TDMS Study 92012-04 Pathology Tables
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
90-DAY
Facility: Microbiological Associates
Chemical CAS #: 693-98-1
Lock Date: 08/31/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + I + + + + + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + M | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + M + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
625 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + I | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I I + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + | 1 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
2500 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10000 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M M + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + M + + + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + M + + M + + M + | 6 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10000 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + I + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
625 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
625 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
625 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + I + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
5000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + M + M | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 92012-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:33:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
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---------- END OF REPORT ----------
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