TDMS Study 92012-03 Pathology Tables
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
90-DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 693-98-1
Lock Date: 08/31/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Accidently Killed 3 3 2 5
Terminal Sacrifice 7 10 10 7 8 5
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (1) (1) (10)
Hepatodiaphragmatic Nodule 1 (100%) 1 (100%) 1 (10%)
Inflammation, Focal 2 (20%) 1 (100%) 1 (100%) 4 (40%)
Mesentery (1) (1) (1)
Fat, Necrosis 1 (100%) 1 (100%) 1 (100%)
Pancreas (10) (1) (10)
Acinus, Degeneration, Focal 2 (20%) 1 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (1) (10)
Cardiomyopathy 1 (10%) 1 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (1) (1) (10) (10)
Necrosis, Acute 1 (100%) 1 (100%) 2 (20%)
Thyroid Gland (10) (9) (10) (10) (10) (10)
Follicular Cell, Hyperplasia, Diffuse 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (1) (1) (10)
Inflammation, Focal 1 (10%) 1 (100%) 1 (100%) 3 (30%)
Ovary (10) (2) (1) (1) (1) (10)
Cyst 1 (50%) 1 (100%) 1 (100%) 1 (100%) 1 (10%)
Bilateral, Cyst 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Uterus (10) (10) (10) (10) (10) (10)
Hydrometra 1 (10%)
Bilateral, Hydrometra 2 (20%) 1 (10%) 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10)
Hyperplasia 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%)
Lymph Node, Mandibular (10) (10)
Hemorrhage 2 (20%) 1 (10%)
Infiltration Cellular, Plasma Cell 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10) (10) (10)
Infiltration Cellular, Histiocyte 8 (80%) 4 (40%) 9 (90%) 5 (50%) 10 (100%) 10 (100%)
Spleen (10) (10)
Lymphoid Follicle, Necrosis 3 (30%) 1 (10%)
Thymus (10) (1) (10)
Hemorrhage 1 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10)
Inflammation, Focal 1 (10%) 1 (100%) 4 (40%)
Nose (10) (10)
Respiratory Epithelium, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Suppurative 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (10) (10)
Inflammation, Chronic, Focal 1 (10%)
Liver (10) (1) (10)
Hepatodiaphragmatic Nodule 1 (100%)
Inflammation, Focal 1 (10%) 1 (10%)
Pancreas (10) (10)
Acinus, Degeneration, Focal 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy 7 (70%) 7 (70%) 8 (80%) 8 (80%) 4 (40%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10) (10) (10) (10)
Follicular Cell, Cyst 1 (10%)
Follicular Cell, Hyperplasia, Diffuse 2 (20%) 8 (80%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10)
Inflammation, Focal 1 (10%) 1 (10%)
Testes (10) (10) (10) (10) (10) (10)
Degeneration 2 (20%) 2 (20%) 1 (10%) 2 (20%) 2 (20%) 9 (90%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 92012-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:23:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (9)
Hemorrhage 1 (11%)
Lymph Node, Mesenteric (10) (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%) 1 (10%) 4 (40%) 3 (30%) 4 (40%) 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Focal 3 (30%) 1 (10%)
Alveolus, Infiltration Cellular, Histiocyte 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10)
Nephropathy 6 (60%) 3 (30%)
Renal Tubule, Dilatation, Focal 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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