TDMS Study 92012-04 Pathology Tables

NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96
Route: DOSED FEED                                                                                                 Time: 20:32:14
                                                             90-DAY
       Facility:  Microbiological Associates
       Chemical CAS #:  693-98-1
       Lock Date:  08/31/94
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10            9           10           10            8           
    Accidently Killed                                                            1                                      2           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                      (1)                                    (10)         
      Infiltration Cellular, Lymphocyte                1 (10%)                                                                      
      Necrosis, Acute                                                                                                   1 (10%)     
      Vacuolization Cytoplasmic, Diffuse               1 (10%)                                                                      
      Periportal, Vacuolization Cytoplasmic            6 (60%)                                                          8 (80%)     
   Stomach, Glandular                                 (10)                      (1)                                    (10)         
      Infiltration Cellular, Mixed Cell                                                                                 1 (10%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (10)         (9)          (8)          (9)          (10)         (10)         
      Follicular Cell, Hypertrophy                                                            7 (78%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (9)                       (1)                                    (6)          
      Cyst                                             6 (67%)                                                          2 (33%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 2 (20%)      1 (10%)      1 (10%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                      (1)                                    (10)         
      Perivascular, Inflammation, Chronic Active       1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Pelvis, Infiltration Cellular, Lymphocyte        1 (10%)                                                                      
      Renal Tubule, Pigmentation, Hemosiderin                                                 3 (30%)      9 (90%)     10 (100%)    
   Urinary Bladder                                    (10)                      (1)                                    (10)         
      Infiltration Cellular, Lymphocyte                2 (20%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9            9           10           10            9           
    Accidently Killed                                               1            1                                      1           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)          (1)                                    (10)         
      Necrosis, Acute                                                                                                   1 (10%)     
      Periportal, Vacuolization Cytoplasmic            9 (90%)                   1 (100%)                              10 (100%)    
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (10)         (9)          (10)         (9)          (10)         (10)         
      Follicular Cell, Hypertrophy                                                            9 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)         (1)          (1)                                    (10)         
      Cyst                                             7 (70%)                                                          3 (30%)     
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                              1 (10%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Nose                                               (10)         (1)          (1)                                    (10)         
      Respiratory Epithelium, Infiltration                                                                                          
          Cellular, Mixed Cell                                                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Cyst                                             1 (10%)                                                                      
      Renal Tubule, Pigmentation, Hemosiderin                                   10 (100%)    10 (100%)    10 (100%)    10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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