TDMS Study 99036-01 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) DATE: 04/21/04
EXPERIMENT: 99036 TEST: 01 TIME: 08:28:09
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: DOSED FEED NTP: C99036
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) DATE: 04/21/04
EXPERIMENT: 99036 TEST: 01 TIME: 8:34:19
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DOSED FEED NTP: C99036
CONT: N01-ES-65406 CAS: 77-09-08
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==================================================================================================================================
0 PPM 200 PPM 375 PPM 750 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.0 21.0 4.0 21.0 1.00 38 4.2 20.7 1.05 77 4.1 20.9 1.03 146
3 4.1 21.4 4.1 21.6 1.00 38 4.2 20.9 1.02 75 3.9 20.8 0.95 142
4 4.2 22.4 4.0 21.8 0.95 37 4.0 21.5 0.95 70 4.3 21.6 1.02 150
5 4.0 22.8 4.4 22.9 1.10 38 4.1 22.6 1.03 68 4.1 22.2 1.03 138
6 4.0 23.8 4.2 23.5 1.05 36 4.5 23.5 1.13 71 4.5 23.3 1.13 143
7 4.2 24.5 4.3 24.6 1.02 35 4.3 23.9 1.02 68 4.3 24.4 1.02 134
8 4.4 25.4 4.6 25.5 1.05 36 4.7 24.8 1.07 72 4.8 25.4 1.09 142
9 4.4 25.8 4.8 26.4 1.09 37 4.9 25.4 1.11 73 4.4 25.9 1.00 127
10 4.5 25.9 4.7 26.6 1.04 36 4.4 25.2 0.98 65 4.5 26.2 1.00 130
11 4.6 26.9 5.0 27.3 1.09 36 4.8 26.2 1.04 69 4.9 26.8 1.07 137
12 4.7 27.0 5.0 28.0 1.06 36 5.0 26.8 1.06 70 5.0 27.5 1.06 136
13 4.6 27.8 4.8 28.2 1.04 34 4.6 27.1 1.00 64 4.9 27.9 1.07 133
14 4.6 28.9 5.0 29.0 1.09 35 5.0 28.4 1.09 66 5.0 29.3 1.09 128
15 4.7 29.4 5.1 29.5 1.09 34 4.7 28.7 1.00 61 4.8 29.8 1.02 121
16 4.6 30.5 5.0 31.1 1.09 32 4.9 29.9 1.07 61 4.9 30.1 1.07 123
17 5.0 30.4 5.1 31.0 1.02 33 4.8 29.2 0.96 62 5.4 30.5 1.08 132
18 5.4 31.8 5.3 32.0 0.98 33 5.4 30.9 1.00 66 5.3 30.9 0.98 130
19 5.3 32.6 5.4 32.1 1.02 34 5.5 31.4 1.04 65 5.6 31.9 1.06 133
20 4.9 32.4 5.3 32.8 1.08 32 5.3 32.0 1.08 62 5.5 32.1 1.12 129
21 5.3 33.0 5.3 33.1 1.00 32 5.2 32.5 0.98 60 5.7 32.4 1.08 132
22 5.2 33.7 5.8 33.7 1.12 34 5.4 33.3 1.04 61 5.8 34.3 1.12 127
23 5.5 34.0 5.6 34.2 1.02 33 5.7 34.1 1.04 63 5.8 33.8 1.05 128
24 5.4 34.1 5.7 34.8 1.06 33 5.5 34.6 1.02 59 5.8 34.3 1.07 127
25 5.5 35.2 5.7 35.6 1.04 32 5.7 35.2 1.04 60 5.6 35.1 1.02 119
26 5.2 34.3 5.6 36.0 1.08 31 5.6 35.4 1.08 59 5.6 35.9 1.08 117
1 TO 13 WEEKS
----------------
MEAN 4.3 24.6 4.5 24.8 1.04 36 4.5 24.0 1.04 70 4.5 24.4 1.04 138
SD(D) 0.2 0.4 0.04 1 0.3 0.05 4 0.4 0.05 7
CV(E) 5.7 8.1 4.1 3.5 7.5 4.9 5.3 8.0 4.5 4.9
14 TO 52 WEEKS
----------------
MEAN 5.1 32.3 5.4 32.7 1.05 33 5.3 31.9 1.03 62 5.4 32.3 1.06 127
SD(D) 0.3 0.3 0.04 1 0.3 0.04 2 0.3 0.04 5
CV(E) 6.3 5.4 3.9 3.3 6.3 3.8 3.7 6.3 3.7 4.0
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
=============================================================================
3000 PPM 12,000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.1 20.8 1.03 596 4.2 20.8 1.05 2436
3 3.9 21.1 0.95 556 4.2 20.6 1.02 2437
4 4.2 21.5 1.00 586 4.0 20.8 0.95 2330
5 4.2 22.4 1.05 562 4.2 22.0 1.05 2313
6 4.4 23.3 1.10 570 4.1 22.6 1.03 2205
7 4.1 24.1 0.98 506 4.4 23.6 1.05 2237
8 4.5 25.0 1.02 541 4.4 24.2 1.00 2191
9 4.6 25.0 1.05 549 4.3 24.8 0.98 2092
10 4.5 25.9 1.00 527 4.4 25.0 0.98 2115
11 5.0 26.8 1.09 558 4.9 25.6 1.07 2280
12 4.7 27.0 1.00 518 4.6 25.4 0.98 2156
13 4.4 27.1 0.96 488 4.8 26.2 1.04 2220
14 4.9 28.2 1.07 525 4.6 26.8 1.00 2068
15 4.9 28.8 1.04 506 4.5 26.9 0.96 2009
16 4.9 29.8 1.07 492 4.4 27.7 0.96 1907
17 5.3 29.6 1.06 538 5.1 28.4 1.02 2142
18 5.4 30.0 1.00 543 4.9 28.2 0.91 2091
19 5.5 29.8 1.04 550 5.0 28.5 0.94 2093
20 5.8 31.1 1.18 559 5.2 28.9 1.06 2156
21 5.6 31.9 1.06 529 5.1 28.6 0.96 2136
22 6.0 32.4 1.15 552 5.2 29.7 1.00 2102
23 5.9 32.1 1.07 554 5.4 29.3 0.98 2232
24 6.0 32.9 1.11 544 5.2 29.8 0.96 2074
25 5.7 32.8 1.04 525 5.3 30.4 0.96 2107
26 5.9 33.6 1.13 524 5.1 30.3 0.98 2023
1 TO 13 WEEKS
----------------
MEAN 4.4 24.2 1.02 546 4.4 23.5 1.02 2251
SD(D) 0.3 0.05 32 0.3 0.04 113
CV(E) 6.8 4.6 5.9 5.9 3.7 5.0
14 TO 52 WEEKS
----------------
MEAN 5.5 31.0 1.08 534 5.0 28.7 0.98 2088
SD(D) 0.4 0.05 20 0.3 0.04 79
CV(E) 7.5 4.9 3.7 6.3 3.9 3.8
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==================================================================================================================================
0 PPM 200 PPM 375 PPM 750 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.0 17.8 4.0 17.4 1.00 46 4.2 17.6 1.05 90 4.1 17.8 1.03 175
3 4.4 18.7 4.2 17.8 0.95 47 4.0 18.2 0.91 82 3.8 17.9 0.86 160
4 4.0 19.0 4.2 18.5 1.05 45 3.9 18.7 0.98 78 4.0 18.6 1.00 161
5 4.1 19.8 4.0 19.3 0.98 41 4.2 19.8 1.02 80 4.0 19.4 0.98 154
6 4.1 20.8 4.3 20.4 1.05 42 4.3 19.9 1.05 81 4.5 20.6 1.10 165
7 4.4 21.3 4.2 20.9 0.95 40 4.7 21.2 1.07 83 4.3 21.0 0.98 152
8 5.2 21.8 4.9 21.9 0.94 45 5.2 21.8 1.00 89 4.8 22.0 0.92 164
9 4.7 22.2 5.2 22.1 1.11 47 5.7 22.4 1.21 95 4.5 22.2 0.96 151
10 5.1 22.4 5.3 21.6 1.04 49 5.3 22.4 1.04 89 5.2 22.0 1.02 178
11 5.2 22.1 5.5 22.3 1.06 50 5.7 23.3 1.10 93 4.8 22.3 0.92 163
12 5.1 22.5 5.6 22.4 1.10 50 5.9 23.1 1.16 96 4.8 22.5 0.94 159
13 5.1 22.7 5.9 23.0 1.16 51 5.4 23.4 1.06 87 5.2 23.1 1.02 170
14 5.5 23.4 6.1 23.1 1.11 53 6.1 23.8 1.11 96 5.2 23.1 0.95 167
15 5.1 22.9 5.9 23.1 1.16 51 5.5 23.4 1.08 88 4.8 23.1 0.94 156
16 5.3 23.7 6.1 23.5 1.15 52 5.4 24.2 1.02 83 5.1 23.5 0.96 163
17 5.4 23.6 5.7 23.8 1.06 48 5.4 23.8 1.00 84 5.4 24.1 1.00 168
18 5.8 24.0 5.8 23.8 1.00 49 5.5 24.4 0.95 84 5.3 24.2 0.91 164
19 5.9 24.5 6.1 24.4 1.03 50 6.0 24.7 1.02 91 6.1 24.6 1.03 185
20 5.4 24.5 6.5 25.0 1.20 52 5.6 25.1 1.04 84 5.8 24.8 1.07 174
21 5.4 24.7 5.9 24.8 1.09 48 5.0 25.0 0.93 75 5.4 24.5 1.00 167
22 5.7 24.4 6.1 25.6 1.07 48 5.2 24.6 0.91 80 5.6 25.4 0.98 165
23 5.8 24.2 5.7 24.8 0.98 46 6.0 25.6 1.03 88 5.4 24.3 0.93 167
24 5.7 24.8 6.0 25.0 1.05 48 5.6 25.4 0.98 83 5.9 25.5 1.04 173
25 6.2 25.6 6.3 25.6 1.02 50 6.3 26.4 1.02 89 5.8 25.1 0.94 172
26 6.3 25.3 6.1 25.5 0.97 48 6.1 26.5 0.97 86 5.6 25.1 0.89 166
1 TO 13 WEEKS
----------------
MEAN 4.6 20.9 4.8 20.6 1.03 46 4.9 21.0 1.05 87 4.5 20.8 0.98 163
SD(D) 0.5 0.7 0.07 4 0.7 0.08 6 0.5 0.06 9
CV(E) 11.1 14.8 6.6 7.7 15.1 7.5 6.8 10.6 6.3 5.3
14 TO 52 WEEKS
----------------
MEAN 5.6 24.3 6.0 24.5 1.07 49 5.7 24.8 1.00 85 5.5 24.4 0.97 168
SD(D) 0.4 0.2 0.07 2 0.4 0.06 5 0.4 0.05 7
CV(E) 6.3 3.7 6.7 4.1 7.1 5.6 6.2 6.4 5.5 4.2
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
=============================================================================
3000 PPM 12,000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.3 18.0 1.08 724 4.2 17.7 1.05 2840
3 3.9 18.2 0.89 637 4.3 18.6 0.98 2782
4 3.9 18.5 0.98 636 4.2 19.1 1.05 2644
5 4.1 19.8 1.00 619 4.5 19.8 1.10 2731
6 4.5 20.8 1.10 648 4.6 20.9 1.12 2646
7 4.6 21.4 1.05 649 4.7 21.6 1.07 2622
8 4.6 22.0 0.88 623 5.0 22.0 0.96 2714
9 4.6 21.7 0.98 639 5.2 22.2 1.11 2800
10 5.0 22.0 0.98 683 5.1 22.5 1.00 2700
11 4.8 22.3 0.92 646 5.4 23.2 1.04 2779
12 4.9 22.7 0.96 654 5.3 23.1 1.04 2750
13 5.0 22.8 0.98 663 5.5 23.4 1.08 2829
14 5.2 23.1 0.95 677 5.4 23.5 0.98 2741
15 5.3 22.7 1.04 695 5.6 23.6 1.10 2830
16 5.7 23.6 1.08 721 5.7 23.9 1.08 2861
17 5.4 24.1 1.00 678 5.6 24.0 1.04 2778
18 5.9 24.0 1.02 737 5.5 24.1 0.95 2755
19 5.9 24.4 1.00 726 5.8 24.5 0.98 2862
20 6.0 24.7 1.11 727 6.1 25.0 1.13 2927
21 5.5 24.3 1.02 682 5.3 24.7 0.98 2568
22 6.0 25.2 1.05 709 5.5 24.9 0.96 2664
23 5.6 24.6 0.97 687 6.2 25.6 1.07 2908
24 6.1 25.2 1.07 726 6.1 25.5 1.07 2873
25 6.2 25.3 1.00 731 5.9 25.4 0.95 2798
26 6.0 25.1 0.95 719 6.0 25.4 0.95 2850
1 TO 13 WEEKS
----------------
MEAN 4.5 20.8 0.98 652 4.8 21.2 1.05 2736
SD(D) 0.4 0.07 28 0.5 0.05 73
CV(E) 8.9 6.8 4.3 9.7 4.8 2.7
14 TO 52 WEEKS
----------------
MEAN 5.7 24.3 1.02 709 5.7 24.6 1.02 2801
SD(D) 0.3 0.05 22 0.3 0.06 101
CV(E) 5.5 4.9 3.1 5.2 6.2 3.6
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==================================================================================================================================
0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 20.1 15 20.0 15 19.9 15 20.0 15 19.9 15
1 20.1 15 20.0 15 19.9 15 20.0 15 19.9 15
2 4.0 2485 21.0 15 4.0 2482 21.0 15 4.2 2334 20.7 15 4.1 2506 20.9 15 4.1 2475 20.8 15
3 4.1 2014 21.4 15 4.1 2539 21.6 15 4.2 2333 20.9 15 3.9 2184 20.8 15 3.9 2535 21.1 15
4 4.2 2193 22.4 14 4.0 2348 21.8 15 4.0 2556 21.5 15 4.3 2328 21.6 14 4.2 2366 21.5 15
5 4.0 2188 22.8 14 4.4 2515 22.9 15 4.1 2505 22.6 15 4.1 2367 22.2 14 4.2 2515 22.4 15
6 4.0 2180 23.8 14 4.2 2536 23.5 15 4.5 2505 23.5 15 4.5 2353 23.3 14 4.4 2490 23.3 15
7 4.2 2361 24.5 14 4.3 2505 24.6 15 4.3 2550 23.9 15 4.3 2184 24.4 13 4.1 2520 24.1 15
8 4.4 2357 25.4 14 4.6 2535 25.5 15 4.7 2510 24.8 15 4.8 2149 25.4 13 4.5 2505 25.0 15
9 4.4 2324 25.8 14 4.8 2490 26.4 15 4.9 2490 25.4 15 4.4 2172 25.9 13 4.6 2535 25.0 15
10 4.5 2357 25.9 14 4.7 2565 26.6 15 4.4 2540 25.2 15 4.5 2197 26.2 13 4.5 2500 25.9 15
11 4.6 2361 26.9 14 5.0 2333 27.3 15 4.8 2306 26.2 15 4.9 2028 26.8 13 5.0 2505 26.8 15
12 4.7 2180 27.0 13 5.0 2490 28.0 15 5.0 2545 26.8 15 5.0 2184 27.5 13 4.7 2541 27.0 15
13 4.6 2210 27.8 13 4.8 2352 28.2 15 4.6 2365 27.1 15 4.9 1977 27.9 13 4.4 2507 27.1 15
14 4.6 2145 28.9 13 5.0 2520 29.0 15 5.0 2339 28.4 15 5.0 2210 29.3 13 4.9 2546 28.2 15
15 4.7 2209 29.4 13 5.1 2560 29.5 15 4.7 2385 28.7 15 4.8 2171 29.8 13 4.9 2490 28.8 15
16 4.6 1984 30.5 13 5.0 2307 31.1 15 4.9 2310 29.9 15 4.9 2188 30.1 13 4.9 2544 29.8 15
17 5.0 2040 30.4 13 5.1 2550 31.0 15 4.8 2562 29.2 15 5.4 2163 30.5 13 5.3 2158 29.6 15
18 5.4 1992 31.8 13 5.3 2490 32.0 15 5.4 2481 30.9 15 5.3 2040 30.9 13 5.4 2553 30.0 15
19 5.3 2028 32.6 13 5.4 2565 32.1 15 5.5 2385 31.4 15 5.6 2171 31.9 13 5.5 2171 29.8 15
20 4.9 2180 32.4 13 5.3 2158 32.8 15 5.3 2490 32.0 15 5.5 2040 32.1 13 5.8 2546 31.1 15
21 5.3 2023 33.0 13 5.3 2525 33.1 15 5.2 2525 32.5 15 5.7 2025 32.4 13 5.6 2366 31.9 15
22 5.2 2223 33.7 13 5.8 2530 33.7 15 5.4 2540 33.3 15 5.8 2146 34.3 13 6.0 2475 32.4 15
23 5.5 1992 34.0 13 5.6 2342 34.2 15 5.7 2320 34.1 15 5.8 2016 33.8 13 5.9 2338 32.1 15
24 5.4 2176 34.1 13 5.7 2545 34.8 15 5.5 2560 34.6 15 5.8 2004 34.3 13 6.0 2520 32.9 15
25 5.5 1987 35.2 13 5.7 2141 35.6 15 5.7 2465 35.2 15 5.6 2039 35.1 13 5.7 2550 32.8 15
26 5.2 2188 34.3 13 5.6 2520 36.0 15 5.6 2520 35.4 15 5.6 2172 35.9 13 5.9 2521 33.6 15
27 5.3 507 5.7 676 5.5 847 5.6 507 6.6 839
MEAN BODY WGT FOR WEEKS
1 TO 13 24.2 24.4 23.7 24.1 23.8
14 TO 52 32.3 32.7 31.9 32.3 31.0
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==============================
12,000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 19.6 15
1 19.6 15
2 4.2 2495 20.8 15
3 4.2 2485 20.6 15
4 4.0 2562 20.8 15
5 4.2 2542 22.0 15
6 4.1 2329 22.6 14
7 4.4 2352 23.6 14
8 4.4 2365 24.2 14
9 4.3 2315 24.8 14
10 4.4 2379 25.0 14
11 4.9 2145 25.6 14
12 4.6 2379 25.4 14
13 4.8 2149 26.2 14
14 4.6 2394 26.8 14
15 4.5 2324 26.9 14
16 4.4 2371 27.7 14
17 5.1 2320 28.4 14
18 4.9 2216 28.2 14
19 5.0 2370 28.5 14
20 5.2 2168 28.9 14
21 5.1 2361 28.6 14
22 5.2 2145 29.7 14
23 5.4 2324 29.3 14
24 5.2 2202 29.8 14
25 5.3 2385 30.4 14
26 5.1 2346 30.3 14
27 5.4 1176
MEAN BODY WGT FOR WEEKS
1 TO 13 23.2
14 TO 52 28.7
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==================================================================================================================================
0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 16.4 15 16.4 15 16.4 15 16.5 15 16.5 15
1 16.4 15 16.4 15 16.4 15 16.5 15 16.5 15
2 4.0 2486 17.8 15 4.0 2490 17.4 15 4.2 2499 17.6 15 4.1 2505 17.8 15 4.3 2314 18.0 15
3 4.4 2347 18.7 15 4.2 2197 17.8 14 4.0 2180 18.2 14 3.8 2520 17.9 15 3.9 2366 18.2 15
4 4.0 2525 19.0 15 4.2 2197 18.5 13 3.9 2039 18.7 14 4.0 2505 18.6 15 3.9 2371 18.5 15
5 4.1 2520 19.8 15 4.0 2167 19.3 13 4.2 2329 19.8 14 4.0 2523 19.4 15 4.1 2343 19.8 14
6 4.1 2520 20.8 15 4.3 2197 20.4 13 4.3 2338 19.9 14 4.5 2525 20.6 15 4.5 2158 20.8 14
7 4.4 2520 21.3 15 4.2 2171 20.9 13 4.7 2366 21.2 14 4.3 2352 21.0 15 4.6 2025 21.4 14
8 5.2 2530 21.8 15 4.9 2191 21.9 13 5.2 2352 21.8 14 4.8 2310 22.0 15 4.6 2338 22.0 14
9 4.7 2488 22.2 15 5.2 2158 22.1 13 5.7 2324 22.4 14 4.5 2514 22.2 15 4.6 2365 21.7 14
10 5.1 2525 22.4 15 5.3 2052 21.6 13 5.3 2364 22.4 14 5.2 2366 22.0 15 5.0 2329 22.0 14
11 5.2 2530 22.1 15 5.5 2158 22.3 13 5.7 2308 23.3 14 4.8 2370 22.3 15 4.8 2344 22.3 14
12 5.1 2181 22.5 15 5.6 1992 22.4 13 5.9 2380 23.1 14 4.8 2352 22.5 15 4.9 2365 22.7 14
13 5.1 2380 22.7 15 5.9 2184 23.0 13 5.4 2197 23.4 14 5.2 2310 23.1 15 5.0 2171 22.8 14
14 5.5 2475 23.4 15 6.1 1848 23.1 13 6.1 2338 23.8 14 5.2 2550 23.1 15 5.2 1866 23.1 14
15 5.1 2380 22.9 15 5.9 2213 23.1 13 5.5 2223 23.4 14 4.8 2338 23.1 15 5.3 2325 22.7 14
16 5.3 2153 23.7 15 6.1 1976 23.5 13 5.4 2141 24.2 14 5.1 2352 23.5 15 5.7 2028 23.6 14
17 5.4 2380 23.6 15 5.7 2223 23.8 13 5.4 2223 23.8 14 5.4 2493 24.1 15 5.4 2158 24.1 14
18 5.8 2491 24.0 15 5.8 2155 23.8 13 5.5 1980 24.4 14 5.3 2380 24.2 15 5.9 2045 24.0 14
19 5.9 2535 24.5 15 6.1 1879 24.4 13 6.0 2052 24.7 14 6.1 1837 24.6 15 5.9 2004 24.4 14
20 5.4 2508 24.5 15 6.5 2164 25.0 13 5.6 2324 25.1 14 5.8 2556 24.8 15 6.0 2371 24.7 14
21 5.4 1852 24.7 15 5.9 2191 24.8 13 5.0 2366 25.0 14 5.4 2197 24.5 15 5.5 2361 24.3 14
22 5.7 2220 24.4 15 6.1 2184 25.6 13 5.2 2022 24.6 14 5.6 2475 25.4 15 6.0 2145 25.2 14
23 5.8 1992 24.2 15 5.7 2016 24.8 13 6.0 1997 25.6 14 5.4 2016 24.3 15 5.6 2171 24.6 14
24 5.7 2180 24.8 15 6.0 1860 25.0 13 5.6 2210 25.4 14 5.9 2171 25.5 15 6.1 1848 25.2 14
25 6.2 2315 25.6 15 6.3 1811 25.6 13 6.3 2145 26.4 14 5.8 2040 25.1 15 6.2 2219 25.3 14
26 6.3 2352 25.3 15 6.1 2184 25.5 13 6.1 2352 26.5 14 5.6 2338 25.1 15 6.0 2166 25.1 14
27 6.3 2535 6.4 2028 6.4 2364 6.2 2360 5.9 2192
MEAN BODY WGT FOR WEEKS
1 TO 13 20.6 20.3 20.6 20.5 20.5
14 TO 52 24.3 24.5 24.8 24.4 24.3
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)
==============================
12,000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 16.5 15
1 16.5 15
2 4.2 2495 17.7 15
3 4.3 2495 18.6 15
4 4.2 2561 19.1 15
5 4.5 2520 19.8 15
6 4.6 2490 20.9 15
7 4.7 2520 21.6 15
8 5.0 2535 22.0 15
9 5.2 2490 22.2 15
10 5.1 2540 22.5 15
11 5.4 2475 23.2 15
12 5.3 2550 23.1 15
13 5.5 2319 23.4 15
14 5.4 2391 23.5 15
15 5.6 2324 23.6 15
16 5.7 2545 23.9 15
17 5.6 2490 24.0 15
18 5.5 2381 24.1 15
19 5.8 2548 24.5 15
20 6.1 2340 25.0 15
21 5.3 2197 24.7 15
22 5.5 2310 24.9 15
23 6.2 2324 25.6 15
24 6.1 2545 25.5 15
25 5.9 2385 25.4 15
26 6.0 2347 25.4 15
27 6.4 2520
MEAN BODY WGT FOR WEEKS
1 TO 13 20.8
14 TO 52 24.6
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.