TDMS Study 99036-01 Pathology Tables
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 77-09-08
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 13 14 15 14 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (15) (14) (15) (15) (15) (15)
Infiltration Cellular, Polymorphonuclear 1 (7%)
Liver (15) (15) (15) (15) (15) (15)
Basophilic Focus 1 (7%)
Inflammation, Chronic 10 (67%) 8 (53%) 12 (80%) 10 (67%) 7 (47%) 8 (53%)
Necrosis, Focal 1 (7%) 1 (7%)
Stomach, Forestomach (15) (14) (15) (15) (15) (15)
Ulcer 1 (7%)
Stomach, Glandular (15) (14) (15) (15) (15) (15)
Hemorrhage 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (15) (14) (15) (15) (15) (15)
Inflammation, Granulomatous 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (15) (14) (15) (15) (14) (15)
Cyst 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Uterus (15) (15) (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 15 (100%) 12 (80%) 14 (93%) 15 (100%) 13 (87%) 14 (93%)
Vagina (1)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15) (15) (15)
Atrophy 2 (13%) 2 (13%)
Hematopoietic Cell Proliferation 1 (7%)
Hemorrhage 1 (7%)
Hyperplasia, Lymphoid 4 (27%) 2 (13%) 2 (13%) 1 (7%) 6 (40%)
Lymph Node, Mesenteric (15) (14) (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 1 (7%) 2 (13%) 2 (13%)
Hematopoietic Cell Proliferation 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
Infiltration Cellular, Polymorphonuclear 1 (7%)
Spleen (15) (14) (14) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 5 (36%) 9 (64%) 8 (53%) 7 (47%) 13 (87%)
Lymphoid Follicle, Atrophy 1 (7%) 2 (13%)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (15) (15) (15) (15) (14) (15)
Atrophy, Diffuse 1 (7%) 1 (7%) 1 (7%)
Hyperplasia, Atypical 1 (7%) 3 (21%) 5 (33%)
Hyperplasia, Lymphoid 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Brain (15) (15) (15) (15) (15) (15)
Hemorrhage 1 (7%)
Neuron, Necrosis 1 (7%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Inflammation, Chronic 2 (13%) 1 (7%) 1 (7%) 3 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Hydronephrosis 1 (7%) 1 (7%)
Nephropathy 10 (67%) 6 (40%) 8 (53%) 8 (53%) 7 (47%) 11 (73%)
Renal Tubule, Mineralization 1 (7%)
Ureter (1)
Cyst 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 15 15 13 15 14
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (14) (15) (14)
Hematopoietic Cell Proliferation 1 (7%)
Inflammation, Chronic 11 (73%) 8 (53%) 7 (47%) 9 (64%) 10 (67%) 5 (36%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Stomach, Glandular (14) (15) (15) (14) (15) (14)
Epithelium, Cyst 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (14) (15) (15) (14) (15) (14)
Hyperplasia, Focal 4 (29%) 1 (7%)
Hypertrophy, Focal 4 (29%) 3 (20%) 1 (7%) 1 (7%) 2 (13%)
Thyroid Gland (14) (15) (15) (14) (15) (15)
Infiltration Cellular, Polymorphonuclear 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (15) (15) (15) (15) (15) (15)
Hypospermia 1 (7%) 15 (100%) 14 (93%)
Inflammation, Chronic 1 (7%)
Inflammation, Granulomatous 1 (7%)
Mineralization 1 (7%)
Testes (15) (15) (15) (15) (15) (15)
Germinal Epithelium, Atrophy 1 (7%) 1 (7%) 15 (100%) 14 (93%)
Interstitial Cell, Hyperplasia 1 (7%) 1 (7%) 15 (100%) 14 (93%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (15) (15) (15) (15) (15) (15)
Hyperplasia 1 (7%)
Lymph Node, Mandibular (14) (15) (15) (14) (15) (13)
Hyperplasia, Lymphoid 2 (14%) 1 (7%) 2 (13%) 3 (20%) 1 (8%)
Lymph Node, Mesenteric (14) (15) (15) (14) (15) (14)
Atrophy 1 (7%) 1 (7%) 1 (7%)
Hyperplasia, Lymphoid 1 (7%) 2 (13%) 1 (7%)
Spleen (14) (15) (15) (14) (15) (14)
Hematopoietic Cell Proliferation 2 (14%) 5 (33%) 3 (20%) 1 (7%) 2 (13%) 14 (100%)
Infiltration Cellular, Mononuclear Cell 1 (7%)
Pigmentation 1 (7%)
Capsule, Fibrosis 1 (7%)
Lymphoid Follicle, Atrophy 1 (7%)
Thymus (14) (15) (15) (14) (15) (14)
Atrophy, Diffuse 1 (7%)
Hyperplasia, Atypical 1 (7%) 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:32:03
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14) (15) (15)
Inflammation, Chronic 2 (13%) 2 (14%) 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (14) (15) (15) (14) (15) (15)
Nephropathy 6 (43%) 7 (47%) 8 (53%) 6 (43%) 15 (100%) 14 (93%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (7%)
Renal Tubule, Hypertrophy 10 (71%) 15 (100%) 14 (93%)
a Number of animals examined microscopically at site and number of animals with lesion
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