TDMS Study 91005-07 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst METHYLENE BLUE TRIHYDRATE DATE: 03/25/05
EXPERIMENT: 91005 TEST: 07 TIME: 10:00:56
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C91005C
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE METHYLENE BLUE TRIHYDRATE DATE: 03/25/05
EXPERIMENT: 91005 TEST: 07 TIME: 10:11:43
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 91005C
CONT: N01-ES-05451 CAS: 7220-79-3
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF METHYLENE BLUE TRIHYDRATE
==========================================================================================================
WEEK 0 MG/KG 5 MG/KG 25 MG/KG 50 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 110.5 50 109.4 99.0 50 108.9 98.6 50 109.8 99.4 50
1 110.5 50 109.4 99.0 50 108.9 98.6 50 109.8 99.4 50
2 150.1 50 149.7 99.7 50 150.0 99.9 50 150.9 100.5 50
3 181.0 50 181.3 100.2 50 179.4 99.1 50 184.5 101.9 50
4 205.5 50 205.3 99.9 50 204.3 99.4 50 211.7 103.0 50
5 229.6 50 227.4 99.0 50 224.6 97.8 50 232.7 101.4 50
6 248.5 50 245.8 98.9 50 242.7 97.7 50 252.4 101.6 50
7 264.4 50 259.7 98.2 50 258.2 97.7 50 267.0 101.0 50
8 279.6 50 274.1 98.0 50 271.7 97.2 50 280.2 100.2 50
9 292.8 50 287.3 98.1 50 284.2 97.1 50 291.3 99.5 50
10 306.0 50 300.2 98.1 50 296.8 97.0 50 302.8 99.0 50
11 317.2 50 312.3 98.5 50 308.9 97.4 50 313.9 99.0 50
12 328.1 50 324.3 98.8 50 319.5 97.4 50 324.4 98.9 50
13 337.9 50 333.9 98.8 50 327.7 97.0 50 331.8 98.2 50
17 368.3 50 363.4 98.7 50 355.5 96.5 50 353.4 96.0 50
21 390.6 50 386.7 99.0 50 379.0 97.0 50 369.6 94.6 50
25 406.9 50 404.2 99.3 50 390.5 96.0 50 381.3 93.7 50
29 423.8 50 418.4 98.7 50 403.6 95.2 50 396.4 93.5 49
33 441.3 50 431.4 97.8 50 413.2 93.6 50 406.0 92.0 49
37 453.8 50 444.2 97.9 50 424.8 93.6 50 413.6 91.1 49
41 468.0 50 458.6 98.0 50 437.4 93.5 50 421.4 90.0 49
45 476.5 50 468.6 98.3 50 445.8 93.6 50 430.3 90.3 49
49 489.2 50 482.6 98.7 50 460.4 94.1 50 441.4 90.2 49
53 494.8 50 487.3 98.5 50 461.3 93.2 50 445.2 90.0 49
57 502.9 50 495.4 98.5 50 470.6 93.6 50 448.3 89.1 49
61 499.0 50 504.6 101.1 50 470.3 94.2 50 441.7 88.5 48
65 509.2 50 503.3 98.8 50 461.8 90.7 50 444.9 87.4 48
69 514.2 49 504.6 98.1 49 474.3 92.2 50 452.5 88.0 47
73 518.6 49 501.6 96.7 49 472.3 91.1 49 454.2 87.6 45
77 518.5 49 509.5 98.3 49 475.1 91.6 49 453.1 87.4 44
81 520.6 47 511.9 98.3 46 474.8 91.2 49 454.5 87.3 43
85 512.1 45 505.0 98.6 42 478.0 93.3 48 451.9 88.2 42
89 513.8 44 510.1 99.3 42 473.2 92.1 46 453.3 88.2 41
93 506.0 40 502.9 99.4 42 473.3 93.5 45 451.5 89.2 39
97 506.7 36 506.7 100.0 38 470.0 92.8 44 447.6 88.3 36
101 499.6 32 497.4 99.6 37 454.7 91.0 42 435.5 87.2 33
TERM. SAC. 31 33 39 31
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF METHYLENE BLUE TRIHYDRATE
==========================================================================================================
WEEK 0 MG/KG 5 MG/KG 25 MG/KG 50 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 95.6 50 96.2 100.6 50 97.3 101.8 50 96.2 100.6 50
1 95.6 50 96.2 100.6 50 97.3 101.8 50 96.2 100.6 50
2 117.6 50 118.1 100.4 50 120.2 102.2 50 120.0 102.0 50
3 130.7 50 132.1 101.1 50 134.1 102.6 50 135.3 103.5 50
4 140.8 50 143.2 101.7 50 143.2 101.7 50 145.2 103.1 50
5 151.2 50 154.0 101.9 50 153.7 101.7 50 153.8 101.7 50
6 159.6 50 160.6 100.6 50 162.2 101.6 50 163.0 102.1 50
7 166.4 50 166.4 100.0 50 168.9 101.5 50 167.9 100.9 50
8 169.5 50 172.3 101.7 50 174.5 102.9 50 173.7 102.5 50
9 174.1 50 175.2 100.6 50 178.2 102.4 50 177.9 102.2 50
10 177.2 50 180.1 101.6 50 182.3 102.9 50 180.8 102.0 50
11 182.4 50 183.6 100.7 50 186.3 102.1 50 186.2 102.1 50
12 184.1 50 187.0 101.6 50 190.4 103.4 50 188.8 102.6 50
13 187.1 50 189.0 101.0 50 193.9 103.6 50 191.8 102.5 50
17 196.8 50 199.4 101.3 50 202.0 102.6 50 198.7 101.0 50
21 209.1 50 212.3 101.5 49 212.5 101.6 50 207.7 99.3 50
25 211.1 50 215.2 101.9 49 217.1 102.8 50 210.8 99.9 50
29 215.3 50 221.5 102.9 49 222.1 103.2 50 218.4 101.4 50
33 226.4 50 229.0 101.1 49 226.6 100.1 50 222.6 98.3 49
37 234.4 50 236.8 101.0 49 233.7 99.7 50 227.6 97.1 48
41 244.0 50 246.0 100.8 49 240.2 98.4 50 233.6 95.7 47
45 249.7 50 252.3 101.0 49 245.7 98.4 50 237.5 95.1 46
49 257.6 50 259.5 100.7 49 252.8 98.1 50 246.1 95.5 46
53 265.6 49 271.9 102.4 49 259.2 97.6 50 254.0 95.6 45
57 277.9 49 282.4 101.6 48 268.8 96.7 50 261.7 94.2 45
61 287.9 49 292.7 101.7 48 273.0 94.8 50 264.4 91.8 45
65 293.7 49 301.3 102.6 48 281.2 95.7 50 272.9 92.9 45
69 302.6 49 306.7 101.4 48 286.6 94.7 50 279.1 92.2 44
73 309.4 49 314.5 101.6 48 292.3 94.5 49 283.0 91.5 44
77 317.7 48 322.1 101.4 48 293.4 92.4 48 289.0 91.0 42
81 321.4 47 325.3 101.2 48 300.8 93.6 44 292.4 91.0 41
85 328.2 46 328.1 100.0 45 302.5 92.2 43 293.9 89.5 39
89 330.8 46 333.1 100.7 44 303.8 91.8 41 291.3 88.1 39
93 334.6 42 336.3 100.5 40 303.5 90.7 40 295.2 88.2 39
97 335.9 37 340.1 101.3 39 307.2 91.5 39 296.5 88.3 37
101 335.9 36 341.7 101.7 33 305.2 90.9 37 294.1 87.6 36
TERM. SAC. 35 32 36 35
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.