TDMS Study 99034-01 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus TRANSGENIC MODEL EVALUATION II (BENZENE) DATE: 11/05/03
EXPERIMENT: 99034 TEST: 01 TIME: 14:48:55
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: GAVAGE NTP: C99034
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS TRANSGENIC MODEL EVALUATION II (BENZENE) DATE: 11/05/03
EXPERIMENT: 99034 TEST: 01 TIME: 14:53:23
SPECIES: MICE, TG:P16-INK4A
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: ORAL GAVAGE NTP: C99034
CONT: N01-ES-65406 CAS: 71-43-2
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
SUBCHRONIC (26-WEEK) ORAL GAVAGE STUDY OF TRANSGENIC MODEL EVALUATION II (BENZENE)
===================================================================================================================================
WEEK 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG 200 MG/KG
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 25.4 15 25.1 98.8 15 24.9 98.0 15 24.8 97.6 15 25.1 98.8 15
1 25.4 15 25.1 98.8 15 24.9 98.0 15 24.8 97.6 15 25.1 98.8 15
2 26.4 15 25.2 95.5 15 25.5 96.6 15 24.8 93.9 15 25.0 94.7 15
3 27.1 15 26.4 97.4 15 26.5 97.8 15 26.0 95.9 15 25.9 95.6 14
4 27.8 15 26.5 95.3 15 26.6 95.7 15 26.7 96.0 15 25.7 92.4 14
5 28.7 15 27.6 96.2 15 27.7 96.5 15 27.2 94.8 15 26.6 92.7 14
6 29.2 15 28.4 97.3 15 28.2 96.6 15 27.6 94.5 15 27.6 94.5 14
7 30.8 15 29.3 95.1 15 29.1 94.5 15 27.8 90.3 15 27.4 89.0 14
8 30.6 15 30.0 98.0 15 29.1 95.1 15 28.1 91.8 15 27.8 90.8 14
9 31.6 15 30.7 97.2 15 29.5 93.4 15 28.2 89.2 15 28.2 89.2 14
10 32.3 15 31.7 98.1 15 30.8 95.4 15 29.1 90.1 15 28.7 88.9 14
11 32.9 15 33.0 100.3 15 31.9 97.0 15 29.9 90.9 15 29.2 88.8 14
12 34.4 15 33.6 97.7 15 32.2 93.6 15 29.9 86.9 15 28.6 83.1 14
13 36.0 15 34.2 95.0 15 32.7 90.8 15 29.6 82.2 15 29.0 80.6 14
14 36.3 15 34.1 93.9 15 32.0 88.2 15 29.7 81.8 15 28.4 78.2 14
15 37.2 15 35.1 94.4 15 33.3 89.5 15 30.6 82.3 15 29.4 79.0 14
16 37.7 15 35.2 93.4 15 34.0 90.2 15 30.7 81.4 15 29.7 78.8 14
17 38.6 15 35.6 92.2 15 34.5 89.4 15 31.3 81.1 15 30.8 79.8 14
18 39.9 15 36.5 91.5 15 35.0 87.7 15 31.6 79.2 15 30.8 77.2 14
19 40.9 15 37.7 92.2 15 35.2 86.1 15 31.7 77.5 15 31.0 75.8 14
20 40.9 15 37.4 91.4 15 36.4 89.0 15 32.3 79.0 15 31.3 76.5 14
21 40.3 15 37.4 92.8 15 36.1 89.6 15 31.6 78.4 15 31.6 78.4 14
22 41.9 15 37.5 89.5 15 36.4 86.9 15 32.3 77.1 15 32.3 77.1 14
23 42.6 15 38.3 89.9 15 37.2 87.3 15 32.6 76.5 15 32.3 75.8 14
24 43.7 15 37.9 86.7 15 37.5 85.8 15 33.1 75.7 15 31.7 72.5 14
25 44.5 15 37.9 85.2 15 37.9 85.2 15 33.5 75.3 15 32.5 73.0 14
26 44.4 15 39.1 88.1 15 38.4 86.5 15 33.3 75.0 15 31.5 70.9 14
27 45.3 15 40.0 88.3 15 39.3 86.8 15 33.5 74.0 15 32.1 70.9 14
TERM. SAC. 15 15 15 15 14
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) ORAL GAVAGE STUDY OF TRANSGENIC MODEL EVALUATION II (BENZENE)
===================================================================================================================================
WEEK 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG 200 MG/KG
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 20.0 15 20.0 100.0 15 20.0 100.0 15 20.1 100.5 15 20.3 101.5 15
1 20.0 15 20.0 100.0 15 20.0 100.0 15 20.1 100.5 15 20.3 101.5 15
2 20.3 15 19.9 98.0 15 20.1 99.0 15 20.9 103.0 15 21.0 103.4 15
3 21.2 15 21.1 99.5 15 21.2 100.0 15 21.8 102.8 15 21.7 102.4 15
4 21.5 15 21.7 100.9 15 22.1 102.8 15 21.7 100.9 15 22.4 104.2 15
5 22.6 15 22.6 100.0 15 22.6 100.0 15 22.4 99.1 15 22.5 99.6 15
6 23.2 15 23.2 100.0 15 23.3 100.4 15 23.3 100.4 15 23.2 100.0 15
7 23.6 15 23.8 100.8 15 24.0 101.7 15 23.6 100.0 15 23.8 100.8 15
8 23.7 15 23.6 99.6 15 24.1 101.7 15 23.9 100.8 15 23.7 100.0 15
9 23.7 15 23.6 99.6 15 24.2 102.1 15 23.9 100.8 15 23.9 100.8 15
10 24.6 15 24.6 100.0 15 25.0 101.6 15 24.4 99.2 15 24.5 99.6 15
11 25.1 15 25.3 100.8 15 25.6 102.0 15 25.4 101.2 15 25.1 100.0 15
12 25.3 15 25.2 99.6 15 25.5 100.8 15 25.5 100.8 15 25.3 100.0 15
13 25.5 15 25.4 99.6 15 25.9 101.6 15 25.2 98.8 15 24.9 97.6 15
14 25.4 15 25.6 100.8 15 25.6 100.8 15 25.1 98.8 15 24.6 96.9 15
15 26.2 15 26.2 100.0 15 26.3 100.4 15 26.1 99.6 15 25.7 98.1 15
16 26.8 15 26.3 98.1 15 26.8 100.0 15 26.2 97.8 15 24.8 92.5 15
17 26.9 15 26.9 100.0 15 26.7 99.3 15 26.5 98.5 15 26.0 96.7 15
18 28.1 15 27.6 98.2 15 27.0 96.1 15 27.3 97.2 15 26.0 92.5 15
19 27.8 15 27.5 98.9 15 27.4 98.6 15 26.8 96.4 15 25.9 93.2 15
20 28.6 15 27.6 96.5 15 27.4 95.8 15 27.2 95.1 15 26.3 92.0 15
21 28.6 15 27.5 96.2 15 27.8 97.2 15 27.6 96.5 15 26.3 92.0 15
22 28.8 15 27.9 96.9 15 28.3 98.3 15 28.2 97.9 15 26.9 93.4 15
23 29.6 15 28.7 97.0 15 28.8 97.3 15 28.7 97.0 15 27.1 91.6 15
24 29.3 15 28.4 96.9 15 29.4 100.3 15 28.9 98.6 15 26.8 91.5 15
25 29.6 15 29.4 99.3 15 28.9 97.6 15 29.4 99.3 15 26.9 90.9 15
26 30.3 15 28.4 93.7 15 30.0 99.0 15 29.7 98.0 15 27.5 90.8 15
27 30.4 15 28.7 94.4 15 29.3 96.4 15 29.7 97.7 15 27.3 89.8 15
TERM. SAC. 15 15 15 15 15
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.