P=0.181N P=0.510N | P=0.299N P=0.542N P=0.535N |
|LOGISTIC REGRESSION | P=0.311N P=0.181N P=0.510N | P=0.299N P=0.542N P=0.535N |
|COCHRAN-ARMITAGE | P=0.176N | P=0.269N |
|FISHER EXACT | P=0.122N P=0.309N | P=0.496N P=0.500N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 2/60 (3%) 3/60 (5%) | 0/60 (0%) 1/61 (2%) 0/60 (0%) |
|ADJUSTED (b) | 11.0% 5.3% 9.1% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 3/41 (7%) 1/30 (3%) 1/24 (4%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 499 553 465 | --- 707 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N P=0.339N P=0.607N | P=0.698 P=0.468 (e) |
|INCIDENTAL TUMOR | P=0.313N P=0.212N P=0.371N | P=0.714 P=0.533 (e) |
|LOGISTIC REGRESSION | P=0.298N P=0.215N P=0.392N | P=0.712 P=0.489 (e) |
|COCHRAN-ARMITAGE | P=0.275N | P=0.731 |
|FISHER EXACT | P=0.219N P=0.359N | P=0.504 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 0/60 (0%) | 1/60 (2%) 0/61 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 5.0% 0.0% | 2.2% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 1/30 (3%) 0/24 (0%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 306 --- | 688 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.473N P=0.424 P=0.607N | P=0.313N P=0.538N P=0.560N |
|INCIDENTAL TUMOR | P=0.226N P=0.691 P=0.607N | P=0.286N P=0.467N P=0.540N |
|LOGISTIC REGRESSION | P=0.278N P=0.627 P=0.607N | P=0.278N P=0.501N P=0.517N |
|COCHRAN-ARMITAGE | P=0.361N | P=0.269N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.496N P=0.500N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 4/60 (7%) 3/60 (5%) | 1/60 (2%) 1/61 (2%) 1/60 (2%) |
|ADJUSTED (b) | 15.7% 10.2% 9.1% | 2.2% 2.9% 1.9% |
|TERMINAL (d) | 5/41 (12%) 2/30 (7%) 1/24 (4%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 499 306 465 | 688 707 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.312N P=0.426N P=0.403N | P=0.584 P=0.721 P=0.718 |
|INCIDENTAL TUMOR | P=0.111N P=0.196N P=0.211N | P=0.557N P=0.727N P=0.644N |
|LOGISTIC REGRESSION | P=0.113N P=0.220N P=0.215N | P=0.597N P=0.758 P=0.705N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.640 |
|FISHER EXACT | P=0.264N P=0.161N | P=0.748N P=0.752N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 0/60 (0%) | 1/60 (2%) 1/61 (2%) 1/60 (2%) |
|ADJUSTED (b) | 4.9% 5.0% 0.0% | 2.2% 2.9% 1.9% |
|TERMINAL (d) | 2/41 (5%) 1/30 (3%) 0/24 (0%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 306 --- | 688 707 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.284N P=0.604 P=0.362N | P=0.584 P=0.721 P=0.718 |
|INCIDENTAL TUMOR | P=0.116N P=0.609N P=0.362N | P=0.557N P=0.727N P=0.644N |
|LOGISTIC REGRESSION | P=0.145N P=0.634N P=0.362N | P=0.597N P=0.758 P=0.705N |
|COCHRAN-ARMITAGE | P=0.176N | P=0.640 |
|FISHER EXACT | P=0.691N P=0.248N | P=0.748N P=0.752N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 4/60 (7%) 1/60 (2%) | 0/60 (0%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 13.3% 4.2% | 0.0% 3.3% 6.5% |
|TERMINAL (d) | 0/41 (0%) 4/30 (13%) 1/24 (4%) | 0/37 (0%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | --- 738 (T) 738 (T) | --- 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|INCIDENTAL TUMOR | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|LOGISTIC REGRESSION | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|COCHRAN-ARMITAGE | P=0.391 | P=0.142 |
|FISHER EXACT | P=0.059 P=0.500 | P=0.504 P=0.248 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 4/60 (7%) 1/60 (2%) | 0/60 (0%) 1/61 (2%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 13.3% 4.2% | 0.0% 3.3% 6.5% |
|TERMINAL (d) | 0/41 (0%) 4/30 (13%) 1/24 (4%) | 0/37 (0%) 1/30 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | --- 738 (T) 738 (T) | --- 743 (T) 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|INCIDENTAL TUMOR | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|LOGISTIC REGRESSION | P=0.215 P=0.031 * P=0.393 | P=0.119 P=0.458 P=0.200 |
|COCHRAN-ARMITAGE | P=0.391 | P=0.142 |
|FISHER EXACT | P=0.059 P=0.500 | P=0.504 P=0.248 |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 51/60 (85%) 50/60 (83%) 46/60 (77%) | |
|ADJUSTED (b) | 92.6% 96.1% 100.0% | |
|TERMINAL (d) | 37/41 (90%) 28/30 (93%) 24/24 (100%) | |
|FIRST INCIDENCE (DAYS) | 474 474 405 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.031 * P=0.004 ** | |
|INCIDENTAL TUMOR | P=0.037 * P=0.263 P=0.057 | |
|LOGISTIC REGRESSION | P=0.018 * P=0.195 P=0.042 * | |
|COCHRAN-ARMITAGE | P=0.144N | |
|FISHER EXACT | P=0.500N P=0.177N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 9/55 (16%) 9/58 (16%) | 9/60 (15%) 8/57 (14%) 7/59 (12%) |
|ADJUSTED (b) | 29.3% 23.7% 26.8% | 22.4% 22.4% 21.4% |
|TERMINAL (d) | 12/41 (29%) 4/30 (13%) 2/24 (8%) | 7/37 (19%) 4/30 (13%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 509 612 | 622 631 653 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383 P=0.594 P=0.405 | P=0.500N P=0.546 P=0.548N |
|INCIDENTAL TUMOR | P=0.544N P=0.526N P=0.534 | P=0.524N P=0.573N P=0.574N |
|LOGISTIC REGRESSION | P=0.549 P=0.512N P=0.538 | P=0.501N P=0.601N P=0.558N |
|COCHRAN-ARMITAGE | P=0.300N | P=0.358N |
|FISHER EXACT | P=0.398N P=0.347N | P=0.546N P=0.409N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/55 (0%) 1/58 (2%) | 1/60 (2%) 3/57 (5%) 0/59 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 3.2% | 1.8% 10.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 0/30 (0%) 0/24 (0%) | 0/37 (0%) 3/30 (10%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 738 (T) --- 690 | 598 743 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.565 P=0.562N P=0.654 | P=0.443N P=0.243 P=0.549N |
|INCIDENTAL TUMOR | P=0.608 P=0.562N P=0.702 | P=0.469N P=0.262 P=0.638N |
|LOGISTIC REGRESSION | P=0.591 P=0.562N P=0.685 | P=0.424N P=0.277 P=0.461N |
|COCHRAN-ARMITAGE | P=0.659 | P=0.385N |
|FISHER EXACT | P=0.522N P=0.744 | P=0.290 P=0.504N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/60 (22%) 9/55 (16%) 9/58 (16%) | 10/60 (17%) 11/57 (19%) 7/59 (12%) |
|ADJUSTED (b) | 31.7% 23.7% 26.8% | 23.8% 31.4% 21.4% |
|TERMINAL (d) | 13/41 (32%) 4/30 (13%) 2/24 (8%) | 7/37 (19%) 7/30 (23%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | 738 (T) 509 612 | 598 631 653 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.460 P=0.516N P=0.476 | P=0.428N P=0.326 P=0.455N |
|INCIDENTAL TUMOR | P=0.463N P=0.445N P=0.589N | P=0.459N P=0.409 P=0.501N |
|LOGISTIC REGRESSION | P=0.467N P=0.430N P=0.583N | P=0.420N P=0.394 P=0.446N |
|COCHRAN-ARMITAGE | P=0.225N | P=0.279N |
|FISHER EXACT | P=0.315N P=0.268N | P=0.448 P=0.314N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/55 (2%) 1/58 (2%) | 1/60 (2%) 0/57 (0%) 1/59 (2%) |
|ADJUSTED (b) | 4.4% 3.3% 4.2% | 2.7% 0.0% 2.9% |
|TERMINAL (d) | 1/41 (2%) 1/30 (3%) 1/24 (4%) | 1/37 (3%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 647 738 (T) 738 (T) | 743 (T) --- 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.543N P=0.603N P=0.667N | P=0.615 P=0.542N P=0.709 |
|INCIDENTAL TUMOR | P=0.509N P=0.597N P=0.622N | P=0.630 P=0.542N P=0.718 |
|LOGISTIC REGRESSION | P=0.495N P=0.566N P=0.611N | P=0.631 P=0.542N P=0.725 |
|COCHRAN-ARMITAGE | P=0.391N | P=0.664 |
|FISHER EXACT | P=0.533N P=0.513N | P=0.513N P=0.748 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 11/60 (18%) 10/61 (16%) 16/60 (27%) |
|ADJUSTED (b) | | 25.3% 25.8% 43.2% |
|TERMINAL (d) | | 7/37 (19%) 5/30 (17%) 11/31 (35%) |
|FIRST INCIDENCE (DAYS) | | 384 570 493 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.072 P=0.525 P=0.087 |
|INCIDENTAL TUMOR | | P=0.067 P=0.487N P=0.100 |
|LOGISTIC REGRESSION | | P=0.086 P=0.504N P=0.103 |
|COCHRAN-ARMITAGE | | P=0.154 |
|FISHER EXACT | | P=0.483N P=0.191 |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/61 (0%) 1/60 (2%) |
|ADJUSTED (b) | 6.7% 5.2% 4.2% | 0.0% 0.0% 3.2% |
|TERMINAL (d) | 2/41 (5%) 1/30 (3%) 1/24 (4%) | 0/37 (0%) 0/30 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 605 484 738 (T) | --- --- 743 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379N P=0.612N P=0.482N | P=0.250 (e) P=0.465 |
|INCIDENTAL TUMOR | P=0.278N P=0.456N P=0.426N | P=0.250 (e) P=0.465 |
|LOGISTIC REGRESSION | P=0.258N P=0.474N P=0.406N | P=0.250 (e) P=0.465 |
|COCHRAN-ARMITAGE | P=0.223N | P=0.269 |
|FISHER EXACT | P=0.500N P=0.309N | (e) P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 12/60 (20%) 11/60 (18%) | 21/60 (35%) 20/61 (33%) 15/60 (25%) |
|ADJUSTED (b) | 30.9% 36.3% 35.3% | 43.3% 45.5% 41.7% |
|TERMINAL (d) | 9/41 (22%) 10/30 (33%) 5/24 (21%) | 11/37 (30%) 7/30 (23%) 11/31 (35%) |
|FIRST INCIDENCE (DAYS) | 474 474 612 | 598 570 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356 P=0.514 P=0.407 | P=0.372N P=0.403 P=0.377N |
|INCIDENTAL TUMOR | P=0.511N P=0.501N P=0.493N | P=0.370N P=0.443N P=0.406N |
|LOGISTIC REGRESSION | P=0.512N P=0.481N P=0.537N | P=0.252N P=0.477N P=0.283N |
|COCHRAN-ARMITAGE | P=0.217N | P=0.139N |
|FISHER EXACT | P=0.331N P=0.253N | P=0.474N P=0.160N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 4/60 (7%) | 0/60 (0%) 0/61 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 8.7% 13.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/41 (0%) 2/30 (7%) 2/24 (8%) | 0/37 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- 583 618 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017 * P=0.081 P=0.023 * | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.026 * P=0.107 P=0.042 * | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.027 * P=0.105 P=0.035 * | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.049 * | (e) |
|FISHER EXACT | P=0.122 P=0.059 | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 59/60 (98%) 55/60 (92%) 48/60 (80%) | 46/60 (77%) 50/61 (82%) 40/60 (67%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 88.2% 94.3% 88.7% |
|TERMINAL (d) | 41/41 (100%) 30/30 (100%) 24/24 (100%) | 31/37 (84%) 27/30 (90%) 26/31 (84%) |
|FIRST INCIDENCE (DAYS) | 474 400 405 | 384 504 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021 * P=0.052 P=0.025 * | P=0.366 P=0.046 * P=0.431 |
|INCIDENTAL TUMOR | P=0.609 P=0.700 P=0.729 | P=0.403 P=0.176 P=0.469 |
|LOGISTIC REGRESSION | P=0.396 P=0.556 P=0.572 | P=0.525 P=0.152 P=0.588 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.123N |
|FISHER EXACT | P=0.103N P=0.001N** | P=0.310 P=0.156N |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.025 G/ 0.05 G/K | VEHICLE 0.025 G/ 0.05 G/K |
| | 79VM KG 79 LM G 79 HM | 79 VF KG 79 LF G 79 HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/60 (40%) 19/60 (32%) 19/60 (32%) | 30/60 (50%) 25/61 (41%) 18/60 (30%) |
|ADJUSTED (b) | 45.4% 50.1% 54.5% | 59.1% 55.7% 45.6% |
|TERMINAL (d) | 13/41 (32%) 13/30 (43%) 9/24 (38%) | 17/37 (46%) 11/30 (37%) 11/31 (35%) |
|FIRST INCIDENCE (DAYS) | 474 306 612 | 342 350 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239 P=0.513 P=0.258 | P=0.136N P=0.540N P=0.136N |
|INCIDENTAL TUMOR | P=0.457N P=0.277N P=0.525N | P=0.060N P=0.235N P=0.081N |
|LOGISTIC REGRESSION | P=0.474N P=0.270N P=0.532N | P=0.037N* P=0.247N P=0.044N* |
|COCHRAN-ARMITAGE | P=0.194N | P=0.016N* |
|FISHER EXACT | P=0.223N P=0.223N | P=0.208N P=0.020N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 60/60 (100%) 56/60 (93%) 48/60 (80%) | 56/60 (93%) 53/61 (87%) 46/60 (77%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 96.5% 96.3% 93.8% |
|TERMINAL (d) | 41/41 (100%) 30/30 (100%) 24/24 (100%) | 35/37 (95%) 28/30 (93%) 28/31 (90%) |
|FIRST INCIDENCE (DAYS) | 474 306 405 | 342 350 344 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.054 P=0.035 * | P=0.519N P=0.226 P=0.524N |
|INCIDENTAL TUMOR | P=0.173N P=0.500N P=0.470N | P=0.196N P=0.310N P=0.265N |
|LOGISTIC REGRESSION | P=0.348N P=0.853N P=0.470N | P=0.092N P=0.267N P=0.119N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.007N** |
|FISHER EXACT | P=0.059N P<0.001N** | P=0.189N P=0.010N** |
|=================================================================================================================================|
DATE: 09/06/94 EXPERIMENT: 05047 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TITANOCENE DICHLORIDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 107 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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