TR 399 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/06/94
EXP: 05047 TITANOCENE DICHLORIDE TIME: 22:05:36
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 04502
CONT: N01ES9561904 CAS: 1271-19-8
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/06/94
EXP: 05047 TITANOCENE DICHLORIDE TIME: 22:05:36
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 04502
CONT: N01ES9561904 CAS: 1271-19-8
PATHOLOGIST: K. MURTHY S. EUSTIS
TITANOCENE DICHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 79 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 474 499 520 550 577 578 579 605 639 647 |
| 647 659 670 681 690 716 717 722 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.025 G/KG 79 |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 29 CENSORED DEATHS 11 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 54 253 306 370 400 474 484 509 526 536 |
| 537 553 567 582 583 603 611 628 634 635 |
| 650 653 659 667 697 701 717 718 732 |
| CENSORED DEATHS |
| 406 457 457 457 457 458 458 458 458 458 |
| 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 G/KG 79 |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 34 CENSORED DEATHS 12 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 68 229 248 251 254 261 264 264 318 338 |
| 383 401 465 467 514 515 540 586 612 612 |
| 612 617 618 620 647 662 675 690 690 708 |
| 709 711 722 734 |
| CENSORED DEATHS |
| 405 457 457 457 457 457 458 458 458 458 |
| 458 639 |
| |
==================================================================================
TITANOCENE DICHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 738 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 79 | 100.0 100.0 100.0 100.0 100.0 98.3 95.0 86.7 80.0 68.3 |
| | |
| | |
|0.025 | 98.6 98.6 97.1 95.7 92.9 89.4 82.5 73.9 61.9 51.6 |
|G/KG 79 | |
| | |
|0.05 | 98.6 98.6 88.6 85.7 82.9 79.3 74.0 72.3 58.1 43.6 |
|G/KG 79 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 79 0.025 0.05 |
| G/KG 79 G/KG 79 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.3% 51.6% 43.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.002 P=0.046 P=0.002 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.2 553.1 500.1 |
|NATURAL DEATHS (C) | (18.0) (28.7) (32.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 667.6 616.6 576.2 |
|(STANDARD ERROR) | (12.8) (17.8) (21.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TITANOCENE DICHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 79 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 304 342 384 413 549 598 611 615 622 624 |
| 624 639 651 652 688 693 694 695 700 702 |
| 707 709 715 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.025 G/KG 79 |
| ---------------------------- |
| |
| TOTAL 71 UNCENSORED DEATHS 30 CENSORED DEATHS 11 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 177 350 430 451 464 504 510 570 574 590 |
| 595 608 610 631 639 639 643 645 645 645 |
| 660 661 688 688 692 694 707 715 721 721 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 464 464 464 |
| 549 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 G/KG 79 |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 232 234 247 307 338 344 345 415 457 457 |
| 471 485 493 493 496 521 575 617 639 643 |
| 653 665 665 673 674 683 693 694 742 |
| CENSORED DEATHS |
| 463 463 463 464 464 464 464 464 464 464 |
| |
==================================================================================
TITANOCENE DICHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 743 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 79 | 100.0 100.0 100.0 97.1 94.3 94.3 94.3 90.9 77.4 62.3 |
| | |
| | |
|0.025 | 100.0 98.6 98.6 97.2 97.2 92.8 89.5 82.7 64.2 50.6 |
|G/KG 79 | |
| | |
|0.05 | 100.0 100.0 95.7 90.0 88.6 82.3 75.4 73.7 63.4 53.1 |
|G/KG 79 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 79 0.025 0.05 |
| G/KG 79 G/KG 79 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.3% 50.6% 53.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.167 P=0.227 P=0.197 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.7 595.6 515.6 |
|NATURAL DEATHS (C) | (25.8) (22.4) (29.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.0 638.6 608.9 |
|(STANDARD ERROR) | (14.7) (15.1) (18.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TITANOCENE DICHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 79 = 1
0.025 G/KG 79 = 2
0.05 G/KG 79 = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 3 32 2 1 1 1
| 33 2 2 2 1 1
| 33 2 2 1 1
P 90 + 2 2 2
E | 3 3 3 2 2 1 1 1
R | 3 3 3 22 11
C | 3 3 2 2 1 1
E 80 + 3 3 2 2 2 11
N | 1 11
T | 3 3 2 22 1 1
| 3 2 2 11
S 70 + 22
U | 33 2 2 1 1
R | 22
V | 3 32 22
I 60 + 3 32 2
V | 3 3 322 2
A |
L | 3 32 22
50 +
| 3 3
| 3 3
| 33
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.
TITANOCENE DICHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 79 = 1
0.025 G/KG 79 = 2
0.05 G/KG 79 = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 1 12
| 3 3 12 1 2
| 3 3 1 1 2 2
95 +
| 3 3 1 2 2 1
| 33 2 2 1 1
| 22 1 1
90 + 3 3 2 2
| 3 3
| 11
| 3 3 2 2 11
P 85 +
E | 3 3
R | 33 2 2 1 1
C | 22 11
E 80 +
N | 2 2 11
T | 3 3 22 1 1
|
S 75 + 3 3
U | 3 3 11
R | 3 22
V |
I 70 +
V | 3 3 11
A | 2 2
L | 3 3 11
65 +
| 2 3 2 11
| 1 1
|
60 + 33
| 322
| 22
| 332 2
55 + 3 3
| 33
|
| 2 2
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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