TDMS Study 99034-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRANSGENIC MODEL EVALUATION II (BENZENE) DATE: 11/05/03
EXPERIMENT: 99034 TEST: 01 TIME: 14:56:12
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: GAVAGE NTP C#: C99034
PATHOLOGIST: MISSING CAS: 71-43-2
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TRANSGENIC MODEL EVALUATION II (BENZENE) DATE: 11/05/03
EXPERIMENT: 99034 TEST: 01 TIME: 14:56:12
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: GAVAGE NTP C#: C99034
PATHOLOGIST: MISSING CAS: 71-43-2
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 188 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 188 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 11 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 188 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 188 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|25 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|MG/KG | |
| | |
|200 | 93.3 93.3 93.3 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|MG/KG | |
| | |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 188 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 25 MG/KG 50 MG/KG 100 200 |
| MG/KG MG/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 100.0% 100.0% 93.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.289 ----- ----- ----- P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . . 11.0 |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 188.0 188.0 188.0 188.0 176.2 |
|(STANDARD ERROR) | ( 0.0) ( 0.0) ( 0.0) ( 0.0) (11.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 189 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 189 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 189 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 189 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|25 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|MG/KG | |
| | |
|200 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|MG/KG | |
| | |
==================================================================================
TRANSGENIC MODEL EVALUATION II (BENZENE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 189 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 25 MG/KG 50 MG/KG 100 200 |
| MG/KG MG/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 100.0% 100.0% 100.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . . . |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 189.0 189.0 189.0 189.0 189.0 |
|(STANDARD ERROR) | ( 0.0) ( 0.0) ( 0.0) ( 0.0) ( 0.0) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRANSGENIC MODEL EVALUATION II (BENZENE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
25 MG/KG = 2
50 MG/KG = 3
100 MG/KG = 4
200 MG/KG = 5
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 7 obs hidden.)
P |
E |
R 100.00 +1 5 1
C |
E |
N |
T 93.33 + 5 5
|
S -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
U 0.0 2.5 5.0 7.5 10.0 12.5 15.0 17.5 20.0 22.5 25.0 27.5
R
WEEK
TRANSGENIC MODEL EVALUATION II (BENZENE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
25 MG/KG = 2
50 MG/KG = 3
100 MG/KG = 4
200 MG/KG = 5
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 8 obs hidden.)
P |
E |
R 200 +
C |
E |
N |
T 100 + 1 1
|
S |
U |
R 0 +
V |
I ---+----------------------------------------------------------------------------------+--
V 0 27
A
WEEK