TDMS Study 96018-03 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 04/29/03
EXPERIMENT: 96018 TEST: 03 TIME: 12:33:29
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96018
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FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 04/29/03
EXPERIMENT: 96018 TEST: 03 TIME: 12:41:38
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96018
CONT: N01-ES-85420 CAS: 75-27-4
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
==================================================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 16.7 200.6 15.4 194.8 0.92 13.9 15.2 193.6 0.91 27.5 14.7 192.7 0.88 53.3
8 17.7 277.6 16.1 269.3 0.91 10.5 15.9 272.0 0.90 20.5 15.8 268.7 0.89 41.3
12 16.9 326.5 15.3 317.9 0.91 8.4 14.9 319.3 0.88 16.3 14.4 314.4 0.85 32.1
16 15.8 360.4 14.2 348.0 0.90 7.1 13.8 347.4 0.87 13.9 13.5 345.1 0.85 27.4
20 16.0 387.3 15.1 375.7 0.94 7.0 14.3 374.8 0.89 13.3 14.4 370.8 0.90 27.1
24 16.1 404.8 15.6 393.3 0.97 6.9 15.3 392.2 0.95 13.6 14.4 390.8 0.89 25.8
28 15.3 429.0 14.7 414.8 0.96 6.2 13.9 414.3 0.91 11.7 13.9 410.0 0.91 23.8
32 14.7 443.9 14.3 430.3 0.97 5.8 14.0 428.4 0.95 11.5 13.8 424.7 0.94 22.8
36 14.7 458.1 13.9 444.4 0.95 5.5 13.7 443.8 0.93 10.8 13.8 438.1 0.94 22.0
40 14.6 468.0 13.8 454.9 0.95 5.3 13.8 454.1 0.95 10.6 13.4 448.6 0.92 20.9
44 14.7 480.6 14.1 468.1 0.96 5.3 13.9 467.9 0.95 10.4 13.5 461.9 0.92 20.5
48 16.1 481.3 15.3 469.7 0.95 5.7 15.1 470.2 0.94 11.2 14.8 464.8 0.92 22.3
52 15.8 491.9 14.7 478.6 0.93 5.4 15.0 478.7 0.95 10.9 14.8 472.3 0.94 21.9
56 14.9 498.2 14.1 484.1 0.95 5.1 14.0 485.7 0.94 10.1 14.0 476.4 0.94 20.5
60 15.4 505.4 14.8 492.6 0.96 5.3 14.0 491.9 0.91 10.0 14.1 486.0 0.92 20.3
64 16.3 506.2 15.2 495.4 0.93 5.4 15.0 495.3 0.92 10.6 14.9 487.0 0.91 21.4
68 15.5 510.9 14.3 497.0 0.92 5.0 14.1 497.3 0.91 9.9 13.7 487.7 0.88 19.7
72 15.3 511.6 15.1 499.5 0.99 5.3 14.4 497.3 0.94 10.1 14.3 487.4 0.93 20.5
76 15.1 509.6 14.2 502.5 0.94 4.9 13.8 495.0 0.91 9.8 13.6 490.2 0.90 19.4
80 14.8 509.4 14.4 503.0 0.97 5.0 13.8 497.2 0.93 9.7 13.3 490.9 0.90 18.9
81 14.0 510.5 13.2 503.8 0.94 4.6 14.0 494.3 1.00 9.9 13.6 488.7 0.97 19.4
84 16.2 507.5 14.8 496.7 0.91 5.2 14.8 495.2 0.91 10.5 14.2 482.3 0.88 20.7
88 14.8 505.5 13.6 500.3 0.92 4.7 13.0 496.1 0.88 9.2 13.6 482.5 0.92 19.7
92 15.8 510.8 14.4 497.9 0.91 5.1 13.4 491.9 0.85 9.6 13.9 477.5 0.88 20.4
96 17.1 511.4 15.4 483.3 0.90 5.6 15.2 489.1 0.89 10.9 15.2 483.1 0.89 22.1
100 16.5 505.7 14.8 473.5 0.90 5.5 16.0 488.1 0.97 11.5 17.6 476.9 1.07 25.9
104 16.9 491.1 15.6 482.3 0.92 5.6 15.1 480.7 0.89 11.0 16.6 473.4 0.98 24.5
1 TO 13 WEEKS
----------------
MEAN 17.1 268.3 15.6 260.7 0.91 10.9 15.4 261.6 0.90 21.4 15.0 258.6 0.87 42.2
SD(D) 0.5 0.5 0.01 2.7 0.5 0.01 5.6 0.8 0.02 10.7
CV(E) 3.0 2.9 1.0 25.1 3.4 1.6 26.3 5.1 2.4 25.3
14 TO 52 WEEKS
----------------
MEAN 15.4 440.5 14.6 427.8 0.95 6.0 14.3 427.2 0.93 11.8 14.0 422.7 0.91 23.5
SD(D) 0.7 0.6 0.02 0.7 0.6 0.03 1.3 0.5 0.03 2.5
CV(E) 4.3 4.2 2.3 12.3 4.3 3.0 11.1 3.7 2.8 10.6
> 52 WEEKS
----------------
MEAN 15.6 506.7 14.6 493.7 0.93 5.2 14.3 492.5 0.92 10.2 14.5 483.6 0.93 21.0
SD(D) 0.9 0.7 0.03 0.3 0.8 0.04 0.6 1.3 0.05 2.0
CV(E) 5.6 4.7 2.9 5.9 5.5 4.1 6.0 8.7 5.6 9.5
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
=========================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 105.5 50 105.6 50 103.6 50 105.2 50
1 105.5 50 105.6 50 103.6 50 105.2 50
4 16.7 8223 200.6 50 15.4 8283 194.8 50 15.2 8161 193.6 50 14.7 8273 192.7 50
8 17.7 8025 277.6 50 16.1 8227 269.3 50 15.9 8230 272.0 50 15.8 7941 268.7 50
12 16.9 7914 326.5 50 15.3 8161 317.9 50 14.9 8052 319.3 50 14.4 8213 314.4 50
16 15.8 8374 360.4 50 14.2 8302 348.0 50 13.8 8078 347.4 50 13.5 8296 345.1 50
20 16.0 8376 387.3 50 15.1 8339 375.7 50 14.3 8333 374.8 50 14.4 8323 370.8 50
24 16.1 8084 404.8 50 15.6 7601 393.3 50 15.3 7939 392.2 50 14.4 7884 390.8 50
28 15.3 7910 429.0 50 14.7 7370 414.8 50 13.9 7907 414.3 50 13.9 7548 410.0 50
32 14.7 8338 443.9 50 14.3 8328 430.3 50 14.0 7076 428.4 50 13.8 8328 424.7 50
36 14.7 8267 458.1 50 13.9 8265 444.4 50 13.7 8169 443.8 50 13.8 8166 438.1 50
40 14.6 8238 468.0 50 13.8 7949 454.9 50 13.8 8017 454.1 50 13.4 8166 448.6 50
44 14.7 8036 480.6 50 14.1 8310 468.1 50 13.9 8383 467.9 50 13.5 8383 461.9 50
48 16.1 8389 481.3 50 15.3 8241 469.7 50 15.1 8471 470.2 50 14.8 8506 464.8 50
52 15.8 8208 491.9 49 14.7 7844 478.6 50 15.0 8084 478.7 50 14.8 7579 472.3 50
56 14.9 7860 498.2 49 14.1 8302 484.1 50 14.0 8144 485.7 50 14.0 8336 476.4 50
60 15.4 7937 505.4 48 14.8 7895 492.6 49 14.0 8103 491.9 50 14.1 8021 486.0 50
64 16.3 7739 506.2 48 15.2 7632 495.4 49 15.0 7904 495.3 49 14.9 7782 487.0 50
68 15.5 7543 510.9 47 14.3 7804 497.0 49 14.1 7890 497.3 49 13.7 8178 487.7 49
72 15.3 7491 511.6 46 15.1 7406 499.5 49 14.4 6983 497.3 49 14.3 7350 487.4 47
76 15.1 7127 509.6 46 14.2 7004 502.5 47 13.8 7673 495.0 49 13.6 6396 490.2 45
80 14.8 4157 509.4 44 14.4 4258 503.0 46 13.8 4448 497.2 47 13.3 3742 490.9 47
81 14.0 6790 510.5 44 13.2 7193 503.8 45 14.0 7481 494.3 47 13.6 7418 488.7 46
84 16.2 6768 507.5 44 14.8 6484 496.7 44 14.8 7230 495.2 46 14.2 7483 482.3 46
88 14.8 7156 505.5 44 13.6 7103 500.3 44 13.0 7211 496.1 45 13.6 7346 482.5 45
92 15.8 6357 510.8 41 14.4 6700 497.9 42 13.4 6945 491.9 43 13.9 6104 477.5 39
96 17.1 5845 511.4 38 15.4 6105 483.3 39 15.2 6321 489.1 40 15.2 5755 483.1 35
100 16.5 6065 505.7 36 14.8 5551 473.5 35 16.0 5844 488.1 36 17.6 4952 476.9 32
104 16.9 4712 491.1 31 15.6 4480 482.3 28 15.1 4823 480.7 31 16.6 4237 473.4 27
MEAN BODY WGT FOR WEEKS
1 TO 13 227.6 221.9 222.1 220.3
14 TO 52 440.5 427.8 427.2 422.7
> 52 506.7 493.7 492.5 483.6
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.