TDMS Study 05002-06 Pathology Tables
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
Facility: Southern Research Institute
Chemical CAS #: 96-48-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Inflammation, Chronic | 1 2 1 1 2 1 |
Mineralization | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 4 3 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | X |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 1 4 3 |
Necrosis | 4 4 |
Pigmentation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Mucosa, Hyperplasia | 1 3 3 2 1 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Inflammation, Chronic | 2 |
Spindle Cell, Hyperplasia | 2 2 3 3 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Zona Fasciculata, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + M + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 2 3 |
Follicular Cell, Hyperplasia | 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + I + + + + + + + + + + + + + + + M + + +|
Cyst | X X X X X|
Hemorrhage | 4 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Hemorrhage | 2 2 |
Hydrometra | 3 |
Hyperplasia, Cystic | 3 3 2 3 2 3 4 4 2 2 3 3 3 4 3 4 3 4 3 4 3 4 3 4|
Metaplasia, Squamous | |
Serosa, Cyst | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 2 1 1 2 3 3 2 1 1 3 2 1 2 1 1 1 1 1 2 2|
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Infiltration Cellular, | |
Polymorphonuclear | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 2 |
Lymphoid Follicle, Depletion Cellular| 2 3 |
Red Pulp, Depletion Cellular | 2 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 2 1 1 1 1 |
Infiltration Cellular, Histiocyte | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | |
Mineralization | 2 1 1 2 2 2 2 2 2 2 1 1 1 2 1 1 2|
Necrosis | 3 |
Pigmentation | 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 3 4 |
Inflammation, Chronic | 3 2 2 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 |
Cyst | |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Osseous | 2 2 |
Mineralization | 1 |
Renal Tubule, Atrophy | 2 2 2 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Regeneration | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 1 2 1 2 2 2 2 2 2 3 3 2 2 3|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3| |
| 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + + + M + + + M + + + + +| 47 |
Inflammation, Chronic | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + M + + + + +| 48 |
Edema | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Hyperplasia, Lymphoid | 3| 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X | 1 |
Inflammation, Chronic | 2 1 2 2 2 2 1 2 | 14 1.6|
Mineralization | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 3| 8 2.4|
Kupffer Cell, Hyperplasia | | 1 2.0|
Kupffer Cell, Pigmentation | | 1 3.0|
Lobules, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Accessory Spleen | | 1 |
Fat, Inflammation, Granulomatous | | 1 4.0|
Fat, Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Chronic | 2 3 2 2 | 7 2.4|
Necrosis | | 2 4.0|
Pigmentation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 3.0|
Mucosa, Hyperplasia | 1 3 | 10 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3| |
| 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 2 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Inflammation, Chronic | | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 43 2.1|
Zona Fasciculata, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 5 1.6|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + M + + M + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 3 | 4 2.5|
Pars Distalis, Hyperplasia | 1 2 1 2 1 2 | 13 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Cyst | X | 2 |
Inflammation, Chronic | 2 | 3 2.3|
Follicular Cell, Hyperplasia | 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X X X X X | 11 |
Hemorrhage | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X | 8 |
Hemorrhage | | 2 2.0|
Hydrometra | 3 4 3 3 3 3 3 4 | 9 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3| |
| 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 4 3 3 3 2 4 2 4 3 4 3 3 3 3 4 4 2 4 3 2 2 3| 46 3.1|
Metaplasia, Squamous | 3 | 1 3.0|
Serosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 3 1 2 1 2 1 3 2 2 2 1 2 3 1 2 2 1| 41 1.7|
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hemorrhage | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | 3 2 2 2| 6 2.5|
Hyperplasia, Lymphoid | 3 | 3 2.3|
Lymphoid Follicle, Depletion Cellular| | 2 2.5|
Red Pulp, Depletion Cellular | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + M + +| 47 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 | 17 1.2|
Infiltration Cellular, Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 2 | 3 2.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3| |
| 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | 1 2 2 1 1 2 1 3 2 2 2 2 3 2 1 2 2 2 2| 36 1.7|
Necrosis | | 1 3.0|
Pigmentation | | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 4 | 4 3.3|
Inflammation, Chronic | 2 3 | 6 2.3|
Mineralization | 2 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 1 2 2 | 9 1.2|
Cyst | X X | 2 |
Inflammation, Chronic | 2 2 4 2 2 2 4 2 2 2 1 2 4 3 2 1| 28 2.1|
Metaplasia, Osseous | 3 | 3 2.3|
Mineralization | | 1 1.0|
Renal Tubule, Atrophy | 1 2 | 5 1.8|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | 1 | 2 1.5|
Renal Tubule, Regeneration | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3| |
| 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 1 2 2 2 3 3 2 3 1 3 2 2 2 3 | 35 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Hyperplasia | 2 3 3 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Angiectasis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 1 2 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | X X X X |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X |
Hemorrhage | 2 2 3 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Exudate | X X X X X X X X|
Hydrometra | 4 |
Hyperplasia, Cystic | 3 3 3 4 3 4 4 4 4 3 2 4 4 4 3 3 3 3 4|
Hyperplasia, Glandular | 3|
Inflammation, Suppurative | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 1 2 3 3 4 2 2 2 2 3 3 1 1 1 3 3 3 2|
Necrosis | 2 |
Proliferation | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Ectasia | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 2 |
Hyperplasia, Lymphoid | 4 4 |
__________________________________________________________________________|
Thymus | + |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 3 3 1 3 1 1 1|
Hyperplasia, Lobular | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coccygeal, Fibrosis | 3 |
Coccygeal, Hyperplasia | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Mineralization | 2 1 2 2 2 3 1 3 2 3 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 3 |
Inflammation, Chronic | 3 2 2 2 |
Inflammation, Suppurative | 3 |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Hyperplasia | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + I + + + M + + + + + + + + + + + + + + M + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 1 1 1 1 1 1 1 |
Cyst | |
Glomerulosclerosis | 2 |
Infarct | 2 2 |
Inflammation, Chronic | 2 2 2 1 1 2 1 2 2 2 2 |
Metaplasia, Osseous | |
Mineralization | 1 |
Renal Tubule, Atrophy | 2 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3| |
| 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Inflammation, Chronic | 2 3 2 1| 7 1.9|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.0|
Kupffer Cell, Hyperplasia | 3 3 3 2 | 8 2.8|
Lobules, Necrosis | 4 1 1 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Inflammation, Suppurative | 4 | 1 4.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Inflammation, Chronic | 1 1 | 3 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 1 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + M +| 48 |
Pars Distalis, Angiectasis | 3 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3| |
| 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 2 1 2 | 12 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X X X X | 9 |
Inflammation, Chronic | 1 | 2 1.0|
Follicular Cell, Hyperplasia | 1 1 1 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Cyst | X X X X X X| 14 |
Hemorrhage | 2 | 5 2.2|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 2 4 4 4 | 6 3.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + +| 41 |
Angiectasis | | 1 2.0|
Exudate | X X X X X X | 14 |
Hydrometra | 3 3 4 | 4 3.5|
Hyperplasia, Cystic | 3 4 4 4 4 2 4 4 3 4 4 2 2 2 3 4 4 4| 37 3.4|
Hyperplasia, Glandular | 3 | 2 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Squamous | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Anemia | 3 | 1 3.0|
Leukocytosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 3 2 1 2 2 2 1 2 3 2 1 1 3 2 2 3 2 3| 41 2.1|
Necrosis | | 1 2.0|
Proliferation | 2 3 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Renal, Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 5 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3| |
| 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 14 |
Hematopoietic Cell Proliferation | 3 3 4 2 | 7 2.9|
Hyperplasia, Lymphoid | | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + | 2 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 2 1 1 | 19 1.4|
Hyperplasia, Lobular | 2 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acanthosis | 3 | 1 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coccygeal, Fibrosis | | 1 3.0|
Coccygeal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | M + + + | 4 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Mineralization | 1 2 2 1 2 1 2 2 2 3 1 1 3| 28 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 3 2.0|
Inflammation, Chronic | 2 2 2 2 2 1 | 10 2.0|
Inflammation, Suppurative | | 1 3.0|
Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 2 | 1 2.0|
Cornea, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3| |
| 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M + M + + + + + + + + + M + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 1 1 1 1 1 | 15 1.0|
Cyst | X X | 2 |
Glomerulosclerosis | 1 | 2 1.5|
Infarct | | 2 2.0|
Inflammation, Chronic | 3 1 2 1 2 2 2 2 1 1 2 2 2 2 1 | 26 1.7|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | | 1 1.0|
Renal Tubule, Atrophy | 2 2| 3 2.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | | 1 1.0|
Renal Tubule, Regeneration | 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | 2 2 1 |
Mineralization | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Cyst | X |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | I + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Cyst | |
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | 1 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 3 2 3 2 3 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Mucosa, Dysplasia | 3 |
Mucosa, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dysplasia | |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Mineralization | 2 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Developmental Malformation | X |
Spindle Cell, Hyperplasia | 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + I + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | I + + + + + + + + + + + + + + + + I + + + + + + +|
Hyperplasia | 3 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + M + + + + M|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Ectasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X |
Hemorrhage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 4 |
Hyperplasia, Cystic | 4 3 3 4 3 3 3 2 3 3 4 3 2 3 3 4 4 3 3 3 3 2 3 3 3|
Inflammation, Suppurative | |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Vagina | + |
Granuloma | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 3 3 3 2 3 3 2 2 2 1 2 1 3 2 2 2 2 3|
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M +|
Iliac, Angiectasis | 4 |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + I + + I M +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 3 2 3 |
Lymphoid Follicle, Depletion Cellular| |
Sinusoid, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + I I + + M +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 1 2 1 1 1 1 1 2 1 |
Hyperplasia, Lobular | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 1 |
Cyst Epithelial Inclusion | |
Fibrosis | 3 |
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Hyperplasia | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 1 2 2 2 2 2 2 1 1 2 2 1 2 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2|
Infiltration Cellular, Histiocyte | 4 3 |
Inflammation, Chronic | 4 2 2 2 |
Inflammation, Suppurative | 3 |
Mineralization | |
Mediastinum, Necrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Fungus | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + |
Cataract | |
Exudate | |
Cornea, Hyperplasia | |
Cornea, Inflammation, Chronic | 2 |
Cornea, Mineralization | 1 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 |
Cyst | |
Glomerulosclerosis | |
Inflammation, Chronic | 2 2 2 2 3 2 2 1 2 4 2 1 1 2|
Metaplasia, Osseous | |
Mineralization | |
Renal Tubule, Atrophy | 3 1 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 1 3 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 3 1 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + A + A + + + + + + + + +| 47 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Inflammation, Chronic | 1 1 2 | 6 1.5|
Mineralization | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 2 2.0|
Kupffer Cell, Hyperplasia | 3 3 4 | 3 3.3|
Lobules, Necrosis | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Cyst | | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Atrophy | 4 4 | 4 2.5|
Cyst | X | 1 |
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Chronic | 2 | 5 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 2 2 2 3 | 4 2.3|
Mucosa, Dysplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | 2 1 1 2 | 7 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Dysplasia | 3 | 1 3.0|
Erosion | 3 3 | 2 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 | 3 2.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Mineralization | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 2 |
Cyst | | 1 |
Developmental Malformation | X | 2 |
Spindle Cell, Hyperplasia | 2 3 2 2 2 3 3 2 3 2 2 2 2 2 2 2 3 2 2 2 3 2 2| 46 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
Hyperplasia | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + + + + + + +| 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + M + + + M + I + + + + + + +| 43 |
Pars Distalis, Angiectasis | 2 | 2 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Chronic | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Ectasia | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + + + + + I + + + + + M + + + +| 46 |
Cyst | X X X X X | 14 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X | 3 |
Hydrometra | 4 3 4 3| 5 3.6|
Hyperplasia, Cystic | 4 3 3 3 3 4 3 2 2 4 4 3 4 2 2 3 3 3 3 3 3 2 4| 48 3.1|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Squamous | 3 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Granuloma | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Anemia | 3 | 1 3.0|
Leukocytosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 3 1 2 2 2 2 1 2 1 2 2 3 2 3 2 3 3 2 3 2 2 1| 42 2.1|
Proliferation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Iliac, Angiectasis | | 1 4.0|
Iliac, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + M M + + + + + M + + +| 45 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + A M + + + + + + + M| 43 |
Hemorrhage | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 2 2 3 2 2 | 8 2.4|
Hyperplasia, Lymphoid | 3 2 | 5 2.6|
Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0|
Sinusoid, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + M + + + + + + + + +| 44 |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 2 1 2 1 1 1 | 18 1.2|
Hyperplasia, Lobular | 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 3 2.3|
Cyst Epithelial Inclusion | X | 1 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 2.0|
Sebaceous Gland, Hyperplasia | | 1 4.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 1 1 2 3 2 1 3 2 1 1 2 | 31 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 2 3.0|
Hemorrhage | 2 2 | 3 2.0|
Infiltration Cellular, Histiocyte | | 2 3.5|
Inflammation, Chronic | 3 2 2 | 7 2.4|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 | 1 2.0|
Mediastinum, Necrosis | 2| 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X | 3 |
Fungus | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3| |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 1 2.0|
Exudate | X | 1 |
Cornea, Hyperplasia | 3 | 1 3.0|
Cornea, Inflammation, Chronic | 4 | 2 3.0|
Cornea, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 | 2 1.0|
Cyst | X | 1 |
Glomerulosclerosis | 3 | 1 3.0|
Inflammation, Chronic | 2 1 2 2 1 1 2 3 1 2 | 24 1.9|
Metaplasia, Osseous | 2 3 | 2 2.5|
Mineralization | 1 3 | 2 2.0|
Renal Tubule, Atrophy | 3 3 1 | 5 2.2|
Renal Tubule, Necrosis | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 1 1| 7 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 2 2 2 3 1 2 1 4 2 2 1 2 2 1 | 29 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|
| 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + M + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M A + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Suppurative | 3 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M A M + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 1 2 |
Mineralization | 4 4 4 |
Hepatocyte, Anisokaryosis | |
Hepatocyte, Atrophy | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 4 3 1 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Hemorrhage | 4 |
Fat, Mineralization | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1|
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic | 1 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Mineralization | 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|
| 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1|
__________________________________________________________________________|
Tooth | + + + + + + +|
Dysplasia | 2 3 3 4 4 3|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Developmental Malformation | X |
Hypertrophy, Focal | 3 |
Vacuolization Cytoplasmic | 2 |
Spindle Cell, Hyperplasia | 2 2 2 1 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Mononuclear | |
Cell | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 3 2 2 4|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + M + + + M + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + M + M + + + + M + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Ectasia | 3 3 3 4 3 |
Inflammation, Chronic | 2 4 3 2 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|
| 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Granuloma Sperm | 3 |
Mineralization | 2 2 |
Seminiferous Tubule, Atrophy | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
Anemia | 4 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Proliferation | 3 3 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | 3 2 3 3 2 3 |
Hyperplasia, Lymphoid | 3 2 3|
Infiltration Cellular, Megakaryocyte | |
Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 2 3 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Lymphoid Follicle, Depletion Cellular| |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + + + + + + + M + M M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 3 2 3 |
Exudate | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|
| 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 3 |
Inflammation, Suppurative | |
Mineralization | |
Pigmentation | 2 2 1 |
Ulcer | 3 3 3 |
Hair Follicle, Atrophy | |
Subcutaneous Tissue, Edema | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | 1 2 1 3 3 3 3 2 3 2 1|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 1 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Foreign Body | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Hyperplasia | |
Cornea, Inflammation, Chronic | |
Cornea, Inflammation, Granulomatous | |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 3 2 |
Cyst | X X X X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|
| 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | |
Inflammation, Chronic | 2 2 2 1 4 2 2 1 2 1 2 2 |
Inflammation, Suppurative | 4 |
Metaplasia, Osseous | |
Mineralization | 1 1 |
Glomerulus, Necrosis | 4 |
Renal Tubule, Atrophy | 3 2 |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Regeneration | 1 4 1 2 1 2 3 1 1 1 3 3 |
__________________________________________________________________________|
Urethra | |
Hemorrhage | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8| |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M M + + + + + + + + + + + I M| 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M M + + + + + + + + I + M + M + + + M| 42 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Edema | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mucosa, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Hyperplasia, Lymphoid | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 4 | 4 2.3|
Mineralization | 3 | 4 3.8|
Hepatocyte, Anisokaryosis | 3 | 1 3.0|
Hepatocyte, Atrophy | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 3.0|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | | 1 2.0|
Lobules, Necrosis | 4 4 | 6 3.3|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Hemorrhage | | 1 4.0|
Fat, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.5|
Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Inflammation, Chronic | 3 1 1 | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8| |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 3 | 2 3.0|
Mineralization | | 1 3.0|
Mucosa, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + + | 10 |
Dysplasia | 3 4 | 8 3.3|
Inflammation, Suppurative | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | X | 1 |
Developmental Malformation | | 1 |
Hypertrophy, Focal | 3 3 | 3 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 | 18 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 3 2| 14 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| 45 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + M + + +| 43 |
Pars Distalis, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
Follicular Cell, Hyperplasia | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8| |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + +| 18 |
Ectasia | 3 4 2 2| 9 3.0|
Inflammation, Chronic | 3 2 3 4 4 4| 11 3.0|
Inflammation, Suppurative | 3 4 4 | 4 3.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 8 |
Fibrosis | 3 2 | 2 2.5|
Inflammation, Chronic | 3 2 | 2 2.5|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Granuloma Sperm | | 1 3.0|
Mineralization | 2 2 1 | 5 1.8|
Seminiferous Tubule, Atrophy | 1 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 7 |
Anemia | | 1 4.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
Proliferation | 2 | 6 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + M + + + + + + + + M + + + + + + +| 45 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Hemorrhage | 3 2 2 3 3 | 11 2.6|
Hyperplasia, Lymphoid | | 3 2.7|
Infiltration Cellular, Megakaryocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8| |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 3 2 2 | 14 2.5|
Hyperplasia, Lymphoid | 2 | 5 2.0|
Lymphoid Follicle, Depletion Cellular| 2 3 | 2 2.5|
Red Pulp, Depletion Cellular | 3| 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + M + + + M + + + +| 42 |
Cyst | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 3 3 3 2 2 2 | 12 2.4|
Exudate | X | 1 |
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic | 2 1 | 4 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 3 4 | 2 3.5|
Pigmentation | | 3 1.7|
Ulcer | 3 | 4 3.0|
Hair Follicle, Atrophy | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Mineralization | 3 2 2 3 3 1 2 3 2 2 2 3 2 2 3 2| 27 2.3|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 2 | 3 2.0|
Inflammation, Chronic | 1 2 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8| |
| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukocytosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X| 4 |
Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Cataract | 1 | 1 1.0|
Cornea, Hyperplasia | 3 | 1 3.0|
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Cornea, Inflammation, Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + +| 9 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 4 1 | 4 2.5|
Cyst | | 4 |
Hemorrhage | 2 | 1 2.0|
Hydronephrosis | 2 2 | 2 2.0|
Inflammation, Chronic | 1 2 2 1 2 1 2 3 1 | 21 1.8|
Inflammation, Suppurative | | 1 4.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 | 3 1.0|
Glomerulus, Necrosis | | 1 4.0|
Renal Tubule, Atrophy | 3 | 3 2.7|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Regeneration | 1 2 1 1 1 1 1 1 1 3 1 1 2| 25 1.6|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.5|
Mucosa, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + M + + M + + + A M + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + M M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + M M + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + A M + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Ectopic Tissue | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 2 1 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Atrophy | 2 |
Fibrosis | |
Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
Diverticulum | 3 3 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 |
Ulcer | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 2 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 2 |
Myocardium, Inflammation, Chronic | |
Myocardium, Karyomegaly | 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Developmental Malformation | X X |
Hypertrophy, Focal | 1 |
Spindle Cell, Hyperplasia | 2 2 3 2 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Suppurative | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | M |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Ectasia | 4 3 4 4 |
Inflammation, Chronic | 3 3 3 4 3 2 2 4 2 |
Inflammation, Suppurative | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + I + + + + + +|
Fibrosis | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 4 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 3 |
Fibrosis | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 1 1 2 1 |
Spermatocele | |
Seminiferous Tubule, Atrophy | 1 2 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Anemia | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | 1 |
Proliferation | 3 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Histiocytic | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 2 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + M + + + M + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 3 |
Hematopoietic Cell Proliferation | 3 4 2 3 |
Hyperplasia, Re Cell | 3 |
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Depletion Cellular| 3 |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | + + + M + M M + + + + + M + + + + + + + + + M M +|
Cyst | X |
Depletion Cellular | 3 |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M I M M M M M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 4 2 3 2 3 3 2 4 2 3 2 2 1 3 3 3 3 1|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Exudate | |
Fibrosis | 4 4 |
Hemorrhage | 3 |
Hyperplasia, Pseudoepitheliomatous | 1 |
Inflammation, Chronic | 2 4 2 2 1 2 1|
Inflammation, Chronic Active | |
Pigmentation | 1 2 2 3 2 2 2 2 |
Ulcer | 1 4 3 4 1 2 2 3 3 |
Hair Follicle, Atrophy | 3 3 3 3 4 2 3|
Lymphatic, Dilatation | 3 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Coccygeal, Hyperplasia | 3 3 |
Coccygeal, Inflammation, Chronic | 3 |
Coccygeal, Inflammation, Suppurative | 3 |
Tarsal, Hyperplasia | |
Tarsal, Inflammation, Suppurative | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 3 3 2 3 2 1 2 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Suppurative | 1 |
Leukocytosis | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 |
Perivascular, Edema | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
262 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
Casts Protein | 2 |
Cyst | X X X X X |
Glomerulosclerosis | 2 |
Infarct | 2 |
Inflammation, Chronic | 2 1 1 2 2 2 2 1 1 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 2 2 |
Mineralization | 1 1 1 1 |
Glomerulus, Hyperplasia | 3 |
Renal Tubule, Atrophy | 2 1 1|
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 3|
__________________________________________________________________________|
Urethra | |
Concretion | |
Inflammation, Suppurative | |
Necrosis | |
Bulbourethral Gland, Hyperplasia | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M M A + + + + M + + + + + + + + + + + + +| 41 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A M + + + + + M + + + + + + + + + + A + + M + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + M + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + M + + + + + + + + + + + + I + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + M + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Ectopic Tissue | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Hyperplasia | 3 3 | 2 3.0|
Lobules, Necrosis | 4 1 1 | 6 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Artery, Inflammation, Chronic Active | 2 2 | 2 2.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Atrophy | | 1 2.0|
Fibrosis | 2 2 | 2 2.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 2 | 9 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | 3 | 1 3.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 5 |
Dysplasia | 3 2 | 4 2.5|
Inflammation, Suppurative | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration | | 1 2.0|
Myocardium, Inflammation, Chronic | 1 | 1 1.0|
Myocardium, Karyomegaly | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Cyst | X | 1 |
Developmental Malformation | | 2 |
Hypertrophy, Focal | | 1 1.0|
Spindle Cell, Hyperplasia | 2 3 2 | 10 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 9 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 5 |
Inflammation, Suppurative | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + | 20 |
Ectasia | 3 2 2 3 3 | 9 3.1|
Inflammation, Chronic | 3 2 3 4 3 3 4 | 16 3.0|
Inflammation, Suppurative | 3 3 4 | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Fibrosis | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 4 2 2 4 | 5 3.2|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 5 |
Dilatation | | 1 3.0|
Fibrosis | 3 | 2 2.5|
Inflammation, Suppurative | 4 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Mineralization | 1 2 2 2 3 | 9 1.7|
Spermatocele | X | 1 |
Seminiferous Tubule, Atrophy | 2 2 1 2| 8 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Anemia | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 3.0|
Myelofibrosis | | 1 1.0|
Proliferation | 2 2 2 3 2 3 2 3 | 12 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Inguinal, Hyperplasia, Histiocytic | 3 2 2 | 4 2.5|
Inguinal, Hyperplasia, Lymphoid | 2 2 | 5 2.2|
Inguinal, Hyperplasia, Plasma Cell | 2 2 2| 4 2.3|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 2 1 2 2| 7 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Erythrophagocytosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 3 2 2 4 2 2 | 12 2.7|
Hyperplasia, Re Cell | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Depletion Cellular| 3 2 | 3 2.7|
Red Pulp, Depletion Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + M + + + + + + + M + + + + +| 39 |
Cyst | X | 2 |
Depletion Cellular | 3 3 3 3 | 5 3.0|
Epithelial Cell, Hyperplasia | 2 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M + M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 3 1 3 3 2 2 2 2 2 2 2 3 3 3 3| 36 2.5|
Exudate | X X X X | 4 |
Fibrosis | 3 | 3 3.7|
Hemorrhage | 3 | 2 3.0|
Hyperplasia, Pseudoepitheliomatous | 2 | 2 1.5|
Inflammation, Chronic | 3 1 1 3 1 1 1 3 2 3| 17 1.9|
Inflammation, Chronic Active | 3 | 1 3.0|
Pigmentation | 3 2 1 3| 12 2.1|
Ulcer | 4 2 3 3 2 2 | 15 2.6|
Hair Follicle, Atrophy | 3 2 2 2 | 11 2.7|
Lymphatic, Dilatation | | 1 3.0|
Subcutaneous Tissue, Edema | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
Coccygeal, Hyperplasia | 3 2 2 3 | 6 2.7|
Coccygeal, Inflammation, Chronic | 2 3 | 3 2.7|
Coccygeal, Inflammation, Suppurative | 3 | 2 3.0|
Tarsal, Hyperplasia | 3 | 1 3.0|
Tarsal, Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 2 1 1 3 2 2 1 2 1 1 2 1| 25 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 2| 1 2.0|
Infiltration Cellular, Histiocyte | 3 | 2 2.0|
Inflammation, Suppurative | | 1 1.0|
Leukocytosis | 2 | 2 2.5|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Perivascular, Edema | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 1.0|
Casts Protein | 1 3 | 3 2.0|
Cyst | X X X X X | 10 |
Glomerulosclerosis | | 1 2.0|
Infarct | 4 | 2 3.0|
Inflammation, Chronic | 3 2 1 2 | 14 1.7|
Inflammation, Suppurative | 2 4 | 3 2.7|
Metaplasia, Osseous | | 2 2.0|
Mineralization | 1 | 5 1.0|
Glomerulus, Hyperplasia | | 1 3.0|
Renal Tubule, Atrophy | 1 1| 5 1.2|
Renal Tubule, Dilatation | 3 2 | 2 2.5|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3| |
| 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
262 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Regeneration | 2 1 1 1 2 1 1 1 3 1| 26 1.3|
__________________________________________________________________________|____________|
Urethra | + + + + | 4 |
Concretion | 4 | 1 4.0|
Inflammation, Suppurative | 3 3 3 | 3 3.0|
Necrosis | 4 | 1 4.0|
Bulbourethral Gland, Hyperplasia | 3 | 1 3.0|
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Chronic | | 3 1.7|
Inflammation, Suppurative | 4 | 1 4.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|
DAY ON TEST | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|
| 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + M M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + + + + + + + + + + + + + + + + M + A|
Edema | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + A|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + A|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + A|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Clear Cell Focus | X X |
Cyst | X |
Hepatocyte, Anisokaryosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
Kupffer Cell, Hyperplasia | 2 |
Lobules, Necrosis | 1 2 3 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Hypertrophy | |
Artery, Inflammation, Chronic Active | |
Fat, Inflammation, Chronic | |
Fat, Inflammation, Suppurative | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Erosion | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|
DAY ON TEST | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|
| 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 1 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | |
Necrosis | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Hypertrophy | |
Artery, Inflammation, Chronic Active | |
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Developmental Malformation | X |
Hyperplasia, Focal | |
Spindle Cell, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + I M M + + + + + + + M + + + + + + + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + + + + M + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | X |
Inflammation, Suppurative | 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Fibrosis | |
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|
DAY ON TEST | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|
| 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Atrophy | 3 |
Ectasia | 3 3 3 3 4 |
Inflammation, Chronic | 3 4 2 3 2 2 4 4 |
Inflammation, Suppurative | 3 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 1 2 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A|
Fibrosis | 2 2 2 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 2 |
Seminiferous Tubule, Atrophy | 2 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Myelofibrosis | 2 |
Proliferation | 4 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Plasma Cell | 2 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + M + + + + + + + + + + M + M|
Depletion Cellular | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 3 4 2 3 3 3|
Hyperplasia, Lymphoid | 2 |
Lymphoid Follicle, Depletion Cellular| 2 3 |
__________________________________________________________________________|
Thymus | + + M + + M + M M + + + M + M + + M + + I + + + +|
Cyst | X |
Depletion Cellular | 2 3 |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|
DAY ON TEST | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|
| 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 2 4 4 2 2 3 1 1 2 3 2 3 2 2 4 3|
Cyst Epithelial Inclusion | |
Dysplasia | 4 |
Exudate | X X X |
Hyperkeratosis | |
Hyperplasia, Pseudoepitheliomatous | 3 2 |
Inflammation, Chronic | 2 2 2 1 2 1 1 1 2 2 2 2|
Pigmentation | 2 1 2 1 2 2 1 1 2 2|
Ulcer | 2 4 3 3 2 4 4|
Hair Follicle, Atrophy | 3 3 1 2 3 3 2 2 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 |
Inflammation, Chronic | 3 |
Coccygeal, Hyperplasia | 3 |
Coccygeal, Inflammation, Chronic | 3 |
Tarsal, Hyperplasia | 3 3 3 3 3 |
Tarsal, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | M + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Mineralization | 3 2 2 2 1 2 1 2 2 1 3 2 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3|
Hemorrhage | 3 1 4 2|
Infiltration Cellular, Histiocyte | |
Leukocytosis | 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
_____________________________________________________________________________________________________________________
| 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|
DAY ON TEST | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|
| 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
525 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts Protein | 1 |
Cyst | X X |
Hemorrhage | 3 |
Hydronephrosis | 3 3 |
Inflammation, Chronic | 1 2 2 |
Inflammation, Suppurative | |
Mineralization | 2 1 |
Renal Tubule, Atrophy | 2 1 2 |
Renal Tubule, Dilatation | 2 3 |
Renal Tubule, Dysplasia | |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 2 1 1 1 1 1 2 3 1 1 2 2 2 2 1 3 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Urethra | + + +|
Inflammation, Suppurative | 3 2 4|
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 |
Mucosa, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + A + + M M M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A A + + + + + + + + + + + + +| 45 |
Edema | 2 | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A A + + + + M + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A A + + + + + + + + + A + + +| 45 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Clear Cell Focus | | 2 |
Cyst | X | 2 |
Hepatocyte, Anisokaryosis | 2 | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
Kupffer Cell, Hyperplasia | | 1 2.0|
Lobules, Necrosis | 4 2 | 6 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 7 |
Artery, Hypertrophy | 4 2 | 2 3.0|
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Inflammation, Chronic | 3 | 1 3.0|
Fat, Inflammation, Suppurative | | 1 2.0|
Fat, Necrosis | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + M +| 48 |
Atrophy | | 1 3.0|
Inflammation, Chronic | 2| 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Diverticulum | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | 2 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | X | 2 |
Erosion | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 2 1.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Dysplasia | 1 | 3 1.3|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Hypertrophy | 4 | 1 4.0|
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
Myocardium, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X | 2 |
Developmental Malformation | X | 2 |
Hyperplasia, Focal | 1 | 1 1.0|
Spindle Cell, Hyperplasia | 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M A + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + M + + + + + + +| 43 |
Cyst | X| 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + M + + + + + A + + + + + + + + + + M + + +| 43 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Cyst | X X | 3 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Ectasia | | 1 3.0|
Fibrosis | 1 | 1 1.0|
Granuloma Sperm | 3 3 | 2 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + +| 17 |
Atrophy | | 1 3.0|
Ectasia | 2 3 | 7 3.0|
Inflammation, Chronic | 4 4 4 3 4| 13 3.3|
Inflammation, Suppurative | 4 4 3 | 6 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 3 | 8 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + +| 9 |
Fibrosis | | 4 2.3|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Mineralization | 2 2 1 3 | 5 2.0|
Seminiferous Tubule, Atrophy | | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 4.0|
Myelofibrosis | 2 | 2 2.0|
Proliferation | 3 3 4 | 8 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Iliac, Hyperplasia, Plasma Cell | 4 | 2 3.5|
Inguinal, Hyperplasia, Lymphoid | 2 3 1 3| 5 2.4|
Inguinal, Hyperplasia, Plasma Cell | 2 | 2 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + + M + M + + + + + + + + + + + + + +| 46 |
Depletion Cellular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + M + + M A + + + + + + + + M + + + +| 41 |
Depletion Cellular | 3 2 3 | 3 2.7|
Hemorrhage | 2 2 2 2 | 5 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + M + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 4 3 2 | 18 2.7|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Lymphoid Follicle, Depletion Cellular| 3 3 3 2 3 3 | 8 2.8|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + I + M + + + + + + + + + + + + + +| 38 |
Cyst | | 1 |
Depletion Cellular | 3 3 3 3 | 6 2.8|
Epithelial Cell, Hyperplasia | 2 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M + M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 2 1 2 2 3 3 3 2 3 3 2 3 2 3 2 2 3 2 3 | 39 2.5|
Cyst Epithelial Inclusion | X | 1 |
Dysplasia | | 1 4.0|
Exudate | X X | 5 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Pseudoepitheliomatous | | 2 2.5|
Inflammation, Chronic | 3 1 3 1 3 2 1 | 19 1.8|
Pigmentation | 1 2 2 3 3 2 2 2 2 | 19 1.8|
Ulcer | 4 3 4 3 4 4 2 3 4 2 | 17 3.2|
Hair Follicle, Atrophy | 2 3 3 4 2 2 3 3 | 16 2.6|
Subcutaneous Tissue, Edema | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Coccygeal, Hyperplasia | | 1 3.0|
Coccygeal, Inflammation, Chronic | | 1 3.0|
Tarsal, Hyperplasia | 3 3 3 | 8 3.0|
Tarsal, Inflammation, Chronic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 2 3 | 3 2.7|
Mineralization | 1 1 2 2 2 1 2 2 2 2 1| 24 1.8|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 | 4 2.5|
Hemorrhage | 2 2 3 | 7 2.4|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Leukocytosis | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Exudate | X X X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 1 4.0|
Casts Protein | 1 | 2 1.0|
Cyst | X X X X X| 7 |
Hemorrhage | | 1 3.0|
Hydronephrosis | | 2 3.0|
Inflammation, Chronic | 1 3 | 5 1.8|
Inflammation, Suppurative | 2 4 | 2 3.0|
Mineralization | 1 1 | 4 1.3|
Renal Tubule, Atrophy | 1 1 3 1 1 | 8 1.5|
Renal Tubule, Dilatation | 1 | 3 2.0|
Renal Tubule, Dysplasia | 2 | 1 2.0|
Renal Tubule, Necrosis | 4 | 1 4.0|
Renal Tubule, Regeneration | 2 2 2 1 1 1 1 1 | 24 1.5|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05002-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:05:58
__________________________________________________________________________________________________________________________________
| 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7| |
DAY ON TEST | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3| |
| 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
525 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urethra | | 3 |
Inflammation, Suppurative | | 3 3.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A A + + + + + + + + + + + + +| 48 |
Congestion | 3| 1 3.0|
Edema | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mucosa, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------