TDMS Study 92012-03 Pathology Tables
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 90-DAY SUBCHRONIC Facility: Microbiological Associates Chemical CAS #: 693-98-1 Lock Date: 08/31/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000 CONTROL PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Accidently Killed 3 3 2 5 Terminal Sacrifice 7 10 10 7 8 5 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (1) (1) (10) Hepatodiaphragmatic Nodule 1 (100%) 1 (100%) 1 (10%) Inflammation, Focal 2 (20%) 1 (100%) 1 (100%) 4 (40%) Mesentery (1) (1) (1) Fat, Necrosis 1 (100%) 1 (100%) 1 (100%) Pancreas (10) (1) (10) Acinus, Degeneration, Focal 2 (20%) 1 (100%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (1) (10) Cardiomyopathy 1 (10%) 1 (100%) 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (1) (1) (10) (10) Necrosis, Acute 1 (100%) 1 (100%) 2 (20%) Thyroid Gland (10) (9) (10) (10) (10) (10) Follicular Cell, Hyperplasia, Diffuse 10 (100%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (1) (1) (10) Inflammation, Focal 1 (10%) 1 (100%) 1 (100%) 3 (30%) Ovary (10) (2) (1) (1) (1) (10) Cyst 1 (50%) 1 (100%) 1 (100%) 1 (100%) 1 (10%) Bilateral, Cyst 1 (50%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000 CONTROL PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Uterus (10) (10) (10) (10) (10) (10) Hydrometra 1 (10%) Bilateral, Hydrometra 2 (20%) 1 (10%) 2 (20%) 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) Hyperplasia 1 (10%) Infiltration Cellular, Histiocyte 1 (10%) Lymph Node, Mandibular (10) (10) Hemorrhage 2 (20%) 1 (10%) Infiltration Cellular, Plasma Cell 1 (10%) Lymph Node, Mesenteric (10) (10) (10) (10) (10) (10) Infiltration Cellular, Histiocyte 8 (80%) 4 (40%) 9 (90%) 5 (50%) 10 (100%) 10 (100%) Spleen (10) (10) Lymphoid Follicle, Necrosis 3 (30%) 1 (10%) Thymus (10) (1) (10) Hemorrhage 1 (100%) 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (1) (10) Inflammation, Focal 1 (10%) 1 (100%) 4 (40%) Nose (10) (10) Respiratory Epithelium, Inflammation, a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000 CONTROL PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Suppurative 2 (20%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000 CONTROL PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Ileum (10) (10) Inflammation, Chronic, Focal 1 (10%) Liver (10) (1) (10) Hepatodiaphragmatic Nodule 1 (100%) Inflammation, Focal 1 (10%) 1 (10%) Pancreas (10) (10) Acinus, Degeneration, Focal 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) (10) (10) Cardiomyopathy 7 (70%) 7 (70%) 8 (80%) 8 (80%) 4 (40%) 4 (40%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Thyroid Gland (10) (10) (10) (10) (10) (10) Follicular Cell, Cyst 1 (10%) Follicular Cell, Hyperplasia, Diffuse 2 (20%) 8 (80%) 10 (100%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) Inflammation, Focal 1 (10%) 1 (10%) Testes (10) (10) (10) (10) (10) (10) Degeneration 2 (20%) 2 (20%) 1 (10%) 2 (20%) 2 (20%) 9 (90%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96 Route: DOSED FEED Time: 20:23:41 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000 CONTROL PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (9) (9) Hemorrhage 1 (11%) Lymph Node, Mesenteric (10) (10) (10) (10) (10) (10) Hemorrhage 1 (10%) Infiltration Cellular, Histiocyte 1 (10%) 1 (10%) 4 (40%) 3 (30%) 4 (40%) 4 (40%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Focal 3 (30%) 1 (10%) Alveolus, Infiltration Cellular, Histiocyte 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (1) (10) Nephropathy 6 (60%) 3 (30%) Renal Tubule, Dilatation, Focal 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------