TR 399 Rat Pathology Tables
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
Facility: TSI Mason Research
Chemical CAS #: 1271-19-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|
| 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | |
Fatty Change, Diffuse | 2 2 2 |
Fatty Change, Focal | 2 2 1 2|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X |
Necrosis | 1 2 |
Pigmentation | 2 2 |
Thrombosis | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 2 |
Hyperkeratosis | 1 2 3 2 |
Inflammation, Acute | |
Necrosis | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Cardiomyopathy | 2 1 2 2 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|
| 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + M + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | 2 2 2 3 3 3 2 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 2 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|
| 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 2 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 2 3 2 3 2 2 2 2 3 2 |
Infiltration Cellular, Histiocyte | 2 2 3 1 3 2 2 2 2 3 3 |
Necrosis | |
Pigmentation, Hemosiderin | 2 2 2 2 2 3|
Pigmentation | |
Capsule, Hemorrhage | |
Capsule, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + M|
Cyst | X |
Depletion Lymphoid | |
Pigmentation | 1 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + M + M + + + +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 1 |
Bacterium | 2 |
Congestion | 3 2 |
Edema | 2 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 3 1 1|
Inflammation, Acute | 2 |
Metaplasia, Osseous | |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|
| 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Synechia | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Inflammation, Chronic Active | 2 |
Nephropathy | 1 1 1 3 1 1 1 2 1 2 2 |
Cortex, Mineralization | 1 1 |
Papilla, Mineralization | 1 1 |
Pelvis, Mineralization | |
Renal Tubule, Pigmentation | 2 1 2 2 2 2 2 2 1 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|
DAY ON TEST | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|
| 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Parasite | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Fatty Change, Diffuse | 2 2 |
Fatty Change, Focal | 1 1 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Necrosis | 2 |
Pigmentation | 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Acanthosis | 3 2 |
Hyperkeratosis | 2 |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Erosion | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Bacterium | |
Cardiomyopathy | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|
DAY ON TEST | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|
| 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + |
Cyst | |
Pars Distalis, Angiectasis | 3 3 2 2 2 3 2 3 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Cervix, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Mediastinal, Angiectasis | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 2 |
Mediastinal, Pigmentation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Degeneration, Cystic | 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|
DAY ON TEST | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|
| 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 3 1 2 |
Infiltration Cellular, Histiocyte | 3 3 2 2 3 2 2 2 |
Necrosis | 2 3 |
Pigmentation, Hemosiderin | 3 1 2 |
Pigmentation | 2 |
Capsule, Hemorrhage | |
Capsule, Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + M + + + |
Cyst | |
Depletion Lymphoid | |
Pigmentation | 1 1 1 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Galactocele | X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Atelectasis | 2 |
Bacterium | |
Congestion | |
Edema | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 1 |
Inflammation, Acute | 2 |
Metaplasia, Osseous | 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
Fungus | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|
DAY ON TEST | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|
| 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Synechia | 2 |
Lens, Cataract | |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Bacterium | |
Inflammation, Chronic Active | |
Nephropathy | 1 1 1 1 1 1 1 2 2 |
Cortex, Mineralization | 1 |
Papilla, Mineralization | 1 |
Pelvis, Mineralization | 2 |
Renal Tubule, Pigmentation | 2 1 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|
DAY ON TEST | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|
| 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + M + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | |
Fatty Change, Diffuse | 2 2 2 2 2 2|
Fatty Change, Focal | 1 2 1 1 2 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 3 2 2 |
Mixed Cell Focus | X |
Necrosis | |
Pigmentation | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 1 3 |
Hyperkeratosis | 2 2 2 1 2 |
Inflammation, Acute | 2 |
Necrosis | 3 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|
DAY ON TEST | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|
| 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 2 2 3 2 2 3 2 2 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + M + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Cervix, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 2 1 2 1 |
Mediastinal, Pigmentation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|
DAY ON TEST | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|
| 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 1 2 2 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 3 3 1 2 1 2 2 2 2 2 2 |
Necrosis | |
Pigmentation, Hemosiderin | |
Pigmentation | |
Capsule, Hemorrhage | 2 |
Capsule, Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | 2 |
Pigmentation | 1 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Atelectasis | 1 |
Bacterium | |
Congestion | 2 |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 2 1 2 1 |
Inflammation, Acute | |
Metaplasia, Osseous | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|
DAY ON TEST | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|
| 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
79 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Acute | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Synechia | |
Lens, Cataract | |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Chronic Active | |
Nephropathy | 2 1 2 1 1 2 2 2 1 1 3 |
Cortex, Mineralization | 1 |
Papilla, Mineralization | 1 1 |
Pelvis, Mineralization | 1 |
Renal Tubule, Pigmentation | 1 1 2 2 1 1 2 2 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 4| 0| 7| | |
| 0| 0| 4| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| | L |
79 VF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 57 |
Parasite | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + | 60 |
Basophilic Focus | X X X X | 45 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | | 1 1.0|
Fatty Change, Diffuse | | 11 2.0|
Fatty Change, Focal | 2 | 15 1.5|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Granulomatous | 1 2 | 6 2.0|
Mixed Cell Focus | | 2 |
Necrosis | | 3 1.7|
Pigmentation | | 3 1.7|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | 2 | 17 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 60 |
Acinus, Hyperplasia | | 6 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 60 |
Acanthosis | | 11 2.3|
Hyperkeratosis | | 10 1.9|
Inflammation, Acute | | 1 2.0|
Necrosis | | 6 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 60 |
Erosion | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 4| 0| 7| | |
| 0| 0| 4| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| | L |
79 VF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 60 |
Bacterium | | 1 1.0|
Cardiomyopathy | | 23 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 59 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 58 |
Hyperplasia | | 13 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 59 |
Cyst | | 1 |
Pars Distalis, Angiectasis | | 27 2.4|
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia | 2 | 13 1.9|
Pars Distalis, Pigmentation | 2 | 1 2.0|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 60 |
C-Cell, Hyperplasia | | 8 1.3|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 56 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + M | 58 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + | 60 |
Cervix, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 4| 0| 7| | |
| 0| 0| 4| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| | L |
79 VF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 12 1.8|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M | 56 |
Infiltration Cellular, Histiocyte | | 9 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 60 |
Degeneration, Cystic | | 1 3.0|
Infiltration Cellular, Histiocyte | | 27 1.9|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 60 |
Depletion Lymphoid | | 2 2.0|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 | 33 2.1|
Infiltration Cellular, Histiocyte | 2 2 | 34 2.2|
Necrosis | | 2 2.5|
Pigmentation, Hemosiderin | | 9 2.1|
Pigmentation | | 1 2.0|
Capsule, Hemorrhage | | 1 2.0|
Capsule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + | 55 |
Cyst | | 1 |
Depletion Lymphoid | | 1 2.0|
Pigmentation | | 5 1.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + | 56 |
Galactocele | | 21 |
__________________________________________________________________________|____________|
Skin | + + + + | 60 |
Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 4| 0| 7| | |
| 0| 0| 4| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
VEHICLE | 4| 4| 4| 4| 4| | L |
79 VF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 60 |
Atelectasis | | 3 1.3|
Bacterium | | 1 2.0|
Congestion | | 3 2.3|
Edema | | 3 1.7|
Hemorrhage | | 2 2.0|
Infiltration Cellular, Histiocyte | 3 | 22 1.5|
Inflammation, Acute | | 2 2.0|
Metaplasia, Osseous | | 1 2.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 60 |
Fungus | | 1 2.0|
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute | 1 | 7 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Synechia | 2 | 2 2.0|
Lens, Cataract | 2 | 1 2.0|
Retina, Atrophy | 2 | 3 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 60 |
Bacterium | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Nephropathy | 1 | 32 1.4|
Cortex, Mineralization | | 4 1.0|
Papilla, Mineralization | | 5 1.0|
Pelvis, Mineralization | | 2 1.5|
Renal Tubule, Pigmentation | 1 1 2 | 35 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 60 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|
DAY ON TEST | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|
| 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + M + + + + + + |
Erosion | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + |
Hyperplasia, Adenomatous | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + |
Fibrosis | |
Inflammation, Acute | |
Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + |
Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | |
Fatty Change, Diffuse | 2 3 |
Fatty Change, Focal | 2 2 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Inflammation, Granulomatous | 1 3 2 1 1 1 2 3 2 |
Mixed Cell Focus | X X |
Necrosis | 1 |
Pigmentation | 1 1 1 1 2 1 2 1 1 1 2 1 1 1 1 2 1 |
Bile Duct, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 3 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
Fat, Proliferation | 1 1 1 1 1 |
Polyp Adenomatous, Inflammation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 2 2 2 |
Hyperkeratosis | 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|
DAY ON TEST | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|
| 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Erosion | 1 1 1 |
Fibrosis | 1 1 2 1 2 2 2 2 2 2 2 |
Hemorrhage | |
Hyperplasia | 1 2 1 2 2 1 1 |
Hyperplasia, Adenomatous | 2 |
Inflammation, Acute | 1 |
Metaplasia | 1 1 1 1 2 2 1 2 1 |
Mineralization | 2 |
Pigmentation | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 2 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Degeneration, Cystic | 3 |
Degeneration | |
Hemorrhage | |
Hyperplasia | 2 2 |
Necrosis | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 2 2 2 2 2 2 3 1 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + A + + + |
C-Cell, Hyperplasia | 1 2 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|
DAY ON TEST | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|
| 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Degeneration, Cystic | |
Hyperplasia, Tubular | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 2 2 2 1 1 1 |
Mediastinal, Pigmentation | 1 1 2 2 1 1 1 |
Pancreatic, Angiectasis | 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Pigmentation | 2 2 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M |
Infiltration Cellular, Histiocyte | 2 1 1 |
Pigmentation | 1 1 1 2 2 1 2 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 1 2 2 2 2 2 2 |
Pigmentation | 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 2 2 2 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 1 1 2 2 2 2 |
Pigmentation, Hemosiderin | 1 2 2 2 2 2 2 2 |
Pigmentation | 2 2 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Depletion Lymphoid | |
Pigmentation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|
DAY ON TEST | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|
| 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + M + + |
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Atelectasis | 2 1 |
Congestion | 3 2 |
Edema | 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 2 1 1 1 2 2 1 1 1 1 1 1 1 1 2 2 2 |
Inflammation, Acute | 3 |
Inflammation, Granulomatous | 1 |
Pigmentation | 1 1 1 1 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Fungus | |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Canal, Abscess | 4 |
__________________________________________________________________________|
Eye | + + |
Inflammation, Acute | |
Synechia | |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + + |
Pigmentation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Nephropathy | 1 1 2 1 1 2 1 2 1 1 2 |
Cortex, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|
DAY ON TEST | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|
| 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Mineralization | 1 1 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 2 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|
| 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + |
Erosion | 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + A + + + A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + A + + + + + + + + + + |
Hyperplasia, Adenomatous | |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + A + + + + + A + + + + |
Fibrosis | |
Inflammation, Acute | |
Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + + A + + + + |
Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Fatty Change, Diffuse | 2 4 2 |
Fatty Change, Focal | 2 2 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Inflammation, Granulomatous | 2 2 1 2 2 2 |
Mixed Cell Focus | X X X |
Necrosis | 2 2 |
Pigmentation | 2 1 1 2 1 2 2 1 2 2 1 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + |
Fat, Proliferation | 1 1 1 |
Polyp Adenomatous, Inflammation | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + |
Acanthosis | 2 2 2 2 2 2 |
Hyperkeratosis | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|
| 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + |
Erosion | 2 2 2 |
Fibrosis | 2 2 2 1 1 4 3 2 2 1 2 2 |
Hemorrhage | |
Hyperplasia | 1 1 2 1 1 1 1 |
Hyperplasia, Adenomatous | |
Inflammation, Acute | |
Metaplasia | 2 2 1 1 1 1 1 2 |
Mineralization | 2 2 2 2 1 |
Pigmentation | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 |
Mineralization | 2 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Degeneration, Cystic | |
Degeneration | 3 |
Hemorrhage | 2 |
Hyperplasia | |
Necrosis | |
Pigmentation, Ceroid | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 3 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 |
Pars Intermedia, Cyst | |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + A + + + + |
C-Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|
| 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Cyst | X X |
Degeneration, Cystic | 2 |
Hyperplasia, Tubular | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 2 2 1 1 1 |
Mediastinal, Pigmentation | 1 2 2 2 1 2 1 |
Pancreatic, Angiectasis | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 2 2 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + M + + + + |
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 2 2 2 2 2 2 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 1 2 2 1 2 |
Pigmentation, Hemosiderin | 1 2 1 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + + + + + + |
Cyst | |
Depletion Lymphoid | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|
| 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + M + + + + + |
Galactocele | X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Atelectasis | 2 2 |
Congestion | 3 |
Edema | 2 |
Hemorrhage | 2 3 2 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 2 1 1 2 1 2 |
Inflammation, Acute | 1 |
Inflammation, Granulomatous | |
Pigmentation | 2 1 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Fungus | |
Inflammation, Acute | 2 1 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Abscess | |
__________________________________________________________________________|
Eye | + |
Inflammation, Acute | |
Synechia | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Cyst | |
Nephropathy | 2 1 2 2 1 2 1 1 1 |
Cortex, Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|
DAY ON TEST | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|
| 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Mineralization | 2 1 |
Renal Tubule, Pigmentation | 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + A + + + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|
| 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | |
Pigmentation | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Acute | 3 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X|
Degeneration, Cystic | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 1 2 2 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 2 |
Inflammation, Granulomatous | 2 2 2 3 1 2 1|
Mixed Cell Focus | |
Necrosis | 1 2 |
Pigmentation | 2 1 2 1 1 1 1 1 1 2 1 1 1 1|
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 2 4 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | 1 1 1 1 1 1 |
Polyp Adenomatous, Inflammation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 2 3 2|
Hyperkeratosis | 2 2 2 2 2 2 3 2 3 2|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|
| 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 1 1 2 |
Fibrosis | 2 1 2 2 2 2 2 2 1 2 2 2 2 2 |
Hemorrhage | 2 1 1 |
Hyperplasia | 1 1 2 1 1 1 1 1 2 3 |
Hyperplasia, Adenomatous | |
Inflammation, Acute | 2 2 1 |
Metaplasia | 1 1 1 2 2 1 1 2 1 1 2 2 1 1 1 1|
Mineralization | 2 |
Pigmentation | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Degeneration | |
Hemorrhage | |
Hyperplasia | |
Necrosis | 2 |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 3 |
Pars Intermedia, Cyst | |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + M + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|
| 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Degeneration, Cystic | |
Hyperplasia, Tubular | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 2 1 |
Mediastinal, Pigmentation | 2 1 1 2 2 2 2 |
Pancreatic, Angiectasis | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Pigmentation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 1 1 2 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 3 2 2 3 2 2 2 2 2|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 1 1 3 2 2 1 3 2 1 2 2 3 2|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 2 2 2 2 1 2 1|
Pigmentation, Hemosiderin | 1 1 1 2 2 2 2 2|
Pigmentation | 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + + + + + + M|
Cyst | |
Depletion Lymphoid | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|
| 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 2 |
Edema | 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 2 1 1 2 1 2 1 1 1 1 1 1 2 1 2|
Inflammation, Acute | 1 1 |
Inflammation, Granulomatous | 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Abscess | |
__________________________________________________________________________|
Eye | + + + + + + + + |
Inflammation, Acute | 2 |
Synechia | 2 |
Lens, Cataract | 3 2 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 2|
Cortex, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|
| 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.025 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 79 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Mineralization | 1 1 1|
Renal Tubule, Pigmentation | 1 2 2 1 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| | |
DAY ON TEST | 4| 4| 4| 3| 7| | |
| 4| 4| 9| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0.025 G/ | 0| 0| 0| 0| 0| | L |
KG 79 LF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 59 |
Erosion | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 57 |
Hyperplasia, Adenomatous | | 1 2.0|
Pigmentation | 1 | 25 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 56 |
Fibrosis | | 1 2.0|
Inflammation, Acute | | 2 2.5|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 56 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + | 61 |
Angiectasis | | 2 1.0|
Basophilic Focus | X X X X | 45 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | | 1 1.0|
Fatty Change, Diffuse | | 6 2.5|
Fatty Change, Focal | | 11 1.5|
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia | | 1 2.0|
Inflammation, Granulomatous | 2 2 | 24 1.8|
Mixed Cell Focus | | 5 |
Necrosis | 1 | 6 1.5|
Pigmentation | 1 1 1 | 45 1.3|
Bile Duct, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Fat, Inflammation, Chronic Active | 2 | 2 2.0|
Fat, Necrosis | 4 | 7 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + | 61 |
Acinus, Atrophy | | 1 3.0|
Acinus, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 61 |
__________________________________________________________________________|____________|
Stomach | + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| | |
DAY ON TEST | 4| 4| 4| 3| 7| | |
| 4| 4| 9| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0.025 G/ | 0| 0| 0| 0| 0| | L |
KG 79 LF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Proliferation | 1 | 15 1.0|
Polyp Adenomatous, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 60 |
Acanthosis | 2 3 | 20 2.1|
Hyperkeratosis | 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 60 |
Erosion | | 11 1.4|
Fibrosis | 2 2 | 39 1.9|
Hemorrhage | | 3 1.3|
Hyperplasia | | 24 1.3|
Hyperplasia, Adenomatous | | 1 2.0|
Inflammation, Acute | | 4 1.5|
Metaplasia | 2 1 1 | 36 1.3|
Mineralization | | 7 1.9|
Pigmentation | 2 | 19 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 61 |
Cardiomyopathy | 2 2 2 | 23 2.0|
Mineralization | | 1 2.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 61 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 61 |
Degeneration, Cystic | | 1 3.0|
Degeneration | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 2 2.0|
Necrosis | | 1 2.0|
Pigmentation, Ceroid | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 60 |
Hyperplasia | 1 | 8 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 61 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 59 |
Pars Distalis, Angiectasis | | 21 2.1|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | | 18 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| | |
DAY ON TEST | 4| 4| 4| 3| 7| | |
| 4| 4| 9| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0.025 G/ | 0| 0| 0| 0| 0| | L |
KG 79 LF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Cyst | X | 1 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 57 |
C-Cell, Hyperplasia | 1 | 17 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M | 55 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + | 61 |
Cyst | | 6 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia, Tubular | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + | 61 |
Hemorrhage | | 2 3.0|
Endometrium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 61 |
Pigmentation | | 8 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 61 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 21 1.3|
Mediastinal, Pigmentation | 1 1 | 23 1.5|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 5 2.0|
Pancreatic, Pigmentation | 3 | 10 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 59 |
Infiltration Cellular, Histiocyte | 1 | 6 1.2|
Pigmentation | 2 2 1 | 34 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 61 |
Depletion Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 2 2 3 | 45 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| | |
DAY ON TEST | 4| 4| 4| 3| 7| | |
| 4| 4| 9| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0.025 G/ | 0| 0| 0| 0| 0| | L |
KG 79 LF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 2 3 2 | 47 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + | 60 |
Depletion Lymphoid | 2 | 3 1.7|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 | 43 2.1|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 1 | 28 1.6|
Pigmentation, Hemosiderin | 2 2 | 25 1.8|
Pigmentation | 2 2 2 | 34 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + | 56 |
Cyst | | 1 |
Depletion Lymphoid | | 1 2.0|
Pigmentation | 1 | 34 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 56 |
Galactocele | X | 12 |
__________________________________________________________________________|____________|
Skin | + + + + | 61 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 61 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 61 |
Hemorrhage | | 1 1.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 61 |
Atelectasis | 2 | 5 1.8|
Congestion | | 4 2.5|
Edema | 3 2 | 5 2.4|
Hemorrhage | 1 | 7 1.6|
Infiltration Cellular, Histiocyte | 2 3 1 2 | 48 1.4|
Inflammation, Acute | | 4 1.5|
Inflammation, Granulomatous | | 3 1.0|
Pigmentation | 1 1 2 | 23 1.2|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 61 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| | |
DAY ON TEST | 4| 4| 4| 3| 7| | |
| 4| 4| 9| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| | A |
0.025 G/ | 0| 0| 0| 0| 0| | L |
KG 79 LF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | 2 | 2 2.0|
Inflammation, Acute | 2 1 | 13 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + | 59 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Canal, Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 11 |
Inflammation, Acute | | 1 2.0|
Synechia | | 1 2.0|
Lens, Cataract | | 5 2.2|
__________________________________________________________________________|____________|
Harderian Gland | | 8 |
Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 61 |
Cyst | | 1 |
Nephropathy | 2 | 26 1.4|
Cortex, Mineralization | 1 | 4 1.5|
Papilla, Mineralization | 1 | 10 1.1|
Renal Tubule, Pigmentation | 1 1 1 | 32 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|
DAY ON TEST | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|
| 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + +|
Pigmentation | 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + +|
Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + +|
Pigmentation | 1 1 1 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 2 1 2 |
Fatty Change, Focal | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 2 2 1 1 2 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis | 2 |
Pigmentation | 1 1 2 1 1 1 2 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | |
Acinus, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | 3 4 2 4 2 2 1 3 3 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 1 2 1 3 |
Hyperkeratosis | 3 2 2 2 1 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|
DAY ON TEST | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|
| 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | 2 2 2 2 2 2 1 2 2 2 1 1 2 1 2 2 2 |
Hemorrhage | |
Hyperplasia | 1 2 1 1 2 1 1 |
Inflammation, Acute | 2 |
Metaplasia | 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1 1|
Mineralization | |
Pigmentation | 2 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M + + + + M + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia | 1 2 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Cyst | X |
Decidual Reaction | |
Hemorrhage | 3 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|
DAY ON TEST | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|
| 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | 2 |
Prolapse | X |
Thrombosis | |
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Lumbar, Degeneration, Cystic | |
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 2 2 1 1 2 1 2 2 2 1|
Mediastinal, Pigmentation | 1 1 1 2 2 2 2 1 1|
Pancreatic, Angiectasis | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 2 2 2 2 2 |
Pancreatic, Pigmentation | 3 2 3 3 2 2 2|
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 1 2 2 1 1 |
Pigmentation | 1 2 2 1 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Histiocyte | 3 2 3 2 2 3 3 2 2 3 2 2 |
Pigmentation | 2 2 3 2 2 3 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 2|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 1 2 1 2 3 2 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 2 2 1 1 |
Inflammation, Granulomatous | 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation | 1 2 1 2 1 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M M + + + + M M M|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|
DAY ON TEST | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|
| 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 2 |
Congestion | 1 |
Edema | 2 3|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 2 2 1 1 2 1 1 1 2|
Inflammation, Acute | 3 1 2 2|
Inflammation, Granulomatous | 1 2 1 |
Pigmentation | 1 1 1 1 1 1 2 2 1 1 |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 1 2 2 |
Submucosa, Glands, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
Inflammation, Acute | |
Canal, Abscess | 4 |
__________________________________________________________________________|
Eye | + + + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
Synechia | 2 1 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|
DAY ON TEST | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|
| 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 2 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
Pigmentation | 3 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 2 2 1 2 3 1 1 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 1 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 1 1 2 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|
DAY ON TEST | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|
| 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
0.05 G/K | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + A + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + + + + + + + +|
Pigmentation | 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 2 2 |
Fatty Change, Focal | 1 1 1 2 2 1 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 2 1 2 1 1 1 2 2 1 1 1 1|
Mixed Cell Focus | X |
Necrosis | 1 1 1 1 |
Pigmentation | 2 1 1 2 2 2 2 2 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic Active | 3 |
Acinus, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | 3 4 4 3 3 2 1 4 3 2 2 3 2 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 2 2 3 1 |
Hyperkeratosis | 2 2 2 2 2 2 2 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|
DAY ON TEST | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|
| 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
0.05 G/K | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | 2 1 3 2 2 2 2 2 2 2 3 2 2 2 2 |
Hemorrhage | 1 |
Hyperplasia | 1 1 2 2 1 2 2 2 |
Inflammation, Acute | 1 1 |
Metaplasia | 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1|
Mineralization | 1 |
Pigmentation | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 3 2 2 2 2 2 2 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 1 |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + M + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Decidual Reaction | |
Hemorrhage | 3 4 |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|
DAY ON TEST | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|
| 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
0.05 G/K | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | |
Prolapse | |
Thrombosis | 3 |
Cervix, Inflammation, Acute | 2 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + M + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Degeneration, Cystic | |
Mediastinal, Congestion | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 1 1 1 1 1|
Mediastinal, Pigmentation | 1 1 2 1 1 1 1 1 1|
Pancreatic, Angiectasis | 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 |
Pancreatic, Pigmentation | 2 1 2 3 3 |
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 2 1 |
Pigmentation | 2 1 1 1 1 2 1 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 3 2 2 2 3 3 2 1 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 2 3 1 2 2 3 3 2 2 2 3 2 1 3 2 2|
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 2 1 1 1 1 2 |
Inflammation, Granulomatous | |
Pigmentation, Hemosiderin | 2 1 2 2 2 2 2 2 2 2 1 2 2 2|
Pigmentation | 2 2 2 1 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|
DAY ON TEST | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|
| 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
0.05 G/K | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | X X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2|
Congestion | |
Edema | 2 2 2|
Hemorrhage | 3 1 |
Infiltration Cellular, Histiocyte | 2 1 2 2 1 1 1 2 1 1 1 1 1 1 1 2 2|
Inflammation, Acute | 3 3 2 1 |
Inflammation, Granulomatous | 2 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 2|
Pigmentation, Cholesterol | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 1 3 2 2 2 1 |
Submucosa, Glands, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Inflammation, Acute | 3 |
Canal, Abscess | 4 |
__________________________________________________________________________|
Eye | + + + + + |
Hemorrhage | 3 |
Inflammation, Acute | 4 |
Synechia | 2 |
Lens, Cataract | 3 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|
DAY ON TEST | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|
| 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
0.05 G/K | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + |
Pigmentation | 2 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 2 1 2 2 1 1 3 3 |
Cortex, Mineralization | 1 1 |
Papilla, Mineralization | 1 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 2 1 2 1 1 1 1 1 1 2 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|
| 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite | 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A|
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 2 2 |
Fatty Change, Focal | 2 1 1 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | 1 1 1 2 1 1 1 2 1 1 1 2 |
Mixed Cell Focus | X |
Necrosis | 1 1 |
Pigmentation | 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 2 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | 3 3 2 3 4 1 1 3 2 3 3 3 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 2 2 2 1 |
Hyperkeratosis | 2 2 1 2 2 1 |
Inflammation, Acute | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|
| 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | 2 2 2 2 1 2 1 1 1 2 2 2 1 2 2 2 2 1|
Hemorrhage | 1 |
Hyperplasia | 1 2 1 1 1 1 2 |
Inflammation, Acute | 1 |
Metaplasia | 2 1 1 2 1 2 1 1 1 1 2 1 1 2 2 1 2 |
Mineralization | 1 |
Pigmentation | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 2 1 2 2 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Decidual Reaction | 1 |
Hemorrhage | |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|
| 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | |
Prolapse | |
Thrombosis | |
Cervix, Inflammation, Acute | 3 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Lumbar, Degeneration, Cystic | 2 |
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 2 2 2 2 2|
Mediastinal, Pigmentation | 1 1 2 2 1 |
Pancreatic, Angiectasis | |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 2 3 3 2 |
Pancreatic, Pigmentation | 3 3 2 3 3 2 |
Renal, Angiectasis | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 |
Pigmentation | 2 1 2 1 2 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Histiocyte | 2 2 2 2 3 2 2 1 3 2 2 2 2 2 1 2 2 2|
Pigmentation | 2 2 3 2 3 3 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 3 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 3 2 1 2 3|
Inflammation, Granulomatous | |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + M + M M +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|
| 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | X X X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 2 |
Congestion | 3 |
Edema | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 2 2 1 1 2 1 1 1 2 1 1 |
Inflammation, Acute | 1 |
Inflammation, Granulomatous | 1 |
Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 2 2 3 2 3 |
Submucosa, Glands, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Acute | |
Canal, Abscess | |
__________________________________________________________________________|
Eye | + + + + + |
Hemorrhage | |
Inflammation, Acute | |
Synechia | |
Lens, Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|
| 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.05 G/K | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G 79 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + |
Pigmentation | 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 1 1 1 2 3 1 2 1 1 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 2 1 2 2 2 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| | |
DAY ON TEST | 7| 6| 6| 4| 4| | |
| 4| 4| 3| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
0.05 G/K | 6| 6| 6| 6| 6| | L |
G 79 HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 59 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 56 |
Pigmentation | 1 | 34 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 58 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 56 |
Pigmentation | | 9 1.0|
__________________________________________________________________________|____________|
Liver | + + | 60 |
Abscess | | 1 3.0|
Angiectasis | | 2 1.5|
Basophilic Focus | | 48 |
Clear Cell Focus | | 10 |
Eosinophilic Focus | | 2 |
Fatty Change, Diffuse | | 10 1.7|
Fatty Change, Focal | 1 | 14 1.3|
Hepatodiaphragmatic Nodule | | 10 |
Inflammation, Granulomatous | | 33 1.3|
Mixed Cell Focus | | 3 |
Necrosis | | 7 1.1|
Pigmentation | 1 1 | 50 1.3|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Fat, Inflammation, Chronic Active | | 2 2.0|
Fat, Necrosis | | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + | 59 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Acinus, Hyperplasia | | 8 1.9|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + | 60 |
Fat, Proliferation | 2 | 41 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| | |
DAY ON TEST | 7| 6| 6| 4| 4| | |
| 4| 4| 3| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
0.05 G/K | 6| 6| 6| 6| 6| | L |
G 79 HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 1 | 27 1.9|
Hyperkeratosis | 2 | 21 2.0|
Inflammation, Acute | | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 60 |
Erosion | | 10 1.2|
Fibrosis | 2 | 51 1.8|
Hemorrhage | | 2 1.0|
Hyperplasia | 1 | 23 1.4|
Inflammation, Acute | 2 | 5 1.4|
Metaplasia | 1 | 51 1.3|
Mineralization | | 2 1.0|
Pigmentation | | 24 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 60 |
Cardiomyopathy | 2 | 23 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 60 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 59 |
Hyperplasia | | 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + | 60 |
Pars Distalis, Angiectasis | | 23 2.3|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 24 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 59 |
C-Cell, Hyperplasia | | 13 1.5|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| | |
DAY ON TEST | 7| 6| 6| 4| 4| | |
| 4| 4| 3| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
0.05 G/K | 6| 6| 6| 6| 6| | L |
G 79 HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 56 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + | 60 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + | 60 |
Cyst | | 2 |
Decidual Reaction | | 1 1.0|
Hemorrhage | | 3 3.3|
Inflammation, Acute | | 2 3.0|
Necrosis | | 1 2.0|
Prolapse | | 1 |
Thrombosis | | 1 3.0|
Cervix, Inflammation, Acute | | 2 2.5|
Endometrium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 59 |
Pigmentation | 1 | 26 1.1|
__________________________________________________________________________|____________|
Lymph Node | + + | 60 |
Lumbar, Degeneration, Cystic | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 27 1.6|
Mediastinal, Pigmentation | 1 1 | 25 1.3|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 17 2.1|
Pancreatic, Pigmentation | | 18 2.4|
Renal, Angiectasis | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 60 |
Infiltration Cellular, Histiocyte | | 22 1.3|
Pigmentation | 1 | 26 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 60 |
Angiectasis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| | |
DAY ON TEST | 7| 6| 6| 4| 4| | |
| 4| 4| 3| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
0.05 G/K | 6| 6| 6| 6| 6| | L |
G 79 HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 2 | 47 2.1|
Pigmentation | 2 | 49 2.1|
__________________________________________________________________________|____________|
Spleen | + + | 60 |
Angiectasis | | 3 2.0|
Depletion Lymphoid | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 43 2.1|
Infiltration Cellular, Histiocyte | | 34 1.8|
Inflammation, Granulomatous | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 36 1.9|
Pigmentation | 1 | 33 1.8|
__________________________________________________________________________|____________|
Thymus | + + | 58 |
Pigmentation | 1 | 41 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 49 |
Galactocele | | 7 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + | 58 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 60 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 60 |
Atelectasis | | 5 2.0|
Congestion | 3 | 3 2.3|
Edema | 2 | 6 2.2|
Hemorrhage | | 3 1.7|
Infiltration Cellular, Histiocyte | 2 | 46 1.3|
Inflammation, Acute | | 9 2.0|
Inflammation, Granulomatous | 2 | 8 1.4|
Pigmentation | 2 | 35 1.1|
Pigmentation, Cholesterol | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| | |
DAY ON TEST | 7| 6| 6| 4| 4| | |
| 4| 4| 3| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| | A |
0.05 G/K | 6| 6| 6| 6| 6| | L |
G 79 HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + | 60 |
Fungus | | 1 2.0|
Inflammation, Acute | | 15 2.0|
Submucosa, Glands, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 60 |
Erosion | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 6 |
Inflammation, Acute | | 1 3.0|
Canal, Abscess | | 2 4.0|
__________________________________________________________________________|____________|
Eye | | 18 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Synechia | | 3 1.7|
Lens, Cataract | | 4 2.3|
Retina, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 14 |
Pigmentation | | 5 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 60 |
Nephropathy | | 35 1.5|
Cortex, Mineralization | | 2 1.0|
Papilla, Mineralization | | 6 1.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | | 40 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|
DAY ON TEST | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|
| 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + |
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + A + + + + + + + + |
Parasite | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + A + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Cyst | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 3 1 1 1 |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Infarct | |
Mixed Cell Focus | X |
Necrosis | |
Pigmentation | |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Necrosis, Fibrinoid | |
Fat, Inflammation, Chronic Active | 1 |
Fat, Mineralization | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + |
Hyperplasia | |
Acinus, Focal Cellular Change | |
Acinus, Hyperplasia | 3 2 |
Artery, Inflammation, Chronic Active | 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 2 |
Hemorrhage | |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|
DAY ON TEST | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|
| 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 3 2 3 2 2 3 2 2 2 |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + M + |
Cyst | |
Pars Distalis, Angiectasis | 2 2 2 1 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 1 1 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Abscess | |
Epithelium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 1 1 2 2 2 2 |
Seminiferous Tubule, Atrophy | 2 3 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|
DAY ON TEST | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|
| 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Degeneration, Cystic | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 1 1 |
Mediastinal, Pigmentation | 1 1 1 |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + |
Degeneration, Cystic | 2 2 |
Degeneration | |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 1 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Histiocyte | 1 2 2 1 1 2 2 1 2 |
Pigmentation | 1 2 1 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 2 2 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 1 2 1 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + + + + + + + |
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|
DAY ON TEST | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|
| 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | 3 4 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Fungus | |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Nephropathy | 3 2 2 2 2 2 3 1 1 2 2 2 2 2 2 2 |
Artery, Necrosis, Fibrinoid | 2 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 1 1 1 1 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|
| 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + |
Parasite | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + |
Parasite | 2 X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Cyst | |
Degeneration, Cystic | |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 2 3 |
Fatty Change, Focal | 1 1 |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X |
Infarct | 4 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Necrosis, Fibrinoid | 2 |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Acinus, Focal Cellular Change | |
Acinus, Hyperplasia | 2 3 2 3 2 2 2 2 |
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + |
Acanthosis | 2 |
Hemorrhage | |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|
| 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + M |
Cyst | X |
Pars Distalis, Angiectasis | 3 3 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 2 2 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 |
Necrosis | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + |
Abscess | |
Epithelium, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 2 1 2 2 1 1 2 1 2 |
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|
| 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
Mediastinal, Degeneration, Cystic | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 1 2 |
Mediastinal, Pigmentation | 1 1 1 |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + |
Degeneration, Cystic | 2 2 |
Degeneration | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + |
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 |
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + |
Depletion Lymphoid | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + M + + + + + M + |
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|
| 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + |
Congestion | 3 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Acute | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + |
Fungus | |
Inflammation, Acute | 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
Nephropathy | 2 2 2 2 2 2 2 1 3 2 2 3 2 3 2 2 2 |
Artery, Necrosis, Fibrinoid | |
Cortex, Mineralization | 2 |
Papilla, Mineralization | 2 2 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 2 1 1 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|
| 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + A|
Parasite | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A M + + + + + + A A + + + + +|
Parasite | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + + + + + + + A A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Cyst | X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 1 2 |
Fatty Change, Focal | 2 1|
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Mixed Cell Focus | |
Necrosis | 3 2 |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + +|
Artery, Necrosis, Fibrinoid | |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | 2 |
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Acinus, Focal Cellular Change | 1|
Acinus, Hyperplasia | 3 2 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + M + +|
Acanthosis | 2 2 1 1 |
Hemorrhage | 1 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|
| 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 2 2 2 3 3 2 3|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + M + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | 2 3 |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Epithelium, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 2 2 2|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|
| 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Degeneration, Cystic | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Degeneration | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + +|
Depletion Lymphoid | 2 2|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + M + M + + + M + + M M M + M M|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + M + + + M + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|
| 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
79VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 2|
Infiltration Cellular, Histiocyte | 1 1 3 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 2 2 3 1 2 2 1 2 3 2 1 2 2 2 3 2|
Artery, Necrosis, Fibrinoid | |
Cortex, Mineralization | |
Papilla, Mineralization | 1 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 2 2 2 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 5| 4| 4| 9| | |
| 0| 7| 7| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| | L |
79VM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 56 |
Parasite | X | 4 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Parasite | | 5 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + | 60 |
Basophilic Focus | X X X X | 46 |
Clear Cell Focus | | 16 |
Cyst | | 1 |
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | | 4 |
Fatty Change, Diffuse | | 5 2.0|
Fatty Change, Focal | 2 | 9 1.4|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Infarct | | 1 4.0|
Mixed Cell Focus | | 1 |
Necrosis | | 2 2.5|
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | 2 | 30 2.1|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Artery, Necrosis, Fibrinoid | | 1 2.0|
Fat, Inflammation, Chronic Active | | 1 1.0|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + | 59 |
Hyperplasia | | 1 3.0|
Acinus, Focal Cellular Change | | 1 1.0|
Acinus, Hyperplasia | 2 | 14 2.3|
Artery, Inflammation, Chronic Active | | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 5| 4| 4| 9| | |
| 0| 7| 7| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| | L |
79VM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 2 | 8 1.9|
Hemorrhage | | 1 1.0|
Hyperkeratosis | 2 | 5 2.0|
Inflammation, Chronic Active | | 1 3.0|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 58 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 60 |
Cardiomyopathy | 2 2 2 2 | 50 2.1|
Artery, Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 60 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 60 |
Hyperplasia | 2 2 1 | 25 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 56 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 56 |
Cyst | | 1 |
Pars Distalis, Angiectasis | 3 2 | 18 2.4|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 14 1.8|
Pars Distalis, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 60 |
C-Cell, Hyperplasia | | 6 1.3|
Follicular Cell, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 60 |
Spermatocele | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 5| 4| 4| 9| | |
| 0| 7| 7| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| | L |
79VM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + M + | 56 |
Inflammation, Chronic Active | | 2 2.0|
Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + | 59 |
Abscess | 4 | 1 4.0|
Epithelium, Hyperplasia | 1 | 12 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 26 1.6|
Seminiferous Tubule, Atrophy | | 29 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 60 |
Mediastinal, Degeneration, Cystic | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 8 1.4|
Mediastinal, Pigmentation | | 6 1.0|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 58 |
Degeneration, Cystic | 2 | 5 2.0|
Degeneration | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 59 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 26 1.8|
Pigmentation | | 9 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + | 58 |
Depletion Lymphoid | | 2 2.0|
Fibrosis | | 3 2.3|
Hematopoietic Cell Proliferation | 2 | 24 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 15 1.7|
Pigmentation, Hemosiderin | | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 5| 4| 4| 9| | |
| 0| 7| 7| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| | L |
79VM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + | 55 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + | 42 |
Galactocele | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 60 |
Congestion | 2 | 6 2.8|
Hemorrhage | | 4 1.8|
Infiltration Cellular, Histiocyte | | 9 1.3|
Inflammation, Acute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + | 59 |
Fungus | | 1 2.0|
Inflammation, Acute | 2 | 8 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 6 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| | |
DAY ON TEST | 5| 5| 4| 4| 9| | |
| 0| 7| 7| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
VEHICLE | 6| 6| 6| 6| 6| | L |
79VM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 60 |
Nephropathy | 4 3 3 1 | 56 2.1|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Cortex, Mineralization | | 1 2.0|
Papilla, Mineralization | 1 | 6 1.3|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 1 | 24 1.2|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|
| 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + |
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + A + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + |
Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + A + + + |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 2 1 2 2 1 |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Inflammation, Granulomatous | 1 2 1 1 1 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 1 1 2 1 1 1 1 1 1 2 |
Bile Duct, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + |
Acinus, Hyperplasia | 2 3 2 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + |
Fat, Proliferation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + |
Acanthosis | 2 3 1 2 |
Fibrosis | |
Hyperkeratosis | 2 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|
| 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 1 |
Fibrosis | 1 2 2 2 3 |
Hemorrhage | |
Hyperplasia | 1 |
Hyperplasia, Adenomatous | |
Inflammation, Acute | 2 |
Metaplasia | 2 1 2 |
Mineralization | 2 |
Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 3 2 2 2 2 2 2 |
Mineralization | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + |
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 3 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
Pars Intermedia, Hyperplasia | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|
| 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + |
Atrophy | |
Interstitial Cell, Hyperplasia | 2 2 1 2 |
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + |
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | 2 2 2 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 2 1 |
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + |
Degeneration, Cystic | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation | 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + |
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 1 2 |
Pigmentation | 2 2 2 2 3 2 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + M + A + + + |
Angiectasis | |
Depletion Lymphoid | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 2 |
Pigmentation, Hemosiderin | 2 2 1 2 2 2 2 3 |
Pigmentation | 2 1 2 2 1 2 1 |
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | + + + M M + + + M + + + + + |
Depletion Lymphoid | 2 |
Hemorrhage | 2 |
Pigmentation | 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|
| 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + M + M M M + M + |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
Hyperkeratosis | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
Costochondral Junction, Fibrosis | |
Costochondral Junction, Inflammation,| |
Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Atelectasis | 2 1 |
Congestion | 2 |
Edema | 2 1 1 |
Fibrosis | |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 2 2 2 2 2 2 1 2 2 |
Inflammation, Acute | 3 1 |
Inflammation, Granulomatous | 1 2 1 1 |
Mineralization | 2 |
Pigmentation | 1 1 2 2 1 1 1 2 2 |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + |
Fungus | 2 2 |
Inflammation, Acute | 3 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + |
Erosion | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Inflammation, Acute | |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|
| 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
Lens, Cataract | 2 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Pigmentation | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Nephropathy | 2 2 1 2 2 2 2 1 2 2 |
Pigmentation | 1 |
Cortex, Mineralization | 3 |
Papilla, Mineralization | 1 1 1 1 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + |
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|
DAY ON TEST | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|
| 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + A A + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + A + + + + + + A|
Parasite | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + A + + + + + + A|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + M A + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + + + A|
Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 2 1 1 2|
Hepatodiaphragmatic Nodule | X |
Infarct | |
Inflammation, Granulomatous | 1 1 1 2 |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 1 1 2 1 1 1 2 2 1 2 1 1 1 |
Bile Duct, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + A + + + + + + +|
Acinus, Hyperplasia | 2 2 2 2 2 2 2 2 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 3 2 2 1 1 2 1|
Fibrosis | |
Hyperkeratosis | 2 2 3 2 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|
DAY ON TEST | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|
| 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Fibrosis | 2 1 1 2 1 2 2 2 2|
Hemorrhage | |
Hyperplasia | 1 2 |
Hyperplasia, Adenomatous | 2 |
Inflammation, Acute | 2 |
Metaplasia | 2 2 1 1 1 1 1 |
Mineralization | |
Pigmentation | 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 3 2 2 2 3 2 3 2 3|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + A + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 3 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 |
Pars Intermedia, Hyperplasia | 2 |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + A + + + + + + A|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|
DAY ON TEST | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|
| 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 1 |
Seminiferous Tubule, Atrophy | 2 2 2 2 4 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + +|
Pigmentation | 1 1 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 2 |
Mediastinal, Pigmentation | 2 2 2 2 2 2 2 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Pigmentation | 2 2 |
Renal, Angiectasis | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + +|
Degeneration, Cystic | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + M M|
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 1 2 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | 1 2 |
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 1 1 2 1 2 1 |
Pigmentation, Hemosiderin | 2 1 1 2 2 2 2 2 2 2 2 2 |
Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 |
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | M + + + + M + + M + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Hemorrhage | |
Pigmentation | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|
DAY ON TEST | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|
| 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + + + M + + + + + + + M +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Costochondral Junction, Fibrosis | |
Costochondral Junction, Inflammation,| |
Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Atelectasis | 1 1 1 2 |
Congestion | 2 3 3 |
Edema | 2 2 |
Fibrosis | 1 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 2 2 2 2 1 2 2 2 1 2 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Granulomatous | 1 1 1 |
Mineralization | |
Pigmentation | 1 1 1 1 2 1 1 1 2 1 2 |
Pigmentation, Cholesterol | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 1 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 3 3 |
Inflammation, Acute | 2 2 2 2 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A|
Erosion | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Inflammation, Acute | |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|
DAY ON TEST | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|
| 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.025 G/ | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Acute | |
Lens, Cataract | 3 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + |
Pigmentation | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 2 1 2 3 2 2 2 |
Pigmentation | |
Cortex, Mineralization | |
Papilla, Mineralization | 1 2 1 1 1 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 2 1 1 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + A|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|
| 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + +|
Parasite | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 2 1 |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 2 4 2 1 |
Fatty Change, Focal | 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X X |
Infarct | 3 |
Inflammation, Granulomatous | 1 2 1 2 2 2 2 |
Mixed Cell Focus | |
Necrosis | 2 |
Pigmentation | 1 2 1 1 1 2 2 2 2 1 2 1 2 1 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 3 |
Fat, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + +|
Acinus, Hyperplasia | 2 2 2 2 2 2 2|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
Fat, Proliferation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 1 2 2 2 1 |
Fibrosis | 4 |
Hyperkeratosis | 2 2 2 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|
| 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 1 2 1 |
Fibrosis | 1 2 2 2 2 1 1 2 2 2 2 2 2 2|
Hemorrhage | 1 |
Hyperplasia | 2 1 2 2 2 2|
Hyperplasia, Adenomatous | 2 |
Inflammation, Acute | 1 1 2 1|
Metaplasia | 1 1 1 1 2 2 2 1 2 1 2 1 2 1 1|
Mineralization | 2 |
Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2 2 |
Mineralization | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + +|
Pars Distalis, Angiectasis | 3 1 2 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2|
Pars Intermedia, Hyperplasia | |
Rathke's Cleft, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|
| 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 2 1 2 2 1 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + +|
Pigmentation | 1 2 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | 1 2 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 2 2 |
Pancreatic, Pigmentation | 2 2 2 |
Renal, Angiectasis | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + M + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Infiltration Cellular, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | 1 2 1|
Pigmentation | 1 1 2 1 1 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + A + + + + + +|
Infiltration Cellular, Mast Cell | 2|
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 3 2 2 2 2 2 2 2 2|
Pigmentation | 2 2 2 2 2 2 3 2 2 2 3 3 2 2 1 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + +|
Angiectasis | |
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 3 3 2 2 2 2 2 2 2 2 2 2 3 |
Infiltration Cellular, Histiocyte | 1 1 2 2 2 1 1 1 1 2 2 1|
Pigmentation, Hemosiderin | 2 2 1 2 2 1 2 1 2 2 2 2 2 2 |
Pigmentation | 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Capsule, Cyst | X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hemorrhage | |
Pigmentation | 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|
| 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M M M + + + M + + M + + M + + M +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Metaplasia, Osseous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Costochondral Junction, Fibrosis | |
Costochondral Junction, Inflammation,| |
Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 1 1 2 2 |
Congestion | 3 |
Edema | 3 3 1 |
Fibrosis | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 2 2 2 1 1 1 2 2 3 2 1 1 1 2 2 2 1|
Inflammation, Acute | 2 3 1 1 3 2 1|
Inflammation, Granulomatous | 2 1 1 |
Mineralization | 1 1 |
Pigmentation | 2 2 1 2 1 2 1 1 1 1 2|
Pigmentation, Cholesterol | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 2 3 2 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + +|
Erosion | 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
Canal, Inflammation, Acute | 2 4 |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|
| 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.025 G/ | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
KG 79 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Acute | |
Lens, Cataract | 2 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 1 2 2 1 1 2 2 2 2 1 2 1 1 |
Pigmentation | 1 |
Cortex, Mineralization | 1 1 |
Papilla, Mineralization | 1 1 1 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| | |
DAY ON TEST | 4| 5| 1| 0| 7| | |
| 3| 0| 1| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
0.025 G/ | 2| 2| 2| 2| 2| | L |
KG 79 LM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + | 54 |
Parasite | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + | 54 |
Pigmentation | | 23 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + | 53 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + | 59 |
Basophilic Focus | X | 36 |
Clear Cell Focus | | 14 |
Degeneration, Cystic | | 3 1.3|
Eosinophilic Focus | | 7 |
Fatty Change, Diffuse | 2 | 6 2.2|
Fatty Change, Focal | 2 1 | 19 1.4|
Hepatodiaphragmatic Nodule | | 5 |
Infarct | | 1 3.0|
Inflammation, Granulomatous | | 16 1.4|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 2.0|
Pigmentation | 1 1 | 39 1.3|
Bile Duct, Hyperplasia | | 15 1.9|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fibrosis | | 1 3.0|
Fat, Inflammation, Chronic Active | | 2 2.5|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 56 |
Acinus, Hyperplasia | 1 | 20 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 59 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 59 |
Fat, Proliferation | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 59 |
Acanthosis | 1 1 1 2 | 25 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| | |
DAY ON TEST | 4| 5| 1| 0| 7| | |
| 3| 0| 1| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
0.025 G/ | 2| 2| 2| 2| 2| | L |
KG 79 LM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 4.0|
Hyperkeratosis | 2 2 2 | 13 2.1|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 59 |
Erosion | 1 3 | 9 1.4|
Fibrosis | 1 1 | 30 1.7|
Hemorrhage | 1 | 2 1.0|
Hyperplasia | 2 | 10 1.7|
Hyperplasia, Adenomatous | | 2 2.0|
Inflammation, Acute | 2 2 3 | 9 1.8|
Metaplasia | 1 | 26 1.4|
Mineralization | | 2 2.0|
Pigmentation | 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 60 |
Cardiomyopathy | 2 2 2 | 52 2.1|
Mineralization | | 1 3.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 60 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 60 |
Hyperplasia | 2 3 | 18 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 56 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 54 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 59 |
Pars Distalis, Angiectasis | 3 | 15 2.4|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 | 11 2.1|
Pars Intermedia, Hyperplasia | | 1 2.0|
Rathke's Cleft, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 55 |
C-Cell, Hyperplasia | 2 | 5 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| | |
DAY ON TEST | 4| 5| 1| 0| 7| | |
| 3| 0| 1| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
0.025 G/ | 2| 2| 2| 2| 2| | L |
KG 79 LM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 58 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 59 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 57 |
Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + | 60 |
Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 | 26 1.8|
Seminiferous Tubule, Atrophy | 2 4 2 | 34 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 58 |
Pigmentation | | 20 1.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 59 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 1 | 5 1.6|
Mediastinal, Pigmentation | 2 2 | 20 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 6 2.2|
Pancreatic, Pigmentation | | 7 1.9|
Renal, Angiectasis | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 56 |
Degeneration, Cystic | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | | 3 1.3|
Pigmentation | 1 | 28 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 54 |
Infiltration Cellular, Mast Cell | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | 2 3 3 2 | 40 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| | |
DAY ON TEST | 4| 5| 1| 0| 7| | |
| 3| 0| 1| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
0.025 G/ | 2| 2| 2| 2| 2| | L |
KG 79 LM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 2 3 1 | 42 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 56 |
Angiectasis | | 1 2.0|
Depletion Lymphoid | 2 | 5 1.8|
Fibrosis | | 3 2.3|
Hematopoietic Cell Proliferation | 2 2 | 35 2.2|
Infiltration Cellular, Histiocyte | 1 2 | 24 1.4|
Pigmentation, Hemosiderin | 2 | 35 1.9|
Pigmentation | 2 2 | 33 1.8|
Capsule, Cyst | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + | 50 |
Depletion Lymphoid | 3 | 5 2.2|
Hemorrhage | | 1 2.0|
Pigmentation | 1 | 25 1.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + | 36 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
Metaplasia, Osseous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 60 |
Costochondral Junction, Fibrosis | 2 | 1 2.0|
Costochondral Junction, Inflammation,| | |
Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 59 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 60 |
Atelectasis | | 10 1.4|
Congestion | | 5 2.6|
Edema | 3 | 9 2.0|
Fibrosis | | 1 1.0|
Hemorrhage | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| | |
DAY ON TEST | 4| 5| 1| 0| 7| | |
| 3| 0| 1| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| | A |
0.025 G/ | 2| 2| 2| 2| 2| | L |
KG 79 LM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 2 | 46 1.7|
Inflammation, Acute | 1 3 1 | 13 1.8|
Inflammation, Granulomatous | | 10 1.2|
Mineralization | | 3 1.3|
Pigmentation | 1 1 2 | 34 1.4|
Pigmentation, Cholesterol | | 3 1.7|
Alveolar Epithelium, Hyperplasia | 1 | 6 1.7|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 60 |
Fungus | | 6 2.3|
Inflammation, Acute | 2 1 | 18 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + | 58 |
Erosion | | 1 2.0|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Canal, Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Eye | + | 13 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Lens, Cataract | 2 | 6 2.2|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 10 |
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 60 |
Nephropathy | 1 1 | 39 1.7|
Pigmentation | | 2 1.0|
Cortex, Mineralization | | 3 1.7|
Papilla, Mineralization | 1 | 15 1.1|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 1 1 | 20 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + | 55 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|
| 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + +|
Parasite | |
Pigmentation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + M|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + M A + + + +|
Pigmentation | 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + A + + + +|
Pigmentation | 1 1 1 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + A + + A +|
Pigmentation | 1 1 1 1 1 1 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Congestion | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X |
Fatty Change, Focal | 1 1 1 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 1 1 1 2 1 1 |
Mixed Cell Focus | X X X X |
Necrosis | 2 |
Pigmentation | 1 2 1 2 2 2 2 2 2 2 1 1|
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + |
Artery, Necrosis, Fibrinoid | 3 |
Fat, Hemorrhage | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + +|
Hyperplasia | |
Acinus, Hyperplasia | 2 3 2 2 2 2 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|
| 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | 2 |
Fat, Proliferation | 1 2 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 1 2 2 1 2 1 |
Hyperkeratosis | 3 2 |
Inflammation, Chronic Active | |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + +|
Erosion | 1 |
Fibrosis | 2 2 2 2 1 2 2 2 2 2 2 1|
Hemorrhage | 1 2 |
Hyperplasia | 1 1 2 2 2 2|
Inflammation, Acute | 2 1 1|
Metaplasia | 1 1 2 1 1 1 2 1 2 1 2|
Mineralization | 1 |
Pigmentation | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 2 2 3 2 2 2 2 2 2 2 2 2|
Pigmentation | 1 |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infarct | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|
| 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + +|
Infarct | |
Interstitial Cell, Hyperplasia | 2 1 2 2 1 2 2 1 |
Seminiferous Tubule, Atrophy | 2 4 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | |
Axillary, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mediastinal, Angiectasis | |
Mediastinal, Hematopoietic Cell | |
Proliferation | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 1 2 2 |
Mediastinal, Pigmentation | 1 2 1 2 1 1 1 1 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | 2 1|
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Bacterium | |
Degeneration, Cystic | 2 |
Infiltration Cellular, Histiocyte | 2 2 1 1 2 |
Pigmentation | 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + +|
Bacterium | |
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 3 2 3 3 3 3 3 3 2 3 3 2|
Mineralization | 2 1 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|
| 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 3 2|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 1 2 2 2 2 |
Inflammation, Granulomatous | |
Necrosis | 3 |
Pigmentation, Hemosiderin | 1 2 2 2 2 2 1 2 2 2 2 2 2|
Pigmentation | 1 1 2 2 1 2 2 2 2 1|
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + +|
Depletion Lymphoid | 2 2 |
Ectopic Parathyroid Gland | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + + + + + M + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperkeratosis | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Bacterium | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Atelectasis | 2 2 2|
Bacterium | |
Congestion | 1 3 2 |
Edema | 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2|
Inflammation, Acute | 3 3 2 2 |
Inflammation, Granulomatous | 1 1 2 2 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|
DAY ON TEST | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|
| 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation | 1 1 2 2 2 3 2 1 2 2 1 2 1 2|
Pigmentation, Cholesterol | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | 2 |
Bronchiole, Epithelium, Metaplasia, | |
Squamous | 2 |
Bronchus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Erosion | |
Fungus | 2 3 |
Inflammation, Acute | 3 3 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | 2 |
Metaplasia, Squamous | 1 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 2 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Cyst | |
Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 1 1|
Renal Tubule, Pigmentation | 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|
| 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A A + + + A + + + + + + A + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + A + + + + + + +|
Parasite | 1 2 2|
Pigmentation | |
__________________________________________________________________________|
Intestine Large, Rectum | + A A + + + A + + + + + + A + + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + M + + + + + + A + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + +|
Pigmentation | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + A + + M + + + A + + + + + + +|
Pigmentation | 1 1 1 1 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Congestion | |
Degeneration, Cystic | 2 2 |
Eosinophilic Focus | X X X |
Fatty Change, Focal | 1 1 2 1 1 1 2 1 1 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 1 1 2 |
Mixed Cell Focus | X |
Necrosis | 1 |
Pigmentation | 1 1 1 2 2 1 1 1 1 1 2 1 1 1|
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Necrosis, Fibrinoid | |
Fat, Hemorrhage | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Acinus, Hyperplasia | 2 2 2 1 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|
| 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | |
Fat, Proliferation | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 1 2 2 2 |
Hyperkeratosis | 2 2 2 2 2 3 3 |
Inflammation, Chronic Active | 1 |
Necrosis | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 1 1 1 |
Fibrosis | 2 1 2 2 1 1 2 2 2 1 1 1 2 |
Hemorrhage | |
Hyperplasia | 2 2 1 2 1 1 |
Inflammation, Acute | 2 2 2 |
Metaplasia | 2 1 2 2 1 1 1 1 1 1 1 |
Mineralization | |
Pigmentation | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Pigmentation | 1 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infarct | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2 1 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|
| 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + M + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 1 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Interstitial Cell, Hyperplasia | 1 2 1 1 2 2 1 1 2 2 |
Seminiferous Tubule, Atrophy | 2 4 2 3 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | |
Axillary, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mediastinal, Angiectasis | 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 1 2 1 2 2 1 2 2 2 2 3|
Mediastinal, Pigmentation | 1 2 1 1 2 1 1 1 2|
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 2 1 |
Pancreatic, Pigmentation | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + + + + + + + + + + + +|
Bacterium | 1 |
Degeneration, Cystic | |
Infiltration Cellular, Histiocyte | 2 2 1 2 1 2 1|
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + +|
Bacterium | 1 |
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 3 3 2 2 3 2 1 2 3 3 2|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|
| 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 2 2 1 2 2 2 2 2 2 1 1 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 2 2 2 1 2 1 2 2 1 2 2 1 2|
Inflammation, Granulomatous | |
Necrosis | |
Pigmentation, Hemosiderin | 1 1 2 2 2 2 2 2 2 1 1 2|
Pigmentation | 1 2 2 1 2 2 1 1 2 1 2|
Thrombosis | |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + M M M + + + + + + +|
Depletion Lymphoid | 2 2 |
Ectopic Parathyroid Gland | 2 |
Pigmentation | 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M M + M M M + + M + + + M M + + M|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperkeratosis | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 1 3 2 2 2|
Bacterium | |
Congestion | |
Edema | 2 2 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 2 2 1 2 2 2 2 2 1 2 2|
Inflammation, Acute | 4 3 3 |
Inflammation, Granulomatous | 1 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|
| 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation | 2 1 2 2 1 2 3 2 2 2 1 2 2 1 1 1 2|
Pigmentation, Cholesterol | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | |
Bronchiole, Epithelium, Metaplasia, | |
Squamous | |
Bronchus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + M M M + + + + + + + + + + + + + + + +|
Erosion | |
Fungus | 2 2 3 2|
Inflammation, Acute | 2 2 2 4 2 1 3 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Metaplasia, Squamous | 1 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Bacterium | 2 |
Cyst | X |
Nephropathy | 3 1 2 2 2 2 1 1 2 1 1 |
Cortex, Mineralization | 2 |
Papilla, Mineralization | 1 1 |
Renal Tubule, Pigmentation | 2 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + A + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|
DAY ON TEST | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|
| 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + +|
Pigmentation | 1 1 1 1 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Congestion | 2 |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X X X |
Fatty Change, Focal | 2 1 2 2 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 2 3 2 2 |
Mixed Cell Focus | X X X |
Necrosis | 1 1 1 |
Pigmentation | 1 2 1 1 1 1 1 2 1 1 1 1 2 1 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + |
Artery, Necrosis, Fibrinoid | |
Fat, Hemorrhage | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Acinus, Hyperplasia | 3 2 3 2 2 |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|
DAY ON TEST | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|
| 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | |
Fat, Proliferation | 2 3 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 1 2 2 2 2 2 1 |
Hyperkeratosis | 2 2 3 3 3 1 |
Inflammation, Chronic Active | |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 1 2 2 1 |
Fibrosis | 1 2 2 2 2 2 2 2 2 2 2 |
Hemorrhage | 2 1 1|
Hyperplasia | 1 2 2 1 2 2 1 2 2 1 2 1 |
Inflammation, Acute | 1 1 1 2 |
Metaplasia | 1 1 1 2 2 1 1 1 1 2 1 1 |
Mineralization | |
Pigmentation | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 |
Pigmentation | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
Infarct | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M M + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + M + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|
DAY ON TEST | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|
| 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + M|
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Interstitial Cell, Hyperplasia | 2 2 1 2 1 1 1 2 2 1 2 2 |
Seminiferous Tubule, Atrophy | 2 2 3 2 2 2 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | 2 |
Axillary, Infiltration Cellular, | |
Histiocyte | 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 3 |
Lumbar, Pigmentation | 2 |
Mediastinal, Angiectasis | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 1 2 2 1 1 |
Mediastinal, Pigmentation | 1 1 1 1 1 1 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
Pancreatic, Pigmentation | |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +|
Bacterium | |
Degeneration, Cystic | 2 3 |
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 2 1 |
Pigmentation | 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Mast Cell | 2 |
Infiltration Cellular, Histiocyte | 3 2 2 3 3 3 3 3 2 3 3 3 3 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|
DAY ON TEST | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|
| 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 2 2|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 2 3 3 2 1 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 1 2 2 2 2 2 |
Inflammation, Granulomatous | 1 |
Necrosis | |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 1 2 2 |
Thrombosis | 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M + + + + + + + + +|
Depletion Lymphoid | 3 3 2 |
Ectopic Parathyroid Gland | |
Pigmentation | 1 1 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + M + + + M + + M M M|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperkeratosis | |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Metaplasia, Osseous | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 1 2 2 2 |
Bacterium | 2 |
Congestion | 3 3 3|
Edema | 1 2 2 2 2 2 2|
Hemorrhage | 2 2 2 2|
Infiltration Cellular, Histiocyte | 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Acute | 4 1 3 |
Inflammation, Granulomatous | 1 1 2 1 2 2 1 2 2 2 1|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|
DAY ON TEST | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|
| 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 G/K | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
G 79 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation | 2 1 1 1 2 1 1 2 2 2 1 1 2 2 1 1 1|
Pigmentation, Cholesterol | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | |
Bronchiole, Epithelium, Metaplasia, | |
Squamous | |
Bronchus, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M|
Erosion | 1 |
Fungus | 2 |
Inflammation, Acute | 2 2 2 2 2 3 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Acute | 1 2 |
Metaplasia, Squamous | 1 |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Cyst | |
Nephropathy | 2 2 2 1 2 2 1 2 1 2 1 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 1 1 1 |
Renal Tubule, Pigmentation | 2 1 2 2 2 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + +|
Calculus Gross Observation | X|
Calculus Micro Observation Only | X|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 55 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 57 |
Parasite | | 4 1.8|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 54 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 53 |
Pigmentation | 1 | 36 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 57 |
Pigmentation | | 3 1.0|
Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 51 |
Pigmentation | | 14 1.0|
Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X | 40 |
Clear Cell Focus | | 14 |
Congestion | | 1 2.0|
Degeneration, Cystic | | 4 2.0|
Eosinophilic Focus | X | 14 |
Fatty Change, Focal | 1 | 19 1.4|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Granulomatous | 2 | 14 1.6|
Mixed Cell Focus | | 8 |
Necrosis | | 5 1.2|
Pigmentation | 1 | 41 1.3|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | | 11 1.9|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Artery, Necrosis, Fibrinoid | | 1 3.0|
Fat, Hemorrhage | | 1 3.0|
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Acinus, Hyperplasia | 2 | 16 2.1|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | M + | 59 |
__________________________________________________________________________|____________|
Stomach | + + | 60 |
Artery, Necrosis, Fibrinoid | | 1 2.0|
Fat, Proliferation | 1 | 14 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 59 |
Acanthosis | 2 | 26 1.8|
Hyperkeratosis | 2 2 | 17 2.3|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | | 1 1.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 58 |
Erosion | | 13 1.4|
Fibrosis | 2 | 37 1.8|
Hemorrhage | | 5 1.4|
Hyperplasia | | 24 1.6|
Inflammation, Acute | | 10 1.5|
Metaplasia | 2 1 | 36 1.3|
Mineralization | | 1 1.0|
Pigmentation | 1 | 19 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 60 |
Bacterium | | 1 3.0|
Cardiomyopathy | 2 | 43 2.0|
Pigmentation | | 2 1.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 60 |
Hyperplasia | | 3 1.7|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 59 |
Hyperplasia | | 13 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 56 |
Pars Distalis, Angiectasis | | 11 2.2|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 | 13 2.1|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 58 |
C-Cell, Hyperplasia | 2 | 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 56 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + | 60 |
Epithelium, Hyperplasia | 3 | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 60 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + | 60 |
Infarct | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 2 | 32 1.6|
Seminiferous Tubule, Atrophy | 2 | 36 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 60 |
Pigmentation | 2 | 37 1.2|
__________________________________________________________________________|____________|
Lymph Node | + + | 60 |
Axillary, Angiectasis | | 1 2.0|
Axillary, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Lumbar, Pigmentation | | 1 2.0|
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 30 1.7|
Mediastinal, Pigmentation | | 25 1.2|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 5 1.8|
Pancreatic, Pigmentation | | 2 1.5|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 56 |
Bacterium | | 1 1.0|
Degeneration, Cystic | | 3 2.3|
Infiltration Cellular, Histiocyte | | 20 1.5|
Pigmentation | | 17 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 58 |
Bacterium | | 1 1.0|
Infiltration Cellular, Mast Cell | | 3 2.0|
Infiltration Cellular, Histiocyte | 3 2 | 45 2.5|
Mineralization | | 3 1.7|
Pigmentation | 2 | 44 1.9|
__________________________________________________________________________|____________|
Spleen | + + | 59 |
Depletion Lymphoid | | 6 2.0|
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | | 28 2.1|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | 2 | 33 1.8|
Inflammation, Granulomatous | | 1 1.0|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 37 1.8|
Pigmentation | 2 | 32 1.7|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + | 52 |
Depletion Lymphoid | | 7 2.3|
Ectopic Parathyroid Gland | | 1 2.0|
Pigmentation | 2 | 31 1.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 41 |
Galactocele | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + | 59 |
Hemorrhage | | 1 2.0|
Hyperkeratosis | | 1 3.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 60 |
Bacterium | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 60 |
Atelectasis | | 14 1.9|
Bacterium | | 1 2.0|
Congestion | | 6 2.5|
Edema | 1 | 11 1.8|
Hemorrhage | | 8 1.8|
Infiltration Cellular, Histiocyte | 2 | 49 1.9|
Inflammation, Acute | | 10 2.8|
Inflammation, Granulomatous | | 20 1.4|
Necrosis | | 1 3.0|
Pigmentation | 1 2 | 50 1.6|
Pigmentation, Cholesterol | | 5 1.4|
Alveolar Epithelium, Hyperplasia | | 5 1.8|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | | 1 2.0|
Bronchiole, Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Bronchus, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 56 |
Erosion | | 1 1.0|
Fungus | 2 | 8 2.3|
Inflammation, Acute | 2 | 22 2.5|
__________________________________________________________________________|____________|
Trachea | + + | 60 |
Erosion | | 1 2.0|
Inflammation, Acute | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05047-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 04/29/97
Route: GAVAGE Time: 10:11:19
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 4| | |
DAY ON TEST | 3| 5| 7| 7| 6| | |
| 9| 8| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| | A |
0.05 G/K | 8| 8| 8| 8| 8| | L |
G 79 HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | | 3 1.0|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 9 |
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 7 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 60 |
Abscess | | 1 2.0|
Bacterium | | 1 2.0|
Cyst | | 1 |
Nephropathy | 2 | 34 1.8|
Cortex, Mineralization | | 1 2.0|
Papilla, Mineralization | 1 | 10 1.0|
Renal Tubule, Pigmentation | 2 | 29 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 56 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
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