TDMS Study 99036-01 Pathology Tables
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 77-09-08
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 13 14 15 14 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (15) (14) (15) (15) (15) (15)
Infiltration Cellular, Polymorphonuclear 1 [1.0]
Liver (15) (15) (15) (15) (15) (15)
Basophilic Focus 1
Inflammation, Chronic 10 [1.0] 8 [1.0] 12 [1.0] 10 [1.0] 7 [1.0] 8 [1.0]
Necrosis, Focal 1 [1.0] 1 [1.0]
Stomach, Forestomach (15) (14) (15) (15) (15) (15)
Ulcer 1 [3.0]
Stomach, Glandular (15) (14) (15) (15) (15) (15)
Hemorrhage 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (15) (14) (15) (15) (15) (15)
Inflammation, Granulomatous 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (15) (14) (15) (15) (14) (15)
Cyst 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Uterus (15) (15) (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 15 [1.1] 12 [1.2] 14 [1.2] 15 [1.3] 13 [1.2] 14 [1.4]
Vagina (1)
Epithelium, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15) (15) (15)
Atrophy 2 [2.0] 2 [2.0]
Hematopoietic Cell Proliferation 1 [3.0]
Hemorrhage 1 [3.0]
Hyperplasia, Lymphoid 4 [1.3] 2 [1.0] 2 [1.0] 1 [2.0] 6 [1.7]
Lymph Node, Mesenteric (15) (14) (15) (15) (15) (15)
Atrophy 1 [1.0] 1 [2.0] 1 [1.0] 2 [2.0] 2 [1.0]
Hematopoietic Cell Proliferation 1 [1.0]
Hyperplasia, Lymphoid 1 [1.0]
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Spleen (15) (14) (14) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0] 5 [1.0] 9 [1.1] 8 [1.0] 7 [1.3] 13 [1.0]
Lymphoid Follicle, Atrophy 1 [4.0] 2 [4.0]
Lymphoid Follicle, Hyperplasia 1 [1.0]
Thymus (15) (15) (15) (15) (14) (15)
Atrophy, Diffuse 1 [3.0] 1 [3.0] 1 [3.0]
Hyperplasia, Atypical 1 [3.0] 3 [2.0] 5 [2.6]
Hyperplasia, Lymphoid 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) FEMALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Brain (15) (15) (15) (15) (15) (15)
Hemorrhage 1 [3.0]
Neuron, Necrosis 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Inflammation, Chronic 2 [1.0] 1 [1.0] 1 [1.0] 3 [1.3] 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Hydronephrosis 1 [3.0] 1 [4.0]
Nephropathy 10 [1.0] 6 [1.0] 8 [1.0] 8 [1.0] 7 [1.0] 11 [1.0]
Renal Tubule, Mineralization 1 [1.0]
Ureter (1)
Cyst 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 15 15 13 15 14
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (14) (15) (14)
Hematopoietic Cell Proliferation 1 [4.0]
Inflammation, Chronic 11 [1.0] 8 [1.0] 7 [1.0] 9 [1.0] 10 [1.0] 5 [1.0]
Mesentery (1)
Fat, Necrosis 1 [2.0]
Stomach, Glandular (14) (15) (15) (14) (15) (14)
Epithelium, Cyst 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (14) (15) (15) (14) (15) (14)
Hyperplasia, Focal 4 [1.5] 1 [2.0]
Hypertrophy, Focal 4 [1.3] 3 [1.0] 1 [1.0] 1 [1.0] 2 [1.0]
Thyroid Gland (14) (15) (15) (14) (15) (15)
Infiltration Cellular, Polymorphonuclear 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (15) (15) (15) (15) (15) (15)
Hypospermia 1 [4.0] 15 [1.1] 14 [3.0]
Inflammation, Chronic 1 [1.0]
Inflammation, Granulomatous 1 [1.0]
Mineralization 1 [1.0]
Testes (15) (15) (15) (15) (15) (15)
Germinal Epithelium, Atrophy 1 [1.0] 1 [4.0] 15 [1.6] 14 [2.6]
Interstitial Cell, Hyperplasia 1 [1.0] 1 [2.0] 15 [1.5] 14 [1.8]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (15) (15) (15) (15) (15) (15)
Hyperplasia 1 [4.0]
Lymph Node, Mandibular (14) (15) (15) (14) (15) (13)
Hyperplasia, Lymphoid 2 [1.5] 1 [1.0] 2 [2.0] 3 [1.0] 1 [2.0]
Lymph Node, Mesenteric (14) (15) (15) (14) (15) (14)
Atrophy 1 [1.0] 1 [1.0] 1 [3.0]
Hyperplasia, Lymphoid 1 [1.0] 2 [1.0] 1 [1.0]
Spleen (14) (15) (15) (14) (15) (14)
Hematopoietic Cell Proliferation 2 [1.0] 5 [1.4] 3 [2.0] 1 [1.0] 2 [1.0] 14 [1.0]
Infiltration Cellular, Mononuclear Cell 1 [3.0]
Pigmentation 1 [2.0]
Capsule, Fibrosis 1 [1.0]
Lymphoid Follicle, Atrophy 1 [2.0]
Thymus (14) (15) (15) (14) (15) (14)
Atrophy, Diffuse 1 [4.0]
Hyperplasia, Atypical 1 [2.0] 1 [3.0]
Hyperplasia, Lymphoid 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 99036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 04/21/04
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN) Time: 08:38:26
____________________________________________________________________________________________________________________________________
P16(INK4A)/(+/-) (C57BL/6) MALE 0 PPM 200 PPM 375 PPM 750 PPM 3000 PPM 12,000
PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14) (15) (15)
Inflammation, Chronic 2 [1.0] 2 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (14) (15) (15) (14) (15) (15)
Nephropathy 6 [1.0] 7 [1.0] 8 [1.0] 6 [1.0] 15 [1.0] 14 [1.4]
Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0]
Renal Tubule, Hypertrophy 10 [1.0] 15 [1.0] 14 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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