TDMS Study 96018-03 Pathology Tables
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/19/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
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FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 19 14 15
Natural Death 5 2 7 9
Accidently Killed 1
Survivors
Terminal Sacrifice 28 27 29 26
Moribund Sacrifice 1 1
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (46) (44)
Intestine Large, Rectum (49) (49) (46) (46)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (46) (49) (44) (43)
Intestine Small, Duodenum (48) (50) (48) (45)
Intestine Small, Jejunum (47) (49) (46) (44)
Intestine Small, Ileum (46) (49) (45) (42)
Liver (49) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 2 (4%) 3 (6%)
Mesentery (15) (13) (14) (15)
Oral Mucosa (2) (1)
Squamous Cell Papilloma 1 (50%)
Gingival, Squamous Cell Carcinoma 1 (100%)
Pancreas (49) (50) (50) (49)
Acinus, Adenoma 3 (6%) 1 (2%) 3 (6%) 4 (8%)
Acinus, Adenoma, Multiple 1 (2%)
Salivary Glands (50) (50) (50) (49)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (50) (50) (50)
Fibrosarcoma 1 (2%)
Tongue (1) (1) (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Benign 1 (2%) 1 (2%)
Myocardium, Pericardium, Epicardium,
Mesothelioma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Complex 2 (4%) 1 (2%)
Pheochromocytoma Benign 5 (10%) 8 (16%) 10 (20%) 8 (16%)
Bilateral, Pheochromocytoma Benign 3 (6%) 1 (2%) 2 (4%)
Islets, Pancreatic (49) (50) (50) (49)
Adenoma 3 (6%) 1 (2%) 5 (10%) 3 (6%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50) (48)
Pars Distalis, Adenoma 22 (45%) 29 (58%) 28 (56%) 26 (54%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (46) (48) (44) (42)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (17%) 6 (13%) 9 (20%) 7 (17%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 4 (10%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
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GENERAL BODY SYSTEM
Peritoneum (2) (2) (2) (1)
Tissue NOS (3) (4) (2) (4)
Schwannoma Malignant 1 (25%)
Abdominal, Schwannoma Malignant 1 (25%)
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Preputial Gland (50) (50) (50) (49)
Adenoma 2 (4%) 2 (4%) 3 (6%)
Carcinoma 1 (2%) 3 (6%) 1 (2%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 41 (82%) 40 (80%) 40 (80%) 39 (78%)
Interstitial Cell, Adenoma 4 (8%) 7 (14%) 1 (2%) 8 (16%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (45) (49) (49)
Lymph Node (25) (28) (26) (26)
Mediastinal, C-Cell, Carcinoma, Metastatic,
Thyroid Gland 1 (4%)
Lymph Node, Mandibular (3) (1)
Lymph Node, Mesenteric (50) (49) (50) (50)
Spleen (48) (49) (49) (50)
Hemangiosarcoma 1 (2%)
Thymus (48) (48) (50) (47)
Thymoma Benign 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (44) (45) (47) (42)
Adenoma 1 (2%) 1 (2%)
Fibroadenoma 1 (2%) 3 (7%) 2 (4%) 2 (5%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Fibroma 2 (4%)
Keratoacanthoma 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Basal Cell Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 6 (12%) 8 (16%) 6 (12%) 6 (12%)
Subcutaneous Tissue, Fibroma, Multiple 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Chordoma 1 (2%)
Cranium, Schwannoma Malignant, Metastatic,
Brain 1 (2%)
Turbinate, Sarcoma 1 (2%)
Skeletal Muscle (3) (2)
Fibrosarcoma 1 (33%)
Sarcoma 1 (33%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
Oligodendroglioma Benign 1 (2%)
Cerebrum, Schwannoma Malignant, Metastatic,
Skin 1 (2%)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Neural Crest Tumor, Metastatic, Ear 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
C-Cell, Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Sarcoma 1 (2%)
Pleura (1)
Trachea (50) (50) (50) (50)
C-Cell, Carcinoma, Metastatic, Thyroid Gland 1 (2%)
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Neural Crest Tumor 1 (100%) 1 (100%)
Eye (49) (49) (48) (47)
Schwannoma Malignant, Metastatic, Brain 1 (2%)
Harderian Gland (50) (50) (50) (48)
Adenoma 1 (2%) 1 (2%)
Zymbal's Gland (3) (1) (2)
Adenoma 1 (100%)
Carcinoma 1 (33%) 1 (50%)
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URINARY SYSTEM
Kidney (49) (50) (50) (49)
Urinary Bladder (49) (50) (50) (49)
Transitional Epithelium, Papilloma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 16 (32%) 18 (36%) 16 (32%) 15 (30%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 3 (6%) 3 (6%) 3 (6%) 2 (4%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 04/15/03
Route: DOSED WATER Time: 15:27:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 49
Total Primary Neoplasms 142 146 159 143
Total Animals with Benign Neoplasms 49 49 50 49
Total Benign Neoplasms 108 114 130 111
Total Animals with Malignant Neoplasms 28 27 27 27
Total Malignant Neoplasms 33 32 28 32
Total Animals with Metastatic Neoplasms 2 3 2 1
Total Metastatic Neoplasm 2 10 4 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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