TDMS Study 96018-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 05/24/04
EXPERIMENT: 96018 TEST: 03 TIME: 09:34:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: FARNELL, DANIEL R. CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL #2/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 05/24/04
EXPERIMENT: 96018 TEST: 03 TIME: 09:34:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: FARNELL, DANIEL R. CAS: 75-27-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION BYPRODUCTS (BROMODICHL
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Bone Marrow: Myeloid Cell, Erythroid Cell
Hyperplasia
Brain Compression Focal
Islets, Pancreatic Hyperplasia Focal
Kidney Nephropathy
Kidney: Renal Tubule Pigmentation
Liver Basophilic Focus
Clear Cell Focus
Degeneration Cystic Focal
Inflammation Chronic
Mixed Cell Focus
Liver: Bile Duct Hyperplasia
Liver: Hepatocyte Vacuolization Cytoplasmic
Mammary Gland Dilatation
Pancreas: Acinus Atrophy Focal
Pituitary Gland: Pars Distalis Cytoplasmic Alteration Focal
Degeneration Cystic Focal
Hyperplasia Focal
Prostate Inflammation Chronic
Mineralization Focal
Skin Cyst Epithelial Inclusion
Spleen Hemorrhage
Stomach, Glandular: Epithelium Hyperplasia
Thyroid Gland: Follicular Cell Hyperplasia
===============================================================
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/50 (28%) 8/50 (16%) 8/50 (16%) 14/49 (29%) |
|POLY-3 RATE (b) | 14/43.85 8/43.48 8/45.09 14/45.27 |
|POLY-3 PERCENT (g) | 31.9% 18.4% 17.7% 30.9% |
|TERMINAL (d) | 10/29 (35%) 5/28 (18%) 4/29 (14%) 6/26 (23%) |
|FIRST INCIDENCE | 479 660 628 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.336 P=0.141N P=0.122N P=0.489 |
|POLY 3 | P=0.440 P=0.110N P=0.093N P=0.550N |
|POLY 1.5 | P=0.422 P=0.109N P=0.099N P=0.568N |
|POLY 6 | P=0.453 P=0.116N P=0.089N P=0.544N |
|LOGISTIC REGRESSION| P=0.386 P=0.111N P=0.100N P=0.559 |
|COCH-ARM / FISHERS | P=0.386 P=0.114N P=0.114N P=0.563 |
|ORDER RESTRICTED | P=0.231N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Cytoplasmic Alteration Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 3/50 (6%) 2/49 (4%) |
|POLY-3 RATE (b) | 1/42.98 3/43.88 3/44.50 2/42.48 |
|POLY-3 PERCENT (g) | 2.3% 6.8% 6.7% 4.7% |
|TERMINAL (d) | 0/29 (0%) 1/28 (4%) 2/29 (7%) 0/26 (0%) |
|FIRST INCIDENCE | 680 498 633 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.453 P=0.311 P=0.312 P=0.477 |
|POLY 3 | P=0.472 P=0.312 P=0.318 P=0.496 |
|POLY 1.5 | P=0.473 P=0.311 P=0.314 P=0.497 |
|POLY 6 | P=0.462 P=0.310 P=0.317 P=0.490 |
|LOGISTIC REGRESSION| P=0.450 P=0.285 P=0.308 P=0.476 |
|COCH-ARM / FISHERS | P=0.468 P=0.309 P=0.309 P=0.492 |
|ORDER RESTRICTED | P=0.346 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/49 (2%) |
|POLY-3 RATE (b) | 2/42.93 0/42.97 1/44.15 1/41.94 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 2.3% 2.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 0/26 (0%) |
|FIRST INCIDENCE | 702 --- 729 (T) 705 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.530N P=0.268N P=0.503N P=0.547N |
|POLY 3 | P=0.505N P=0.237N P=0.490N P=0.508N |
|POLY 1.5 | P=0.505N P=0.236N P=0.492N P=0.506N |
|POLY 6 | P=0.505N P=0.240N P=0.492N P=0.516N |
|LOGISTIC REGRESSION| P=0.514N P=0.239N P=0.491N P=0.513N |
|COCH-ARM / FISHERS | P=0.506N P=0.247N P=0.500N P=0.508N |
|ORDER RESTRICTED | P=0.275N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 5/50 (10%) 8/50 (16%) 12/49 (24%) |
|POLY-3 RATE (b) | 9/44.03 5/43.14 8/45.05 12/44.06 |
|POLY-3 PERCENT (g) | 20.4% 11.6% 17.8% 27.2% |
|TERMINAL (d) | 6/29 (21%) 4/28 (14%) 2/29 (7%) 5/26 (19%) |
|FIRST INCIDENCE | 553 683 642 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.112 P=0.209N P=0.492N P=0.262 |
|POLY 3 | P=0.139 P=0.202N P=0.479N P=0.309 |
|POLY 1.5 | P=0.136 P=0.195N P=0.483N P=0.307 |
|POLY 6 | P=0.143 P=0.217N P=0.481N P=0.305 |
|LOGISTIC REGRESSION| P=0.129 P=0.191N P=0.490N P=0.292 |
|COCH-ARM / FISHERS | P=0.128 P=0.194N P=0.500N P=0.294 |
|ORDER RESTRICTED | P=0.140 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/50 (22%) 18/50 (36%) 15/50 (30%) 13/49 (27%) |
|POLY-3 RATE (b) | 11/43.29 18/44.89 15/44.95 13/42.80 |
|POLY-3 PERCENT (g) | 25.4% 40.1% 33.4% 30.4% |
|TERMINAL (d) | 8/29 (28%) 10/28 (36%) 12/29 (41%) 8/26 (31%) |
|FIRST INCIDENCE | 620 526 605 636 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.414 P=0.087 P=0.251 P=0.305 |
|POLY 3 | P=0.511 P=0.104 P=0.278 P=0.392 |
|POLY 1.5 | P=0.516 P=0.100 P=0.270 P=0.395 |
|POLY 6 | P=0.491 P=0.105 P=0.278 P=0.377 |
|LOGISTIC REGRESSION| P=0.496 P=0.091 P=0.271 P=0.358 |
|COCH-ARM / FISHERS | P=0.504 P=0.093 P=0.247 P=0.385 |
|ORDER RESTRICTED | P=0.284 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 3/45 (7%) 5/49 (10%) 2/49 (4%) |
|POLY-3 RATE (b) | 2/43.06 3/39.89 5/43.55 2/41.76 |
|POLY-3 PERCENT (g) | 4.6% 7.5% 11.5% 4.8% |
|TERMINAL (d) | 0/29 (0%) 2/27 (7%) 4/29 (14%) 2/26 (8%) |
|FIRST INCIDENCE | 680 709 721 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.530 P=0.463 P=0.218 P=0.649 |
|POLY 3 | P=0.573 P=0.465 P=0.220 P=0.683 |
|POLY 1.5 | P=0.575N P=0.463 P=0.217 P=0.687 |
|POLY 6 | P=0.552 P=0.462 P=0.218 P=0.673 |
|LOGISTIC REGRESSION| P=0.552 P=0.466 P=0.222 P=0.679 |
|COCH-ARM / FISHERS | P=0.573N P=0.450 P=0.210 P=0.684 |
|ORDER RESTRICTED | P=0.414 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow: Myeloid Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/45 (0%) 3/49 (6%) 1/49 (2%) |
|POLY-3 RATE (b) | 2/42.82 0/39.81 3/44.14 1/41.76 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 6.8% 2.4% |
|TERMINAL (d) | 1/29 (3%) 0/27 (0%) 2/29 (7%) 1/26 (4%) |
|FIRST INCIDENCE | 722 --- 526 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.582N P=0.259N P=0.506 P=0.541N |
|POLY 3 | P=0.560N P=0.253N P=0.514 P=0.509N |
|POLY 1.5 | P=0.555N P=0.255N P=0.507 P=0.506N |
|POLY 6 | P=0.568N P=0.254N P=0.518 P=0.517N |
|LOGISTIC REGRESSION| P=0.551N P=0.261N P=0.489 P=0.544N |
|COCH-ARM / FISHERS | P=0.551N P=0.274N P=0.490 P=0.508N |
|ORDER RESTRICTED | P=0.452N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow: Myeloid Cell, Erythroid Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/45 (11%) 0/49 (0%) 5/49 (10%) |
|POLY-3 RATE (b) | 1/43.18 5/41.48 0/43.51 5/43.00 |
|POLY-3 PERCENT (g) | 2.3% 12.1% 0.0% 11.6% |
|TERMINAL (d) | 0/29 (0%) 1/27 (4%) 0/29 (0%) 2/26 (8%) |
|FIRST INCIDENCE | 620 556 --- 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.159 P=0.111 P=0.491N P=0.105 |
|POLY 3 | P=0.167 P=0.091 P=0.498N P=0.100 |
|POLY 1.5 | P=0.167 P=0.087 P=0.500N P=0.100 |
|POLY 6 | P=0.164 P=0.094 P=0.499N P=0.097 |
|LOGISTIC REGRESSION| P=0.147 P=0.040 * P=0.548N P=0.088 |
|COCH-ARM / FISHERS | P=0.165 P=0.080 P=0.505N P=0.098 |
|ORDER RESTRICTED | P=0.052 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Compression Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 14/50 (28%) 14/50 (28%) |
|POLY-3 RATE (b) | 6/44.19 8/44.04 14/46.55 14/43.91 |
|POLY-3 PERCENT (g) | 13.6% 18.2% 30.1% 31.9% |
|TERMINAL (d) | 3/29 (10%) 2/28 (7%) 6/29 (21%) 5/26 (19%) |
|FIRST INCIDENCE | 526 624 430 605 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.018 * P=0.376 P=0.058 P=0.034 * |
|POLY 3 | P=0.017 * P=0.383 P=0.048 * P=0.033 * |
|POLY 1.5 | P=0.018 * P=0.388 P=0.045 * P=0.036 * |
|POLY 6 | P=0.014 * P=0.374 P=0.049 * P=0.029 * |
|LOGISTIC REGRESSION| P=0.020 * P=0.383 P=0.030 * P=0.040 * |
|COCH-ARM / FISHERS | P=0.020 * P=0.387 P=0.039 * P=0.039 * |
|ORDER RESTRICTED | P=0.028 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 1/50 (2%) 3/50 (6%) |
|POLY-3 RATE (b) | 2/43.54 4/45.24 1/44.39 3/43.52 |
|POLY-3 PERCENT (g) | 4.6% 8.8% 2.3% 6.9% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 479 405 665 616 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.536 P=0.342 P=0.486N P=0.500 |
|POLY 3 | P=0.542 P=0.355 P=0.493N P=0.500 |
|POLY 1.5 | P=0.545 P=0.350 P=0.494N P=0.502 |
|POLY 6 | P=0.536 P=0.355 P=0.494N P=0.493 |
|LOGISTIC REGRESSION| P=0.436 P=0.214 P=0.571N P=0.450 |
|COCH-ARM / FISHERS | P=0.544 P=0.339 P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.507 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Hydrocephalus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.79 0/42.97 2/44.82 0/42.45 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.5% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- --- 633 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.595 (e) P=0.253 (e) |
|POLY 3 | P=0.587 (e) P=0.247 (e) |
|POLY 1.5 | P=0.593 (e) P=0.244 (e) |
|POLY 6 | P=0.572 (e) P=0.250 (e) |
|LOGISTIC REGRESSION| P=0.577 (e) P=0.201 (e) |
|COCH-ARM / FISHERS | P=0.595 (e) P=0.247 (e) |
|ORDER RESTRICTED | P=0.256 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/43.51 2/44.43 0/44.15 0/42.45 |
|POLY-3 PERCENT (g) | 2.3% 4.5% 0.0% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 479 405 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.185N P=0.512 P=0.492N P=0.492N |
|POLY 3 | P=0.189N P=0.507 P=0.497N P=0.505N |
|POLY 1.5 | P=0.188N P=0.506 P=0.497N P=0.502N |
|POLY 6 | P=0.192N P=0.505 P=0.499N P=0.512N |
|LOGISTIC REGRESSION| P=0.368N P=0.281 P=0.698N P=0.665N |
|COCH-ARM / FISHERS | P=0.188N P=0.500 P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.176N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Eye |
| Cataract |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 1/49 (2%) 7/48 (15%) 0/47 (0%) |
|POLY-3 RATE (b) | 2/42.07 1/42.65 7/43.43 0/40.57 |
|POLY-3 PERCENT (g) | 4.8% 2.3% 16.1% 0.0% |
|TERMINAL (d) | 2/29 (7%) 1/28 (4%) 3/29 (10%) 0/26 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 605 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.411N P=0.512N P=0.087 P=0.262N |
|POLY 3 | P=0.389N P=0.495N P=0.085 P=0.245N |
|POLY 1.5 | P=0.386N P=0.495N P=0.082 P=0.244N |
|POLY 6 | P=0.400N P=0.500N P=0.088 P=0.249N |
|LOGISTIC REGRESSION| P=0.391N P=0.512N P=0.084 (e) |
|COCH-ARM / FISHERS | P=0.391N P=0.500N P=0.075 P=0.258N |
|ORDER RESTRICTED | P=0.097N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Eye: Retina |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 1/49 (2%) 8/48 (17%) 1/47 (2%) |
|POLY-3 RATE (b) | 3/42.07 1/42.65 8/43.66 1/40.89 |
|POLY-3 PERCENT (g) | 7.1% 2.3% 18.3% 2.5% |
|TERMINAL (d) | 3/29 (10%) 1/28 (4%) 3/29 (10%) 0/26 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 605 644 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.490N P=0.316N P=0.109 P=0.345N |
|POLY 3 | P=0.460N P=0.300N P=0.109 P=0.315N |
|POLY 1.5 | P=0.460N P=0.300N P=0.103 P=0.315N |
|POLY 6 | P=0.465N P=0.304N P=0.114 P=0.318N |
|LOGISTIC REGRESSION| P=0.464N P=0.316N P=0.104 P=0.320N |
|COCH-ARM / FISHERS | P=0.467N P=0.309N P=0.093 P=0.324N |
|ORDER RESTRICTED | P=0.181N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 16/50 (32%) 18/50 (36%) 21/50 (42%) 14/50 (28%) |
|POLY-3 RATE (b) | 16/46.51 18/45.23 21/46.21 14/44.13 |
|POLY-3 PERCENT (g) | 34.4% 39.8% 45.5% 31.7% |
|TERMINAL (d) | 9/29 (31%) 11/28 (39%) 13/29 (45%) 8/26 (31%) |
|FIRST INCIDENCE | 354 405 548 605 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.470N P=0.390 P=0.241 P=0.515N |
|POLY 3 | P=0.424N P=0.374 P=0.189 P=0.481N |
|POLY 1.5 | P=0.394N P=0.394 P=0.194 P=0.452N |
|POLY 6 | P=0.463N P=0.347 P=0.184 P=0.519N |
|LOGISTIC REGRESSION| P=0.355N P=0.400 P=0.179 P=0.422N |
|COCH-ARM / FISHERS | P=0.353N P=0.417 P=0.204 P=0.414N |
|ORDER RESTRICTED | P=0.332N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Heart |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.79 2/43.23 0/44.15 2/42.90 |
|POLY-3 PERCENT (g) | 0.0% 4.6% 0.0% 4.7% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- 681 --- 644 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.224 P=0.226 (e) P=0.219 |
|POLY 3 | P=0.249 P=0.239 (e) P=0.237 |
|POLY 1.5 | P=0.250 P=0.239 (e) P=0.239 |
|POLY 6 | P=0.244 P=0.237 (e) P=0.233 |
|LOGISTIC REGRESSION| P=0.247 P=0.238 (e) P=0.235 |
|COCH-ARM / FISHERS | P=0.247 P=0.247 (e) P=0.247 |
|ORDER RESTRICTED | P=0.116 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 2/43.01 0/42.97 0/44.15 0/41.84 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/29 (3%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 620 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.119N P=0.241N P=0.235N P=0.252N |
|POLY 3 | P=0.110N P=0.237N P=0.231N P=0.243N |
|POLY 1.5 | P=0.111N P=0.235N P=0.231N P=0.240N |
|POLY 6 | P=0.107N P=0.242N P=0.233N P=0.250N |
|LOGISTIC REGRESSION| P=0.115N P=0.233N P=0.238N P=0.237N |
|COCH-ARM / FISHERS | P=0.114N P=0.242N P=0.242N P=0.247N |
|ORDER RESTRICTED | P=0.031N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 3/50 (6%) 1/50 (2%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/42.62 3/43.54 1/44.39 0/41.61 |
|POLY-3 PERCENT (g) | 0.0% 6.9% 2.3% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- 660 665 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.392N P=0.121 P=0.515 (e) |
|POLY 3 | P=0.373N P=0.122 P=0.508 (e) |
|POLY 1.5 | P=0.369N P=0.123 P=0.507 (e) |
|POLY 6 | P=0.384N P=0.121 P=0.508 (e) |
|LOGISTIC REGRESSION| P=0.367N P=0.124 P=0.495 (e) |
|COCH-ARM / FISHERS | P=0.367N P=0.125 P=0.505 (e) |
|ORDER RESTRICTED | P=0.230N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/49 (100%) 50/50 (100%) 49/50 (98%) 46/49 (94%) |
|POLY-3 RATE (b) | 49/49.00 50/50.00 49/49.85 46/48.22 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 98.3% 95.4% |
|TERMINAL (d) | 29/29 (100%) 28/28 (100%) 29/29 (100%) 25/26 (96%) |
|FIRST INCIDENCE | 354 405 430 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.504 (e) P=0.539N P=0.489 |
|POLY 3 | P=0.032N* (e) P=0.572N P=0.172N |
|POLY 1.5 | P=0.024N* (e) P=0.537N P=0.142N |
|POLY 6 | P=0.055N (e) P=0.650N P=0.248N |
|LOGISTIC REGRESSION| P=0.020N* (e) P=0.504N P=0.119N |
|COCH-ARM / FISHERS | P=0.020N* (e) P=0.505N P=0.121N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/49 (20%) 13/50 (26%) 7/50 (14%) 3/49 (6%) |
|POLY-3 RATE (b) | 10/45.95 13/44.78 7/45.64 3/42.31 |
|POLY-3 PERCENT (g) | 21.8% 29.0% 15.3% 7.1% |
|TERMINAL (d) | 1/29 (3%) 8/28 (29%) 4/29 (14%) 1/26 (4%) |
|FIRST INCIDENCE | 354 498 526 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.021N* P=0.312 P=0.301N P=0.060N |
|POLY 3 | P=0.015N* P=0.289 P=0.301N P=0.048N* |
|POLY 1.5 | P=0.013N* P=0.309 P=0.293N P=0.042N* |
|POLY 6 | P=0.020N* P=0.263 P=0.315N P=0.058N |
|LOGISTIC REGRESSION| P=0.010N* P=0.334 P=0.344N P=0.031N* |
|COCH-ARM / FISHERS | P=0.011N* P=0.337 P=0.282N P=0.035N* |
|ORDER RESTRICTED | P=0.017N* (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 5/50 (10%) 2/50 (4%) |
|POLY-3 RATE (b) | 4/42.79 4/43.05 5/44.26 2/42.66 |
|POLY-3 PERCENT (g) | 9.4% 9.3% 11.3% 4.7% |
|TERMINAL (d) | 4/29 (14%) 3/28 (11%) 4/29 (14%) 1/26 (4%) |
|FIRST INCIDENCE | 729 (T) 709 703 672 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.326N P=0.619 P=0.498 P=0.386N |
|POLY 3 | P=0.278N P=0.641N P=0.521 P=0.338N |
|POLY 1.5 | P=0.276N P=0.639N P=0.515 P=0.335N |
|POLY 6 | P=0.288N P=0.641 P=0.522 P=0.348N |
|LOGISTIC REGRESSION| P=0.312N P=0.605 P=0.504 P=0.369N |
|COCH-ARM / FISHERS | P=0.278N P=0.643N P=0.500 P=0.339N |
|ORDER RESTRICTED | P=0.307N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 33/50 (66%) 25/50 (50%) 24/50 (48%) 17/50 (34%) |
|POLY-3 RATE (b) | 33/45.53 25/44.29 24/44.93 17/43.23 |
|POLY-3 PERCENT (g) | 72.5% 56.5% 53.4% 39.3% |
|TERMINAL (d) | 26/29 (90%) 21/28 (75%) 18/29 (62%) 15/26 (58%) |
|FIRST INCIDENCE | 459 526 642 486 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003N** P=0.082N P=0.048N* P=0.002N** |
|POLY 3 | P<0.001N** P=0.074N P=0.040N* P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.072N P=0.042N* P<0.001N** |
|POLY 6 | P<0.001N** P=0.081N P=0.039N* P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.061N P=0.027N* P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.078N P=0.053N P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/42.79 2/42.97 1/44.78 1/42.45 |
|POLY-3 PERCENT (g) | 2.3% 4.7% 2.2% 2.4% |
|TERMINAL (d) | 1/29 (3%) 2/28 (7%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 526 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.556N P=0.488 P=0.753N P=0.738 |
|POLY 3 | P=0.530N P=0.501 P=0.751N P=0.759 |
|POLY 1.5 | P=0.528N P=0.502 P=0.753N P=0.760N |
|POLY 6 | P=0.536N P=0.497 P=0.750N P=0.753 |
|LOGISTIC REGRESSION| P=0.530N P=0.488 P=0.728 P=0.738 |
|COCH-ARM / FISHERS | P=0.531N P=0.500 P=0.753N P=0.753N |
|ORDER RESTRICTED | P=0.581N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 28/50 (56%) 24/50 (48%) 19/50 (38%) 17/50 (34%) |
|POLY-3 RATE (b) | 28/43.00 24/43.88 19/44.15 17/42.86 |
|POLY-3 PERCENT (g) | 65.1% 54.7% 43.0% 39.7% |
|TERMINAL (d) | 25/29 (86%) 22/28 (79%) 19/29 (66%) 15/26 (58%) |
|FIRST INCIDENCE | 709 526 729 (T) 637 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.010N* P=0.291N P=0.016N* P=0.030N* |
|POLY 3 | P=0.007N** P=0.208N P=0.025N* P=0.011N* |
|POLY 1.5 | P=0.009N** P=0.228N P=0.033N* P=0.013N* |
|POLY 6 | P=0.007N** P=0.200N P=0.020N* P=0.010N* |
|LOGISTIC REGRESSION| P=0.015N* P=0.312N P=0.016N* P=0.032N* |
|COCH-ARM / FISHERS | P=0.013N* P=0.274N P=0.054N P=0.022N* |
|ORDER RESTRICTED | P=0.009N** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 2/42.84 1/42.97 1/44.26 4/42.88 |
|POLY-3 PERCENT (g) | 4.7% 2.3% 2.3% 9.3% |
|TERMINAL (d) | 1/29 (3%) 1/28 (4%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 718 729 (T) 703 672 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.140 P=0.524N P=0.503N P=0.287 |
|POLY 3 | P=0.165 P=0.499N P=0.489N P=0.337 |
|POLY 1.5 | P=0.166 P=0.498N P=0.492N P=0.340 |
|POLY 6 | P=0.162 P=0.504N P=0.489N P=0.328 |
|LOGISTIC REGRESSION| P=0.156 P=0.522N P=0.491N P=0.325 |
|COCH-ARM / FISHERS | P=0.165 P=0.500N P=0.500N P=0.339 |
|ORDER RESTRICTED | P=0.131 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Degeneration Cystic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 31/50 (62%) 24/50 (48%) 23/50 (46%) 29/50 (58%) |
|POLY-3 RATE (b) | 31/43.97 24/45.18 23/45.49 29/45.16 |
|POLY-3 PERCENT (g) | 70.5% 53.1% 50.6% 64.2% |
|TERMINAL (d) | 24/29 (83%) 18/28 (64%) 16/29 (55%) 19/26 (73%) |
|FIRST INCIDENCE | 620 556 628 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.398 P=0.150N P=0.085N P=0.502 |
|POLY 3 | P=0.444N P=0.061N P=0.036N* P=0.334N |
|POLY 1.5 | P=0.456N P=0.076N P=0.048N* P=0.359N |
|POLY 6 | P=0.443N P=0.052N P=0.028N* P=0.328N |
|LOGISTIC REGRESSION| P=0.517N P=0.095N P=0.041N* P=0.458N |
|COCH-ARM / FISHERS | P=0.490N P=0.114N P=0.080N P=0.419N |
|ORDER RESTRICTED | P=0.110N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 4/50 (8%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.79 1/42.97 4/44.23 0/42.45 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 9.0% 0.0% |
|TERMINAL (d) | 0/29 (0%) 1/28 (4%) 3/29 (10%) 0/26 (0%) |
|FIRST INCIDENCE | --- 729 (T) 709 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.558 P=0.493 P=0.062 (e) |
|POLY 3 | P=0.583 P=0.501 P=0.064 (e) |
|POLY 1.5 | P=0.591 P=0.501 P=0.063 (e) |
|POLY 6 | P=0.564 P=0.498 P=0.064 (e) |
|LOGISTIC REGRESSION| P=0.562 P=0.493 P=0.063 (e) |
|COCH-ARM / FISHERS | P=0.591 P=0.500 P=0.059 (e) |
|ORDER RESTRICTED | P=0.155 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Fibrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 3/50 (6%) |
|POLY-3 RATE (b) | 1/42.79 1/42.97 1/44.15 3/43.48 |
|POLY-3 PERCENT (g) | 2.3% 2.3% 2.3% 6.9% |
|TERMINAL (d) | 1/29 (3%) 1/28 (4%) 1/29 (3%) 1/26 (4%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.148 P=0.754 P=0.762 P=0.292 |
|POLY 3 | P=0.168 P=0.760N P=0.754N P=0.311 |
|POLY 1.5 | P=0.167 P=0.759N P=0.755N P=0.311 |
|POLY 6 | P=0.165 P=0.759 P=0.754N P=0.305 |
|LOGISTIC REGRESSION| P=0.161 P=0.754 P=0.762 P=0.286 |
|COCH-ARM / FISHERS | P=0.163 P=0.753N P=0.753N P=0.309 |
|ORDER RESTRICTED | P=0.192 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 12/50 (24%) 4/50 (8%) |
|POLY-3 RATE (b) | 5/43.24 5/43.76 12/46.20 4/43.18 |
|POLY-3 PERCENT (g) | 11.6% 11.4% 26.0% 9.3% |
|TERMINAL (d) | 3/29 (10%) 2/28 (7%) 6/29 (21%) 2/26 (8%) |
|FIRST INCIDENCE | 610 624 430 486 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.524 P=0.612 P=0.069 P=0.551N |
|POLY 3 | P=0.533N P=0.623N P=0.069 P=0.501N |
|POLY 1.5 | P=0.524N P=0.623N P=0.064 P=0.496N |
|POLY 6 | P=0.553 P=0.628N P=0.072 P=0.518N |
|LOGISTIC REGRESSION| P=0.531N P=0.628N P=0.052 P=0.499N |
|COCH-ARM / FISHERS | P=0.528N P=0.630N P=0.054 P=0.500N |
|ORDER RESTRICTED | P=0.270N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 30/50 (60%) 31/50 (62%) 34/50 (68%) 34/50 (68%) |
|POLY-3 RATE (b) | 30/46.17 31/47.01 34/48.03 34/47.45 |
|POLY-3 PERCENT (g) | 65.0% 66.0% 70.8% 71.7% |
|TERMINAL (d) | 22/29 (76%) 21/28 (75%) 21/29 (72%) 18/26 (69%) |
|FIRST INCIDENCE | 354 498 430 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 P=0.446 P=0.317 P=0.164 |
|POLY 3 | P=0.243 P=0.549 P=0.347 P=0.312 |
|POLY 1.5 | P=0.233 P=0.529 P=0.316 P=0.299 |
|POLY 6 | P=0.243 P=0.569 P=0.382 P=0.316 |
|LOGISTIC REGRESSION| P=0.207 P=0.511 P=0.286 P=0.269 |
|COCH-ARM / FISHERS | P=0.205 P=0.500 P=0.266 P=0.266 |
|ORDER RESTRICTED | P=0.378 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/50 (46%) 29/50 (58%) 33/50 (66%) 34/50 (68%) |
|POLY-3 RATE (b) | 23/44.55 29/46.18 33/46.05 34/46.72 |
|POLY-3 PERCENT (g) | 51.6% 62.8% 71.7% 72.8% |
|TERMINAL (d) | 20/29 (69%) 21/28 (75%) 24/29 (83%) 22/26 (85%) |
|FIRST INCIDENCE | 459 498 526 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** P=0.121 P=0.032 * P=0.006 ** |
|POLY 3 | P=0.018 * P=0.187 P=0.033 * P=0.024 * |
|POLY 1.5 | P=0.019 * P=0.177 P=0.034 * P=0.024 * |
|POLY 6 | P=0.014 * P=0.194 P=0.030 * P=0.019 * |
|LOGISTIC REGRESSION| P=0.016 * P=0.163 P=0.045 * P=0.021 * |
|COCH-ARM / FISHERS | P=0.017 * P=0.158 P=0.035 * P=0.021 * |
|ORDER RESTRICTED | P=0.017 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 10/50 (20%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/42.79 3/42.97 10/44.62 4/42.61 |
|POLY-3 PERCENT (g) | 0.0% 7.0% 22.4% 9.4% |
|TERMINAL (d) | 0/29 (0%) 3/28 (11%) 7/29 (24%) 3/26 (12%) |
|FIRST INCIDENCE | --- 729 (T) 667 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.057 P=0.114 P=0.002 ** P=0.053 |
|POLY 3 | P=0.069 P=0.119 P<0.001 ** P=0.059 |
|POLY 1.5 | P=0.073 P=0.120 P<0.001 ** P=0.061 |
|POLY 6 | P=0.060 P=0.116 P<0.001 ** P=0.056 |
|LOGISTIC REGRESSION| P=0.061 P=0.114 P<0.001 ** P=0.053 |
|COCH-ARM / FISHERS | P=0.079 P=0.121 P<0.001 ** P=0.059 |
|ORDER RESTRICTED | P=0.007 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/44.43 0/42.97 0/44.15 1/42.45 |
|POLY-3 PERCENT (g) | 4.5% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 354 --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.468N P=0.237N P=0.237N P=0.510N |
|POLY 3 | P=0.454N P=0.245N P=0.238N P=0.516N |
|POLY 1.5 | P=0.457N P=0.241N P=0.238N P=0.508N |
|POLY 6 | P=0.450N P=0.250N P=0.241N P=0.529N |
|LOGISTIC REGRESSION| P=0.628N P=0.450N P=0.605N P=0.682N |
|COCH-ARM / FISHERS | P=0.461N P=0.247N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.141N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/50 (90%) 49/50 (98%) 49/50 (98%) 50/50 (100%) |
|POLY-3 RATE (b) | 45/47.87 49/50.00 49/50.00 50/50.00 |
|POLY-3 PERCENT (g) | 94.0% 98.0% 98.0% 100.0% |
|TERMINAL (d) | 28/29 (97%) 27/28 (96%) 28/29 (97%) 26/26 (100%) |
|FIRST INCIDENCE | 459 405 430 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.112 P=0.247 P=0.338 P=0.104 |
|POLY 3 | P=0.068 P=0.299 P=0.299 P=0.100 |
|POLY 1.5 | P=0.038 * P=0.205 P=0.205 P=0.059 |
|POLY 6 | P=0.106 P=0.396 P=0.396 P=0.155 |
|LOGISTIC REGRESSION| P=0.022 * P=0.127 P=0.164 P=0.045 * |
|COCH-ARM / FISHERS | P=0.016 * P=0.102 P=0.102 P=0.028 * |
|ORDER RESTRICTED | P=0.030 * (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Fatty Change |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 36/50 (72%) 34/50 (68%) 36/50 (72%) 40/50 (80%) |
|POLY-3 RATE (b) | 36/47.08 34/47.41 36/47.46 40/48.57 |
|POLY-3 PERCENT (g) | 76.5% 71.7% 75.9% 82.4% |
|TERMINAL (d) | 24/29 (83%) 19/28 (68%) 23/29 (79%) 21/26 (81%) |
|FIRST INCIDENCE | 405 405 548 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.110 P=0.498N P=0.545N P=0.161 |
|POLY 3 | P=0.198 P=0.382N P=0.570N P=0.317 |
|POLY 1.5 | P=0.182 P=0.384N P=0.572N P=0.293 |
|POLY 6 | P=0.214 P=0.393N P=0.573N P=0.337 |
|LOGISTIC REGRESSION| P=0.158 P=0.399N P=0.524N P=0.247 |
|COCH-ARM / FISHERS | P=0.153 P=0.414N P=0.588N P=0.241 |
|ORDER RESTRICTED | P=0.255 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/50 (22%) 10/50 (20%) 19/50 (38%) 18/50 (36%) |
|POLY-3 RATE (b) | 11/45.09 10/44.80 19/45.17 18/45.46 |
|POLY-3 PERCENT (g) | 24.4% 22.3% 42.1% 39.6% |
|TERMINAL (d) | 2/29 (7%) 3/28 (11%) 16/29 (55%) 10/26 (39%) |
|FIRST INCIDENCE | 553 405 526 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.026 * P=0.526N P=0.082 P=0.083 |
|POLY 3 | P=0.030 * P=0.507N P=0.056 P=0.090 |
|POLY 1.5 | P=0.032 * P=0.497N P=0.061 P=0.095 |
|POLY 6 | P=0.024 * P=0.533N P=0.045 * P=0.075 |
|LOGISTIC REGRESSION| P=0.033 * P=0.512N P=0.070 P=0.090 |
|COCH-ARM / FISHERS | P=0.033 * P=0.500N P=0.063 P=0.093 |
|ORDER RESTRICTED | P=0.049 * (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 1/43.18 1/43.15 1/44.78 4/43.59 |
|POLY-3 PERCENT (g) | 2.3% 2.3% 2.2% 9.2% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 620 681 526 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.066 P=0.758N P=0.748N P=0.178 |
|POLY 3 | P=0.068 P=0.761 P=0.753N P=0.181 |
|POLY 1.5 | P=0.068 P=0.760N P=0.755N P=0.182 |
|POLY 6 | P=0.067 P=0.757 P=0.753N P=0.175 |
|LOGISTIC REGRESSION| P=0.052 P=0.755 P=0.683 P=0.156 |
|COCH-ARM / FISHERS | P=0.067 P=0.753N P=0.753N P=0.181 |
|ORDER RESTRICTED | P=0.076 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 3/50 (6%) 5/50 (10%) |
|POLY-3 RATE (b) | 4/44.66 1/43.25 3/44.83 5/43.93 |
|POLY-3 PERCENT (g) | 9.0% 2.3% 6.7% 11.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 0/26 (0%) |
|FIRST INCIDENCE | 405 651 548 486 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.247 P=0.187N P=0.489N P=0.470 |
|POLY 3 | P=0.265 P=0.188N P=0.498N P=0.490 |
|POLY 1.5 | P=0.266 P=0.184N P=0.497N P=0.496 |
|POLY 6 | P=0.261 P=0.196N P=0.503N P=0.476 |
|LOGISTIC REGRESSION| P=0.210 P=0.223N P=0.639N P=0.422 |
|COCH-ARM / FISHERS | P=0.264 P=0.181N P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.241 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 3/42.82 1/43.34 2/44.15 2/42.78 |
|POLY-3 PERCENT (g) | 7.0% 2.3% 4.5% 4.7% |
|TERMINAL (d) | 2/29 (7%) 0/28 (0%) 2/29 (7%) 1/26 (4%) |
|FIRST INCIDENCE | 722 624 729 (T) 636 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.530N P=0.319N P=0.500N P=0.542N |
|POLY 3 | P=0.501N P=0.301N P=0.486N P=0.500N |
|POLY 1.5 | P=0.499N P=0.301N P=0.489N P=0.497N |
|POLY 6 | P=0.506N P=0.303N P=0.487N P=0.510N |
|LOGISTIC REGRESSION| P=0.503N P=0.304N P=0.498N P=0.512N |
|COCH-ARM / FISHERS | P=0.500N P=0.309N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.389N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 1/43.54 1/43.60 0/44.15 2/43.85 |
|POLY-3 PERCENT (g) | 2.3% 2.3% 0.0% 4.6% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 459 520 --- 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.375 P=0.753N P=0.496N P=0.515 |
|POLY 3 | P=0.369 P=0.760N P=0.497N P=0.502 |
|POLY 1.5 | P=0.369 P=0.760N P=0.497N P=0.504 |
|POLY 6 | P=0.365 P=0.759 P=0.499N P=0.496 |
|LOGISTIC REGRESSION| P=0.155 P=0.665 P=0.729N P=0.243 |
|COCH-ARM / FISHERS | P=0.366 P=0.753N P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.273 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/42.79 0/42.97 0/44.15 1/42.58 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 2/29 (7%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- 695 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.487N P=0.246N P=0.238N P=0.539N |
|POLY 3 | P=0.459N P=0.236N P=0.230N P=0.502N |
|POLY 1.5 | P=0.460N P=0.236N P=0.232N P=0.499N |
|POLY 6 | P=0.455N P=0.239N P=0.230N P=0.510N |
|LOGISTIC REGRESSION| P=0.474N (e) (e) P=0.522N |
|COCH-ARM / FISHERS | P=0.461N P=0.247N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.131N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.79 2/42.97 3/44.39 2/42.45 |
|POLY-3 PERCENT (g) | 0.0% 4.7% 6.8% 4.7% |
|TERMINAL (d) | 0/29 (0%) 2/28 (7%) 1/29 (3%) 2/26 (8%) |
|FIRST INCIDENCE | --- 729 (T) 697 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.204 P=0.230 P=0.122 P=0.214 |
|POLY 3 | P=0.233 P=0.238 P=0.125 P=0.235 |
|POLY 1.5 | P=0.238 P=0.239 P=0.123 P=0.237 |
|POLY 6 | P=0.220 P=0.234 P=0.125 P=0.229 |
|LOGISTIC REGRESSION| P=0.213 P=0.230 P=0.125 P=0.214 |
|COCH-ARM / FISHERS | P=0.237 P=0.247 P=0.121 P=0.247 |
|ORDER RESTRICTED | P=0.140 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) 9/50 (18%) 5/50 (10%) |
|POLY-3 RATE (b) | 7/43.44 6/43.45 9/44.68 5/42.61 |
|POLY-3 PERCENT (g) | 16.1% 13.8% 20.1% 11.7% |
|TERMINAL (d) | 4/29 (14%) 3/28 (11%) 6/29 (21%) 4/26 (15%) |
|FIRST INCIDENCE | 651 681 649 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.459N P=0.523N P=0.394 P=0.459N |
|POLY 3 | P=0.390N P=0.500N P=0.415 P=0.392N |
|POLY 1.5 | P=0.379N P=0.496N P=0.411 P=0.382N |
|POLY 6 | P=0.417N P=0.512N P=0.412 P=0.417N |
|LOGISTIC REGRESSION| P=0.394N P=0.499N P=0.417 P=0.400N |
|COCH-ARM / FISHERS | P=0.376N P=0.500N P=0.393 P=0.380N |
|ORDER RESTRICTED | P=0.415N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/43.18 0/42.10 0/44.15 1/42.45 |
|POLY-3 PERCENT (g) | 4.6% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 1/29 (3%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 620 --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.478N P=0.241N P=0.235N P=0.525N |
|POLY 3 | P=0.456N P=0.243N P=0.232N P=0.506N |
|POLY 1.5 | P=0.458N P=0.241N P=0.233N P=0.501N |
|POLY 6 | P=0.452N P=0.247N P=0.233N P=0.518N |
|LOGISTIC REGRESSION| P=0.459N P=0.243N P=0.243N P=0.500N |
|COCH-ARM / FISHERS | P=0.459N P=0.253N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.135N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/49 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.79 2/42.10 0/44.15 1/42.45 |
|POLY-3 PERCENT (g) | 0.0% 4.8% 0.0% 2.4% |
|TERMINAL (d) | 0/29 (0%) 2/28 (7%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | --- 729 (T) --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.514 P=0.230 (e) P=0.478 |
|POLY 3 | P=0.540 P=0.233 (e) P=0.498 |
|POLY 1.5 | P=0.543 P=0.234 (e) P=0.500 |
|POLY 6 | P=0.530 P=0.230 (e) P=0.493 |
|LOGISTIC REGRESSION| (e) P=0.230 (e) P=0.478 |
|COCH-ARM / FISHERS | P=0.541 P=0.242 (e) P=0.500 |
|ORDER RESTRICTED | P=0.323 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/25 (8%) 0/28 (0%) 0/26 (0%) 1/26 (4%) |
|POLY-3 RATE (b) | 2/22.00 0/24.43 0/22.94 1/21.69 |
|POLY-3 PERCENT (g) | 9.1% 0.0% 0.0% 4.6% |
|TERMINAL (d) | 0/11 (0%) 0/16 (0%) 0/14 (0%) 0/11 (0%) |
|FIRST INCIDENCE | 354 --- --- 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.457N P=0.237N P=0.237N P=0.493N |
|POLY 3 | P=0.455N P=0.211N P=0.225N P=0.505N |
|POLY 1.5 | P=0.456N P=0.211N P=0.225N P=0.496N |
|POLY 6 | P=0.451N P=0.209N P=0.223N P=0.523N |
|LOGISTIC REGRESSION| P=0.579 P=0.334N (e) (e) |
|COCH-ARM / FISHERS | P=0.459N P=0.218N P=0.235N P=0.485N |
|ORDER RESTRICTED | P=0.127N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/25 (12%) 1/28 (4%) 3/26 (12%) 4/26 (15%) |
|POLY-3 RATE (b) | 3/20.36 1/24.43 3/22.94 4/21.25 |
|POLY-3 PERCENT (g) | 14.7% 4.1% 13.1% 18.8% |
|TERMINAL (d) | 3/11 (27%) 1/16 (6%) 3/14 (21%) 3/11 (27%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 637 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.214 P=0.173N P=0.551N P=0.498 |
|POLY 3 | P=0.262 P=0.237N P=0.610N P=0.524 |
|POLY 1.5 | P=0.272 P=0.247N P=0.623N P=0.528 |
|POLY 6 | P=0.243 P=0.227N P=0.597N P=0.509 |
|LOGISTIC REGRESSION| P=0.195 P=0.173N P=0.551N P=0.452 |
|COCH-ARM / FISHERS | P=0.277 P=0.263N P=0.647N P=0.523 |
|ORDER RESTRICTED | P=0.277 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/25 (0%) 0/28 (0%) 1/26 (4%) 2/26 (8%) |
|POLY-3 RATE (b) | 0/20.36 0/24.43 1/23.16 2/21.85 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.3% 9.2% |
|TERMINAL (d) | 0/11 (0%) 0/16 (0%) 0/14 (0%) 0/11 (0%) |
|FIRST INCIDENCE | --- --- 669 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.067 (e) P=0.500 P=0.238 |
|POLY 3 | P=0.067 (e) P=0.526 P=0.250 |
|POLY 1.5 | P=0.068 (e) P=0.519 P=0.250 |
|POLY 6 | P=0.063 (e) P=0.533 P=0.245 |
|LOGISTIC REGRESSION| P=0.056 (e) P=0.498 P=0.179 |
|COCH-ARM / FISHERS | P=0.067 (e) P=0.510 P=0.255 |
|ORDER RESTRICTED | P=0.082 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/25 (12%) 4/28 (14%) 6/26 (23%) 3/26 (12%) |
|POLY-3 RATE (b) | 3/21.25 4/25.11 6/23.64 3/21.40 |
|POLY-3 PERCENT (g) | 14.1% 15.9% 25.4% 14.0% |
|TERMINAL (d) | 2/11 (18%) 2/16 (13%) 4/14 (29%) 1/11 (9%) |
|FIRST INCIDENCE | 354 556 548 633 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.526 P=0.614 P=0.326 P=0.657 |
|POLY 3 | P=0.538 P=0.594 P=0.286 P=0.665N |
|POLY 1.5 | P=0.557 P=0.580 P=0.272 P=0.656N |
|POLY 6 | P=0.505 P=0.613 P=0.305 P=0.659 |
|LOGISTIC REGRESSION| P=0.571N P=0.513 P=0.211 P=0.662N |
|COCH-ARM / FISHERS | P=0.571N P=0.566 P=0.253 P=0.647N |
|ORDER RESTRICTED | P=0.495 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/25 (12%) 5/28 (18%) 3/26 (12%) 5/26 (19%) |
|POLY-3 RATE (b) | 3/20.36 5/25.45 3/23.02 5/20.92 |
|POLY-3 PERCENT (g) | 14.7% 19.7% 13.0% 23.9% |
|TERMINAL (d) | 3/11 (27%) 2/16 (13%) 1/14 (7%) 5/11 (46%) |
|FIRST INCIDENCE | 729 (T) 556 709 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.296 P=0.486 P=0.588N P=0.333 |
|POLY 3 | P=0.336 P=0.483 P=0.608N P=0.363 |
|POLY 1.5 | P=0.352 P=0.457 P=0.622N P=0.373 |
|POLY 6 | P=0.304 P=0.516 P=0.593N P=0.335 |
|LOGISTIC REGRESSION| P=0.312 P=0.436 P=0.554N P=0.333 |
|COCH-ARM / FISHERS | P=0.358 P=0.419 P=0.647N P=0.374 |
|ORDER RESTRICTED | P=0.366 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/25 (4%) 0/28 (0%) 2/26 (8%) 1/26 (4%) |
|POLY-3 RATE (b) | 1/21.11 0/24.43 2/22.94 1/20.92 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 8.7% 4.8% |
|TERMINAL (d) | 0/11 (0%) 0/16 (0%) 2/14 (14%) 1/11 (9%) |
|FIRST INCIDENCE | 459 --- 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.476 P=0.496N P=0.559 P=0.758N |
|POLY 3 | P=0.471 P=0.471N P=0.529 P=0.760 |
|POLY 1.5 | P=0.487 P=0.473N P=0.524 P=0.757N |
|POLY 6 | P=0.443 P=0.468N P=0.534 P=0.748 |
|LOGISTIC REGRESSION| P=0.498 P=0.628N P=0.447 P=0.747 |
|COCH-ARM / FISHERS | P=0.501 P=0.472N P=0.515 P=0.745N |
|ORDER RESTRICTED | P=0.383 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/25 (12%) 7/28 (25%) 0/26 (0%) 5/26 (19%) |
|POLY-3 RATE (b) | 3/21.11 7/24.43 0/22.94 5/21.33 |
|POLY-3 PERCENT (g) | 14.2% 28.7% 0.0% 23.4% |
|TERMINAL (d) | 2/11 (18%) 7/16 (44%) 0/14 (0%) 3/11 (27%) |
|FIRST INCIDENCE | 459 729 (T) --- 637 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.457 P=0.309 P=0.093N P=0.339 |
|POLY 3 | P=0.513 P=0.206 P=0.098N P=0.354 |
|POLY 1.5 | P=0.520 P=0.203 P=0.101N P=0.366 |
|POLY 6 | P=0.499 P=0.210 P=0.095N P=0.329 |
|LOGISTIC REGRESSION| P=0.496 P=0.225 P=0.133N P=0.372 |
|COCH-ARM / FISHERS | P=0.522 P=0.197 P=0.110N P=0.374 |
|ORDER RESTRICTED | P=0.279N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/44 (18%) 18/45 (40%) 16/47 (34%) 12/42 (29%) |
|POLY-3 RATE (b) | 8/40.17 18/40.66 16/43.49 12/37.23 |
|POLY-3 PERCENT (g) | 19.9% 44.3% 36.8% 32.2% |
|TERMINAL (d) | 3/27 (11%) 9/26 (35%) 6/27 (22%) 4/20 (20%) |
|FIRST INCIDENCE | 526 620 548 605 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.246 P=0.027 * P=0.078 P=0.152 |
|POLY 3 | P=0.290 P=0.015 * P=0.069 P=0.163 |
|POLY 1.5 | P=0.314 P=0.017 * P=0.070 P=0.177 |
|POLY 6 | P=0.248 P=0.014 * P=0.067 P=0.141 |
|LOGISTIC REGRESSION| P=0.331 P=0.021 * P=0.066 P=0.192 |
|COCH-ARM / FISHERS | P=0.332 P=0.021 * P=0.069 P=0.188 |
|ORDER RESTRICTED | P=0.071 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/44 (5%) 3/45 (7%) 2/47 (4%) 1/42 (2%) |
|POLY-3 RATE (b) | 2/38.47 3/38.66 2/41.23 1/35.29 |
|POLY-3 PERCENT (g) | 5.2% 7.8% 4.9% 2.8% |
|TERMINAL (d) | 2/27 (7%) 3/26 (12%) 2/27 (7%) 1/20 (5%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.417N P=0.482 P=0.697 P=0.605N |
|POLY 3 | P=0.341N P=0.502 P=0.669N P=0.530N |
|POLY 1.5 | P=0.333N P=0.507 P=0.668N P=0.522N |
|POLY 6 | P=0.358N P=0.494 P=0.675N P=0.548N |
|LOGISTIC REGRESSION| P=0.417N P=0.482 P=0.697 P=0.605N |
|COCH-ARM / FISHERS | P=0.327N P=0.511 P=0.666N P=0.518N |
|ORDER RESTRICTED | P=0.392N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/15 (53%) 4/13 (31%) 9/14 (64%) 7/15 (47%) |
|POLY-3 RATE (b) | 8/14.60 4/11.24 9/12.44 7/12.93 |
|POLY-3 PERCENT (g) | 54.8% 35.6% 72.3% 54.2% |
|TERMINAL (d) | 6/9 (67%) 4/6 (67%) 3/4 (75%) 5/7 (71%) |
|FIRST INCIDENCE | 526 729 (T) 548 605 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.338 P=0.334N P=0.152 P=0.596 |
|POLY 3 | P=0.427 P=0.284N P=0.292 P=0.637N |
|POLY 1.5 | P=0.488 P=0.253N P=0.343 P=0.572N |
|POLY 6 | P=0.322 P=0.329N P=0.232 P=0.572 |
|LOGISTIC REGRESSION| P=0.487 P=0.213N P=0.431 P=0.520N |
|COCH-ARM / FISHERS | P=0.543 P=0.207N P=0.413 P=0.500N |
|ORDER RESTRICTED | P=0.277 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) 3/50 (6%) |
|POLY-3 RATE (b) | 2/42.87 3/43.05 3/44.15 3/42.45 |
|POLY-3 PERCENT (g) | 4.7% 7.0% 6.8% 7.1% |
|TERMINAL (d) | 1/29 (3%) 2/28 (7%) 3/29 (10%) 3/26 (12%) |
|FIRST INCIDENCE | 709 709 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.385 P=0.469 P=0.495 P=0.446 |
|POLY 3 | P=0.432 P=0.502 P=0.513 P=0.495 |
|POLY 1.5 | P=0.438 P=0.503 P=0.510 P=0.500 |
|POLY 6 | P=0.417 P=0.496 P=0.512 P=0.482 |
|LOGISTIC REGRESSION| P=0.388 P=0.484 P=0.504 P=0.448 |
|COCH-ARM / FISHERS | P=0.438 P=0.500 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.514 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.79 0/42.97 3/44.29 1/42.45 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 6.8% 2.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 1/26 (4%) |
|FIRST INCIDENCE | --- --- 702 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.223 (e) P=0.122 P=0.478 |
|POLY 3 | P=0.240 (e) P=0.125 P=0.498 |
|POLY 1.5 | P=0.245 (e) P=0.123 P=0.500 |
|POLY 6 | P=0.228 (e) P=0.125 P=0.493 |
|LOGISTIC REGRESSION| P=0.228 (e) P=0.124 P=0.478 |
|COCH-ARM / FISHERS | P=0.247 (e) P=0.121 P=0.500 |
|ORDER RESTRICTED | P=0.120 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 31/49 (63%) 20/50 (40%) 23/50 (46%) 21/49 (43%) |
|POLY-3 RATE (b) | 31/45.31 20/46.06 23/46.25 21/43.93 |
|POLY-3 PERCENT (g) | 68.4% 43.4% 49.7% 47.8% |
|TERMINAL (d) | 21/29 (72%) 10/28 (36%) 15/29 (52%) 13/26 (50%) |
|FIRST INCIDENCE | 459 520 548 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.174N P=0.057N P=0.101N P=0.122N |
|POLY 3 | P=0.078N P=0.011N* P=0.048N* P=0.033N* |
|POLY 1.5 | P=0.072N P=0.012N* P=0.051N P=0.030N* |
|POLY 6 | P=0.094N P=0.010N* P=0.048N* P=0.041N* |
|LOGISTIC REGRESSION| P=0.074N P=0.017N* P=0.052N P=0.035N* |
|COCH-ARM / FISHERS | P=0.074N P=0.017N* P=0.064N P=0.034N* |
|ORDER RESTRICTED | P=0.025N* (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pancreas: Duct |
| Cyst Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 16/49 (33%) 14/50 (28%) 17/50 (34%) 11/49 (22%) |
|POLY-3 RATE (b) | 16/43.24 14/43.69 17/45.47 11/41.94 |
|POLY-3 PERCENT (g) | 37.0% 32.0% 37.4% 26.2% |
|TERMINAL (d) | 11/29 (38%) 10/28 (36%) 11/29 (38%) 10/26 (39%) |
|FIRST INCIDENCE | 651 620 548 705 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.280N P=0.470N P=0.507 P=0.287N |
|POLY 3 | P=0.202N P=0.396N P=0.573 P=0.199N |
|POLY 1.5 | P=0.192N P=0.389N P=0.559 P=0.187N |
|POLY 6 | P=0.229N P=0.415N P=0.579 P=0.228N |
|LOGISTIC REGRESSION| P=0.218N P=0.431N P=0.548 P=0.252N |
|COCH-ARM / FISHERS | P=0.188N P=0.388N P=0.528 P=0.183N |
|ORDER RESTRICTED | P=0.230N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 0/50 (0%) 1/48 (2%) |
|POLY-3 RATE (b) | 2/42.35 2/42.97 0/44.15 1/40.83 |
|POLY-3 PERCENT (g) | 4.7% 4.7% 0.0% 2.5% |
|TERMINAL (d) | 1/29 (3%) 2/28 (7%) 0/29 (0%) 1/25 (4%) |
|FIRST INCIDENCE | 654 729 (T) --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.330N P=0.689 P=0.234N P=0.544N |
|POLY 3 | P=0.302N P=0.689N P=0.228N P=0.513N |
|POLY 1.5 | P=0.301N P=0.686N P=0.228N P=0.508N |
|POLY 6 | P=0.305N P=0.692 P=0.230N P=0.525N |
|LOGISTIC REGRESSION| P=0.310N P=0.692N P=0.231N P=0.512N |
|COCH-ARM / FISHERS | P=0.302N P=0.684N P=0.242N P=0.508N |
|ORDER RESTRICTED | P=0.274N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 2/50 (4%) 2/48 (4%) |
|POLY-3 RATE (b) | 2/42.25 2/43.22 2/44.70 2/40.93 |
|POLY-3 PERCENT (g) | 4.7% 4.6% 4.5% 4.9% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 1/25 (4%) |
|FIRST INCIDENCE | 702 697 561 705 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.554 P=0.658 P=0.690 P=0.640 |
|POLY 3 | P=0.582 P=0.686N P=0.674N P=0.683 |
|POLY 1.5 | P=0.586 P=0.684N P=0.677N P=0.687 |
|POLY 6 | P=0.570 P=0.692N P=0.675N P=0.672 |
|LOGISTIC REGRESSION| P=0.587 P=0.688N P=0.693 P=0.677 |
|COCH-ARM / FISHERS | P=0.586 P=0.684N P=0.684N P=0.684 |
|ORDER RESTRICTED | P=0.721 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cytoplasmic Alteration Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/49 (14%) 6/50 (12%) 1/50 (2%) 6/48 (13%) |
|POLY-3 RATE (b) | 7/43.51 6/44.15 1/44.15 6/41.60 |
|POLY-3 PERCENT (g) | 16.1% 13.6% 2.3% 14.4% |
|TERMINAL (d) | 3/29 (10%) 3/28 (11%) 1/29 (3%) 5/25 (20%) |
|FIRST INCIDENCE | 354 520 729 (T) 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.449N P=0.512N P=0.038N* P=0.588N |
|POLY 3 | P=0.399N P=0.489N P=0.028N* P=0.535N |
|POLY 1.5 | P=0.393N P=0.485N P=0.028N* P=0.522N |
|POLY 6 | P=0.413N P=0.501N P=0.029N* P=0.565N |
|LOGISTIC REGRESSION| P=0.400N P=0.500N P=0.035N* P=0.524N |
|COCH-ARM / FISHERS | P=0.391N P=0.484N P=0.028N* P=0.516N |
|ORDER RESTRICTED | P=0.198N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Degeneration Cystic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 0/50 (0%) 3/48 (6%) |
|POLY-3 RATE (b) | 1/42.82 0/42.97 0/44.15 3/41.17 |
|POLY-3 PERCENT (g) | 2.3% 0.0% 0.0% 7.3% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 2/25 (8%) |
|FIRST INCIDENCE | 459 --- --- 637 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.077 P=0.496N P=0.496N P=0.281 |
|POLY 3 | P=0.080 P=0.499N P=0.494N P=0.291 |
|POLY 1.5 | P=0.080 P=0.497N P=0.494N P=0.296 |
|POLY 6 | P=0.079 P=0.504N P=0.496N P=0.280 |
|LOGISTIC REGRESSION| P=0.073 P=0.644N P=0.728N P=0.274 |
|COCH-ARM / FISHERS | P=0.081 P=0.495N P=0.495N P=0.301 |
|ORDER RESTRICTED | P=0.033 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hemorrhage Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 5/50 (10%) 1/50 (2%) 3/48 (6%) |
|POLY-3 RATE (b) | 3/42.63 5/43.74 1/44.15 3/41.49 |
|POLY-3 PERCENT (g) | 7.0% 11.4% 2.3% 7.2% |
|TERMINAL (d) | 2/29 (7%) 2/28 (7%) 1/29 (3%) 1/25 (4%) |
|FIRST INCIDENCE | 553 654 729 (T) 633 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.468N P=0.361 P=0.302N P=0.625 |
|POLY 3 | P=0.434N P=0.370 P=0.292N P=0.650 |
|POLY 1.5 | P=0.431N P=0.371 P=0.293N P=0.654 |
|POLY 6 | P=0.443N P=0.364 P=0.296N P=0.640 |
|LOGISTIC REGRESSION| P=0.434N P=0.366 P=0.299N P=0.650 |
|COCH-ARM / FISHERS | P=0.433N P=0.369 P=0.301N P=0.651 |
|ORDER RESTRICTED | P=0.328N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 2/50 (4%) 2/50 (4%) 7/48 (15%) |
|POLY-3 RATE (b) | 3/43.38 2/42.97 2/44.15 7/42.19 |
|POLY-3 PERCENT (g) | 6.9% 4.7% 4.5% 16.6% |
|TERMINAL (d) | 1/29 (3%) 2/28 (7%) 2/29 (7%) 4/25 (16%) |
|FIRST INCIDENCE | 459 729 (T) 729 (T) 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.043 * P=0.506N P=0.494N P=0.140 |
|POLY 3 | P=0.049 * P=0.504N P=0.492N P=0.144 |
|POLY 1.5 | P=0.050 P=0.497N P=0.489N P=0.149 |
|POLY 6 | P=0.047 * P=0.518N P=0.500N P=0.135 |
|LOGISTIC REGRESSION| P=0.047 * P=0.516N P=0.552N P=0.128 |
|COCH-ARM / FISHERS | P=0.050 P=0.490N P=0.490N P=0.150 |
|ORDER RESTRICTED | P=0.038 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Rathke's Cleft |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 0/50 (0%) 0/48 (0%) |
|POLY-3 RATE (b) | 2/42.07 2/42.97 0/44.15 0/40.83 |
|POLY-3 PERCENT (g) | 4.8% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 2/29 (7%) 2/28 (7%) 0/29 (0%) 0/25 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.097N P=0.684 P=0.238N P=0.271N |
|POLY 3 | P=0.086N P=0.687N P=0.226N P=0.243N |
|POLY 1.5 | P=0.086N P=0.685N P=0.228N P=0.241N |
|POLY 6 | P=0.087N P=0.693N P=0.227N P=0.250N |
|LOGISTIC REGRESSION| P=0.097N P=0.684 (e) (e) |
|COCH-ARM / FISHERS | P=0.087N P=0.684N P=0.242N P=0.253N |
|ORDER RESTRICTED | P=0.121N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 2/49 (4%) |
|POLY-3 RATE (b) | 1/43.62 0/42.97 1/44.15 2/42.07 |
|POLY-3 PERCENT (g) | 2.3% 0.0% 2.3% 4.8% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 0/25 (0%) |
|FIRST INCIDENCE | 405 --- 729 (T) 633 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.236 P=0.496N P=0.758N P=0.496 |
|POLY 3 | P=0.241 P=0.503N P=0.758N P=0.487 |
|POLY 1.5 | P=0.242 P=0.501N P=0.758N P=0.491 |
|POLY 6 | P=0.238 P=0.507N P=0.760N P=0.480 |
|LOGISTIC REGRESSION| P=0.200 P=0.739N P=0.678 P=0.394 |
|COCH-ARM / FISHERS | P=0.242 P=0.500N P=0.753N P=0.492 |
|ORDER RESTRICTED | P=0.213 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 2/49 (4%) |
|POLY-3 RATE (b) | 2/42.79 1/42.97 1/44.15 2/42.35 |
|POLY-3 PERCENT (g) | 4.7% 2.3% 2.3% 4.7% |
|TERMINAL (d) | 2/29 (7%) 1/28 (4%) 1/29 (3%) 0/25 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.530 P=0.512N P=0.500N P=0.676 |
|POLY 3 | P=0.552 P=0.499N P=0.489N P=0.691 |
|POLY 1.5 | P=0.552 P=0.498N P=0.492N P=0.691 |
|POLY 6 | P=0.549 P=0.503N P=0.489N P=0.685 |
|LOGISTIC REGRESSION| P=0.548 P=0.512N P=0.500N P=0.683 |
|COCH-ARM / FISHERS | P=0.548 P=0.500N P=0.500N P=0.684 |
|ORDER RESTRICTED | P=0.535 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 32/50 (64%) 30/50 (60%) 31/50 (62%) 37/49 (76%) |
|POLY-3 RATE (b) | 32/45.09 30/45.87 31/47.16 37/46.05 |
|POLY-3 PERCENT (g) | 71.0% 65.4% 65.7% 80.3% |
|TERMINAL (d) | 20/29 (69%) 18/28 (64%) 21/29 (72%) 20/25 (80%) |
|FIRST INCIDENCE | 553 526 526 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.062 P=0.508N P=0.493N P=0.098 |
|POLY 3 | P=0.123 P=0.361N P=0.373N P=0.201 |
|POLY 1.5 | P=0.114 P=0.374N P=0.411N P=0.185 |
|POLY 6 | P=0.125 P=0.367N P=0.360N P=0.203 |
|LOGISTIC REGRESSION| P=0.089 P=0.391N P=0.412N P=0.142 |
|COCH-ARM / FISHERS | P=0.095 P=0.418N P=0.500N P=0.152 |
|ORDER RESTRICTED | P=0.121 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/50 (58%) 33/50 (66%) 35/50 (70%) 38/50 (76%) |
|POLY-3 RATE (b) | 29/46.69 33/47.27 35/48.80 38/48.94 |
|POLY-3 PERCENT (g) | 62.1% 69.8% 71.7% 77.6% |
|TERMINAL (d) | 16/29 (55%) 20/28 (71%) 20/29 (69%) 17/26 (65%) |
|FIRST INCIDENCE | 405 520 430 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.044 * P=0.274 P=0.234 P=0.058 |
|POLY 3 | P=0.062 P=0.281 P=0.213 P=0.070 |
|POLY 1.5 | P=0.052 P=0.280 P=0.192 P=0.060 |
|POLY 6 | P=0.070 P=0.270 P=0.223 P=0.078 |
|LOGISTIC REGRESSION| P=0.035 * P=0.275 P=0.148 P=0.044 * |
|COCH-ARM / FISHERS | P=0.035 * P=0.268 P=0.149 P=0.044 * |
|ORDER RESTRICTED | P=0.066 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Prostate |
| Mineralization Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.79 0/42.97 0/44.15 2/42.45 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 2/26 (8%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.039 * (e) (e) P=0.214 |
|POLY 3 | P=0.045 * (e) (e) P=0.235 |
|POLY 1.5 | P=0.045 * (e) (e) P=0.237 |
|POLY 6 | P=0.044 * (e) (e) P=0.229 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.214 |
|COCH-ARM / FISHERS | P=0.046 * (e) (e) P=0.247 |
|ORDER RESTRICTED | P=0.029 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Prostate: Epithelium |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 25/50 (50%) 21/50 (42%) 24/50 (48%) 23/50 (46%) |
|POLY-3 RATE (b) | 25/46.09 21/45.12 24/46.23 23/45.43 |
|POLY-3 PERCENT (g) | 54.2% 46.6% 51.9% 50.6% |
|TERMINAL (d) | 13/29 (45%) 14/28 (50%) 17/29 (59%) 13/26 (50%) |
|FIRST INCIDENCE | 526 561 526 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.452 P=0.332N P=0.486N P=0.560 |
|POLY 3 | P=0.483N P=0.297N P=0.494N P=0.445N |
|POLY 1.5 | P=0.468N P=0.278N P=0.483N P=0.423N |
|POLY 6 | P=0.522N P=0.341N P=0.537N P=0.497N |
|LOGISTIC REGRESSION| P=0.468N P=0.263N P=0.464N P=0.416N |
|COCH-ARM / FISHERS | P=0.471N P=0.274N P=0.500N P=0.421N |
|ORDER RESTRICTED | P=0.520N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.79 0/42.97 0/44.15 2/43.21 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.6% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | --- --- --- 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045 * (e) (e) P=0.232 |
|POLY 3 | P=0.046 * (e) (e) P=0.239 |
|POLY 1.5 | P=0.046 * (e) (e) P=0.240 |
|POLY 6 | P=0.045 * (e) (e) P=0.234 |
|LOGISTIC REGRESSION| P=0.033 * (e) (e) P=0.185 |
|COCH-ARM / FISHERS | P=0.046 * (e) (e) P=0.247 |
|ORDER RESTRICTED | P=0.030 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Angiectasis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/48 (2%) 2/49 (4%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/41.90 2/42.22 0/43.45 0/42.45 |
|POLY-3 PERCENT (g) | 2.4% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 1/29 (3%) 1/28 (4%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 729 (T) 697 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.205N P=0.485 P=0.500N P=0.522N |
|POLY 3 | P=0.184N P=0.503 P=0.493N P=0.497N |
|POLY 1.5 | P=0.183N P=0.506 P=0.493N P=0.494N |
|POLY 6 | P=0.188N P=0.497 P=0.494N P=0.504N |
|LOGISTIC REGRESSION| P=0.192N P=0.490 (e) (e) |
|COCH-ARM / FISHERS | P=0.182N P=0.508 P=0.495N P=0.490N |
|ORDER RESTRICTED | P=0.166N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/48 (8%) 3/49 (6%) 1/49 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 4/41.98 3/42.22 1/43.57 1/42.45 |
|POLY-3 PERCENT (g) | 9.5% 7.1% 2.3% 2.4% |
|TERMINAL (d) | 3/29 (10%) 2/28 (7%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 709 697 697 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.112N P=0.527N P=0.187N P=0.217N |
|POLY 3 | P=0.087N P=0.497N P=0.167N P=0.174N |
|POLY 1.5 | P=0.086N P=0.492N P=0.168N P=0.170N |
|POLY 6 | P=0.090N P=0.507N P=0.167N P=0.185N |
|LOGISTIC REGRESSION| P=0.098N P=0.524N P=0.170N P=0.210N |
|COCH-ARM / FISHERS | P=0.086N P=0.488N P=0.175N P=0.168N |
|ORDER RESTRICTED | P=0.106N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/48 (13%) 7/49 (14%) 5/49 (10%) 11/50 (22%) |
|POLY-3 RATE (b) | 6/43.95 7/44.11 5/44.85 11/44.60 |
|POLY-3 PERCENT (g) | 13.7% 15.9% 11.2% 24.7% |
|TERMINAL (d) | 2/29 (7%) 2/28 (7%) 0/29 (0%) 5/26 (19%) |
|FIRST INCIDENCE | 354 526 526 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.099 P=0.495 P=0.490N P=0.132 |
|POLY 3 | P=0.109 P=0.503 P=0.486N P=0.147 |
|POLY 1.5 | P=0.114 P=0.507 P=0.486N P=0.155 |
|POLY 6 | P=0.101 P=0.498 P=0.485N P=0.134 |
|LOGISTIC REGRESSION| P=0.111 P=0.510 P=0.581N P=0.160 |
|COCH-ARM / FISHERS | P=0.120 P=0.516 P=0.485N P=0.165 |
|ORDER RESTRICTED | P=0.119 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/48 (0%) 0/49 (0%) 0/49 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.90 0/42.10 0/43.45 2/42.83 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | --- --- --- 619 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.044 * (e) (e) P=0.230 |
|POLY 3 | P=0.047 * (e) (e) P=0.242 |
|POLY 1.5 | P=0.048 * (e) (e) P=0.245 |
|POLY 6 | P=0.046 * (e) (e) P=0.235 |
|LOGISTIC REGRESSION| P=0.049 * (e) (e) P=0.247 |
|COCH-ARM / FISHERS | P=0.049 * (e) (e) P=0.258 |
|ORDER RESTRICTED | P=0.031 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/48 (4%) 1/49 (2%) 1/49 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/42.54 1/42.18 1/43.45 0/42.45 |
|POLY-3 PERCENT (g) | 4.7% 2.4% 2.3% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 1/29 (3%) 0/26 (0%) |
|FIRST INCIDENCE | 553 709 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.167N P=0.526N P=0.502N P=0.252N |
|POLY 3 | P=0.151N P=0.503N P=0.493N P=0.237N |
|POLY 1.5 | P=0.149N P=0.498N P=0.491N P=0.232N |
|POLY 6 | P=0.155N P=0.512N P=0.497N P=0.247N |
|LOGISTIC REGRESSION| P=0.147N P=0.494N P=0.511N P=0.234N |
|COCH-ARM / FISHERS | P=0.147N P=0.492N P=0.492N P=0.237N |
|ORDER RESTRICTED | P=0.118N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 4/50 (8%) |
|POLY-3 RATE (b) | 2/42.98 2/43.61 3/44.63 4/44.24 |
|POLY-3 PERCENT (g) | 4.7% 4.6% 6.7% 9.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 702 620 633 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.201 P=0.674 P=0.502 P=0.314 |
|POLY 3 | P=0.227 P=0.689N P=0.517 P=0.350 |
|POLY 1.5 | P=0.225 P=0.689N P=0.512 P=0.348 |
|POLY 6 | P=0.225 P=0.692N P=0.519 P=0.346 |
|LOGISTIC REGRESSION| P=0.193 P=0.692 P=0.505 P=0.295 |
|COCH-ARM / FISHERS | P=0.216 P=0.691N P=0.500 P=0.339 |
|ORDER RESTRICTED | P=0.315 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.79 0/42.97 2/44.79 0/42.45 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.5% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- --- 633 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.587 (e) P=0.250 (e) |
|POLY 3 | P=0.587 (e) P=0.247 (e) |
|POLY 1.5 | P=0.593 (e) P=0.244 (e) |
|POLY 6 | P=0.572 (e) P=0.250 (e) |
|LOGISTIC REGRESSION| P=0.579 (e) P=0.204 (e) |
|COCH-ARM / FISHERS | P=0.595 (e) P=0.247 (e) |
|ORDER RESTRICTED | P=0.256 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/42.87 2/43.13 2/44.52 1/42.53 |
|POLY-3 PERCENT (g) | 2.3% 4.6% 4.5% 2.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 709 709 665 709 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.599N P=0.457 P=0.502 P=0.727 |
|POLY 3 | P=0.557N P=0.502 P=0.513 P=0.759 |
|POLY 1.5 | P=0.554N P=0.503 P=0.509 P=0.760N |
|POLY 6 | P=0.567N P=0.498 P=0.515 P=0.753 |
|LOGISTIC REGRESSION| P=0.557N P=0.499 P=0.502 P=0.757 |
|COCH-ARM / FISHERS | P=0.556N P=0.500 P=0.500 P=0.753N |
|ORDER RESTRICTED | P=0.554 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 4/50 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 1/42.87 4/44.32 4/45.09 4/44.26 |
|POLY-3 PERCENT (g) | 2.3% 9.0% 8.9% 9.0% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 709 520 633 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.195 P=0.177 P=0.191 P=0.178 |
|POLY 3 | P=0.219 P=0.188 P=0.194 P=0.188 |
|POLY 1.5 | P=0.217 P=0.186 P=0.189 P=0.186 |
|POLY 6 | P=0.216 P=0.189 P=0.198 P=0.186 |
|LOGISTIC REGRESSION| P=0.169 P=0.162 P=0.168 P=0.135 |
|COCH-ARM / FISHERS | P=0.205 P=0.181 P=0.181 P=0.181 |
|ORDER RESTRICTED | P=0.182 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 4/50 (8%) 6/50 (12%) |
|POLY-3 RATE (b) | 2/43.62 5/44.10 4/44.90 6/43.89 |
|POLY-3 PERCENT (g) | 4.6% 11.3% 8.9% 13.7% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 479 520 642 633 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.125 P=0.202 P=0.350 P=0.129 |
|POLY 3 | P=0.143 P=0.220 P=0.350 P=0.134 |
|POLY 1.5 | P=0.145 P=0.220 P=0.347 P=0.135 |
|POLY 6 | P=0.140 P=0.217 P=0.352 P=0.130 |
|LOGISTIC REGRESSION| P=0.130 P=0.193 P=0.287 P=0.118 |
|COCH-ARM / FISHERS | P=0.142 P=0.218 P=0.339 P=0.134 |
|ORDER RESTRICTED | P=0.115 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 4/50 (8%) 1/50 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 2/42.20 4/44.87 1/44.30 4/43.57 |
|POLY-3 PERCENT (g) | 4.7% 8.9% 2.3% 9.2% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 702 405 691 616 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.342 P=0.331 P=0.500N P=0.321 |
|POLY 3 | P=0.368 P=0.366 P=0.483N P=0.352 |
|POLY 1.5 | P=0.369 P=0.361 P=0.485N P=0.352 |
|POLY 6 | P=0.361 P=0.365 P=0.485N P=0.344 |
|LOGISTIC REGRESSION| P=0.323 P=0.295 P=0.485N P=0.342 |
|COCH-ARM / FISHERS | P=0.364 P=0.349 P=0.492N P=0.349 |
|ORDER RESTRICTED | P=0.318 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.07 0/42.97 0/44.15 2/43.92 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.6% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- --- --- 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.049 * (e) (e) P=0.251 |
|POLY 3 | P=0.047 * (e) (e) P=0.247 |
|POLY 1.5 | P=0.047 * (e) (e) P=0.247 |
|POLY 6 | P=0.047 * (e) (e) P=0.242 |
|LOGISTIC REGRESSION| P=0.006 ** (e) (e) P=0.061 |
|COCH-ARM / FISHERS | P=0.047 * (e) (e) P=0.253 |
|ORDER RESTRICTED | P=0.033 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Testes |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 9/50 (18%) 9/50 (18%) |
|POLY-3 RATE (b) | 6/43.77 8/44.21 9/46.05 9/43.27 |
|POLY-3 PERCENT (g) | 13.7% 18.1% 19.5% 20.8% |
|TERMINAL (d) | 1/29 (3%) 4/28 (14%) 3/29 (10%) 6/26 (23%) |
|FIRST INCIDENCE | 620 561 526 633 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.220 P=0.370 P=0.314 P=0.239 |
|POLY 3 | P=0.247 P=0.393 P=0.324 P=0.277 |
|POLY 1.5 | P=0.256 P=0.395 P=0.313 P=0.286 |
|POLY 6 | P=0.225 P=0.383 P=0.328 P=0.254 |
|LOGISTIC REGRESSION| P=0.257 P=0.387 P=0.263 P=0.285 |
|COCH-ARM / FISHERS | P=0.257 P=0.387 P=0.288 P=0.288 |
|ORDER RESTRICTED | P=0.312 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 3/50 (6%) 3/50 (6%) |
|POLY-3 RATE (b) | 3/44.81 2/43.53 3/44.72 3/43.64 |
|POLY-3 PERCENT (g) | 6.7% 4.6% 6.7% 6.9% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 354 620 665 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.506 P=0.496N P=0.648N P=0.658 |
|POLY 3 | P=0.512 P=0.513N P=0.662 P=0.650 |
|POLY 1.5 | P=0.518 P=0.507N P=0.662N P=0.657 |
|POLY 6 | P=0.500 P=0.522N P=0.660 P=0.637 |
|LOGISTIC REGRESSION| P=0.423 P=0.627N P=0.498 P=0.511 |
|COCH-ARM / FISHERS | P=0.521 P=0.500N P=0.661N P=0.661N |
|ORDER RESTRICTED | P=0.632 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 44/46 (96%) 46/48 (96%) 40/44 (91%) 41/42 (98%) |
|POLY-3 RATE (b) | 44/46.00 46/47.36 40/42.32 41/41.92 |
|POLY-3 PERCENT (g) | 95.7% 97.1% 94.5% 97.8% |
|TERMINAL (d) | 27/29 (93%) 28/28 (100%) 28/29 (97%) 26/26 (100%) |
|FIRST INCIDENCE | 354 405 526 448 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.482N P=0.359 P=0.286N P=0.517 |
|POLY 3 | P=0.446 P=0.572 P=0.605N P=0.513 |
|POLY 1.5 | P=0.459 P=0.626 P=0.479N P=0.522 |
|POLY 6 | P=0.430 P=0.474 P=0.685 P=0.495 |
|LOGISTIC REGRESSION| P=0.531 P=0.680 P=0.243N P=0.533 |
|COCH-ARM / FISHERS | P=0.481 P=0.675 P=0.317N P=0.534 |
|ORDER RESTRICTED | P=0.446 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Degeneration Cystic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/46 (0%) 2/48 (4%) 0/44 (0%) 0/42 (0%) |
|POLY-3 RATE (b) | 0/40.05 2/41.28 0/39.67 0/37.14 |
|POLY-3 PERCENT (g) | 0.0% 4.8% 0.0% 0.0% |
|TERMINAL (d) | 0/29 (0%) 2/28 (7%) 0/29 (0%) 0/26 (0%) |
|FIRST INCIDENCE | --- 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.424N P=0.230 (e) (e) |
|POLY 3 | P=0.423N P=0.244 (e) (e) |
|POLY 1.5 | P=0.423N P=0.246 (e) (e) |
|POLY 6 | P=0.425N P=0.239 (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.230 (e) (e) |
|COCH-ARM / FISHERS | P=0.427N P=0.258 (e) (e) |
|ORDER RESTRICTED | P=0.268N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/46 (0%) 0/48 (0%) 0/44 (0%) 2/42 (5%) |
|POLY-3 RATE (b) | 0/40.05 0/41.28 0/39.67 2/37.14 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 5.4% |
|TERMINAL (d) | 0/29 (0%) 0/28 (0%) 0/29 (0%) 2/26 (8%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.039 * (e) (e) P=0.214 |
|POLY 3 | P=0.038 * (e) (e) P=0.220 |
|POLY 1.5 | P=0.038 * (e) (e) P=0.219 |
|POLY 6 | P=0.039 * (e) (e) P=0.219 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.214 |
|COCH-ARM / FISHERS | P=0.039 * (e) (e) P=0.225 |
|ORDER RESTRICTED | P=0.024 * (e) (e) (e) |
|=================================================================================================================================|
Date: 05/24/04 EXPERIMENT: 96018 TEST: 03 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia Cystic Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/46 (11%) 4/48 (8%) 4/44 (9%) 3/42 (7%) |
|POLY-3 RATE (b) | 5/40.24 4/41.28 4/40.01 3/38.02 |
|POLY-3 PERCENT (g) | 12.4% 9.7% 10.0% 7.9% |
|TERMINAL (d) | 4/29 (14%) 4/28 (14%) 3/29 (10%) 1/26 (4%) |
|FIRST INCIDENCE | 680 729 (T) 633 554 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.341N P=0.524N P=0.497N P=0.403N |
|POLY 3 | P=0.333N P=0.484N P=0.504N P=0.387N |
|POLY 1.5 | P=0.343N P=0.477N P=0.512N P=0.393N |
|POLY 6 | P=0.324N P=0.498N P=0.497N P=0.383N |
|LOGISTIC REGRESSION| P=0.347N P=0.516N P=0.505N P=0.407N |
|COCH-ARM / FISHERS | P=0.358N P=0.473N P=0.529N P=0.409N |
|ORDER RESTRICTED | P=0.404N (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).