TDMS Study 05002-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/02/94
EXP: 05002 GAMMA-BUTYROLACTONE TIME: 18:11:30
TEST: 05 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55878
CONT: NO1CP9565101 CAS: 96-48-0
PATHOLOGIST: R. THOMPSON S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/02/94
EXP: 05002 GAMMA-BUTYROLACTONE TIME: 18:11:30
TEST: 05 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55878
CONT: NO1CP9565101 CAS: 96-48-0
PATHOLOGIST: R. THOMPSON S. EUSTIS
GAMMA-BUTYROLACTONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 465 469 481 481 498 529 570 574 575 577 |
| 580 596 618 624 641 651 663 664 668 668 |
| 674 681 700 708 714 |
| CENSORED DEATHS |
| 543 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 112. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 3 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 392 399 489 529 533 571 588 590 593 617 |
| 618 640 658 674 689 690 708 712 718 721 |
| CENSORED DEATHS |
| 381 555 645 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 3 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 414 529 550 561 577 581 609 661 663 667 |
| 668 669 695 726 727 |
| CENSORED DEATHS |
| 365 703 704 |
| |
==================================================================================
GAMMA-BUTYROLACTONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 92.0 88.0 75.7 63.4 49.1 |
|CONTROL | |
| | |
|112. | 100.0 100.0 100.0 100.0 95.9 95.9 89.8 81.4 73.0 58.0 |
|MG/KG | |
| | |
|225. | 100.0 100.0 100.0 100.0 98.0 98.0 95.9 87.8 81.6 69.1 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 112. 225. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 49.1% 58.0% 69.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.043N P=0.415N P=0.053N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.8 606.5 619.8 |
|NATURAL DEATHS (C) | (15.9) (22.1) (22.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.2 667.9 687.9 |
|(STANDARD ERROR) | (12.1) (13.7) (11.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GAMMA-BUTYROLACTONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 316 498 512 512 542 556 556 559 574 651 |
| 663 666 667 667 667 668 683 688 690 702 |
| 716 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 287 337 366 376 417 501 511 569 641 652 |
| 678 682 682 689 689 690 700 702 708 708 |
| 710 711 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 450. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 2 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 148 220 221 325 452 574 578 584 596 596 |
| 599 653 668 669 670 670 677 687 726 726 |
| CENSORED DEATHS |
| 141 569 |
| |
==================================================================================
GAMMA-BUTYROLACTONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 98.0 98.0 90.0 82.0 78.0 56.0 |
|CONTROL | |
| | |
|225. | 100.0 100.0 100.0 96.0 90.0 90.0 86.0 84.0 80.0 54.0 |
|MG/KG | |
| | |
|450. | 100.0 98.0 93.9 91.8 91.8 89.8 89.8 77.3 75.2 58.5 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 225. 450. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 54.0% 58.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.927N P=1.000 P=0.969N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.7 596.6 552.0 |
|NATURAL DEATHS (C) | (21.0) (29.9) (40.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 678.4 668.6 643.8 |
|(STANDARD ERROR) | (12.3) (16.6) (22.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
GAMMA-BUTYROLACTONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
112. MG/KG = 2
225. MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 22 3 3
| 2 1 12 2 3 3
| 1 1 22 3 3
P 90 + 1 12 2
E | 1 132 3
R | 112 2 3 3
C | 2 2 33
E 80 +
N | 1 1 2 2
T | 1 1 2 2 3 3
| 11 1 2 2 3 3
S 70 + 11 2 2 3 3
U | 1 1 2 2
R |
V | 11 22
I 60 + 11
V | 11 2 2
A | 1 1
L | 1 1
50 + 1 1
|
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
GAMMA-BUTYROLACTONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
225. MG/KG = 2
450. MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
| 3 3 2 1 2 1
| 2 2 1 1
95 +
| 3 3 22
| 2 2 1 1
| 3 3
90 + 2 3 2 1 1 3
|
| 22 33
| 2 2
P 85 + 33
E | 1 1 3 3 2
R | 1 212
C |
E 80 + 12 1 2
N |
T | 3 3 1122
|
S 75 + 3 3
U | 22
R |
V |
I 70 +
V |
A | 1 122
L | 331122
65 + 3 3
| 22
| 1 1 3
|
60 + 1 1
| 3 3
| 11
| 221 1
55 +
| 2 2
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.