TDMS Study 05002-05 Pathology Tables
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
Facility: Southern Research Institute
Chemical CAS #: 96-48-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|
| 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + A + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 2 |
Hyperplasia, Nodular | 4 |
Inflammation, Granulomatous, Multiple| 2 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic | 2 3 |
Bile Duct, Hyperplasia | 2 2 1 2 1 2 |
Centrilobular, Necrosis, Multiple | 4 |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 4 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 2 2|
Acinar Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | |
Forestomach, Inflammation, Chronic | |
Forestomach, Ulcer | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|
| 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Angiectasis | 4 |
Degeneration, Cystic | 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic | 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Cyst, Multiple | 1 1 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2 1 2 2 2|
Pars Distalis, Cyst, Multiple | 2 2 1 3 2 3 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 2 |
C-Cell, Hyperplasia | 2 3 2 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 4 3 |
Necrosis | |
Duct, Cyst | 3 3 3 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | 2 |
Dilatation | 2 2 3 |
Inflammation, Suppurative | 2 |
Cervix, Cyst | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|
| 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Fibrosis, Focal | |
Endometrium, Fibrosis | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | + |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 4 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Pigmentation | 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 3 |
Duct, Cyst | 2 2 3 3 2 2 2 2 1 2 3 3 3 3 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
Diaphragm, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|
| 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Hemorrhage | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
Lymphatic, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract, Multiple | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Nephropathy, Chronic | 2 3 1 2 2 1 2 2 2 3 1 2|
Cortex, Cyst | 3 |
Medulla, Cyst | X |
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | 1 1 2 1 |
Renal Tubule, Pigmentation | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3| |
| 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lipocyte | 2 | 1 2.0|
Parasite Metazoan | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 | 1 1.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 1 1| 35 1.8|
Eosinophilic Focus | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | 3 3 | 4 2.8|
Hyperplasia, Nodular | 3 2 3 | 4 3.0|
Inflammation, Granulomatous, Multiple| 2 2 2 | 5 1.8|
Mixed Cell Focus | 3 | 1 3.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 | 4 2.3|
Bile Duct, Hyperplasia | 3 1 3 1 2 2 3 1 | 14 1.9|
Centrilobular, Necrosis, Multiple | | 1 4.0|
Serosa, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Inflammation, Chronic | 3 3 | 3 3.3|
Fat, Necrosis, Focal | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinar Cell, Atrophy | 2 2 2 | 5 2.0|
Acinar Cell, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Edema | 4 | 1 4.0|
Forestomach, Inflammation, Chronic | 2 | 1 2.0|
Forestomach, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3| |
| 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 35 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X| 4 2.0|
Angiectasis | | 1 4.0|
Degeneration, Cystic | 3 2 | 4 2.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy, Focal | 2 2 | 3 2.0|
Vacuolization Cytoplasmic | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 2| 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M M + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 1.0|
Cyst, Multiple | | 2 1.0|
Pars Distalis, Angiectasis | 4 2 4 | 4 3.3|
Pars Distalis, Cyst | 2 2 1 2 | 9 1.8|
Pars Distalis, Cyst, Multiple | 3 2 3 3 2 2 1 1 2 | 16 2.1|
Pars Distalis, Hyperplasia, Focal | 2 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 2 2.0|
C-Cell, Hyperplasia | 2 2 3 2 2 2 | 10 2.2|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3| |
| 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 4 3.0|
Necrosis | 4 | 1 4.0|
Duct, Cyst | 3 3 3 3 3 3 3 3 3 3 4 3 4 3| 19 3.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | | 1 2.0|
Dilatation | 3 | 4 2.5|
Inflammation, Suppurative | | 1 2.0|
Cervix, Cyst | 3 3 | 2 3.0|
Endometrium, Fibrosis, Focal | 3 | 1 3.0|
Endometrium, Fibrosis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 2 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 4 | 3 3.7|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 4 | 3 3.3|
Pigmentation | 3 3 3 3| 7 2.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 3 3 3 2| 6 2.7|
Duct, Cyst | 2 2 2 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 2 2 2 2 3 3| 42 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3| |
| 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Hyperostosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Diaphragm, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.5|
Hemorrhage | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 3| 3 2.3|
Lymphatic, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract, Multiple | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 3 | 1 3.0|
Nephropathy, Chronic | 2 1 1 2 1 2 2 2 2 1 2| 23 1.8|
Cortex, Cyst | | 1 3.0|
Medulla, Cyst | | 1 |
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 1 2 2 2 2 | 10 1.5|
Renal Tubule, Pigmentation | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3| |
| 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + |
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Cyst | 3 |
Eosinophilic Focus | 2 |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X 3 3 |
Hyperplasia, Nodular | 3 3 |
Inflammation, Granulomatous, Multiple| 2 2 2 |
Mixed Cell Focus | 3 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 2 1 1 2 2 2 1 2 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Polyarteritis, Multiple | |
Acinar Cell, Atrophy | 2 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + |
Forestomach, Edema | 3 |
Forestomach, Ulcer | 3 |
Glandular, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Media, Hypertrophy | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Fibrosis, Focal | 3 |
Fibrosis, Multiple | 3 |
Inflammation, Chronic | 2 3 1 1 2 3 2 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | 2 X |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + |
Pars Distalis, Angiectasis | 4 4 4 |
Pars Distalis, Cyst | 2 3 3 3 2 |
Pars Distalis, Cyst, Multiple | 2 2 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + |
Angiectasis | |
Degeneration, Cystic | |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + +|
Atrophy | 2 |
Hyperplasia | 3 |
Inflammation, Suppurative | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Cervix, Cyst | X |
Endometrium, Hyperplasia, Cystic | |
Endometrium, Hyperplasia, Glandular | 2 |
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + |
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 4 |
Necrosis | |
Pigmentation | 3 2 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 |
Duct, Cyst | 2 2 3 2 3 2 2 2 3 3 2 2 2 2 3 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Ulcer | |
Subcutaneous Tissue, Thrombosis, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
Calvarium, Hyperostosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Compression | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Congestion | 3 3 |
Alveolus, Pigmentation | |
Lymphatic, Foreign Body | 2 2 |
Mediastinum, Foreign Body | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Eye | |
Cornea, Edema | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
Nephropathy, Chronic | 2 1 1 |
Renal Tubule, Degeneration | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3| |
| 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large | + A M + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A M + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A M M + + + + + + + + + | 20 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A M + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A M + + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 40 2.0|
Cyst | | 1 3.0|
Eosinophilic Focus | 2 2 | 3 2.0|
Eosinophilic Focus, Multiple | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hepatodiaphragmatic Nodule | 3 X | 5 3.0|
Hyperplasia, Nodular | 2 3 | 4 2.8|
Inflammation, Granulomatous, Multiple| 2 2 2 1 1 2 | 9 1.8|
Mixed Cell Focus | | 2 2.5|
Necrosis, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
Bile Duct, Dilatation | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 2 1 1 2 2 2 | 15 1.7|
Serosa, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 24 |
Polyarteritis, Multiple | 4 | 1 4.0|
Acinar Cell, Atrophy | 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 24 |
Forestomach, Edema | 3 | 2 3.0|
Forestomach, Ulcer | 3 | 2 3.0|
Glandular, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3| |
| 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Media, Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 25 |
Fibrosis, Focal | | 1 3.0|
Fibrosis, Multiple | | 1 3.0|
Inflammation, Chronic | 1 2 2 3 2 | 13 1.9|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 25 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 25 |
Accessory Adrenal Cortical Nodule | 2 2 | 4 2.0|
Hypertrophy, Focal | 4 2 | 3 2.7|
Vacuolization Cytoplasmic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 25 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + +| 37 |
Pars Distalis, Angiectasis | 4 2 4 3 4 4| 9 3.7|
Pars Distalis, Cyst | 2 | 6 2.5|
Pars Distalis, Cyst, Multiple | 2 2 2 1 2 | 7 1.9|
Pars Distalis, Hemorrhage | 4 4 | 3 4.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 | 7 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 27 |
Angiectasis | 3 | 1 3.0|
Degeneration, Cystic | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + M + + + + + + + + M + | 22 |
Atrophy | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3| |
| 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 3 | 2 2.5|
Duct, Cyst | 3 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + +| 32 |
Dilatation | | 1 3.0|
Cervix, Cyst | | 1 |
Endometrium, Hyperplasia, Cystic | 3 3 3| 3 3.0|
Endometrium, Hyperplasia, Glandular | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 24 |
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 26 |
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + | 23 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 24 |
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Atrophy | | 2 2.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 3 4 2 | 8 2.8|
Necrosis | 3 | 1 3.0|
Pigmentation | 2 3 3 2 | 9 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M M | 21 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 2 2 2 2 2 2 | 7 2.0|
Duct, Cyst | 2 3 2 2 2 2 3 2 3 2 3 3 2 3 3 2 4| 35 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 28 |
Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Thrombosis, | | |
Multiple | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7| |
DAY ON TEST | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3| |
| 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 28 |
Calvarium, Hyperostosis | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 24 |
Compression | 4 3 3 3 3 | 6 3.0|
Hydrocephalus | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 30 |
Congestion | 2 3 3 | 5 2.8|
Alveolus, Pigmentation | 1 | 1 1.0|
Lymphatic, Foreign Body | | 2 2.0|
Mediastinum, Foreign Body | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Edema | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 24 |
Nephropathy, Chronic | 1 2 3 2 | 7 1.7|
Renal Tubule, Degeneration | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|
| 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
450 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + A + + + + M + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 1 2 1 1 2 2 2 2 1 2 3 2 2 2 2 2 2|
Clear Cell Focus | 2 |
Eosinophilic Focus | 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 3 3 |
Hyperplasia, Nodular | 2 2 3 |
Inflammation, Granulomatous, Multiple| 2 2 2 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Focal, | |
Granulomatous | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 2 3 2 2 |
Acinar Cell, Hyperplasia | 2 2 3 2 |
Acinar Cell, Hyperplasia, Multiple | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 3 |
Forestomach, Inflammation, Chronic | 3 |
Forestomach, Ulcer | 3 2 |
Forestomach, Ulcer, Multiple | |
Glandular, Cyst, Multiple | 2 |
Glandular, Mineralization | 2 3 |
Glandular, Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|
| 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
450 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis, Multiple | 3 |
Inflammation, Chronic | 2 3 2 2 2 2 3 2 2 2 2 2 2|
Atrium, Congestion | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Congestion | |
Degeneration, Cystic | 1 |
Hypertrophy, Focal | 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cyst, Multiple | 2 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Inflammation, Focal, | |
Granulomatous | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + M + + + + M + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|
| 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
450 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Fibrosis | |
Inflammation, Suppurative | 4 4 4 |
Metaplasia, Squamous | 3 |
Duct, Cyst | 4 3 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Tubular | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Dilatation | |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 |
Endometrium, Hyperplasia, Glandular | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, | |
Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 3 4 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 2 |
Hemorrhage | 3 |
Mediastinum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 |
Duct, Cyst | 3 2 2 4 2 3 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|
| 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
450 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Fracture | 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Pigmentation | 2 2 |
Bronchus, Foreign Body | 2 |
Lymphatic, Foreign Body | 3 |
Mediastinum, Edema | |
Mediastinum, Foreign Body | 2 |
Mediastinum, Hemorrhage | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
__________________________________________________________________________|
Eye | M + |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Multiple | 3 |
Nephropathy, Chronic | 1 1 2 1 1 1 3 1 1 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Mineralization | 1 1 2 1 2 2 1 2 2 1 2 |
Renal Tubule, Pigmentation | 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
450 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + A + + + + + + + + + + + + + + + + + +| 43 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + + + A + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3| 1 3.0|
Basophilic Focus | | 1 1.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 | 32 1.9|
Clear Cell Focus | 3 | 2 2.5|
Eosinophilic Focus | | 1 3.0|
Fibrosis, Focal | 3| 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 3 | 6 2.5|
Hyperplasia, Nodular | | 3 2.3|
Inflammation, Granulomatous, Multiple| 2 2 2 2 2 3| 10 2.1|
Mixed Cell Focus | 2 2 1 2 | 4 1.8|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 2 2 1 | 10 1.7|
__________________________________________________________________________|____________|
Mesentery | + + +| 4 |
Fat, Inflammation, Focal, | | |
Granulomatous | 3| 1 3.0|
Fat, Necrosis, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinar Cell, Atrophy | 2 2 | 6 2.2|
Acinar Cell, Hyperplasia | 2 | 5 2.2|
Acinar Cell, Hyperplasia, Multiple | 2 | 1 2.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | 3 | 2 3.0|
Forestomach, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
450 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Ulcer | 2 | 3 2.3|
Forestomach, Ulcer, Multiple | 2 3 | 2 2.5|
Glandular, Cyst, Multiple | | 1 2.0|
Glandular, Mineralization | 2 2 | 4 2.3|
Glandular, Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Fibrosis, Multiple | | 1 3.0|
Inflammation, Chronic | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.1|
Atrium, Congestion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 2 2.0|
Congestion | 2 | 1 2.0|
Degeneration, Cystic | 3 | 2 2.0|
Hypertrophy, Focal | 2 2 2 3| 6 2.2|
Vacuolization Cytoplasmic | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Congestion | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + + + + + + + + + + + + + M + + + +| 48 |
Pars Distalis, Angiectasis | 2 4 4 | 4 2.8|
Pars Distalis, Cyst | 1 2 2 3 | 5 2.2|
Pars Distalis, Cyst, Multiple | 2 3 2| 6 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 3 | 6 2.5|
Pars Distalis, Inflammation, Focal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
450 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | | 1 2.0|
Fibrosis | 3 | 1 3.0|
Inflammation, Suppurative | | 3 4.0|
Metaplasia, Squamous | | 1 3.0|
Duct, Cyst | 4 4 3 2 2 3 4| 11 3.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3| 3 2.7|
Hyperplasia, Tubular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | 3 | 1 3.0|
Dilatation | 2 3 | 2 2.5|
Endometrium, Hyperplasia, Cystic | 2 3 2 | 7 2.3|
Endometrium, Hyperplasia, Glandular | 3 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 3 | 2 3.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Fibrosis | | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
450 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + + + + + + + + + + + + + + + + +| 47 |
Cyst, Multiple | 2 | 2 2.0|
Hemorrhage | | 1 3.0|
Mediastinum, Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 2 2 | 3 2.0|
Duct, Cyst | 4 3 3 2 2 X 3 2 2 2 2 3 2| 23 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Hyperostosis | 3 | 2 2.5|
Femur, Fracture | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 | 6 2.8|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Alveolus, Pigmentation | | 2 2.0|
Bronchus, Foreign Body | | 1 2.0|
Lymphatic, Foreign Body | | 1 3.0|
Mediastinum, Edema | 3 | 1 3.0|
Mediastinum, Foreign Body | 3 | 2 2.5|
Mediastinum, Hemorrhage | 3 2 | 2 2.5|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
450 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 5 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 3 | 2 3.0|
Retina, Degeneration | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Infarct, Multiple | | 1 3.0|
Nephropathy, Chronic | 1 2 1 2 1 1 1 1 1 1| 19 1.3|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Mineralization | 2 2 1 1 2 2 1 2| 19 1.6|
Renal Tubule, Pigmentation | | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|
| 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Basophilic Focus, Multiple | 1 2 2 2 2 1 2 1|
Clear Cell Focus | 1 2 1 |
Degeneration, Cystic | |
Eosinophilic Focus | 2 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 2 2 |
Hyperplasia, Nodular | 3 2 2 3 |
Inflammation, Granulomatous, Multiple| 1 |
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | |
Vacuolization Cytoplasmic | 2 3 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2 2 3 2 1 2 2 4 1 2 1|
Centrilobular, Degeneration | 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Metaplasia, Osseous | 3 |
Fat, Mineralization, Focal | |
Fat, Necrosis, Focal | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 3 |
Acinar Cell, Atrophy | 2 2 3 2 2 2 2 4 1|
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 4 |
Forestomach, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|
| 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Mineralization | |
Forestomach, Polyarteritis | |
Forestomach, Ulcer | |
Forestomach, Epithelium, Hyperplasia | 3 |
Glandular, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Inflammation, Focal | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 3 2 3 2 2 2 3 3 2 2 2 2 3 2 1 2 1 2 2 |
Valve, Bacterium | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 |
Hypertrophy, Focal | 2 2 |
Vacuolization Cytoplasmic | 2 2 4 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 2 |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|
| 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 2 2 3 3 |
Fibrosis | |
Inflammation, Chronic | 3 2 3 |
Inflammation, Suppurative | 3 3 3 3 |
Duct, Cyst | 3 3 4 3 2 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 3 3 2 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 4 3 2 3 3 |
Necrosis | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 3 2 |
Interstitial Cell, Atrophy | 3|
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + M + + +|
Angiectasis | |
Cyst, Multiple | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|
| 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + M + + + +|
Hyperplasia, Lobular | |
Duct, Cyst | 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | 2 |
Ulcer | |
Epidermis, Hyperplasia, Focal | |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Hemorrhage, | |
Chronic | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | 2 3 |
Hippocampus, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 2 4 |
Edema | 2 |
Foreign Body | 2 2 |
Hemorrhage | |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 |
Lumen, Fungus | 2 2 2 2 3|
Lumen, Inflammation, Suppurative | 2 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|
| 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 |
Hemorrhage | 4 |
Inflammation, Suppurative | 4 |
Retina, Degeneration | 2 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infarct | 3 |
Inflammation, Suppurative | |
Nephropathy, Chronic | 2 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2|
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3| |
| 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + + + + +| 47 |
Parasite Metazoan | 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + M + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + A + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + A + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 1 3 2 1 | 7 1.4|
Basophilic Focus, Multiple | 2 1 2 2 2 | 13 1.7|
Clear Cell Focus | 1 | 4 1.3|
Degeneration, Cystic | 2 | 1 2.0|
Eosinophilic Focus | 3 1 | 4 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 2 3 | 5 2.2|
Hyperplasia, Nodular | | 4 2.5|
Inflammation, Granulomatous, Multiple| | 1 1.0|
Mixed Cell Focus | 1 2 | 3 1.7|
Mixed Cell Focus, Multiple | 2| 1 2.0|
Vacuolization Cytoplasmic | 3 | 6 2.3|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 1| 45 1.7|
Centrilobular, Degeneration | 3 | 2 2.5|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Metaplasia, Osseous | | 1 3.0|
Fat, Mineralization, Focal | 2 | 1 2.0|
Fat, Necrosis, Focal | 3 3 2 3 3 | 9 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyarteritis | 3 4 | 3 3.3|
Acinar Cell, Atrophy | 2 2 2 2 2 2 2 2 2| 18 2.1|
Acinar Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3| |
| 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Palate, Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | | 1 4.0|
Forestomach, Inflammation, Chronic | 3 | 2 3.0|
Forestomach, Mineralization | 2 | 1 2.0|
Forestomach, Polyarteritis | 3 | 1 3.0|
Forestomach, Ulcer | 4 | 1 4.0|
Forestomach, Epithelium, Hyperplasia | | 1 3.0|
Glandular, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mesenteric Artery, Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 2 2 2 2 3 3 2 2 2 3 3 3 2 2 3 2 2 2 2 2 2 2 3 2| 46 2.3|
Valve, Bacterium | 4 | 1 4.0|
Valve, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Hyperplasia, Focal | 3 3| 5 2.6|
Hypertrophy, Focal | | 2 2.0|
Vacuolization Cytoplasmic | 2 2 1 2 3 | 11 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Hyperplasia, Focal | 2 2 2 | 5 2.0|
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | | 3 3.0|
Pars Distalis, Cyst | 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3| |
| 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst, Multiple | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 1| 8 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 | 1 3.0|
C-Cell, Hyperplasia | 2 | 9 1.9|
Follicle, Cyst | 2 2 | 2 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 2 2 3 | 12 2.5|
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic | 3 | 4 2.8|
Inflammation, Suppurative | 3 3 4 2 | 8 3.0|
Duct, Cyst | 3 2 2 | 10 2.9|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 3 2 2 3 2 2 | 16 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 4 2 2 4 4 2 | 15 2.9|
Necrosis | 4 | 1 4.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 2 2 2| 8 2.1|
Interstitial Cell, Atrophy | 4 | 2 3.5|
Interstitial Cell, Hyperplasia | 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Leukocytosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3| |
| 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
Cyst, Multiple | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 | 2 3.5|
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M M + + + M + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + M M + + + I + + + + + + + + +| 44 |
Hyperplasia, Lobular | 2 | 1 2.0|
Duct, Cyst | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Fibrosis | | 1 2.0|
Ulcer | 4 | 1 4.0|
Epidermis, Hyperplasia, Focal | 3 | 1 3.0|
Epidermis, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Hemorrhage, | | |
Chronic | 2 | 1 2.0|
Subcutaneous Tissue, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Metaplasia, Osseous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
Hemorrhage | 4 3 4 | 5 3.2|
Hippocampus, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3| |
| 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 6 3.0|
Edema | | 1 2.0|
Foreign Body | | 2 2.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Foreign Body | | 1 2.0|
Lumen, Fungus | 3 X | 7 2.3|
Lumen, Inflammation, Suppurative | 3 3 | 8 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Cataract | 3 3 | 3 3.0|
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Retina, Degeneration | 3 | 4 3.3|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 3 | 1 3.0|
Infarct | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Nephropathy, Chronic | 2 3 2 3 1 2 1 2 2 2 2 2 3 2 3 3 3 3 3| 41 2.2|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | A + + + A + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + A + A M |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + A + + + |
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + A + A + A + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + A + A + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + A + A A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + A + A A |
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Basophilic Focus, Multiple | 2 1 2 2 2 2 2 2|
Congestion | |
Degeneration, Cystic | 2|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Nodular | 3 3 3 |
Inflammation, Granulomatous, Multiple| 2 |
Mixed Cell Focus, Multiple | 2 |
Necrosis, Focal | 4 |
Vacuolization Cytoplasmic | 4 2 2 2 |
Bile Duct, Hyperplasia | 2 1 1 2 3 1 2 2 2 2 2 2 2 2 2 1 2 3 3|
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 3 4 |
Fat, Inflammation, Focal, | |
Granulomatous | 3 |
Fat, Mineralization, Focal | |
Fat, Necrosis, Focal | 3 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + A + |
Acinar Cell, Atrophy | 2 3 3 3 |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + |
Forestomach, Cyst | 2 |
Forestomach, Edema | 2 |
Forestomach, Fibrosis, Chronic | |
Forestomach, Hyperkeratosis | |
Forestomach, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Ulcer | 3 |
Forestomach, Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + +|
Hemorrhage, Focal | |
Hyperkeratosis | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Congestion | |
Inflammation, Chronic | 2 2 3 3 3 3 2 3 3 3 |
Mineralization | 3 |
Atrium, Congestion | 4 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic | 4 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Hemorrhage | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Intermedia, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + |
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Fibrosis | 2 |
Hyperplasia | |
Inflammation, Suppurative | 2 |
Duct, Cyst | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Cyst | 3 |
Cyst, Multiple | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Atrophy | 3 |
Dilatation | 3 |
Inflammation, Chronic | 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 4 2 2 3 2 1 3 2 1 2 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Inguinal, Cyst | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + |
Cyst | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + |
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | A + + + + + A + + + + + + + + A + + + + A + + + +|
Atrophy | 3 |
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Necrosis | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + M + + + + M + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Hyperplasia, Lobular | 2 |
Duct, Cyst | 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis | 3|
Epidermis, Hyperplasia, Focal | 3 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Compression | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Congestion | 3 2 3 |
Hemorrhage | 3 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Edema | 3 |
Alveolus, Foreign Body | 2 |
Alveolus, Pigmentation | 2 |
Artery, Embolus Tumor, Multiple | |
Artery, Mineralization, Multiple | 3 |
Lymphatic, Foreign Body | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
Lumen, Fungus | 2 |
Lumen, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Hydronephrosis | 3 4 |
Hydronephrosis, Multiple | 2 |
Nephropathy, Chronic | 2 2 3 2 4 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Medulla, Necrosis | 3 |
Pelvis, Hemorrhage | 3 |
Pelvis, Necrosis | 4 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| |
| 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
112 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 21 |
Parasite Metazoan | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 19 |
Parasite Metazoan | 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + | 17 |
Metaplasia, Osseous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 2 | 2 1.5|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 1 1 2 | 20 1.9|
Congestion | 4 | 1 4.0|
Degeneration, Cystic | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 4 3.0|
Hyperplasia, Nodular | 4 | 4 3.3|
Inflammation, Granulomatous, Multiple| | 1 2.0|
Mixed Cell Focus, Multiple | 2 | 2 2.0|
Necrosis, Focal | | 1 4.0|
Vacuolization Cytoplasmic | 4 2 1 2| 8 2.4|
Bile Duct, Hyperplasia | 2 1 2 2 1 2 1 2 2 1 2 2 2 2 2 1| 35 1.8|
Centrilobular, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Inflammation, Chronic | | 2 3.5|
Fat, Inflammation, Focal, | | |
Granulomatous | | 1 3.0|
Fat, Mineralization, Focal | 2 | 1 2.0|
Fat, Necrosis, Focal | 3 3 4 3 | 9 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 22 |
Acinar Cell, Atrophy | 3 4 2 | 7 2.9|
Acinar Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| |
| 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
112 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Cyst | | 1 2.0|
Forestomach, Edema | 3 3 | 3 2.7|
Forestomach, Fibrosis, Chronic | 4 | 1 4.0|
Forestomach, Hyperkeratosis | 4 | 1 4.0|
Forestomach, Inflammation, Chronic | 3 3 | 3 3.0|
Forestomach, Ulcer | 4 | 2 3.5|
Forestomach, Epithelium, Hyperplasia | 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Tongue | + + | 4 |
Hemorrhage, Focal | 2 | 1 2.0|
Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 25 |
Congestion | 4 | 1 4.0|
Inflammation, Chronic | 2 2 3 3 2 3 2 2 3 3 3 | 21 2.6|
Mineralization | | 1 3.0|
Atrium, Congestion | | 1 4.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 24 |
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + | 23 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + | 22 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 28 |
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Cyst, Multiple | | 1 2.0|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 3 2 2 | 4 2.3|
Pars Intermedia, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| |
| 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
112 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 25 |
C-Cell, Hyperplasia | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + M + + + + + + + + + | 24 |
Atrophy | 3 3 | 3 3.0|
Fibrosis | 3 | 2 2.5|
Hyperplasia | 4 | 1 4.0|
Inflammation, Suppurative | 4 3 3 3 2 4 2 2 | 9 2.8|
Duct, Cyst | 3 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + +| 24 |
Cyst | | 1 3.0|
Cyst, Multiple | 3 3| 2 3.0|
Inflammation, Chronic | 3 | 2 3.0|
Inflammation, Suppurative | 2 3 3 3 | 11 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 25 |
Atrophy | | 1 3.0|
Dilatation | 3 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 2 2 3 4 | 19 2.4|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 | 2 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 23 |
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 25 |
Inguinal, Cyst | 3 | 1 3.0|
Mediastinal, Hemorrhage | 3 | 2 3.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| |
| 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
112 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + | 21 |
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 23 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Atrophy | | 1 3.0|
Congestion | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 | 2 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + + M + + + | 23 |
Hyperplasia, Lobular | | 1 2.0|
Duct, Cyst | 3 3 2 | 8 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 37 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Fibrosis | | 1 3.0|
Epidermis, Hyperplasia, Focal | | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 24 |
Compression | 4 4 | 2 4.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 29 |
Congestion | 3 3 4 3 2 3 | 9 2.9|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| |
| 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
112 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Edema | | 1 3.0|
Alveolus, Foreign Body | | 1 2.0|
Alveolus, Pigmentation | 2 | 2 2.0|
Artery, Embolus Tumor, Multiple | X | 1 |
Artery, Mineralization, Multiple | | 1 3.0|
Lymphatic, Foreign Body | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 23 |
Lumen, Fungus | 2 | 2 2.0|
Lumen, Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Cataract | 4 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 23 |
Hydronephrosis | | 2 3.5|
Hydronephrosis, Multiple | | 1 2.0|
Nephropathy, Chronic | 2 3 3 3 2 3 2 1 2 2 | 15 2.4|
Medulla, Necrosis | | 1 3.0|
Pelvis, Hemorrhage | | 1 3.0|
Pelvis, Necrosis | | 1 4.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + | 22 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|
| 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Parasite Metazoan | 2 2 1 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 |
Basophilic Focus, Multiple | 2 2 2 1 2 2 2 2 2 2 2 2|
Clear Cell Focus | 1 |
Clear Cell Focus, Multiple | 1 1 |
Congestion | |
Degeneration, Cystic | 1 2 3 |
Eosinophilic Focus | 2 |
Eosinophilic Focus, Multiple | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3|
Hyperplasia, Nodular | 2 2 3 3 |
Inflammation, Granulomatous, Multiple| 2 2 1|
Mixed Cell Focus | 2 |
Vacuolization Cytoplasmic | 1 2 2 2 4 4 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 1 2 2 2 2 1 3 2 2 4 2 2 1 |
Centrilobular, Degeneration | 4 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Polyarteritis | 3 |
Fat, Inflammation, Focal, | |
Granulomatous | 3 |
Fat, Necrosis, Focal | 4 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 4 2 4 3|
Acinar Cell, Atrophy | 2 2 2 2 2 3 2 2 3|
Acinar Cell, Hyperplasia | 3 2 |
Acinar Cell, Hyperplasia, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|
| 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Edema | 4 |
Forestomach, Inflammation, Chronic | 4 |
Forestomach, Polyarteritis | 4 |
Forestomach, Ulcer | 3 |
Forestomach, Epithelium, Hyperplasia | 4 |
Glandular, Polyarteritis | 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Inflammation, Chronic | 3 2 2 2 3 2 2 3 2 2 2 3 2 3 2 3 3 2 2 2 3 2|
Atrium, Congestion | 3 |
Atrium, Fibrosis | 4 |
Atrium, Thrombosis | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Degeneration, Cystic | |
Hyperplasia, Focal | 2 2 |
Vacuolization Cytoplasmic | 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Focal, Multiple | 2 |
Mineralization | 4 |
Thrombosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 3 2 2 1 2 |
Follicle, Cyst | 4 |
Follicle, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|
| 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 3 3 2|
Hyperplasia | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis | |
Duct, Cyst | 3 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 3 2 |
Inflammation, Suppurative | 1 2 2 3 3 3 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 4 4 3 3 3 2|
Mineralization | 2 |
Bilateral, Atrophy | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Cyst, Multiple | |
Hyperplasia, Lymphoid | 2 3|
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Atrophy | 3 |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|
| 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lobular | 3 |
Duct, Cyst | 2 2 3 2 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 3 |
Epidermis, Hyperplasia, Focal | 3 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 3 |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 2 |
Hemorrhage | 3 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Foreign Body | 3 2 |
Artery, Embolus Tumor | |
Lymphatic, Foreign Body | 2 |
Perivascular, Foreign Body | |
Subpleura, Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 2 3 3 2|
Lumen, Inflammation, Suppurative | 2 3 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|
| 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
225 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 2 1 3 2 2 1 2 2 3 2 2 2 4 2 2 2 2 2 3 2|
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 1 3.0|
Parasite Metazoan | 2 2 1 2 2| 8 1.8|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 1 2 1 | 5 2.0|
Basophilic Focus, Multiple | 2 2 2 1 2 2 | 18 1.9|
Clear Cell Focus | 2 | 2 1.5|
Clear Cell Focus, Multiple | 2 | 3 1.3|
Congestion | 3 | 1 3.0|
Degeneration, Cystic | 2 | 4 2.0|
Eosinophilic Focus | | 1 2.0|
Eosinophilic Focus, Multiple | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 3 2 2 3 2 3| 7 2.6|
Hyperplasia, Nodular | 3 2 | 6 2.5|
Inflammation, Granulomatous, Multiple| | 3 1.7|
Mixed Cell Focus | 2 1 2 | 4 1.8|
Vacuolization Cytoplasmic | 2 2 1 2 2 | 11 2.2|
Bile Duct, Hyperplasia | 2 2 2 1 2 2 1 2 2 1 2 2 1 2 1 2 2 2| 38 1.8|
Centrilobular, Degeneration | 2 2 | 3 2.7|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + +| 19 |
Polyarteritis | | 1 3.0|
Fat, Inflammation, Focal, | | |
Granulomatous | 3 | 2 3.0|
Fat, Necrosis, Focal | 2 3 2 3 2 3 2 2| 13 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyarteritis | 3 3 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Atrophy | 3 2 2 3 2 3 2 2 2 2 2 3 | 21 2.3|
Acinar Cell, Hyperplasia | 2 3| 4 2.5|
Acinar Cell, Hyperplasia, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | | 1 4.0|
Forestomach, Inflammation, Chronic | | 1 4.0|
Forestomach, Polyarteritis | | 1 4.0|
Forestomach, Ulcer | | 1 3.0|
Forestomach, Epithelium, Hyperplasia | 2 | 2 3.0|
Glandular, Polyarteritis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 3.0|
Inflammation, Chronic | 2 2 2 3 2 2 2 2 3 3 3 2 2 3 3 3 2 3 3 2 2| 43 2.4|
Atrium, Congestion | 4 3 3 | 4 3.3|
Atrium, Fibrosis | | 1 4.0|
Atrium, Thrombosis | 4 2 | 4 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 2 | 2 2.0|
Degeneration, Cystic | 2 4 2 2 | 4 2.5|
Hyperplasia, Focal | 2 | 3 2.0|
Vacuolization Cytoplasmic | | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Focal, Multiple | 3 | 2 2.5|
Mineralization | | 1 4.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 1 3 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 2 2 2 3 2 2 2 | 13 2.1|
Follicle, Cyst | | 1 4.0|
Follicle, Hyperplasia, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 3 3 3 2 3 | 13 2.7|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 2 3 | 2 2.5|
Necrosis | 4 | 1 4.0|
Duct, Cyst | 3 4 3 2 | 7 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 2 2.5|
Inflammation, Suppurative | 4 3 2 3 2 2 2 3 | 17 2.4|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 4 4 1 4 2 2 3 1 2 2 3| 22 2.7|
Mineralization | | 1 2.0|
Bilateral, Atrophy | 3 | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 2 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2| 14 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Axillary, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Pigmentation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Cyst, Multiple | 3 4 | 2 3.5|
Hyperplasia, Lymphoid | | 2 2.5|
Lymphocyte, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Lymphocyte, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
Atrophy | | 1 3.0|
Developmental Malformation | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lobular | | 1 3.0|
Duct, Cyst | 3 3 2 2 | 10 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3 3 | 4 3.0|
Epidermis, Hyperplasia, Focal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
Subcutaneous Tissue, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05002-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GAMMA-BUTYROLACTONE Date: 04/29/97
Route: GAVAGE Time: 07:03:43
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
225 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2| 5 2.0|
Hemorrhage | | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Foreign Body | | 2 2.5|
Artery, Embolus Tumor | X | 1 |
Lymphatic, Foreign Body | 2 2 | 3 2.0|
Perivascular, Foreign Body | 2 | 1 2.0|
Subpleura, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Fungus | 3 2 2 3 3 | 9 2.6|
Lumen, Inflammation, Suppurative | 2 2 3 3 | 8 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 3 | 3 3.0|
Retina, Degeneration | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 2 2 1 2 3 2 3 2 2 2 2 2 2 2 1 2 2 2 2 2 2 4| 46 2.1|
Renal Tubule, Mineralization | 1 1 | 2 1.0|
Renal Tubule, Pigmentation | 4 | 4 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------