TDMS Study 99036-01 Pathology Tables
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 77-09-08
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 13 14 15 14 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
Pancreas (1)
Histiocytic Sarcoma 1 (100%)
Stomach, Glandular (15) (14) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (15) (14) (15) (15) (15) (15)
Pheochromocytoma Benign 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (14) (15) (15) (14) (15)
Histiocytic Sarcoma 1 (7%) 2 (13%)
Periovarian Tissue, Histiocytic Sarcoma 1 (7%)
Uterus (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%) 1 (7%) 1 (7%)
Lymph Node (13) (10) (13) (14) (13) (13)
Deep Cervical, Histiocytic Sarcoma 1 (10%)
Lymph Node, Mandibular (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
Spleen (15) (14) (14) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
Thymus (15) (15) (15) (15) (14) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Histiocytic Sarcoma 1 (100%)
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Histiocytic Sarcoma 1 (7%) 2 (13%) 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 2 1 2 1
Total Primary Neoplasms 1 2 1 4 1
Total Animals with Benign Neoplasms 1
Total Benign Neoplasms 1
Total Animals with Malignant Neoplasms 1 2 1 1 1
Total Malignant Neoplasms 1 2 1 3 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 15 15 13 15 14
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (14) (15) (15) (14) (15) (14)
Intestine Large, Rectum (14) (15) (15) (14) (15) (14)
Intestine Large, Cecum (14) (15) (15) (14) (15) (14)
Intestine Small, Duodenum (14) (15) (15) (14) (15) (14)
Intestine Small, Jejunum (14) (15) (15) (14) (15) (14)
Intestine Small, Ileum (14) (15) (15) (14) (15) (14)
Liver (15) (15) (15) (14) (15) (14)
Histiocytic Sarcoma 1 (7%)
Stomach, Forestomach (14) (15) (15) (15) (15) (14)
Stomach, Glandular (14) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (14) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%) 1 (7%)
Lymph Node (11) (11) (9) (10) (15) (12)
Mediastinal, Histiocytic Sarcoma 1 (11%)
Lymph Node, Mandibular (14) (15) (15) (14) (15) (13)
Lymph Node, Mesenteric (14) (15) (15) (14) (15) (14)
Spleen (14) (15) (15) (14) (15) (14)
Thymus (14) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (14) (15) (15)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (15) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (14) (15) (15) (14) (15) (15)
Urinary Bladder (14) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Histiocytic Sarcoma 1 (7%) 1 (7%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Date: 04/21/04
Route: DOSED FEED Time: 08:33:43
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 1 1
Total Primary Neoplasms 1 1 1
Total Animals with Benign Neoplasms
Total Benign Neoplasms
Total Animals with Malignant Neoplasms 1 1 1
Total Malignant Neoplasms 1 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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