TDMS Study 96018-04 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/31/03
EXPERIMENT: 96018 TEST: 04 TIME: 09:23:15
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96018
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/31/03
EXPERIMENT: 96018 TEST: 04 TIME: 9:27:04
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96018
CONT: N01-ES-85420 CAS: 75-27-4
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
==================================================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 3.0 21.7 2.2 20.8 0.73 19 1.7 20.1 0.57 29 1.9 20.1 0.63 66
8 3.4 26.4 2.3 24.2 0.68 17 2.5 24.6 0.74 36 2.1 24.4 0.62 61
12 2.9 32.1 2.5 27.2 0.86 16 2.6 28.2 0.90 32 2.3 27.3 0.79 59
16 2.2 37.9 2.0 31.8 0.91 11 1.6 33.3 0.73 17 2.2 31.7 1.00 48
20 2.6 42.6 2.5 34.8 0.96 12 2.2 37.2 0.85 21 2.5 35.5 0.96 50
24 2.7 45.9 2.4 37.8 0.89 11 2.3 38.5 0.85 21 2.8 37.3 1.04 53
28 1.9 50.0 2.2 40.1 1.16 10 2.2 41.4 1.16 18 1.9 40.4 1.00 33
32 2.4 51.8 2.2 43.8 0.92 9 2.2 45.4 0.92 17 2.3 43.7 0.96 37
36 2.4 54.8 2.2 46.6 0.92 8 2.3 48.2 0.96 17 2.2 47.4 0.92 32
40 2.5 58.1 2.5 50.6 1.00 9 2.3 52.8 0.92 15 2.4 51.3 0.96 33
44 2.6 59.4 2.4 54.6 0.92 8 2.3 55.7 0.88 14 2.4 54.3 0.92 31
48 2.7 60.2 2.5 57.0 0.93 8 2.2 58.4 0.81 13 2.2 56.4 0.81 27
52 2.7 61.2 2.5 58.1 0.93 7 2.4 58.1 0.89 14 2.5 55.6 0.93 31
56 2.6 62.3 2.1 57.3 0.81 6 2.1 58.8 0.81 12 2.1 56.3 0.81 27
60 2.5 64.4 2.3 58.3 0.92 7 2.0 61.2 0.80 12 2.2 58.3 0.88 27
64 2.7 64.7 2.2 60.0 0.81 6 2.1 60.5 0.78 12 2.2 59.9 0.81 26
68 2.7 65.4 2.1 60.8 0.78 6 2.2 61.4 0.81 12 2.2 60.3 0.81 25
72 2.9 66.6 2.1 62.2 0.72 6 2.2 62.7 0.76 12 2.2 61.4 0.76 25
76 2.6 66.6 2.0 61.3 0.77 6 2.0 61.7 0.77 11 2.3 60.1 0.88 26
80 2.9 65.1 2.3 59.2 0.79 7 2.1 60.1 0.72 12 2.2 59.1 0.76 27
84 2.9 65.4 2.2 59.9 0.76 6 2.2 60.7 0.76 13 2.4 59.3 0.83 28
88 3.3 66.1 2.2 61.2 0.67 6 2.4 60.9 0.73 14 2.3 60.9 0.70 26
92 3.7 64.0 2.4 59.8 0.65 7 2.3 59.4 0.62 13 2.4 59.6 0.65 28
96 3.6 62.2 3.2 56.5 0.89 10 2.5 55.8 0.69 16 2.4 57.3 0.67 29
100 3.7 60.4 2.8 54.7 0.76 9 2.3 52.4 0.62 16 2.7 56.5 0.73 33
104 3.8 56.9 3.0 53.8 0.79 10 3.4 51.8 0.89 23 2.8 55.3 0.74 35
1 TO 13 WEEKS
----------------
MEAN 3.1 26.7 2.4 24.1 0.76 17 2.3 24.3 0.73 33 2.1 23.9 0.68 62
SD(D) 0.3 0.2 0.10 1 0.5 0.16 3 0.2 0.10 3
CV(E) 8.5 6.6 12.6 7.8 22.0 22.5 10.6 10.3 14.2 5.3
14 TO 52 WEEKS
----------------
MEAN 2.5 52.2 2.3 45.5 0.95 9 2.2 46.9 0.90 17 2.3 45.4 0.95 38
SD(D) 0.3 0.2 0.08 2 0.2 0.11 3 0.2 0.06 9
CV(E) 11.1 7.5 8.2 18.9 9.7 12.5 15.4 10.5 6.4 24.5
> 52 WEEKS
----------------
MEAN 3.1 63.9 2.4 58.8 0.78 7 2.3 59.0 0.75 14 2.3 58.8 0.77 28
SD(D) 0.5 0.4 0.08 1 0.4 0.08 3 0.2 0.08 3
CV(E) 16.0 15.8 9.7 20.1 15.8 10.1 22.5 8.1 9.7 10.7
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
=========================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 18.6 50 18.4 50 18.6 50 18.5 50
1 18.6 50 18.4 50 18.6 50 18.5 50
4 3.0 8313 21.7 50 2.2 7836 20.8 50 1.7 8061 20.1 50 1.9 7704 20.1 50
8 3.4 8018 26.4 50 2.3 6765 24.2 50 2.5 7922 24.6 50 2.1 7321 24.4 50
12 2.9 7917 32.1 50 2.5 8035 27.2 50 2.6 7626 28.2 50 2.3 7939 27.3 50
16 2.2 8258 37.9 50 2.0 4816 31.8 50 1.6 6386 33.3 50 2.2 5518 31.7 50
20 2.6 8315 42.6 50 2.5 7334 34.8 50 2.2 7863 37.2 50 2.5 7326 35.5 50
24 2.7 8206 45.9 50 2.4 6933 37.8 50 2.3 5411 38.5 50 2.8 5841 37.3 50
28 1.9 8224 50.0 50 2.2 5756 40.1 50 2.2 7137 41.4 50 1.9 7989 40.4 50
32 2.4 8280 51.8 50 2.2 8205 43.8 49 2.2 7427 45.4 50 2.3 8375 43.7 50
36 2.4 7750 54.8 50 2.2 7951 46.6 49 2.3 7854 48.2 50 2.2 7355 47.4 50
40 2.5 8205 58.1 50 2.5 8037 50.6 49 2.3 8195 52.8 50 2.4 8189 51.3 50
44 2.6 8390 59.4 50 2.4 8212 54.6 49 2.3 8366 55.7 50 2.4 7748 54.3 50
48 2.7 8257 60.2 50 2.5 7921 57.0 48 2.2 8095 58.4 49 2.2 8154 56.4 50
52 2.7 7938 61.2 49 2.5 7875 58.1 48 2.4 8139 58.1 49 2.5 7799 55.6 50
56 2.6 7848 62.3 49 2.1 6027 57.3 48 2.1 7319 58.8 49 2.1 6321 56.3 50
60 2.5 7320 64.4 49 2.3 6680 58.3 48 2.0 7295 61.2 49 2.2 7354 58.3 50
64 2.7 8035 64.7 48 2.2 8024 60.0 48 2.1 8182 60.5 49 2.2 7723 59.9 49
68 2.7 8243 65.4 48 2.1 8234 60.8 48 2.2 8059 61.4 47 2.2 8298 60.3 49
72 2.9 7559 66.6 48 2.1 7017 62.2 48 2.2 7636 62.7 46 2.2 7614 61.4 48
76 2.6 7826 66.6 48 2.0 4372 61.3 46 2.0 7135 61.7 46 2.3 6124 60.1 47
80 2.9 8074 65.1 48 2.3 6031 59.2 45 2.1 7423 60.1 45 2.2 5231 59.1 46
84 2.9 7878 65.4 46 2.2 6495 59.9 44 2.2 7581 60.7 45 2.4 7842 59.3 46
88 3.3 7186 66.1 44 2.2 6274 61.2 43 2.4 7016 60.9 43 2.3 6735 60.9 45
92 3.7 7427 64.0 44 2.4 6921 59.8 42 2.3 6919 59.4 43 2.4 6929 59.6 44
96 3.6 6993 62.2 43 3.2 4731 56.5 39 2.5 4491 55.8 38 2.4 5798 57.3 43
100 3.7 6321 60.4 41 2.8 4844 54.7 37 2.3 5162 52.4 36 2.7 5770 56.5 40
104 3.8 5740 56.9 38 3.0 5413 53.8 36 3.4 4692 51.8 33 2.8 5181 55.3 39
MEAN BODY WGT FOR WEEKS
1 TO 13 24.7 22.7 22.9 22.6
14 TO 52 52.2 45.5 46.9 45.4
> 52 63.9 58.8 59.0 58.8
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.