TDMS Study 96018-03 Pathology Tables
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
FINAL #2/RATS
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/19/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + A + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Cholangiofibrosis | 2 |
Clear Cell Focus | X X X X X X X X X X X X X X|
Congestion | 3 2 |
Degeneration, Cystic, Focal | 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 1 2|
Fibrosis, Focal | 3 |
Hepatodiaphragmatic Nodule | 3 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 1 2 1 2 2 1 2 2|
Inflammation, Chronic | 2 1 1 3 2 1 1 2 1 1|
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 3 3 2 3 3 3 2 3 3 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3|
Hepatocyte, Fatty Change | 1 4 1 1 1 2 2 2 1 1 1 1 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 2 2 2 |
Hepatocyte, Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 2 2 1 4 2 3 3 2 1 1 1 2|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Hyperplasia, Focal | |
Duct, Cyst, Focal, Multiple | 2 2 2 2 2 2 1 1|
Duct, Cyst | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Focal | 2 |
Ulcer | 3 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Erosion | |
Ulcer | 1 |
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 |
Infiltration Cellular, Mixed Cell | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 1 1 1 1|
Cytoplasmic Alteration, Focal | 2 |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 1 1 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 1 |
Necrosis, Focal | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Angiectasis | |
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 1 1 1 1 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 1 |
Pars Distalis, Hemorrhage, Focal | 2 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Distalis, Necrosis, Focal | |
Rathke's Cleft, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 2 2 2 2 3 2 2 2 3 2 1 1 2 2 1 2 1 1|
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
|__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + I + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia, Cystic | 3 |
Inflammation, Chronic | 2 3 2 2 1 2 2 1 2 1 1 2 2 2 2 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 3 2 3 3 2 1 3 2 3 3 1|
Epithelium, Hyperplasia, Focal | 2 2 1 2 2 2 1 1 1 2 1|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Necrosis | |
Artery, Thrombosis, Focal | |
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia, Focal| 1 |
Tunic, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
Myeloid Cell, Hyperplasia | 3 |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Mediastinal, Angiectasis | 4 |
Mediastinal, Ectasia | |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation | 4 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 |
Pancreatic, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Accessory Spleen | X |
Angiectasis, Focal | 2 |
Fibrosis, Focal | 2 3 3 |
Hematopoietic Cell Proliferation | 2 2 1 3 3 |
Hemorrhage, Chronic | 3 |
Hyperplasia, Lymphoid | 2 |
Infarct | 3 |
Artery, Thrombosis | |
Capsule, Fibrosis, Focal | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + + + + + + M + + + + + + +|
Dilatation | 2 2 |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Angiectasis, | |
Focal | |
Subcutaneous Tissue, Cyst, Chronic | 4 |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | 2 |
Subcutaneous Tissue, Metaplasia, | |
Focal, Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 1 |
Hemorrhage, Focal | 2 |
Necrosis, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + +|
|__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 3 |
Hemorrhage, Focal | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | 1 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Interstitium, Edema | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cataract | |
Retina, Degeneration | 3|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|
| 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 1 1 2 1 2 2 4 3 2 2 3 1 2 1 2 1 2 2 2 3 2 2 1 2|
Renal Tubule, Pigmentation | 1 2 2 2 2 2 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 | 4 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 33 |
Cholangiofibrosis | | 1 2.0|
Clear Cell Focus | X X X X X X X X X X X X X X| 28 |
Congestion | | 2 2.5|
Degeneration, Cystic, Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 31 1.9|
Fibrosis, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | 2 X 3 | 5 2.8|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 30 1.9|
Inflammation, Chronic | 1 2 1 2 1 2 1 1 1 1 1 1 1| 23 1.3|
Necrosis, Focal | 1 | 2 1.0|
Bile Duct, Hyperplasia | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2| 45 2.8|
Hepatocyte, Fatty Change | 1 1 1 1 1 1 2 3 2 2 3 1 2 1 2 1 1 1 1 1 2 1| 36 1.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 4 1 | 11 2.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 15 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis, Focal | 2 3 3 3 2 3 | 8 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Acinus, Atrophy, Focal | 1 1 1 3 2 2 1 1 3 2 1 4 3 1 1 2 1| 31 1.8|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
Duct, Cyst, Focal, Multiple | 1 1 2 2 2 3 1 2| 16 1.8|
Duct, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.5|
Inflammation, Focal | | 1 2.0|
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 1 | 2 1.5|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 2 2 2 1 2 2| 16 1.8|
Infiltration Cellular, Mixed Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 1 1 1 1 | 14 1.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Necrosis, Focal | 3 | 2 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 1 1| 9 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 2 2 1 1 | 11 1.2|
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 | 2 2.0|
Craniopharyngeal Duct, Cyst | 2 | 1 2.0|
Pars Distalis, Cyst | 2 | 2 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 3 | 7 1.4|
Pars Distalis, Degeneration, Cystic, | | |
Focal | | 1 1.0|
Pars Distalis, Hemorrhage, Focal | 3 | 3 2.3|
Pars Distalis, Hyperplasia, Focal | 3 | 3 2.0|
Pars Distalis, Necrosis, Focal | 3 | 1 3.0|
Rathke's Cleft, Cyst | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + A + + + +| 46 |
C-Cell, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 3 1 2 3 2 2 2 2 1 2 3| 44 1.9|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 1 3.0|
Hyperplasia, Cystic | 4 | 2 3.5|
Inflammation, Chronic | 1 2 2 2 2 1 1 2 1 1 2 2 2 1 2 2| 32 1.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 3 1 2 2 2 3 3 2 1 2 2 1 2| 29 2.2|
Epithelium, Hyperplasia, Focal | 2 1 2 1 1 1 2 1 1 2 1 1 1 2| 25 1.4|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 | 5 3.0|
Necrosis | 4 | 1 4.0|
Artery, Thrombosis, Focal | 3 | 1 3.0|
Bilateral, Atrophy | 2 | 1 2.0|
Interstitial Cell, Hyperplasia, Focal| 2 2 | 3 1.7|
Tunic, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.5|
Myeloid Cell, Hyperplasia | 2 | 2 2.5|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + + + + + + + + + + + + +| 25 |
Mediastinal, Angiectasis | 3 | 2 3.5|
Mediastinal, Ectasia | 3 3 3| 3 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3| 1 3.0|
Mediastinal, Inflammation | | 1 4.0|
Pancreatic, Ectasia | 3 3 3 | 3 3.0|
Pancreatic, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | 3 | 3 3.0|
Pancreatic, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M A M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Accessory Spleen | | 1 |
Angiectasis, Focal | | 1 2.0|
Fibrosis, Focal | 2 | 4 2.5|
Hematopoietic Cell Proliferation | 2 | 6 2.2|
Hemorrhage, Chronic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | 3 | 2 3.0|
Artery, Thrombosis | 4 | 1 4.0|
Capsule, Fibrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + A + + M + + M +| 44 |
Dilatation | 2 4 2 2 2 3 | 8 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Angiectasis, | | |
Focal | 2 | 1 2.0|
Subcutaneous Tissue, Cyst, Chronic | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | | 1 2.0|
Subcutaneous Tissue, Metaplasia, | | |
Focal, Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 2 3 3 3 | 6 2.5|
Hemorrhage, Focal | 1 | 2 1.5|
Necrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 4 2.8|
Hemorrhage, Focal | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | | 1 2.0|
Hyperplasia, Focal, Histiocytic | 3 | 1 3.0|
Hyperplasia, Histiocytic | | 1 1.0|
Infiltration Cellular, Mixed Cell | 1 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 2 2 1 | 7 1.7|
Interstitium, Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 3 3 | 2 3.0|
Retina, Degeneration | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Nephropathy | 2 2 2 3 2 2 2 2 1 3 2 3 3 2 3 2 2 2 1 2 2 2 2 3| 49 2.1|
Renal Tubule, Pigmentation | 3 3 1 | 10 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3| |
| 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X |
Cholangiofibrosis | 2 2 |
Clear Cell Focus | X X X X X X X X X X X X X |
Congestion | 2 |
Degeneration, Cystic, Focal | 2 2 2 2 2 1 2 2 1 2 2 1 1 2|
Eosinophilic Focus | X |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | 3 2 1 |
Infiltration Cellular, Mixed Cell | 1 2 1 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2|
Inflammation, Chronic | 1 1 1 1 2 2 1 1 2 1 1 1 2 1 1 1 1 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 3 3 3 2 1 3 2 3 3 3 2 3 3 3 2 3 2 3 3 3 3 3 3 3 2|
Hepatocyte, Fatty Change | 1 1 1 2 1 1 1 3 1 2 1 1 1 1 2 1 2|
Hepatocyte, Hypertrophy | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Hepatocyte, Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis, Focal | 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 1 1 1 2 1 2 1|
Duct, Cyst, Focal, Multiple | 2 2 1 1 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3|
Inflammation, Focal | |
Ulcer | 2|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Infarct | 2 |
Inflammation, Focal | |
Pigmentation, Focal | |
Artery, Inflammation, Chronic | |
Glands, Ectasia, Focal | 1 |
Glands, Necrosis, Focal | |
|__________________________________________________________________________|
Tongue | + |
Infiltration Cellular, Focal, Mixed | |
Cell | 2 |
|__________________________________________________________________________|
Tooth | |
Epithelium Alveolus, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 2 1 2 2 3 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 |
Cytoplasmic Alteration, Focal | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Vacuolization Cytoplasmic, Focal | 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 1 1 1 1 3|
Bilateral, Hyperplasia, Focal | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 |
Pars Distalis, Hemorrhage, Focal | 1 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Intermedia, Cyst | |
Rathke's Cleft, Cyst | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 1 2 2 2 2 2 3 2 1 2 3 1 1 2 1 1 2 1 1 2 |
Follicle, Degeneration, Cystic, Focal| 2 2 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
|__________________________________________________________________________|
Tissue NOS | + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Inflammation, Chronic | 2 1 1 2 1 1 2 2 1 1 1 1 2 2 1 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 3 3 1 1 1 1 1 3 2 2 3 3 1 1 2 |
Epithelium, Hyperplasia, Focal | 1 1 1 2 1 2 2 2 1 2 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2|
Bilateral, Interstitial Cell, | |
Hyperplasia, Focal | 1|
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Focal, Histiocytic | 1 |
Hyperplasia, Histiocytic | 4 |
Hyperplasia | |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | 3 3 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Bronchial, Hyperplasia, Plasma Cell | |
Mediastinal, Ectasia | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 4 |
Pancreatic, Ectasia | 3 3 3|
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Histiocytic | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Congestion | 3 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3|
Hyperplasia, Focal, Histiocytic | |
Infarct | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + + + + + + M + M + + +|
Dilatation | 1 3 2 2 2|
Fibrosis | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Angiectasis, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 |
Hemorrhage, Focal | 3 |
Necrosis, Focal | |
Cerebrum, Ventricle, Hydrocephalus | |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Hemorrhage | 3 |
Hyperplasia, Focal, Histiocytic | 1 |
Hyperplasia, Histiocytic | |
Inflammation, Chronic, Focal | 1 |
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy | 2 2 2 2 2 3 1 1 2 2 2 2 2 2 1 1 2 1 2 1 2 2 2 2 2|
Artery, Thrombosis | |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|
| 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Pigmentation | 2 2 2 3 3 2 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 23
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 2 | 4 2.0|
Basophilic Focus | X X X X X X X X X X X | 25 |
Cholangiofibrosis | | 2 2.0|
Clear Cell Focus | X X X X X X X X X X X | 24 |
Congestion | | 1 2.0|
Degeneration, Cystic, Focal | 2 2 2 2 2 1 1 2 2 3 | 24 1.8|
Eosinophilic Focus | | 1 |
Fibrosis, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | 3 3 | 5 2.4|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 | 31 1.8|
Inflammation, Chronic | 1 2 2 1 1 1 2 1 1 1 1 3 | 29 1.3|
Mixed Cell Focus | X| 3 |
Bile Duct, Hyperplasia | 2 3 3 3 3 3 3 2 3 3 3 3 2 3 2 3 3 3 3 2 3 3 3 3| 49 2.7|
Hepatocyte, Fatty Change | 2 1 1 2 2 3 1 1 1 2 1 1 2 1 1 1 1| 34 1.4|
Hepatocyte, Hypertrophy | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 3 2 3 3 1| 10 2.0|
Hepatocyte, Centrilobular, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + + + + | 13 |
Fat, Necrosis, Focal | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 2 2 2 2 1 2 3 2 2 2 3| 20 1.8|
Duct, Cyst, Focal, Multiple | 2 1 1 2 1 2 1 2 1 | 14 1.4|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 3.0|
Inflammation, Focal | 2 3 | 2 2.5|
Ulcer | 3 3 3 | 4 2.8|
Epithelium, Hyperplasia | 2 3 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Erosion | 3 2 1 2 | 4 2.0|
Infarct | | 1 2.0|
Inflammation, Focal | 3 | 1 3.0|
Pigmentation, Focal | 3 | 1 3.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Glands, Ectasia, Focal | | 1 1.0|
Glands, Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Infiltration Cellular, Focal, Mixed | | |
Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Epithelium Alveolus, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 1 1 2 | 18 1.8|
Thrombosis | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 1 2 | 8 1.1|
Cytoplasmic Alteration, Focal | 1 2| 3 1.7|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 3 4 1 2 2 4 1| 17 1.7|
Bilateral, Hyperplasia, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Pars Distalis, Cyst | 2 | 2 2.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 2 1 1 | 6 1.2|
Pars Distalis, Hemorrhage, Focal | 3 2 | 5 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
Rathke's Cleft, Cyst | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + A + + + + +| 48 |
C-Cell, Hyperplasia | 2 2 1 3 1 1 1 1 2 2 1 2 2 2 2 1 2 2 1 1 1 1| 46 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicle, Degeneration, Cystic, Focal| | 2 2.0|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 2 |
|__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 | 1 3.0|
Inflammation, Chronic | 1 1 2 3 1 1 1 1 2 1 1 2 2 1| 30 1.4|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 3 1 3 2 1 1 3 3 1 2 3 1 3 1 3| 33 2.0|
Epithelium, Hyperplasia, Focal | 1 2 1 2 1 2 2 1 1 4| 21 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3 | 8 2.8|
Bilateral, Interstitial Cell, | | |
Hyperplasia, Focal | | 1 1.0|
Interstitial Cell, Hyperplasia, Focal| 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A A + + + + A + + + + + + + + + +| 45 |
Hyperplasia, Focal, Histiocytic | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Histiocytic | | 1 4.0|
Hyperplasia | 3 4| 2 3.5|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | 3 3 | 5 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Bronchial, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 3 3.3|
Pancreatic, Ectasia | 3 3 | 5 3.0|
Pancreatic, Hyperplasia, Histiocytic | 2 3 2 3 | 7 2.7|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M + M M M M M M M M M M + M + M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Histiocytic | | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Angiectasis, Focal | 3 3| 2 3.0|
Congestion | | 1 3.0|
Fibrosis, Focal | 3 3| 3 2.7|
Hematopoietic Cell Proliferation | 3 2 | 7 2.3|
Hyperplasia, Focal, Histiocytic | 4 | 1 4.0|
Infarct | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Dilatation | 4 3 3 2 3 2 2 3 2 1 2 4 2 | 18 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Fibrosis | 2 | 1 2.0|
Hyperplasia | 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Angiectasis, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 2 3 3 3 3 3 | 8 2.9|
Hemorrhage, Focal | 3 3 2 | 4 2.8|
Necrosis, Focal | 3 3 | 2 3.0|
Cerebrum, Ventricle, Hydrocephalus | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal, Histiocytic | | 1 1.0|
Hyperplasia, Histiocytic | 1 | 1 1.0|
Inflammation, Chronic, Focal | 2 | 2 1.5|
Metaplasia, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3| |
| 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 2 | 6 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 2 | 3 3.3|
Nephropathy | 2 2 1 2 2 2 2 1 2 1 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2| 50 1.8|
Artery, Thrombosis | 3 | 1 3.0|
Renal Tubule, Pigmentation | 1 2 2 3 2 | 13 2.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + A + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + A + A A + + A +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + A + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + A A + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 |
Basophilic Focus | X X X X X X X X X X X X X|
Cholangiofibrosis | 3 |
Clear Cell Focus | X X X X X X X X X|
Congestion | 3 |
Degeneration, Cystic, Focal | 2 2 2 2 1 2 2 2 2 1 2 2|
Eosinophilic Focus | X X |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | 3 3 2 1 3 3 2 3|
Hyperplasia, Focal, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Chronic | 1 1 1 2 2 1 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X X X X |
Tension Lipidosis | 3 |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 2 3 3 2 2 2 2 3 3 3|
Hepatocyte, Fatty Change | 2 1 1 1 1 1 1 1 1 2 1 2 2 1 2 2 1 4 1|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 1 2 2|
Hepatocyte, Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis, Focal | 3 3 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Acinus, Atrophy, Focal | 2 3 2 3 2 2 2 2 2 3 2 2 1 2 1 |
Duct, Cyst, Focal, Multiple | 1 2 1 2 2 1 2 2 2 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Diffuse | 2 |
Inflammation, Focal | 3 |
Ulcer | 2 1 |
Epithelium, Hyperplasia | 3 2 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | |
Erosion | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 2 2 2|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 3 1 1 1 |
Angiectasis | 2 |
Cytoplasmic Alteration, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 1 2 1 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Focal | 1 2 1 1 1 1 1|
Necrosis, Focal | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hemorrhage, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | |
Rathke's Cleft, Hemorrhage | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + A + + A + + A +|
Hemorrhage | 2 |
C-Cell, Hyperplasia | 2 2 2 1 1 1 1 2 2 1 2 1 2 1 2 1 1 2 1|
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia, Cystic | 2 |
Inflammation, Chronic | 2 2 1 1 1 1 1 2 2 1 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 3 3 2 3 3 2 3 2 3 2 2 2 4 1 3 2|
Epithelium, Hyperplasia, Focal | 2 1 1 1 1 2 1 1 2 1 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3|
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia, Focal| 1 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 3 2 3 |
Myeloid Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 |
Pancreatic, Ectasia | 3 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Accessory Spleen | X |
Congestion | 2 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 3 2 2 |
Infarct | 3 |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | |
Dilatation | 2 3 3 3 1 3 2 2 |
Ectasia | 2 |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Mineralization, Focal | 3 |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | |
Subcutaneous Tissue, Epidermis, | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 3 3 3 3|
Hemorrhage, Focal | |
Hydrocephalus | 3 |
Cerebellum, Hemorrhage, Focal | |
Pineal Gland, Vacuolization | |
Cytoplasmic | 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | 1 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + A + + A +|
Cataract | 3 2 3 |
Inflammation, Chronic | 3 |
Retina, Degeneration | 3 2 4 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|
| 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Hyperplasia, Focal, Histiocytic | 2 |
Hyperplasia, Focal, Lymphoid | 2 |
Inflammation, Chronic, Focal | 2 |
Epithelium, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 3 2|
Pelvis, Dilatation | 3 |
Renal Tubule, Pigmentation | 3 2 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
__________________________________________|__________________________________________________________________________
Page 37
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 5 2.0|
Basophilic Focus | X X X X X X X X X X X | 24 |
Cholangiofibrosis | | 1 3.0|
Clear Cell Focus | X X X X X X X X X X | 19 |
Congestion | | 1 3.0|
Degeneration, Cystic, Focal | 1 1 1 1 1 2 2 2 2 2 2| 23 1.7|
Eosinophilic Focus | X X | 4 |
Fibrosis, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | 3 2 2 3 | 12 2.5|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 2 1 1 1 2 2 2 1 1 2 1 1 2 2 2 2 2| 34 1.8|
Inflammation, Chronic | 1 2 2 1 1 2 1 2 1 2 2 1 1 2 2 1 1 2| 33 1.4|
Mixed Cell Focus | X X X X X X | 10 |
Tension Lipidosis | | 1 3.0|
Bile Duct, Hyperplasia | 3 1 3 3 3 3 2 3 3 3 2 2 3 3 3 3 3 2 2 3 3 2 3 3| 49 2.7|
Hepatocyte, Fatty Change | 1 3 1 1 4 1 3 2 1 1 1 1 2 1 1 2 1 | 36 1.5|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 2 1 1 2 2 1 2 2 2 | 19 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 14 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis, Focal | 3 2 2 2 3| 9 2.7|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Acinus, Atrophy, Focal | 1 1 2 1 3 1 1 1 | 23 1.8|
Duct, Cyst, Focal, Multiple | 1 2 1 2 1 1 | 17 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 3 3.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Diffuse | 2 | 2 2.0|
Inflammation, Focal | 2 | 2 2.5|
Ulcer | 3 2 | 4 2.0|
Epithelium, Hyperplasia | | 4 2.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular, Focal | 2 | 1 2.0|
Erosion | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 1 1 2 2 2 1 2 1| 21 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Fibrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1| 8 1.4|
Angiectasis | | 1 2.0|
Cytoplasmic Alteration, Focal | 1 2 | 3 1.7|
Necrosis, Focal | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 1 1| 8 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 1 1 2 2 1 2 2 1 | 15 1.3|
Necrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 | 1 2.0|
Pars Distalis, Hemorrhage, Focal | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 2 2.0|
Rathke's Cleft, Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + A + + + +| 44 |
Hemorrhage | | 1 2.0|
C-Cell, Hyperplasia | 2 2 2 1 2 1 2 1 2 1 2 2 1 1 2 2 1 2 2 2 1| 40 1.6|
Follicular Cell, Hyperplasia, Cystic,| | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Focal | 1 2 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 2 |
|__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 1 3.0|
Hyperplasia, Cystic | | 1 2.0|
Inflammation, Chronic | 1 1 2 1 2 1 1 2 1 1 2 2 1 2 1 2 2 2| 31 1.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 1 1 2 3 3 2 1 2 1 1 2 3 3 2 2 3| 35 2.2|
Epithelium, Hyperplasia, Focal | 2 1 1 1 2 1 2 1 2 3 2 2 2| 24 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 | 8 3.0|
Bilateral, Atrophy | 3 | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 2 | 3 1.7|
Interstitial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 4 4 | 5 3.2|
Myeloid Cell, Hyperplasia | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 26 |
Mediastinal, Ectasia | 3 3 | 3 3.0|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 4 3 3 3 | 6 3.2|
Pancreatic, Ectasia | 3 | 3 3.0|
Pancreatic, Hemorrhage | 3 2 | 2 2.5|
Pancreatic, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | | 1 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2| 5 2.2|
Infarct | | 1 3.0|
Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + M + + +| 47 |
Atypia Cellular, Focal | 2 | 1 2.0|
Dilatation | 2 4 4 3 1 2 2 2 | 16 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Ectasia | | 1 2.0|
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
Mineralization, Focal | | 1 3.0|
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | 2 | 1 2.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | 2 | 1 2.0|
Subcutaneous Tissue, Epidermis, | | |
Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 3 3 4 3 | 14 3.1|
Hemorrhage, Focal | 3 | 1 3.0|
Hydrocephalus | 3 | 2 3.0|
Cerebellum, Hemorrhage, Focal | 1 | 1 1.0|
Pineal Gland, Vacuolization | | |
Cytoplasmic | | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 4 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 3 3.0|
Hemorrhage, Focal | 2 | 2 1.5|
Inflammation, Chronic, Focal | 2 1| 3 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 1 1 2 1| 9 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 2 | 3 1.7|
Nasolacrimal Duct, Inflammation | 2 2| 3 2.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cataract | 3 3 3 3| 7 2.9|
Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | 3 3 3 1| 8 2.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0| |
| 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | 3 | 1 3.0|
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | 2 2 2 1 2 1 3 2 2 1 2 2 2 1 2 2 2 2 2 3 2 2 2 2| 49 2.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Pigmentation | 3 2 2 | 7 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A A + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + A + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 2 |
Basophilic Focus | X X X X X X X X X|
Cholangiofibrosis | 2 |
Clear Cell Focus | X X X X X X X X X X X|
Congestion | 3 3 3 |
Degeneration, Cystic, Focal | 2 2 2 1 1 1 2 2 2 2 1 1 2 2 2|
Fibrosis, Focal | 3 3 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia, Focal, Regenerative | 4 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Inflammation, Chronic | 2 2 2 1 2 1 1 2 1 1 1 1 1 2 1 1 |
Mixed Cell Focus | X X X|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 2 3 3 2 2 3 3 2 3 3 3 2 3 3 2|
Hepatocyte, Fatty Change | 1 1 2 2 1 2 1 1 2 2 2 2 1 2 2 1 1 2 1 2 1 |
Hepatocyte, Hyperplasia, Regenerative| |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 1 2 1 1 2 1 1|
Hepatocyte, Centrilobular, Necrosis | |
Serosa, Bile Duct, Inflammation, | |
Chronic, Focal | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Mesentery | + + + + + |
Hemorrhage, Focal | |
Fat, Necrosis, Focal | 3 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 1 |
Acinus, Atrophy, Focal | 2 2 1 1 3 1 2 1 3|
Duct, Cyst, Focal, Multiple | 1 1 1 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | 1 |
Inflammation, Focal | 2 |
Ulcer | 3 |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Fibrosis, Focal | 3 |
Pigmentation, Focal | 2 |
Epithelium, Hyperplasia | 3 |
Glands, Ectasia, Focal | 3 |
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 2 2 2 2 2|
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 2 1 1 |
Cytoplasmic Alteration, Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 1 1 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | 1 2 1 1 2 1 1 2 2 |
Hyperplasia | |
Thrombosis | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 1 1 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 3 1 |
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A A + A + + + + + A +|
C-Cell, Hyperplasia | 1 2 2 2 2 2 1 2 2 1 1 1 2 2 2 1 2 2 1 2|
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Fibrosis | |
Hyperplasia, Cystic | |
Inflammation, Chronic | 2 2 2 1 1 2 1 2 1 1 1 2 3 1 3 1 2 2 1|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 3 2 2 3 2 3 1 3 3 2 2 1 1 3 3 3 1 2 2 |
Mineralization, Focal | 2 |
Epithelium, Hyperplasia, Focal | 2 1 2 1 2 1 2 1 2 1 1 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Bilateral, Atrophy | 4 |
Interstitial Cell, Hyperplasia, Focal| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 3 |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Deep Cervical, Ectasia | 3 |
Mediastinal, Angiectasis | 3 |
Mediastinal, Ectasia | 3 3 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Ectasia | 3 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2|
Hemorrhage | 3 |
Necrosis, Focal | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + M M M + + + I M + + M + + + M + + + M|
Dilatation | 2 3 2 2 2 |
Ectasia | |
Fibrosis, Focal | |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Hyperkeratosis, Focal | 2 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | 3 |
Subcutaneous Tissue, Necrosis, Fatty,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 2 2 3 3 3 |
Hemorrhage, Focal | 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 1 2 |
Fibrosis, Focal | |
Hemorrhage, Focal | 2 |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Mediastinum, Angiectasis, Focal | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Mineralization,| |
Focal | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|
| 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + A + + + + + + + + +|
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | |
Nephropathy | 1 1 3 2 2 1 1 2 2 2 3 2 2 1 2 2 2 2 3 2 2 1 1|
Cortex, Necrosis, Focal | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia, Atypical, | |
Focal | |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + A + + + + A + + A + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + A + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + A + + A + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + A + + + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + A + + A + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + A + + A + + + + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 2 1.5|
Basophilic Focus | X X X X X X X X | 17 |
Cholangiofibrosis | | 1 2.0|
Clear Cell Focus | X X X X X X | 17 |
Congestion | 2 | 4 2.8|
Degeneration, Cystic, Focal | 2 2 1 2 2 1 2 2 2 2 2 2 2 2 | 29 1.8|
Fibrosis, Focal | 2 | 3 2.7|
Hemorrhage, Focal | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | 2 X 2 | 4 2.3|
Hyperplasia, Focal, Regenerative | | 1 4.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2| 34 1.9|
Inflammation, Chronic | 2 1 1 2 2 1 2 2 2 1 2 1 1 2 1 2 2 1| 34 1.5|
Mixed Cell Focus | X | 4 |
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 3 3 3 2 3 3 3 4 3 2 2 3 3 2 3 3 3 3 3 3 3 3 3 3| 50 2.8|
Hepatocyte, Fatty Change | 1 2 1 2 2 1 2 2 2 2 4 2 2 2 1 1 1 1 2| 40 1.6|
Hepatocyte, Hyperplasia, Regenerative| 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 2 2 1 1| 18 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, Necrosis | 3 2 3 2| 4 2.5|
Serosa, Bile Duct, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 15 |
Hemorrhage, Focal | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 3 3 3 | 7 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Histiocytic | | 1 1.0|
Acinus, Atrophy, Focal | 2 3 3 1 2 2 3 3 2 2 2 1| 21 2.0|
Duct, Cyst, Focal, Multiple | 2 2 2 1 2 2| 11 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 2 | 4 2.8|
Erosion | | 1 1.0|
Inflammation, Focal | | 1 2.0|
Ulcer | 2 2 2 | 4 2.3|
Epithelium, Hyperplasia | 1 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 2 | 4 2.0|
Fibrosis, Focal | | 1 3.0|
Pigmentation, Focal | | 1 2.0|
Epithelium, Hyperplasia | 1 | 2 2.0|
Glands, Ectasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Cardiomyopathy | 2 1 2 1 2 2 | 14 1.9|
Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 1 1 1 1 1 1 1| 14 1.1|
Cytoplasmic Alteration, Focal | 1 | 2 1.0|
Necrosis, Focal | 2| 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 1 1 1 | 12 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Hyperplasia, Focal | 2 2 1 1| 13 1.5|
Hyperplasia | 1 | 1 1.0|
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 1 2| 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 1 | 6 1.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 | 3 2.0|
Pars Distalis, Hemorrhage, Focal | 3 3 2 | 3 2.7|
Pars Distalis, Hyperplasia, Focal | 2 2 | 7 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + A + + + + A + + A + + + + +| 42 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | 2 1 1 1 2 2 1 1 2 2 1 2 1 3 1 3 1 2 2 2 2| 41 1.7|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 3 2 2 | 3 2.3|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
|__________________________________________________________________________|____________|
Tissue NOS | + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 3 2 | 2 2.5|
Fibrosis | 3 | 1 3.0|
Hyperplasia, Cystic | 2 2 | 2 2.0|
Inflammation, Chronic | 2 2 2 2 1 1 1 2 1 2 1 2 2 2 2 2 2 2| 37 1.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 3 3 3 2 3 3 1 3 2 2 1 1 3 2| 38 2.2|
Mineralization, Focal | 2 | 2 2.0|
Epithelium, Hyperplasia, Focal | 2 2 2 1 2 1 2 1 2 2 2 | 23 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3 3 | 8 3.0|
Bilateral, Atrophy | | 1 4.0|
Interstitial Cell, Hyperplasia, Focal| 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Hyperplasia | 4 | 2 3.5|
Myeloid Cell, Hyperplasia | | 1 3.0|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | 3 3 3 2 | 5 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 26 |
Deep Cervical, Ectasia | | 1 3.0|
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Ectasia | 3 3 | 4 3.0|
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Hyperplasia, Histiocytic| 3 | 2 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Pancreatic, Angiectasis | 3 | 1 3.0|
Pancreatic, Ectasia | 3 3 3 | 5 3.0|
Pancreatic, Hemorrhage | 3 | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | 3 3 | 5 3.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 3 2 2 | 11 2.3|
Hemorrhage | 3 | 2 3.0|
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + + + + + + + A + + + I + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 |
Dilatation | 3 2 3 2 2 2 3 | 12 2.3|
Ectasia | 2 | 1 2.0|
Fibrosis, Focal | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis, Focal | | 1 2.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | | 1 3.0|
Subcutaneous Tissue, Necrosis, Fatty,| | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Hemorrhage, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 2 3 3 3 3 | 14 2.8|
Hemorrhage, Focal | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 5 2.4|
Fibrosis, Focal | 2 | 1 2.0|
Hemorrhage, Focal | 2 | 2 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 1 1 | 2 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic, Focal | | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 3 | 5 2.2|
Mediastinum, Angiectasis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 3 1.3|
Nasolacrimal Duct, Inflammation | 1 | 1 1.0|
Olfactory Epithelium, Mineralization,| | |
Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + A + + + + + + A + + + + + + + +| 47 |
Retina, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + A + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 96018-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 05/24/04
Route: DOSED WATER Time: 09:32:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0| |
| 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Nephropathy | 1 2 2 1 2 2 3 1 1 2 2 2 2 1 1 1 2 2 2 2 2 2 2| 46 1.8|
Cortex, Necrosis, Focal | 2 | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2| 1 2.0|
Renal Tubule, Hyperplasia, Atypical, | | |
Focal | 1 | 1 1.0|
Renal Tubule, Pigmentation | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
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---------- END OF REPORT ----------
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