TDMS Study 05004-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURAN
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Adrenal Medulla Pheochromocytoma Benign
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
Spleen Hemangiosarcoma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURAN
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 17.0% 13.2% 0.0% | 0.0% 0.0% 4.8% |
|TERMINAL (d) | 5/33 (15%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 550 719 --- | --- --- 701 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.068N P=0.540N P=0.072N | P=0.221 (e) P=0.398 |
|INCIDENTAL TUMOR | P=0.022N* P=0.338N P=0.033N* | P=0.413 (e) P=0.662 |
|LOGISTIC REGRESSION | P=0.015N* P=0.308N P=0.018N* | P=0.254 (e) P=0.440 |
|COCHRAN-ARMITAGE | P=0.011N* | P=0.293 |
|FISHER EXACT | P=0.243N P=0.013N* | (e) P=0.500 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 6/50 (12%) 10/50 (20%) | 2/50 (4%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 2.6% 24.6% 32.9% | 5.9% 4.0% 47.1% |
|TERMINAL (d) | 0/33 (0%) 2/17 (12%) 2/16 (13%) | 1/29 (3%) 1/25 (4%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 723 701 423 | 680 736 (T) 642 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.016 * P=0.001 ** | P=0.003 ** P=0.537N P=0.003 ** |
|INCIDENTAL TUMOR | P=0.012 * P=0.091 P=0.026 * | P=0.146 P=0.501N P=0.324 |
|LOGISTIC REGRESSION | P=0.004 ** P=0.032 * P=0.009 ** | P=0.028 * P=0.499N P=0.040 * |
|COCHRAN-ARMITAGE | P=0.004 ** | P=0.081 |
|FISHER EXACT | P=0.059 P=0.004 ** | P=0.500N P=0.134 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.7% 0.0% 2.3% | 3.4% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 660 --- 610 | 736 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397N P=0.290N P=0.550N | P=0.490N P=0.530N P=0.962N |
|INCIDENTAL TUMOR | P=0.145N P=0.133N P=0.205N | P=0.490N P=0.530N P=0.962N |
|LOGISTIC REGRESSION | P=0.340N P=0.238N P=0.442N | P=0.490N P=0.530N P=0.962N |
|COCHRAN-ARMITAGE | P=0.352N | P=0.274N |
|FISHER EXACT | P=0.247N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 0/50 (0%) | 2/50 (4%) 4/50 (8%) 2/50 (4%) |
|ADJUSTED (b) | 7.9% 15.2% 0.0% | 6.9% 14.2% 13.9% |
|TERMINAL (d) | 1/33 (3%) 1/17 (6%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 715 663 --- | 736 (T) 673 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.273N P=0.308 P=0.193N | P=0.083 P=0.281 P=0.150 |
|INCIDENTAL TUMOR | P=0.085N P=0.600 P=0.084N | P=0.273 P=0.302 P=0.507 |
|LOGISTIC REGRESSION | P=0.159N P=0.429 P=0.146N | P=0.357 P=0.332 P=0.482 |
|COCHRAN-ARMITAGE | P=0.132N | P=0.578 |
|FISHER EXACT | P=0.500 P=0.121N | P=0.339 P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 0/50 (0%) | 2/50 (4%) 4/50 (8%) 2/50 (4%) |
|ADJUSTED (b) | 7.9% 17.2% 0.0% | 6.9% 14.2% 13.9% |
|TERMINAL (d) | 1/33 (3%) 1/17 (6%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 715 556 --- | 736 (T) 673 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291N P=0.200 P=0.193N | P=0.083 P=0.281 P=0.150 |
|INCIDENTAL TUMOR | P=0.069N P=0.526 P=0.084N | P=0.273 P=0.302 P=0.507 |
|LOGISTIC REGRESSION | P=0.159N P=0.329 P=0.146N | P=0.357 P=0.332 P=0.482 |
|COCHRAN-ARMITAGE | P=0.152N | P=0.578 |
|FISHER EXACT | P=0.357 P=0.121N | P=0.339 P=0.691N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 15.2% 8.4% | 0.0% 0.0% 7.1% |
|TERMINAL (d) | 1/33 (3%) 0/17 (0%) 1/16 (6%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 715 704 610 | --- --- 717 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372 P=0.188 P=0.539 | P=0.180 (e) P=0.329 |
|INCIDENTAL TUMOR | P=0.460N P=0.487 P=0.659N | P=0.413 (e) P=0.662 |
|LOGISTIC REGRESSION | P=0.536 P=0.251 P=0.698 | P=0.220 (e) P=0.390 |
|COCHRAN-ARMITAGE | P=0.578 | P=0.293 |
|FISHER EXACT | P=0.339 P=0.691N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 33/50 (66%) 42/50 (84%) | 5/50 (10%) 31/50 (62%) 48/50 (96%) |
|ADJUSTED (b) | 51.7% 86.4% 100.0% | 17.2% 78.5% 100.0% |
|TERMINAL (d) | 15/33 (45%) 12/17 (71%) 16/16 (100%) | 5/29 (17%) 17/25 (68%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 550 444 498 | 736 (T) 446 360 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.002 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.008 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 33/50 (66%) 34/50 (68%) | 2/50 (4%) 7/50 (14%) 27/50 (54%) |
|ADJUSTED (b) | 17.1% 77.4% 77.9% | 5.8% 21.8% 94.7% |
|TERMINAL (d) | 0/33 (0%) 8/17 (47%) 7/16 (44%) | 1/29 (3%) 3/25 (12%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 646 499 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.070 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.082 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.081 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.080 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 33/50 (66%) 34/50 (68%) | 2/50 (4%) 7/50 (14%) 27/50 (54%) |
|ADJUSTED (b) | 17.1% 77.4% 77.9% | 5.8% 21.8% 94.7% |
|TERMINAL (d) | 0/33 (0%) 8/17 (47%) 7/16 (44%) | 1/29 (3%) 3/25 (12%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 646 499 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.070 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.082 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.081 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.080 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 44/50 (88%) 50/50 (100%) | 7/50 (14%) 35/50 (70%) 50/50 (100%) |
|ADJUSTED (b) | 58.9% 97.8% 100.0% | 22.6% 82.7% 100.0% |
|TERMINAL (d) | 15/33 (45%) 16/17 (94%) 16/16 (100%) | 6/29 (21%) 18/25 (72%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 646 446 360 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 44/50 (88%) 50/50 (100%) | 7/50 (14%) 35/50 (70%) 50/50 (100%) |
|ADJUSTED (b) | 58.9% 97.8% 100.0% | 22.6% 82.7% 100.0% |
|TERMINAL (d) | 15/33 (45%) 16/17 (94%) 16/16 (100%) | 6/29 (21%) 18/25 (72%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 646 446 360 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 557 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613 P=0.204 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.505N P=0.439 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.669 P=0.261 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.650 | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 7/50 (14%) 16/50 (32%) | 3/50 (6%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 23.8% 30.3% 58.4% | 8.7% 13.6% 37.0% |
|TERMINAL (d) | 6/33 (18%) 4/17 (24%) 6/16 (38%) | 1/29 (3%) 2/25 (8%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 638 556 577 | 690 673 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** P=0.410 P=0.004 ** | P=0.104 P=0.454 P=0.159 |
|INCIDENTAL TUMOR | P=0.056 P=0.475N P=0.097 | P=0.520N P=0.555 P=0.490N |
|LOGISTIC REGRESSION | P=0.041 * P=0.478N P=0.044 * | P=0.391 P=0.502 P=0.474 |
|COCHRAN-ARMITAGE | P=0.065 | P=0.578 |
|FISHER EXACT | P=0.393N P=0.083 | P=0.500 P=0.661N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 11.0% 11.6% 0.0% | 6.0% 4.9% 2.7% |
|TERMINAL (d) | 3/33 (9%) 1/17 (6%) 0/16 (0%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 542 584 --- | 690 627 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.151N P=0.571 P=0.148N | P=0.612N P=0.685 P=0.704 |
|INCIDENTAL TUMOR | P=0.083N P=0.577N P=0.173N | P=0.223N P=0.635N P=0.496N |
|LOGISTIC REGRESSION | P=0.052N P=0.507N P=0.053N | P=0.388N P=0.695 P=0.511N |
|COCHRAN-ARMITAGE | P=0.053N | P=0.402N |
|FISHER EXACT | P=0.500N P=0.059N | P=0.691N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 10/50 (20%) 16/50 (32%) | 4/50 (8%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 33.7% 39.5% 58.4% | 11.9% 17.9% 38.7% |
|TERMINAL (d) | 9/33 (27%) 5/17 (29%) 6/16 (38%) | 2/29 (7%) 2/25 (8%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 542 556 577 | 690 627 586 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * P=0.373 P=0.029 * | P=0.089 P=0.336 P=0.099 |
|INCIDENTAL TUMOR | P=0.250 P=0.425N P=0.282 | P=0.441N P=0.437 P=0.557N |
|LOGISTIC REGRESSION | P=0.241 P=0.387N P=0.248 | P=0.445 P=0.372 P=0.507 |
|COCHRAN-ARMITAGE | P=0.303 | P=0.561 |
|FISHER EXACT | P=0.318N P=0.330 | P=0.370 P=0.643N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.3% 2.9% 28.3% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 3/29 (10%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 736 (T) 702 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.168 P=0.346N P=0.046 * |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.560 P=0.319N P=0.397 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.415 P=0.310N P=0.342 |
|COCHRAN-ARMITAGE | (e) | P=0.583N |
|FISHER EXACT | (e) (e) | P=0.309N P=0.661N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/44 (0%) 1/48 (2%) | 25/49 (51%) 19/47 (40%) 9/46 (20%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% | 68.7% 58.2% 35.9% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 18/29 (62%) 11/24 (46%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 641 | 557 646 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.280 (e) P=0.477 | P=0.284 P=0.357N P=0.215 |
|INCIDENTAL TUMOR | P=0.514 (e) P=0.814 | P=0.017N* P=0.225N P=0.044N* |
|LOGISTIC REGRESSION | P=0.292 (e) P=0.541 | P=0.009N** P=0.204N P=0.008N** |
|COCHRAN-ARMITAGE | P=0.290 | P=0.001N** |
|FISHER EXACT | (e) P=0.490 | P=0.201N P=0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/44 (0%) 1/48 (2%) | 26/49 (53%) 19/47 (40%) 9/46 (20%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% | 71.5% 58.2% 35.9% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 19/29 (66%) 11/24 (46%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 641 | 557 646 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.280 (e) P=0.477 | P=0.328 P=0.295N P=0.225 |
|INCIDENTAL TUMOR | P=0.514 (e) P=0.814 | P=0.012N* P=0.170N P=0.040N* |
|LOGISTIC REGRESSION | P=0.292 (e) P=0.541 | P=0.005N** P=0.149N P=0.005N** |
|COCHRAN-ARMITAGE | P=0.290 | P<0.001N** |
|FISHER EXACT | (e) P=0.490 | P=0.150N P<0.001N** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.1% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/33 (9%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.259N P=0.273N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.108N P=0.259N P=0.273N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.108N P=0.259N P=0.273N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.035N* | (e) |
|FISHER EXACT | P=0.121N P=0.121N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 11.4% 3.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 698 722 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.245 P=0.071 P=0.439 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.546 P=0.220 P=0.621 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.315 P=0.092 P=0.468 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360 | (e) |
|FISHER EXACT | P=0.121 P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibroma or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.1% 5.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/33 (9%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187N P=0.561N P=0.273N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.187N P=0.561N P=0.273N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.187N P=0.561N P=0.273N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.061N | (e) |
|FISHER EXACT | P=0.309N P=0.121N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 6/50 (12%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 11.2% 23.8% 8.4% | 0.0% 5.4% 0.0% |
|TERMINAL (d) | 3/33 (9%) 2/17 (12%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.419 P=0.138 P=0.597 | P=0.538 P=0.238 (e) |
|INCIDENTAL TUMOR | P=0.353N P=0.358 P=0.415N | P=0.493N P=0.297 (e) |
|LOGISTIC REGRESSION | P=0.481N P=0.287 P=0.502N | P=0.650 P=0.237 (e) |
|COCHRAN-ARMITAGE | P=0.450N | P=0.650 |
|FISHER EXACT | P=0.370 P=0.500N | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 2.3% 18.7% 8.4% | 0.0% 5.4% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.150 P=0.048 * P=0.251 | P=0.538 P=0.238 (e) |
|INCIDENTAL TUMOR | P=0.520 P=0.214 P=0.622 | P=0.493N P=0.297 (e) |
|LOGISTIC REGRESSION | P=0.247 P=0.085 P=0.346 | P=0.650 P=0.237 (e) |
|COCHRAN-ARMITAGE | P=0.250 | P=0.650 |
|FISHER EXACT | P=0.102 P=0.309 | P=0.247 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 2.3% 8.2% 5.1% | 0.0% 5.4% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314 P=0.386 P=0.458 | P=0.538 P=0.238 (e) |
|INCIDENTAL TUMOR | P=0.614 P=0.620 P=0.687N | P=0.493N P=0.297 (e) |
|LOGISTIC REGRESSION | P=0.404 P=0.505 P=0.565 | P=0.650 P=0.237 (e) |
|COCHRAN-ARMITAGE | P=0.393 | P=0.650 |
|FISHER EXACT | P=0.500 P=0.500 | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/49 (4%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 7.4% 0.0% 8.5% | 3.4% 0.0% 15.6% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 1/16 (6%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 660 --- 621 | 736 (T) --- 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508N P=0.183N P=0.649N | P=0.125 P=0.530N P=0.100 |
|INCIDENTAL TUMOR | P=0.224N P=0.045N* P=0.280N | P=0.395 P=0.530N P=0.471 |
|LOGISTIC REGRESSION | P=0.386N P=0.130N P=0.491N | P=0.228 P=0.530N P=0.253 |
|COCHRAN-ARMITAGE | P=0.380N | P=0.388 |
|FISHER EXACT | P=0.121N P=0.510N | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) | 2/50 (4%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 3.3% 15.2% | 6.9% 19.7% 26.9% |
|TERMINAL (d) | 0/33 (0%) 0/17 (0%) 2/16 (13%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | --- 719 716 | 736 (T) 638 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029 * P=0.453 P=0.047 * | P=0.018 * P=0.108 P=0.025 * |
|INCIDENTAL TUMOR | P=0.051 P=0.602 P=0.070 | P=0.287 P=0.138 P=0.365 |
|LOGISTIC REGRESSION | P=0.045 * P=0.467 P=0.077 | P=0.172 P=0.133 P=0.178 |
|COCHRAN-ARMITAGE | P=0.065 | P=0.406 |
|FISHER EXACT | P=0.500 P=0.121 | P=0.134 P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 3.0% 0.0% 0.0% | 6.9% 12.0% 6.5% |
|TERMINAL (d) | 1/33 (3%) 0/17 (0%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- --- | 736 (T) 736 (T) 601 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392N P=0.632N P=0.644N | P=0.112 P=0.431 P=0.252 |
|INCIDENTAL TUMOR | P=0.392N P=0.632N P=0.644N | P=0.232 P=0.431 P=0.540 |
|LOGISTIC REGRESSION | P=0.392N P=0.632N P=0.644N | P=0.481 P=0.431 P=0.659 |
|COCHRAN-ARMITAGE | P=0.274N | P=0.592 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.691N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 3.0% 0.0% 6.3% | 6.9% 12.0% 6.5% |
|TERMINAL (d) | 1/33 (3%) 0/17 (0%) 1/16 (6%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 736 (T) | 736 (T) 736 (T) 601 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.518 P=0.632N P=0.592 | P=0.112 P=0.431 P=0.252 |
|INCIDENTAL TUMOR | P=0.518 P=0.632N P=0.592 | P=0.232 P=0.431 P=0.540 |
|LOGISTIC REGRESSION | P=0.518 P=0.632N P=0.592 | P=0.481 P=0.431 P=0.659 |
|COCHRAN-ARMITAGE | P=0.665N | P=0.592 |
|FISHER EXACT | P=0.500N P=0.753N | P=0.500 P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | | 6.4% 0.0% 14.0% |
|TERMINAL (d) | | 1/29 (3%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | | 718 --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.085 P=0.267N P=0.082 |
|INCIDENTAL TUMOR | | P=0.468 P=0.223N P=0.580 |
|LOGISTIC REGRESSION | | P=0.270 P=0.240N P=0.345 |
|COCHRAN-ARMITAGE | | P=0.249 |
|FISHER EXACT | | P=0.247N P=0.339 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 5.5% 0.0% 0.0% |
|TERMINAL (d) | | 1/29 (3%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | | 494 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.152N P=0.256N P=0.454N |
|INCIDENTAL TUMOR | | P=0.126N P=0.313N P=0.371N |
|LOGISTIC REGRESSION | | P=0.072N P=0.234N P=0.184N |
|COCHRAN-ARMITAGE | | P=0.094N |
|FISHER EXACT | | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | | 11.6% 0.0% 14.0% |
|TERMINAL (d) | | 2/29 (7%) 0/25 (0%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | | 494 --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.327 P=0.079N P=0.217 |
|INCIDENTAL TUMOR | | P=0.398N P=0.081N P=0.543N |
|LOGISTIC REGRESSION | | P=0.503N P=0.063N P=0.597N |
|COCHRAN-ARMITAGE | | P=0.563N |
|FISHER EXACT | | P=0.059N P=0.643N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 5/50 (10%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 12.2% 19.0% 19.1% | 5.4% 8.0% 21.7% |
|TERMINAL (d) | 1/33 (3%) 0/17 (0%) 2/16 (13%) | 1/29 (3%) 2/25 (8%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 660 704 610 | 430 736 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.315 P=0.405 P=0.403 | P=0.076 P=0.654 P=0.132 |
|INCIDENTAL TUMOR | P=0.307N P=0.364N P=0.391N | P=0.321 P=0.607 P=0.607 |
|LOGISTIC REGRESSION | P=0.533 P=0.546 P=0.614N | P=0.386 P=0.694 P=0.506 |
|COCHRAN-ARMITAGE | P=0.571 | P=0.417 |
|FISHER EXACT | P=0.630N P=0.630N | P=0.691N P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 5/50 (10%) | 3/50 (6%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 12.2% 19.0% 19.1% | 8.8% 8.0% 21.7% |
|TERMINAL (d) | 1/33 (3%) 0/17 (0%) 2/16 (13%) | 2/29 (7%) 2/25 (8%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 660 704 610 | 430 736 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.315 P=0.405 P=0.403 | P=0.139 P=0.554N P=0.154 |
|INCIDENTAL TUMOR | P=0.307N P=0.364N P=0.391N | P=0.433 P=0.600N P=0.629 |
|LOGISTIC REGRESSION | P=0.533 P=0.546 P=0.614N | P=0.552 P=0.501N P=0.639 |
|COCHRAN-ARMITAGE | P=0.571 | P=0.586N |
|FISHER EXACT | P=0.630N P=0.630N | P=0.500N P=0.661N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 12/50 (24%) 1/50 (2%) | 20/50 (40%) 14/50 (28%) 7/50 (14%) |
|ADJUSTED (b) | 13.5% 44.2% 2.3% | 55.9% 41.8% 50.1% |
|TERMINAL (d) | 3/33 (9%) 5/17 (29%) 0/16 (0%) | 14/29 (48%) 7/25 (28%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 676 600 612 | 414 446 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.006 ** P=0.242N | P=0.438 P=0.266N P=0.217 |
|INCIDENTAL TUMOR | P=0.145N P=0.046 * P=0.072N | P=0.019N* P=0.170N P=0.071N |
|LOGISTIC REGRESSION | P=0.218N P=0.025 * P=0.105N | P=0.011N* P=0.141N P=0.023N* |
|COCHRAN-ARMITAGE | P=0.173N | P=0.003N** |
|FISHER EXACT | P=0.054 P=0.102N | P=0.146N P=0.003N** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 12/50 (24%) 1/50 (2%) | 20/50 (40%) 14/50 (28%) 7/50 (14%) |
|ADJUSTED (b) | 13.5% 44.2% 2.3% | 55.9% 41.8% 50.1% |
|TERMINAL (d) | 3/33 (9%) 5/17 (29%) 0/16 (0%) | 14/29 (48%) 7/25 (28%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 676 600 612 | 414 446 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.006 ** P=0.242N | P=0.438 P=0.266N P=0.217 |
|INCIDENTAL TUMOR | P=0.145N P=0.046 * P=0.072N | P=0.019N* P=0.170N P=0.071N |
|LOGISTIC REGRESSION | P=0.218N P=0.025 * P=0.105N | P=0.011N* P=0.141N P=0.023N* |
|COCHRAN-ARMITAGE | P=0.173N | P=0.003N** |
|FISHER EXACT | P=0.054 P=0.102N | P=0.146N P=0.003N** |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 32/50 (64%) 38/50 (76%) 46/50 (92%) | 34/50 (68%) 38/50 (76%) 48/50 (96%) |
|ADJUSTED (b) | 77.6% 94.9% 100.0% | 86.9% 88.1% 100.0% |
|TERMINAL (d) | 24/33 (73%) 15/17 (88%) 16/16 (100%) | 24/29 (83%) 20/25 (80%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 550 444 423 | 557 446 360 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.136 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.017 * P<0.001 ** | P<0.001 ** P=0.244 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.017 * P<0.001 ** | P<0.001 ** P=0.264 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.138 P<0.001 ** | P=0.252 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. |
| | CONTROL MG/KG | CONTROL MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 41/50 (82%) 39/50 (78%) | 30/50 (60%) 24/50 (48%) 32/50 (64%) |
|ADJUSTED (b) | 41.7% 89.1% 86.1% | 73.9% 59.7% 95.9% |
|TERMINAL (d) | 7/33 (21%) 12/17 (71%) 10/16 (63%) | 19/29 (66%) 10/25 (40%) 1/2 (50%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 414 446 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.336N P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P=0.002 ** | P=0.503 P=0.193N P=0.281 |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.289 P=0.158N P=0.224 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.408 |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.158N P=0.418 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 43/50 (86%) 45/50 (90%) 50/50 (100%) | 43/50 (86%) 43/50 (86%) 50/50 (100%) |
|ADJUSTED (b) | 87.8% 97.8% 100.0% | 97.7% 93.4% 100.0% |
|TERMINAL (d) | 27/33 (82%) 16/17 (94%) 16/16 (100%) | 28/29 (97%) 22/25 (88%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 514 444 423 | 414 446 360 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.002 ** P<0.001 ** | P<0.001 ** P=0.315 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.028 * P=0.255 P=0.059 | P=0.003 ** P=0.530 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.002 ** P=0.050 * P=0.009 ** | P=0.006 ** P=0.606N P=0.005 ** |
|COCHRAN-ARMITAGE | P=0.009 ** | P=0.015 * |
|FISHER EXACT | P=0.380 P=0.006 ** | P=0.613N P=0.006 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
TERMINAL SACRIFICE AT 106 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 138311-138311/138311
--multipart-boundary--