TDMS Study 05004-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FURAN
NTP Experiment-Test: 05004-04 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 02:49:48
Facility: Southern Research Institute
Chemical CAS #: 110-00-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 16 16 35
Natural Death 1 1
Dead 4 8 11
Dosing Accident 1
Survivors
Terminal Sacrifice 28 25 2
Dead 1
Other 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50)
Perforation 1 (2%)
Gallbladder (49) (49) (43)
Infarct 1 (2%)
Intestine Large, Cecum (49) (49) (46)
Edema 1 (2%)
Intestine Large, Rectum (49) (49) (48)
Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (49) (47) (45)
Congestion 1 (2%)
Inflammation, Chronic 1 (2%)
Mucosa, Hyperplasia, Adenomatous 1 (2%)
Mucosa, Ulcer 1 (2%) 1 (2%)
Intestine Small, Ileum (48) (47) (44)
Lymphoid Tissue, Mineralization 1 (2%)
Intestine Small, Jejunum (49) (47) (44)
Mucosa, Amyloid Deposition 1 (2%)
Liver (50) (50) (50)
Angiectasis 2 (4%) 3 (6%)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Congestion 2 (4%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%) 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 9 (18%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 27 (54%) 33 (66%) 42 (84%)
Hyperplasia, Multifocal 48 (96%) 48 (96%)
Infarct 7 (14%) 11 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Mixed Cell 8 (16%) 23 (46%) 32 (64%)
Inflammation, Multifocal 27 (54%) 13 (26%)
Mineralization 1 (2%) 2 (4%)
Mixed Cell Focus 1 (2%) 5 (10%) 3 (6%)
Necrosis, Multifocal 3 (6%) 1 (2%) 3 (6%)
Thrombosis 3 (6%)
Vacuolization Cytoplasmic 6 (12%) 29 (58%) 36 (72%)
Bile Duct, Dilatation 1 (2%) 11 (22%)
Biliary Tract, Fibrosis 47 (94%) 50 (100%)
Biliary Tract, Granuloma 1 (2%)
Biliary Tract, Hyperplasia 47 (94%) 50 (100%)
Biliary Tract, Inflammation, Chronic 2 (4%) 48 (96%) 50 (100%)
Hepatocyte, Cytomegaly 48 (96%) 50 (100%)
Hepatocyte, Degeneration 47 (94%) 48 (96%)
Hepatocyte, Necrosis 44 (88%) 47 (94%)
Kupffer Cell, Pigmentation 5 (10%) 48 (96%) 50 (100%)
Parenchyma, Atrophy, Focal 1 (2%)
Parenchyma, Atrophy, Multifocal 47 (94%) 50 (100%)
Mesentery (24) (27) (4)
Edema 1 (4%)
Inflammation, Chronic 1 (4%) 1 (25%)
Inflammation, Suppurative 8 (33%) 7 (26%) 3 (75%)
Fat, Necrosis 4 (17%) 7 (26%) 1 (25%)
Pancreas (50) (49) (50)
Atrophy, Focal 1 (2%) 2 (4%)
Fibrosis, Focal 1 (2%)
Hyperplasia, Lymphoid 5 (10%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Acinar Cell, Hyperplasia 1 (2%)
Acinus, Hypoplasia 1 (2%)
Artery, Inflammation, Chronic 2 (4%)
Duct, Cyst 2 (4%)
Duct, Dilatation 1 (2%)
Salivary Glands (50) (50) (50)
Hyperplasia, Lymphoid 2 (4%) 4 (8%)
Stomach, Forestomach (50) (49) (49)
Edema 1 (2%)
Erosion 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Hyperplasia, Papillary 1 (2%)
Hyperplasia, Squamous 2 (4%)
Inflammation, Focal 10 (20%) 7 (14%) 9 (18%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Mucosa, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mucosa, Erosion 1 (2%) 2 (4%) 1 (2%)
Mucosa, Hyperplasia, Papillary 10 (20%) 10 (20%) 8 (16%)
Mucosa, Ulcer 2 (4%) 2 (4%)
Stomach, Glandular (49) (49) (50)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Focal 1 (2%)
Mineralization 1 (2%) 3 (6%)
Epithelium, Degeneration, Hyaline 2 (4%) 5 (10%) 2 (4%)
Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%)
Epithelium, Vacuolization Cytoplasmic,
Multifocal 1 (2%)
Mucosa, Cyst 11 (22%) 12 (24%) 10 (20%)
Mucosa, Dysplasia, Focal 1 (2%)
Mucosa, Erosion 1 (2%) 2 (4%) 2 (4%)
Mucosa, Hemorrhage 2 (4%)
Mucosa, Hyperplasia 3 (6%) 5 (10%) 3 (6%)
Mucosa, Mineralization 1 (2%) 2 (4%)
Mucosa, Necrosis, Focal 1 (2%)
Mucosa, Necrosis, Multifocal 1 (2%)
Mucosa, Pigmentation 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Tongue (2) (1)
Angiectasis 1 (50%)
Hemorrhage 1 (100%)
Necrosis 1 (100%)
Tooth (2) (1) (3)
Incisor, Dysplasia 2 (100%) 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (2) (3)
Abdominal, Inflammation, Chronic 1 (33%)
Mesenteric Artery, Inflammation, Chronic 1 (50%) 1 (50%) 2 (67%)
Pulmonary Artery, Inflammation, Chronic 1 (50%)
Pulmonary Artery, Mineralization 1 (50%)
Heart (50) (50) (50)
Artery, Inflammation, Chronic 1 (2%)
Atrium, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%)
Cyst 1 (2%)
Cytologic Alterations, Focal 1 (2%)
Developmental Malformation 1 (2%)
Hyperplasia, Focal 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Extra Adrenal Tissue, Accessory Adrenal
Cortical Nodule 2 (4%)
Subcapsular, Hyperplasia, Focal 4 (8%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Ectopic Tissue 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%) 8 (16%)
Parathyroid Gland (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Pituitary Gland (49) (47) (46)
Pars Distalis, Angiectasis 3 (6%) 2 (4%) 4 (9%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Focal Cellular Change 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 8 (16%) 8 (17%) 5 (11%)
Pars Intermedia, Vacuolization Cytoplasmic 1 (2%)
Pars Nervosa, Hyperplasia, Focal 1 (2%)
Rathke's Cleft, Hemorrhage 1 (2%)
Thyroid Gland (50) (50) (50)
Degeneration, Cystic 4 (8%) 4 (8%) 7 (14%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 14 (28%) 11 (22%) 8 (16%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Inflammation, Suppurative 1 (100%)
Ovary (49) (49) (50)
Angiectasis 2 (4%) 2 (4%)
Cyst 1 (2%)
Ectopic Tissue 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 7 (14%) 10 (20%) 3 (6%)
Mineralization 1 (2%)
Pigmentation 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Corpus Luteum, Degeneration 1 (2%) 1 (2%)
Corpus Luteum, Granuloma 1 (2%) 1 (2%)
Follicle, Cyst 19 (39%) 15 (31%) 21 (42%)
Oviduct (4) (4) (1)
Ectopic Tissue 1 (100%)
Inflammation, Suppurative 3 (75%) 2 (50%)
Uterus (50) (50) (50)
Angiectasis 1 (2%) 3 (6%)
Hydrometra 8 (16%) 7 (14%) 7 (14%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 8 (16%) 9 (18%) 5 (10%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 48 (96%) 47 (94%) 42 (84%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Neutrophil 2 (4%) 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (50) (50) (50)
Iliac, Hyperplasia 2 (4%) 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia 2 (4%)
Inguinal, Hyperplasia, Lymphoid 3 (6%) 2 (4%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Inflammation, Suppurative 1 (2%)
Popliteal, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia 5 (10%) 2 (4%) 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Bronchial (21) (29) (21)
Hyperplasia 1 (5%) 4 (14%) 1 (5%)
Hyperplasia, Lymphoid 4 (19%) 4 (14%)
Lymph Node, Mandibular (47) (46) (48)
Angiectasis 1 (2%)
Cyst 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 4 (9%)
Lymph Node, Mediastinal (41) (45) (43)
Angiectasis 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 7 (17%) 6 (13%) 2 (5%)
Hyperplasia, Lymphoid 1 (2%) 6 (13%) 2 (5%)
Inflammation, Suppurative 2 (5%) 2 (4%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Lymph Node, Mesenteric (49) (49) (49)
Angiectasis 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 2 (4%)
Hyperplasia, Lymphoid 7 (14%) 5 (10%) 5 (10%)
Inflammation, Suppurative 1 (2%)
Spleen (50) (50) (50)
Hematopoietic Cell Proliferation 17 (34%) 17 (34%) 34 (68%)
Hyperplasia, Lymphoid 8 (16%) 14 (28%) 7 (14%)
Thymus (46) (46) (45)
Angiectasis 1 (2%)
Depletion Lymphoid 4 (9%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (48)
Dilatation 19 (39%) 17 (34%) 18 (38%)
Hyperplasia, Cystic 1 (2%)
Inflammation 1 (2%)
Skin (50) (50) (50)
Inflammation, Chronic 5 (10%) 5 (10%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 2 (4%)
Subcutaneous Tissue, Hyperplasia, Lymphoid 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Mixed Cell 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 2 (4%) 1 (2%)
Subcutaneous Tissue, Fat, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Distal, Joint, Femur, Arthrosis 1 (2%)
Femur, Fracture 1 (2%)
Trabecula, Cranium, Hyperostosis 1 (2%)
Skeletal Muscle (3) (2)
Necrosis, Multifocal 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hindlimb, Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 4 (8%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 22 (44%) 27 (54%) 28 (56%)
Hyperplasia, Macrophage 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Mixed Cell 2 (4%) 7 (14%) 2 (4%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Fat, Mediastinum, Necrosis 1 (2%)
Mediastinum, Foreign Body 1 (2%)
Mediastinum, Hemorrhage 1 (2%)
Mediastinum, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Mediastinum, Inflammation, Suppurative 3 (6%) 5 (10%) 1 (2%)
Pleura, Fibrosis 1 (2%)
Pleura, Inflammation, Suppurative 1 (2%)
Nose (50) (50) (50)
Lumen, Exudate 23 (46%) 18 (36%) 20 (40%)
Lumen, Foreign Body 27 (54%) 26 (52%) 26 (52%)
Lumen, Hemorrhage 1 (2%)
Lumen, Inflammation, Suppurative 1 (2%)
Mucosa, Cyst 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%)
Trachea (50) (50) (50)
Artery, Peritracheal Tissue, Inflammation,
Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (6) (4)
Acinus, Dilatation 1 (17%) 1 (25%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Atrophy 1 (2%)
Cyst 1 (2%)
Fibrosis 2 (4%) 4 (8%)
Hydronephrosis 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 3 (6%)
Metaplasia, Osseous 1 (2%) 2 (4%)
Mineralization 2 (4%) 2 (4%) 4 (8%)
Nephropathy 16 (32%) 21 (42%) 22 (45%)
Artery, Inflammation, Chronic 2 (4%)
Capsule, Fibrosis, Focal 1 (2%)
Interstitial Tissue, Pigmentation 2 (4%)
Renal Tubule, Bacterium 1 (2%)
Renal Tubule, Casts 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%) 1 (2%)
Renal Tubule, Dilatation 2 (4%) 1 (2%) 4 (8%)
Renal Tubule, Necrosis 4 (8%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Renal Tubule, Epithelium, Depletion Cellular 1 (2%)
Urinary Bladder (50) (50) (50)
Hyperplasia, Lymphoid 3 (6%) 6 (12%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 16 24 24
Dead 1 5 8
Natural Death 1 1
Dosing Accident 2
Accident 1
Survivors
Terminal Sacrifice 33 17 16
Other 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50)
Perforation 2 (4%)
Intestine Large, Cecum (50) (50) (49)
Mucosa, Epithelium, Metaplasia, Squamous 1 (2%)
Intestine Large, Colon (50) (50) (49)
Mucosa, Cyst 1 (2%)
Intestine Small, Duodenum (49) (49) (48)
Angiectasis 1 (2%)
Inflammation, Chronic 2 (4%)
Mucosa, Hyperplasia, Papillary 1 (2%)
Mucosa, Ulcer 1 (2%)
Intestine Small, Ileum (50) (49) (48)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Jejunum (50) (49) (48)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%)
Mucosa, Hyperplasia, Papillary 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 3 (6%)
Basophilic Focus 1 (2%)
Basophilic Focus, Multiple, Two 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%)
Clear Cell Focus, Multiple, Three 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Cyst, Multiple 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Degeneration, Cystic 1 (2%)
Depletion Glycogen 2 (4%) 1 (2%)
Eosinophilic Focus 1 (2%) 1 (2%) 1 (2%)
Fibrosis, Focal 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 4 (8%) 2 (4%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 26 (52%) 24 (48%) 22 (44%)
Hyperplasia, Multifocal 1 (2%) 44 (88%) 49 (98%)
Infarct 1 (2%) 13 (26%) 11 (22%)
Infarct, Multiple, Two 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%) 23 (46%) 29 (58%)
Inflammation, Multifocal 17 (34%) 7 (14%) 2 (4%)
Mineralization 3 (6%)
Mixed Cell Focus 5 (10%) 1 (2%)
Necrosis, Multifocal 1 (2%) 2 (4%) 3 (6%)
Thrombosis 4 (8%) 1 (2%)
Vacuolization Cytoplasmic 8 (16%) 24 (48%) 36 (72%)
Artery, Inflammation, Chronic 1 (2%)
Bile Duct, Dilatation 6 (12%)
Biliary Tract, Fibrosis 45 (90%) 49 (98%)
Biliary Tract, Hyperplasia 46 (92%) 49 (98%)
Biliary Tract, Inflammation, Chronic 44 (88%) 49 (98%)
Centrilobular, Necrosis 1 (2%) 3 (6%) 1 (2%)
Hepatocyte, Cytomegaly 8 (16%) 45 (90%) 50 (100%)
Hepatocyte, Degeneration 43 (86%) 43 (86%)
Hepatocyte, Mitotic Alteration 1 (2%) 1 (2%)
Hepatocyte, Necrosis 2 (4%) 39 (78%) 41 (82%)
Hepatocyte, Pigmentation 1 (2%)
Kupffer Cell, Pigmentation 2 (4%) 43 (86%) 50 (100%)
Parenchyma, Atrophy, Focal 1 (2%)
Parenchyma, Atrophy, Multifocal 45 (90%) 50 (100%)
Serosa, Fibrosis, Focal 1 (2%)
Serosa, Pigmentation, Focal 1 (2%)
Mesentery (6) (10) (3)
Fibrosis 1 (17%) 1 (33%)
Hyperplasia, Lymphoid 1 (10%)
Infarct 1 (10%)
Inflammation, Chronic 1 (17%) 1 (33%)
Mineralization 1 (10%) 1 (33%)
Necrosis 1 (33%)
Fat, Necrosis 3 (50%)
Pancreas (50) (50) (50)
Atrophy, Focal 1 (2%)
Atypia Cellular, Focal 1 (2%)
Hyperplasia, Lymphoid 3 (6%)
Duct, Dilatation 1 (2%)
Salivary Glands (50) (50) (48)
Depletion Cellular 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 4 (8%)
Adventitia, Inflammation, Chronic 1 (2%)
Stomach, Forestomach (49) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Focal 9 (18%) 13 (26%) 21 (42%)
Mineralization, Focal 1 (2%)
Mucosa, Edema 1 (2%)
Mucosa, Erosion 2 (4%) 5 (10%) 6 (12%)
Mucosa, Hyperplasia, Papillary 7 (14%) 14 (28%) 23 (46%)
Mucosa, Inflammation, Focal 1 (2%)
Mucosa, Mineralization 2 (4%)
Mucosa, Ulcer 3 (6%) 3 (6%) 3 (6%)
Mucosa, Ulcer, Multiple, Two 1 (2%)
Stomach, Glandular (49) (50) (50)
Inflammation, Focal 1 (2%) 6 (12%) 4 (8%)
Mineralization 3 (6%)
Epithelium, Degeneration, Hyaline 1 (2%) 2 (4%)
Epithelium, Metaplasia, Squamous 1 (2%)
Mucosa, Cyst 1 (2%) 1 (2%) 1 (2%)
Mucosa, Cyst, Multiple 1 (2%)
Mucosa, Dysplasia 1 (2%)
Mucosa, Erosion 1 (2%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Mucosa, Hyperplasia, Papillary 1 (2%)
Mucosa, Mineralization 1 (2%) 1 (2%)
Tongue (1) (1)
Hemorrhage 1 (100%)
Tooth (43) (36) (32)
Incisor, Dysplasia 43 (100%) 35 (97%) 32 (100%)
Incisor, Inflammation, Suppurative 4 (9%) 3 (8%) 5 (16%)
Molar, Inflammation, Suppurative 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (2) (4)
Abdominal, Inflammation, Chronic 1 (25%)
Abdominal, Thrombosis 1 (50%)
Abdominal, Adventitia, Thrombosis 1 (25%)
Aorta, Mineralization 1 (50%)
Aorta, Media, Mineralization 2 (50%)
Mesenteric Artery, Inflammation, Chronic 1 (50%) 2 (50%)
Mesenteric Artery, Media, Mineralization 1 (25%)
Renal Artery, Mineralization 1 (50%)
Thoracic, Artery, Mineralization 1 (50%)
Heart (50) (50) (50)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Coronary Artery, Mineralization 1 (2%)
Myocardium, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Depletion Cellular 1 (2%)
Focal Cellular Change 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Subcapsular, Hyperplasia 2 (4%)
Subcapsular, Hyperplasia, Focal 7 (14%) 2 (4%) 1 (2%)
Adrenal Gland, Medulla (49) (50) (50)
Hyperplasia 2 (4%) 3 (6%) 3 (6%)
Hyperplasia, Focal 3 (6%) 9 (18%)
Extra Adrenal Tissue, Ectopic Tissue 1 (2%)
Parathyroid Gland (49) (48) (50)
Cyst 1 (2%)
Cyst, Multiple 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (50) (44) (48)
Cyst 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 6 (12%) 1 (2%) 3 (6%)
Pars Distalis, Focal Cellular Change 1 (2%)
Pars Distalis, Hyperplasia, Focal 2 (4%) 1 (2%) 1 (2%)
Pars Nervosa, Angiectasis 1 (2%)
Thyroid Gland (50) (50) (50)
Degeneration 1 (2%)
Degeneration, Cystic 6 (12%) 7 (14%) 4 (8%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 4 (8%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Dilatation 1 (100%) 1 (100%)
Hyperplasia, Adenomatous 1 (100%)
Epididymis (50) (50) (50)
Granuloma 1 (2%)
Granuloma Sperm 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (6) (6) (5)
Degeneration, Cystic 1 (17%) 4 (67%) 4 (80%)
Fibrosis 1 (17%)
Inflammation, Suppurative 5 (83%) 3 (50%) 3 (60%)
Prostate (49) (50) (50)
Degeneration, Cystic 1 (2%) 1 (2%)
Dilatation 1 (2%) 1 (2%) 2 (4%)
Edema 2 (4%) 2 (4%)
Granuloma 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 2 (4%)
Artery, Media, Hyperplasia 1 (2%)
Seminal Vesicle (50) (50) (50)
Dilatation 2 (4%)
Inflammation, Chronic 1 (2%)
Testes (50) (50) (50)
Granuloma Sperm 1 (2%)
Mineralization 1 (2%) 4 (8%) 1 (2%)
Germinal Epithelium, Degeneration 3 (6%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Lymph Node (50) (50) (49)
Iliac, Hyperplasia 1 (2%)
Inguinal, Angiectasis 2 (4%) 1 (2%)
Inguinal, Congestion 1 (2%)
Inguinal, Hyperplasia 4 (8%) 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Inflammation, Chronic, Focal 1 (2%)
Renal, Hyperplasia 1 (2%)
Lymph Node, Bronchial (14) (27) (26)
Hyperplasia, Lymphoid 2 (7%)
Lymph Node, Mandibular (49) (48) (43)
Hyperplasia 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 4 (8%)
Pigmentation 1 (2%)
Lymph Node, Mediastinal (38) (45) (41)
Depletion Lymphoid 1 (2%)
Hyperplasia 1 (2%) 2 (5%)
Hyperplasia, Lymphoid 1 (3%) 5 (11%)
Lymph Node, Mesenteric (50) (50) (48)
Angiectasis 21 (42%) 7 (14%) 6 (13%)
Hematopoietic Cell Proliferation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Spleen (50) (50) (49)
Depletion Cellular 2 (4%)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 11 (22%) 15 (31%)
Hyperplasia, Lymphoid 2 (4%) 7 (14%)
Artery, Degeneration, Hyaline 1 (2%)
Red Pulp, Depletion Cellular 2 (4%)
Thymus (42) (44) (42)
Cyst 1 (2%)
Depletion Lymphoid 3 (7%) 4 (9%) 1 (2%)
Hyperplasia, Lymphoid 3 (7%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Erosion 1 (2%)
Exudate 1 (2%) 1 (2%)
Inflammation, Chronic 10 (20%) 6 (12%) 7 (14%)
Ulcer 4 (8%) 2 (4%) 4 (8%)
Hair Follicle, Atrophy 1 (2%)
Prepuce, Fibrosis 1 (2%) 1 (2%)
Prepuce, Inflammation, Chronic 1 (2%) 1 (2%)
Prepuce, Ulcer 1 (2%)
Subcutaneous Tissue, Congestion 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%) 1 (2%)
Subcutaneous Tissue, Thrombosis 1 (2%)
Subcutaneous Tissue, Fat, Necrosis 1 (2%)
Subcutaneous Tissue, Head, Hyperplasia, Mast
Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Hyperostosis 1 (2%)
Distal, Joint, Femur, Arthrosis 5 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%) 4 (8%) 4 (8%)
Granuloma 2 (4%)
Hyperplasia, Lymphoid 23 (46%) 20 (40%) 23 (46%)
Hyperplasia, Macrophage 15 (30%) 12 (24%) 17 (34%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Focal 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 2 (4%)
Bronchiole, Hyperplasia 1 (2%)
Bronchus, Epithelium, Hyperplasia, Papillary 1 (2%)
Mediastinum, Foreign Body 2 (4%)
Mediastinum, Hemorrhage 1 (2%)
Mediastinum, Inflammation, Suppurative 2 (4%)
Pleura, Inflammation, Suppurative 1 (2%)
Nose (50) (50) (50)
Lumen, Exudate 16 (32%) 9 (18%) 1 (2%)
Lumen, Foreign Body 16 (32%) 13 (26%) 6 (12%)
Lumen, Hemorrhage 2 (4%)
Lumen, Inflammation, Suppurative 2 (4%) 2 (4%) 3 (6%)
Mucosa, Inflammation, Suppurative 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Congestion 3 (6%) 1 (2%)
Cyst 1 (2%)
Fibrosis 2 (4%) 2 (4%) 1 (2%)
Fibrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05004-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/03/94
Route: GAVAGE Time: 02:49:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 8. MG/KG 15.
CONTROL MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 1 (2%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infarct 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 36 (72%) 34 (68%) 41 (82%)
Nephropathy 41 (82%) 36 (72%) 38 (76%)
Thrombosis 1 (2%)
Capsule, Fibrosis 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Cyst 3 (6%)
Renal Tubule, Dilatation 3 (6%) 2 (4%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 6 (12%) 2 (4%)
Ureter (1) (2) (2)
Mineralization 1 (50%)
Necrosis 1 (50%)
Serosa, Hyperplasia, Lymphoid 1 (50%) 2 (100%)
Urinary Bladder (50) (49) (50)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
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