TDMS Study 96018-03 Pathology Tables
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
FINAL #2/RATS
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/19/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 19 14 15
Natural Death 5 2 7 9
Accidently Killed 1
Survivors
Terminal Sacrifice 28 27 29 26
Moribund Sacrifice 1 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (49) (44) (43)
Edema 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis, Focal 4 [2.0] 4 [2.0] 5 [2.0] 2 [1.5]
Basophilic Focus 33 25 24 17
Cholangiofibrosis 1 [2.0] 2 [2.0] 1 [3.0] 1 [2.0]
Clear Cell Focus 28 24 19 17
Congestion 2 [2.5] 1 [2.0] 1 [3.0] 4 [2.8]
Degeneration, Cystic, Focal 31 [1.9] 24 [1.8] 23 [1.7] 29 [1.8]
Eosinophilic Focus 1 4
Fibrosis, Focal 1 [3.0] 1 [2.0] 1 [2.0] 3 [2.7]
Hemorrhage, Focal 1 [3.0]
Hepatodiaphragmatic Nodule 5 [2.8] 5 [2.4] 12 [2.5] 4 [2.3]
Hyperplasia, Focal, Histiocytic 1 [2.0]
Hyperplasia, Focal, Regenerative 1 [4.0]
Infiltration Cellular, Mixed Cell 30 [1.9] 31 [1.8] 34 [1.8] 34 [1.9]
Inflammation, Chronic 23 [1.3] 29 [1.3] 33 [1.4] 34 [1.5]
Mixed Cell Focus 3 10 4
Necrosis, Focal 2 [1.0] 1 [2.0]
Tension Lipidosis 1 [3.0]
Bile Duct, Hyperplasia 45 [2.8] 49 [2.7] 49 [2.7] 50 [2.8]
Hepatocyte, Fatty Change 36 [1.5] 34 [1.4] 36 [1.5] 40 [1.6]
Hepatocyte, Hyperplasia, Regenerative 1 [1.0]
Hepatocyte, Hypertrophy 1 [3.0]
Hepatocyte, Vacuolization Cytoplasmic 11 [2.0] 10 [2.0] 19 [1.5] 18 [1.4]
Hepatocyte, Centrilobular, Necrosis 1 [3.0] 1 [2.0] 1 [3.0] 4 [2.5]
Serosa, Bile Duct, Inflammation, Chronic,
Focal 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (15) (13) (14) (15)
Hemorrhage, Focal 1 [3.0]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Fat, Necrosis, Focal 8 [2.6] 4 [3.0] 9 [2.7] 7 [2.9]
Pancreas (49) (50) (50) (49)
Cyst 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [1.0]
Acinus, Atrophy, Focal 31 [1.8] 20 [1.8] 23 [1.8] 21 [2.0]
Acinus, Hyperplasia, Focal 1 [2.0]
Duct, Cyst 1 [2.0]
Duct, Cyst, Focal, Multiple 16 [1.8] 14 [1.4] 17 [1.5] 11 [1.5]
Stomach, Forestomach (50) (50) (50) (50)
Edema 2 [2.5] 2 [3.0] 3 [3.0] 4 [2.8]
Erosion 1 [1.0]
Inflammation, Chronic, Diffuse 1 [3.0]
Inflammation, Diffuse 2 [2.0]
Inflammation, Focal 1 [2.0] 2 [2.5] 2 [2.5] 1 [2.0]
Ulcer 1 [3.0] 4 [2.8] 4 [2.0] 4 [2.3]
Epithelium, Hyperplasia 2 [2.0] 5 [2.4] 4 [2.8] 6 [1.8]
Stomach, Glandular (49) (50) (50) (50)
Atypia Cellular, Focal 1 [2.0]
Edema 1 [2.0]
Erosion 2 [1.5] 4 [2.0] 1 [3.0] 4 [2.0]
Fibrosis, Focal 1 [3.0]
Infarct 1 [2.0]
Inflammation, Focal 1 [3.0]
Pigmentation, Focal 1 [3.0] 1 [2.0]
Ulcer 1 [1.0]
Artery, Inflammation, Chronic 1 [3.0]
Epithelium, Hyperplasia 2 [2.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
Glands, Ectasia, Focal 1 [1.0] 1 [3.0]
Glands, Necrosis, Focal 1 [2.0]
Tongue (1) (1) (1) (1)
Infiltration Cellular, Focal, Mixed Cell 1 [2.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
Tooth (1)
Epithelium Alveolus, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Cardiomyopathy 16 [1.8] 18 [1.8] 21 [1.7] 14 [1.9]
Fibrosis, Focal 1 [2.0]
Infiltration Cellular, Mixed Cell 1 [1.0]
Thrombosis 2 [3.5] 2 [2.5]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 14 [1.0] 8 [1.1] 8 [1.4] 14 [1.1]
Angiectasis 1 [2.0]
Cytoplasmic Alteration, Focal 1 [2.0] 3 [1.7] 3 [1.7] 2 [1.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Necrosis, Focal 2 [2.0] 1 [3.0] 1 [2.0]
Vacuolization Cytoplasmic, Focal 9 [1.2] 5 [1.0] 8 [1.4] 12 [1.2]
Adrenal Medulla (50) (50) (50) (49)
Cytoplasmic Alteration, Focal 1 [1.0]
Hemorrhage 1 [4.0]
Hyperplasia 1 [1.0]
Hyperplasia, Focal 11 [1.2] 17 [1.7] 15 [1.3] 13 [1.5]
Necrosis, Focal 1 [3.0] 1 [2.0]
Thrombosis 1 [3.0]
Bilateral, Hyperplasia, Focal 1 [4.0]
Islets, Pancreatic (49) (50) (50) (49)
Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0]
Hyperplasia, Focal 2 [2.0]
Parathyroid Gland (48) (49) (50) (50)
Cyst 1 [3.0]
Hyperplasia, Focal 1 [2.0]
Pituitary Gland (49) (50) (50) (48)
Angiectasis 2 [2.0] 2 [2.0] 1 [2.0]
Craniopharyngeal Duct, Cyst 1 [2.0]
Pars Distalis, Cyst 2 [2.0] 2 [2.5] 2 [1.5] 2 [1.5]
Pars Distalis, Cytoplasmic Alteration, Focal 7 [1.4] 6 [1.2] 1 [2.0] 6 [1.0]
Pars Distalis, Degeneration, Cystic, Focal 1 [1.0] 3 [2.0]
Pars Distalis, Hemorrhage, Focal 3 [2.3] 5 [2.0] 1 [3.0] 3 [2.7]
Pars Distalis, Hyperplasia, Focal 3 [2.0] 2 [2.0] 2 [2.0] 7 [2.1]
Pars Distalis, Necrosis, Focal 1 [3.0]
Pars Intermedia, Cyst 1 [1.0]
Rathke's Cleft, Cyst 2 [2.0] 2 [2.5]
Rathke's Cleft, Hemorrhage 1 [2.0]
Thyroid Gland (46) (48) (44) (42)
Hemorrhage 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 44 [1.9] 46 [1.6] 40 [1.6] 41 [1.7]
Follicle, Degeneration, Cystic, Focal 2 [2.0]
Follicular Cell, Hyperplasia 2 [1.0]
Follicular Cell, Hyperplasia, Cystic, Focal 5 [1.4] 4 [1.8] 4 [1.5] 3 [2.3]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Inflammation, Chronic 1 [3.0]
Preputial Gland (50) (50) (50) (49)
Degeneration, Cystic 1 [3.0] 1 [3.0] 2 [2.5]
Fibrosis 1 [3.0]
Hyperplasia, Cystic 2 [3.5] 1 [3.0] 1 [2.0] 2 [2.0]
Inflammation, Chronic 32 [1.7] 30 [1.4] 31 [1.5] 37 [1.7]
Prostate (50) (50) (50) (50)
Inflammation, Chronic 29 [2.2] 33 [2.0] 35 [2.2] 38 [2.2]
Mineralization, Focal 2 [2.0]
Epithelium, Hyperplasia, Focal 25 [1.4] 21 [1.6] 24 [1.5] 23 [1.6]
Seminal Vesicle (50) (50) (50) (50)
Dilatation 1 [3.0]
Inflammation, Chronic 1 [3.0]
Testes (50) (50) (50) (50)
Atrophy 5 [3.0] 8 [2.8] 8 [3.0] 8 [3.0]
Necrosis 1 [4.0]
Artery, Thrombosis, Focal 1 [3.0]
Bilateral, Atrophy 1 [2.0] 1 [3.0] 1 [4.0]
Bilateral, Interstitial Cell, Hyperplasia,
Focal 1 [1.0]
Interstitial Cell, Hyperplasia 1 [1.0]
Interstitial Cell, Hyperplasia, Focal 3 [1.7] 1 [1.0] 3 [1.7] 3 [2.0]
Tunic, Inflammation, Chronic 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (45) (49) (49)
Hyperplasia 2 [3.5] 2 [3.5] 5 [3.2] 2 [3.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Focal, Histiocytic 1 [1.0] 1 [1.0]
Hyperplasia, Histiocytic 1 [4.0]
Myeloid Cell, Hyperplasia 2 [2.5] 3 [2.7] 1 [3.0]
Myeloid Cell, Erythroid Cell, Hyperplasia 1 [3.0] 5 [2.8] 5 [2.8]
Lymph Node (25) (28) (26) (26)
Bronchial, Hyperplasia, Plasma Cell 1 [3.0]
Deep Cervical, Ectasia 1 [3.0]
Mediastinal, Angiectasis 2 [3.5] 1 [3.0]
Mediastinal, Ectasia 3 [3.0] 1 [3.0] 3 [3.0] 4 [3.0]
Mediastinal, Hemorrhage 1 [3.0] 2 [2.5]
Mediastinal, Hyperplasia 1 [3.0]
Mediastinal, Hyperplasia, Histiocytic 2 [3.0] 1 [3.0] 2 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 1 [3.0]
Mediastinal, Hyperplasia, Plasma Cell 1 [3.0] 3 [3.3] 6 [3.2] 1 [3.0]
Mediastinal, Inflammation 1 [4.0]
Pancreatic, Angiectasis 1 [3.0]
Pancreatic, Ectasia 3 [3.0] 5 [3.0] 3 [3.0] 5 [3.0]
Pancreatic, Hemorrhage 1 [3.0] 2 [2.5] 1 [3.0]
Pancreatic, Hyperplasia, Histiocytic 3 [3.0] 7 [2.7] 5 [3.0]
Pancreatic, Pigmentation 1 [3.0] 1 [2.0] 1 [2.0]
Lymph Node, Mesenteric (50) (49) (50) (50)
Ectasia 1 [3.0]
Hemorrhage 2 [2.5] 1 [3.0]
Hyperplasia, Histiocytic 2 [3.0] 1 [3.0]
Spleen (48) (49) (49) (50)
Accessory Spleen 1 1 1
Angiectasis, Focal 1 [2.0] 2 [3.0]
Congestion 1 [3.0] 1 [2.0]
Fibrosis, Focal 4 [2.5] 3 [2.7] 1 [3.0] 1 [2.0]
Hematopoietic Cell Proliferation 6 [2.2] 7 [2.3] 5 [2.2] 11 [2.3]
Hemorrhage 2 [3.0]
Hemorrhage, Chronic 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [4.0]
Hyperplasia, Lymphoid 1 [2.0]
Infarct 2 [3.0] 1 [3.0] 1 [3.0]
Necrosis, Focal 1 [3.0]
Pigmentation 1 [4.0]
Artery, Thrombosis 1 [4.0]
Capsule, Fibrosis, Focal 1 [2.0]
Thymus (48) (48) (50) (47)
Hemorrhage 1 [2.0]
Hyperplasia, Lymphoid 1 [3.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (45) (47) (42)
Atypia Cellular, Focal 1 [2.0]
Dilatation 8 [2.4] 18 [2.4] 16 [2.4] 12 [2.3]
Ectasia 1 [2.0] 1 [2.0]
Fibrosis 1 [2.0]
Fibrosis, Focal 1 [3.0]
Hyperplasia 2 [2.0] 3 [2.7] 2 [2.0] 1 [3.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2
Hyperkeratosis, Focal 1 [2.0]
Inflammation, Chronic, Focal 1 [3.0]
Mineralization, Focal 1 [3.0]
Subcutaneous Tissue, Angiectasis, Focal 1 [2.0] 1 [2.0]
Subcutaneous Tissue, Cyst, Chronic 1 [4.0]
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 [2.0]
Subcutaneous Tissue, Edema 1 [3.0]
Subcutaneous Tissue, Hemorrhage, Focal 1 [2.0] 1 [3.0] 1 [3.0]
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 1 [2.0]
Subcutaneous Tissue, Metaplasia, Focal,
Osseous 1 [2.0]
Subcutaneous Tissue, Necrosis, Fatty, Focal 1 [2.0]
Subcutaneous Tissue, Epidermis, Hyperplasia,
Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 [2.0]
Skeletal Muscle (3) (2)
Hemorrhage, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression, Focal 6 [2.5] 8 [2.9] 14 [3.1] 14 [2.8]
Hemorrhage, Focal 2 [1.5] 4 [2.8] 1 [3.0] 3 [2.7]
Hydrocephalus 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Necrosis, Focal 1 [2.0] 2 [3.0]
Cerebellum, Hemorrhage, Focal 1 [1.0]
Cerebrum, Ventricle, Hydrocephalus 1 [3.0]
Pineal Gland, Vacuolization Cytoplasmic 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 4 [2.8] 1 [2.0] 3 [3.0] 5 [2.4]
Fibrosis, Focal 1 [2.0]
Hemorrhage 1 [2.0] 1 [3.0] 1 [3.0]
Hemorrhage, Focal 3 [1.7] 1 [2.0] 2 [1.5] 2 [2.0]
Hyperplasia, Focal, Histiocytic 1 [3.0] 1 [1.0]
Hyperplasia, Histiocytic 1 [1.0] 1 [1.0] 2 [1.0]
Infiltration Cellular, Mixed Cell 2 [1.5] 1 [2.0]
Inflammation, Chronic, Focal 2 [1.5] 3 [1.7] 2 [1.0]
Metaplasia, Squamous 1 [4.0]
Alveolar Epithelium, Hyperplasia, Focal 7 [1.7] 6 [1.7] 9 [1.4] 5 [2.2]
Interstitium, Edema 1 [3.0]
Mediastinum, Angiectasis, Focal 1 [2.0]
Nose (50) (50) (50) (50)
Hemorrhage 1 [3.0]
Inflammation, Suppurative 2 [2.0] 3 [2.0] 3 [1.7] 3 [1.3]
Nasolacrimal Duct, Inflammation 3 [2.3] 1 [1.0]
Olfactory Epithelium, Mineralization, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (49) (48) (47)
Cataract 2 [3.0] 1 [3.0] 7 [2.9]
Inflammation, Chronic 1 [3.0]
Retina, Degeneration 3 [3.0] 1 [3.0] 8 [2.8] 1 [3.0]
Harderian Gland (50) (50) (50) (48)
Hyperplasia, Focal, Histiocytic 1 [2.0]
Hyperplasia, Focal, Lymphoid 1 [2.0]
Hyperplasia, Lymphoid 1 [2.0]
Inflammation, Chronic, Focal 1 [1.0] 1 [2.0]
Epithelium, Hyperplasia, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96018-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/24/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 10:03:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Cyst 1 [2.0]
Infarct 3 [3.3] 1 [3.0]
Metaplasia, Focal, Osseous 1 [2.0]
Nephropathy 49 [2.1] 50 [1.8] 49 [2.0] 46 [1.8]
Artery, Thrombosis 1 [3.0]
Cortex, Necrosis, Focal 1 [2.0]
Pelvis, Dilatation 1 [3.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [2.0]
Renal Tubule, Hyperplasia, Atypical, Focal 1 [1.0]
Renal Tubule, Pigmentation 10 [2.1] 13 [2.2] 7 [2.3] 3 [2.3]
Urinary Bladder (49) (50) (50) (49)
Hemorrhage 1 [3.0] 1 [3.0]
Inflammation, Chronic 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------