TDMS Study 05004-04 Pathology Tables
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
Facility: Southern Research Institute
Chemical CAS #: 110-00-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 1 1 2 |
Hyperplasia, Lymphoid | 1 1 1 1 2 2 1 1 2 2 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Multifocal | 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 |
Mixed Cell Focus | 2 |
Necrosis, Multifocal | 1 |
Vacuolization Cytoplasmic | 2 2 |
Biliary Tract, Inflammation, Chronic | 2 |
Kupffer Cell, Pigmentation | 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Infarct | 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Focal | 1 1 |
Mineralization | 1 |
Mucosa, Erosion | |
Mucosa, Hyperplasia, Papillary | 1 1 2 |
Mucosa, Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Focal | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Degeneration, Hyaline | 2 2 |
Epithelium, Metaplasia, Squamous | 2 2 |
Mucosa, Cyst | 2 2 1 2 2 2|
Mucosa, Erosion | 2 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
Pulmonary Artery, Mineralization | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Subcapsular, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
Follicular Cell, Hyperplasia | 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Suppurative | 4 |
Follicle, Cyst | 2 3 2 3 4 3 3 2 1 3|
__________________________________________________________________________|
Oviduct | + + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 2 2 2 |
Inflammation, Suppurative | 4 3 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 3 4 4 2 3 2 3 3 4 2 3 3 4 3 3 4 3 3 3 2 4 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + M + M M M M + M + M M M M + M M + M + + + M|
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + M M + M M + M M M + + M + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 2 3 |
Hyperplasia, Lymphoid | 2 1 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M + + + + + + + + + M|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 1 2 2 2 3 |
Hyperplasia, Cystic | 2 |
Inflammation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + +|
Necrosis, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 2 1 1 2 1 2 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Hyperplasia, Lymphoid | 2 |
Mediastinum, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 1 1 1 2 2 1 1 2 1 1 3 3|
Lumen, Foreign Body | 1 1 1 1 2 2 2 1 2 1 3 3|
Mucosa, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Peritracheal Tissue, | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
Infiltration Cellular, Mixed Cell | |
Metaplasia, Osseous | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|
| 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 2 3 1 2 1 1 |
Capsule, Fibrosis, Focal | 2 |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Dilatation | 3 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Epithelium, Depletion | |
Cellular | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3| |
| 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoid Tissue, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 2 2 3 1 | 11 1.8|
Hyperplasia, Lymphoid | 2 1 2 1 2 1 1 1 2 1 1 2 1 1 1 1| 27 1.4|
Infiltration Cellular, Mixed Cell | 2 2 2 2 1 2 2 2 | 8 1.9|
Inflammation, Multifocal | 1 1 1 2 2 1 2 1 1 1 3 1 | 27 1.3|
Mixed Cell Focus | | 1 2.0|
Necrosis, Multifocal | 1 2 | 3 1.3|
Vacuolization Cytoplasmic | 1 1 2 2 | 6 1.7|
Biliary Tract, Inflammation, Chronic | 1 | 2 1.5|
Kupffer Cell, Pigmentation | 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 24 |
Edema | | 1 2.0|
Inflammation, Suppurative | 3 4 4 4 1 4 4 | 8 3.4|
Fat, Necrosis | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
Infarct | | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation, Focal | 2 2 2 1 2 2 2 2 | 10 1.7|
Mineralization | | 1 1.0|
Mucosa, Erosion | 2 | 1 2.0|
Mucosa, Hyperplasia, Papillary | 2 2 2 2 2 2 2 | 10 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3| |
| 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Ulcer | 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Focal | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Epithelium, Degeneration, Hyaline | | 2 2.0|
Epithelium, Metaplasia, Squamous | | 2 2.0|
Mucosa, Cyst | 2 2 2 2 2| 11 1.9|
Mucosa, Erosion | | 1 2.0|
Mucosa, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Tooth | + +| 2 |
Incisor, Dysplasia | 3 1| 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
Pulmonary Artery, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Subcapsular, Hyperplasia, Focal | 4 1 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 2 2 | 8 1.8|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 4 1.3|
Follicular Cell, Hyperplasia | 2 2 3 2 1 1 2| 14 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3| |
| 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 2 2.0|
Inflammation, Suppurative | 4 4 4 4 4 4 | 7 4.0|
Follicle, Cyst | 4 2 2 2 4 3 1 1 2 | 19 2.5|
__________________________________________________________________________|____________|
Oviduct | + + | 4 |
Inflammation, Suppurative | 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 1 2 | 8 2.1|
Inflammation, Suppurative | 3 2 2 3 4 4 | 8 3.1|
Thrombosis | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 2 3 3 4 3 3 2 4 3 4 3 3 4 4 2 3 3 3 3 3 3 4 4| 48 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Neutrophil | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Hyperplasia | 2 3 | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | 2 1 2 | 3 1.7|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia | 4 3 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + M M + + M + + M M M M M M + + M M M + +| 21 |
Hyperplasia, Lymphoid | 1 3 1| 4 1.8|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + M + +| 47 |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 41 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | 3 2 3 2 3 3 | 7 2.4|
Inflammation, Suppurative | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 2 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3| |
| 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 2 2 4 3 4 4 3 | 17 3.0|
Hyperplasia, Lymphoid | 2 3 2 2 2| 8 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Depletion Lymphoid | 2 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 1 2 1 1 2 2 1 3 2 2 1 2| 19 1.7|
Hyperplasia, Cystic | | 1 2.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 4 | 5 1.8|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Necrosis, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 | 1 4.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1| 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 3 | 2 2.0|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 2 1 1 1 1 2 2| 22 1.3|
Hyperplasia, Macrophage | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Mediastinum, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinum, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3| |
| 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 2 2 3 2 2 2 3 1 1 1 | 23 1.7|
Lumen, Foreign Body | 2 1 2 2 3 2 2 2 2 1 2 2 1 1 1 | 27 1.7|
Mucosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Peritracheal Tissue, | | |
Inflammation, Chronic | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Fibrosis | 1 3 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Mineralization | 2 | 2 1.5|
Nephropathy | 2 1 2 1 1 3 1 1 | 16 1.5|
Capsule, Fibrosis, Focal | | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Renal Tubule, Epithelium, Depletion | | |
Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|
| 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Gallbladder | M + + + + + M + + + + A + M + + + + + + + + + + +|
Infarct | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + A + + + + + + + + + + + + + + + + +|
Congestion | 2|
Mucosa, Hyperplasia, Adenomatous | |
Mucosa, Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Clear Cell Focus | |
Cyst | 3 |
Eosinophilic Focus | 2 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 2 2 3 3 3|
Infarct | 4 2 4 4 4 4 2 4 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2|
Mineralization | 3 |
Mixed Cell Focus | 2 |
Necrosis, Multifocal | |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Bile Duct, Dilatation | 3 2 4 |
Biliary Tract, Fibrosis | 3 3 3 3 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
Biliary Tract, Granuloma | |
Biliary Tract, Hyperplasia | 3 3 3 3 3 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
Biliary Tract, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2|
Hepatocyte, Cytomegaly | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hepatocyte, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Hepatocyte, Necrosis | 2 2 2 1 2 1 2 1 2 2 4 1 1 1 1 1 2 2 2 3 1 1 1 2|
Kupffer Cell, Pigmentation | 3 2 2 2 2 2 2 2 3 1 2 1 2 2 2 2 2 2 1 2 1 2 2 2 2|
Parenchyma, Atrophy, Multifocal | 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 2 3 3 3|
__________________________________________________________________________|
Mesentery | + + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|
| 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Fibrosis, Focal | |
Inflammation, Chronic | |
Acinus, Hypoplasia | 4 |
Artery, Inflammation, Chronic | 4 |
Duct, Cyst | 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Hyperplasia, Squamous | |
Inflammation, Focal | 1 2 1 2 1 1 2 |
Ulcer | |
Mucosa, Cyst | |
Mucosa, Erosion | 2 |
Mucosa, Hyperplasia, Papillary | 2 1 2 1 1 2 |
Mucosa, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Degeneration, Hyaline | 2|
Mucosa, Cyst | 1 2 2 1 2 2|
Mucosa, Dysplasia, Focal | |
Mucosa, Erosion | 1 2|
Mucosa, Hemorrhage | 2|
Mucosa, Hyperplasia | 2 2 2|
Mucosa, Mineralization | 2 |
Mucosa, Necrosis, Focal | 1 |
Mucosa, Necrosis, Multifocal | |
Mucosa, Pigmentation | |
__________________________________________________________________________|
Tongue | |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Tooth | + + + |
Incisor, Dysplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Abdominal, Inflammation, Chronic | 2 |
Mesenteric Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|
| 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 4 1 4 1 3|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 3|
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Ectopic Tissue | |
Fibrosis | 3 |
Inflammation, Suppurative | 4 4 |
Mineralization | 3 |
Pigmentation | 3 |
Artery, Inflammation, Chronic | |
Corpus Luteum, Degeneration | 3 |
Corpus Luteum, Granuloma | 3 |
Follicle, Cyst | 3 3 2 1 3 3 3 3 4 4 3 |
__________________________________________________________________________|
Oviduct | |
Ectopic Tissue | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|
| 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 4 2|
Hydrometra | 1 2 |
Inflammation, Suppurative | 3 2 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 3 2 3 3 3 3 3 3 3 2 3 3 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M M M M + M M + M + M + + + + M + M + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + M + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 3 3 3 2 3 3 3 2 3 3 4 3 3|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M M + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 2 |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|
| 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia, Lymphoid | 1 1 2 1 1 3 1 2 2 1 2 1 1 1 1 1 1 1|
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | |
Mediastinum, Foreign Body | |
Mediastinum, Hemorrhage | |
Mediastinum, Hyperplasia, Lymphoid | |
Mediastinum, Inflammation, | |
Suppurative | |
Pleura, Fibrosis | |
Pleura, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 3 2 2 3 2|
Lumen, Foreign Body | 2 2 2 2 1 2 1 3 2 2|
Lumen, Hemorrhage | |
Lumen, Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + +|
Acinus, Dilatation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, | |
Polymorphonuclear | |
Mineralization | 1 1 |
Nephropathy | 3 3 1 1 1 4 1 2 1 1 1|
Artery, Inflammation, Chronic | 2 |
Interstitial Tissue, Pigmentation | |
Renal Tubule, Casts | 3 |
Renal Tubule, Dilatation | 3 1 |
Renal Tubule, Necrosis | 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + + M M| 43 |
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + A + + + + + + + A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + + + + + + + A + + + + + + + + + + +| 45 |
Congestion | | 1 2.0|
Mucosa, Hyperplasia, Adenomatous | 3 | 1 3.0|
Mucosa, Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A + + + + + + + A + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + + + + + A + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 4 | 3 3.7|
Clear Cell Focus | 2 | 1 2.0|
Cyst | | 1 3.0|
Eosinophilic Focus | | 1 2.0|
Granuloma | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1 1 2 | 42 1.2|
Hyperplasia, Multifocal | 3 3 3 2 3 3 3 3 3 3 4 2 3 3 3 3 3 3 3 4 3 3 3| 48 2.9|
Infarct | 4 4 3 | 11 3.5|
Infiltration Cellular, Mixed Cell | 1 2 2 2 2 2 2 1 2 2 3 1 2 2 2 2 2 | 32 1.9|
Mineralization | 2 | 2 2.5|
Mixed Cell Focus | 3 3 | 3 2.7|
Necrosis, Multifocal | 1 3 2 | 3 2.0|
Thrombosis | 3 3 | 3 3.0|
Vacuolization Cytoplasmic | 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| 36 1.9|
Bile Duct, Dilatation | 1 3 3 4 2 2 3 3 | 11 2.7|
Biliary Tract, Fibrosis | 2 2 3 3 3 1 2 3 2 2 2 2 2 2 3 3 2 2 2 2 2 3 2 2 2| 50 2.3|
Biliary Tract, Granuloma | 3 | 1 3.0|
Biliary Tract, Hyperplasia | 2 2 3 3 2 1 2 3 2 3 2 2 2 2 3 2 3 2 2 2 2 3 2 2 2| 50 2.3|
Biliary Tract, Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2| 50 2.0|
Hepatocyte, Cytomegaly | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Degeneration | 2 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0|
Hepatocyte, Necrosis | 1 1 1 3 1 2 1 2 1 1 2 1 1 1 2 2 2 2 1 1 2 1 1| 47 1.6|
Kupffer Cell, Pigmentation | 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2| 50 2.0|
Parenchyma, Atrophy, Multifocal | 3 2 3 3 3 1 2 2 3 3 2 3 3 2 3 3 3 3 3 3 2 3 3 2 3| 50 2.7|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Suppurative | 4 | 3 3.3|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 3 | 2 2.5|
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Hypoplasia | | 1 4.0|
Artery, Inflammation, Chronic | 4 | 2 4.0|
Duct, Cyst | 3 | 2 3.5|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Hyperplasia | 2 2 | 2 2.0|
Hyperplasia, Squamous | 2 3 | 2 2.5|
Inflammation, Focal | 2 2 | 9 1.6|
Ulcer | 2 | 1 2.0|
Mucosa, Cyst | 2 | 1 2.0|
Mucosa, Erosion | | 1 2.0|
Mucosa, Hyperplasia, Papillary | 1 2 | 8 1.5|
Mucosa, Ulcer | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Degeneration, Hyaline | 2 | 2 2.0|
Mucosa, Cyst | 1 2 2 2 | 10 1.7|
Mucosa, Dysplasia, Focal | 1 | 1 1.0|
Mucosa, Erosion | | 2 1.5|
Mucosa, Hemorrhage | 2 | 2 2.0|
Mucosa, Hyperplasia | | 3 2.0|
Mucosa, Mineralization | 2 | 2 2.0|
Mucosa, Necrosis, Focal | | 1 1.0|
Mucosa, Necrosis, Multifocal | 2 | 1 2.0|
Mucosa, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Dysplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Abdominal, Inflammation, Chronic | | 1 2.0|
Mesenteric Artery, Inflammation, | | |
Chronic | 4 | 2 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 3 | 1 3.0|
Atrium, Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 1 | 8 2.5|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + + M + + + + + + + + + + M + + + + + + + +| 46 |
Pars Distalis, Angiectasis | 2 3 3 | 4 2.5|
Pars Distalis, Cyst | 2 | 2 2.5|
Pars Distalis, Hyperplasia, Focal | 2 | 5 1.6|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 1 | 7 1.4|
Follicular Cell, Hyperplasia | 1 1 2 1 3 2| 8 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Ectopic Tissue | 4 | 1 4.0|
Fibrosis | | 1 3.0|
Inflammation, Suppurative | 4 | 3 4.0|
Mineralization | | 1 3.0|
Pigmentation | | 1 3.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Corpus Luteum, Degeneration | | 1 3.0|
Corpus Luteum, Granuloma | | 1 3.0|
Follicle, Cyst | 4 3 3 4 3 3 2 3 4 2| 21 3.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Ectopic Tissue | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 3 3.0|
Hydrometra | 3 1 2 1 4 | 7 2.0|
Inflammation, Suppurative | 4 1 | 5 2.4|
Endometrium, Hyperplasia, Cystic | 2 3 3 2 2 3 3 3 3 3 3 2 3 3 3 2 4 2 3 4 2 2 2| 42 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M + M M + M + M M + M M + + M M M M M M + M| 21 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + + + M + + + M + + + + + M + + +| 43 |
Angiectasis | 3 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Hyperplasia | 3 | 2 2.5|
Inflammation, Suppurative | 3 | 1 3.0|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 3 2 3 3 3 3 3 3 3 2 3 | 34 2.8|
Hyperplasia, Lymphoid | 2 2 2 2 2 3 | 7 2.3|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + M + + + + M + + + +| 45 |
Depletion Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
Dilatation | 2 2 2 2 2 2 2 2 2 3 2| 18 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.5|
Ulcer | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | 3 4 | 2 3.5|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fracture | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 | 4 2.3|
Hyperplasia, Lymphoid | 2 1 2 2 1 2 1 1 1 1 | 28 1.4|
Hyperplasia, Macrophage | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 2 | 2 2.0|
Mediastinum, Foreign Body | 4 | 1 4.0|
Mediastinum, Hemorrhage | 4 | 1 4.0|
Mediastinum, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 | 1 4.0|
Pleura, Fibrosis | 3 | 1 3.0|
Pleura, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1| |
| 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Exudate | 2 2 3 2 2 3 1 1 3 2 1 1 1 3 3| 20 2.1|
Lumen, Foreign Body | 2 2 2 2 2 1 2 2 2 3 2 1 2 1 3 3| 26 2.0|
Lumen, Hemorrhage | 2 | 1 2.0|
Lumen, Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
Acinus, Dilatation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Hydronephrosis | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
Mineralization | 2 3 | 4 1.8|
Nephropathy | 4 2 1 1 2 2 2 1 1 2 2 | 22 1.8|
Artery, Inflammation, Chronic | 3 | 2 2.5|
Interstitial Tissue, Pigmentation | 2 2 | 2 2.0|
Renal Tubule, Casts | | 1 3.0|
Renal Tubule, Dilatation | 2 1 | 4 1.8|
Renal Tubule, Necrosis | 1 2 | 4 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | 3 |
Mucosa, Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Mucosa, Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 |
Congestion | |
Cyst | 2 |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 4 3 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 1 2 1 2 2 2 2 1 1 1 1 2 1 |
Hyperplasia, Multifocal | 2 2 2 2 3 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 3 2 2 2 2|
Infarct | 4 3 4 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 3 2 |
Inflammation, Multifocal | 2 2 2 2 2 |
Mineralization | 2 |
Mixed Cell Focus | |
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic | 2 1 2 1 3 2 3 1 1 1 1 1 1|
Bile Duct, Dilatation | 3 |
Biliary Tract, Fibrosis | 1 3 2 3 2 2 1 2 2 1 1 1 1 2 3 1 1 1 1 2 2 1 2 1|
Biliary Tract, Hyperplasia | 1 2 2 3 2 2 1 1 2 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1|
Biliary Tract, Inflammation, Chronic | 1 1 2 1 2 2 2 1 2 2 1 1 1 1 2 2 1 1 1 1 2 2 1 1 1|
Hepatocyte, Cytomegaly | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Hepatocyte, Degeneration | 2 1 2 2 2 2 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2|
Hepatocyte, Necrosis | 1 1 2 1 2 1 1 1 2 1 1 1 1 2 2 1 1 1 1 1 3 1|
Kupffer Cell, Pigmentation | 1 1 2 1 3 2 2 1 2 2 1 1 1 1 2 2 1 1 1 1 3 2 2 2 1|
Parenchyma, Atrophy, Focal | 3 |
Parenchyma, Atrophy, Multifocal | 2 2 2 3 3 3 1 1 2 2 1 2 2 2 3 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fat, Necrosis | 3 3 1 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Papillary | 3 |
Inflammation, Focal | 1 1 1 |
Mucosa, Erosion | 2 |
Mucosa, Hyperplasia, Papillary | 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 |
Mineralization | |
Epithelium, Degeneration, Hyaline | 2 2 |
Epithelium, Metaplasia, Squamous | 2 |
Epithelium, Vacuolization | |
Cytoplasmic, Multifocal | |
Mucosa, Cyst | 2 2 1 2 1 |
Mucosa, Erosion | 1 |
Mucosa, Hyperplasia | 2 2 |
Mucosa, Mineralization | |
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | |
Angiectasis | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
Pulmonary Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | 2 |
Cytologic Alterations, Focal | 1 |
Developmental Malformation | |
Vacuolization Cytoplasmic, Focal | 2 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | 1 1|
Subcapsular, Hyperplasia, Focal | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 1 |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | 1 1 2 1 1 2|
Pars Intermedia, Vacuolization | |
Cytoplasmic | 2 |
Pars Nervosa, Hyperplasia, Focal | 2 |
Rathke's Cleft, Hemorrhage | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 1 |
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 4 4 4|
Corpus Luteum, Degeneration | 3 |
Corpus Luteum, Granuloma | 3 |
Follicle, Cyst | 2 2 4 2 1 1 2 3 1|
__________________________________________________________________________|
Oviduct | +|
Inflammation, Suppurative | 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 2 2 2 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 2 3 2 2 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 4 3 3 3 2 3 3 4 1 3 3 4 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | |
Hyperplasia, Neutrophil | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia | |
Lumbar, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Inflammation, Suppurative| |
Popliteal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + M M M + M + + + + M + + + + M + + + +|
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 4 3 3 |
Hyperplasia, Lymphoid | 2 2 2 1 2 2|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 1 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1|
Ulcer | |
Subcutaneous Tissue, Infiltration | |
Cellular, Mixed Cell | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 3 |
Subcutaneous Tissue, Fat, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | 2 |
Trabecula, Cranium, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Hindlimb, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 1 1 1 2|
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Suppurative | 3 |
Fat, Mediastinum, Necrosis | 2 |
Mediastinum, Hyperplasia, Lymphoid | |
Mediastinum, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 2 2 2 2 2 2 1 1|
Lumen, Foreign Body | 1 2 2 2 1 2 2 1 2 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Acinus, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|
| 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Infiltration Cellular, Mixed Cell | |
Metaplasia, Osseous | |
Mineralization | 2 2 |
Nephropathy | 1 2 2 2 2 1 1 1 |
Renal Tubule, Bacterium | |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 |
Inflammation, Chronic | | 1 3.0|
Mucosa, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 |
Mucosa, Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | | 1 2.0|
Congestion | 4 | 1 4.0|
Cyst | | 1 2.0|
Eosinophilic Focus | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 | 9 2.6|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 1 1 2 2 1 2 1 2 2 2 1 2 2 2 1 1 1| 33 1.5|
Hyperplasia, Multifocal | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2 2| 48 2.0|
Infarct | 3 2 2 4 | 7 3.1|
Infiltration Cellular, Mixed Cell | 3 2 1 3 3 2 2 2 1 2 1 1 | 23 2.0|
Inflammation, Multifocal | 1 1 1 2 2 1 1 1| 13 1.5|
Mineralization | | 1 2.0|
Mixed Cell Focus | 3 2 3 3 2 | 5 2.6|
Necrosis, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic | 1 3 1 1 1 1 1 2 1 1 1 2 1 1 1 1| 29 1.4|
Bile Duct, Dilatation | | 1 3.0|
Biliary Tract, Fibrosis | 2 1 1 1 1 3 2 3 1 2 2 1 1 1 1 2 2 1 1 1 1 1 1| 47 1.5|
Biliary Tract, Hyperplasia | 2 1 1 1 1 2 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 47 1.3|
Biliary Tract, Inflammation, Chronic | 1 1 1 1 1 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.3|
Hepatocyte, Cytomegaly | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 48 2.0|
Hepatocyte, Degeneration | 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 2 2 2 2| 47 2.0|
Hepatocyte, Necrosis | 1 1 1 1 1 2 1 1 1 1 3 1 1 1 1 2 1 2 1 1 1 1| 44 1.3|
Kupffer Cell, Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 1 2 1 1 1 1 1 1| 48 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Parenchyma, Atrophy, Focal | | 1 3.0|
Parenchyma, Atrophy, Multifocal | 2 2 2 1 1 3 2 2 2 2 2 2 2 1 1 3 2 2 2 2 2 1 2 2| 47 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + | 27 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 4 3 4 3 4 | 7 3.7|
Fat, Necrosis | 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 1 1 1 1 | 5 1.2|
Inflammation, Chronic | | 1 3.0|
Acinar Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
Hyperplasia, Papillary | | 1 3.0|
Inflammation, Focal | 1 2 1 2 | 7 1.3|
Mucosa, Erosion | 1 | 2 1.5|
Mucosa, Hyperplasia, Papillary | 1 2 1 2 | 10 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Mineralization | 1 2 1 | 3 1.3|
Epithelium, Degeneration, Hyaline | 2 2 2 | 5 2.0|
Epithelium, Metaplasia, Squamous | | 1 2.0|
Epithelium, Vacuolization | | |
Cytoplasmic, Multifocal | 3 | 1 3.0|
Mucosa, Cyst | 2 2 2 1 2 1 1| 12 1.6|
Mucosa, Erosion | 1 | 2 1.0|
Mucosa, Hyperplasia | 2 2 1| 5 1.8|
Mucosa, Mineralization | 1 | 1 1.0|
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + +| 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mesenteric Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
Pulmonary Artery, Inflammation, | | |
Chronic | 1| 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.5|
Cytologic Alterations, Focal | | 1 1.0|
Developmental Malformation | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | | 2 1.0|
Subcapsular, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | | 1 1.0|
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + M + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis | 2 | 2 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 2 | 8 1.4|
Pars Intermedia, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Pars Nervosa, Hyperplasia, Focal | | 1 2.0|
Rathke's Cleft, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 4 1.3|
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 2 3 2 | 11 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Angiectasis | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 4 4 4 4 4 | 10 3.9|
Corpus Luteum, Degeneration | | 1 3.0|
Corpus Luteum, Granuloma | | 1 3.0|
Follicle, Cyst | 2 3 2 2 1 1 | 15 1.9|
__________________________________________________________________________|____________|
Oviduct | + + + | 4 |
Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hydrometra | 3 4 3| 7 2.7|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Suppurative | 3 3 1 | 9 2.3|
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 2 3 3 4 3 3 4 3 3 3 4 3 3 3 3 4 4| 47 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Neutrophil | 3 | 1 3.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 1| 2 1.5|
Inguinal, Hyperplasia | 2 3 | 2 2.5|
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Inflammation, Suppurative| 3 | 1 3.0|
Popliteal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M M M M M M + M + + M M M M M + + + + M +| 29 |
Hyperplasia, Lymphoid | 2 2 | 4 1.8|
Hyperplasia | 3 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + M + + + + + + + M + + + + + +| 46 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 2 2 | 4 1.8|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
Hyperplasia, Lymphoid | 3 2 2 2 2 | 6 2.3|
Hyperplasia | 3 4 2 3 2 | 6 2.8|
Inflammation, Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 2 | 3 2.3|
Hyperplasia, Lymphoid | 2 3 2 | 5 2.2|
Hyperplasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 4 2 3 4 4 3 2 2 3 3 | 17 3.2|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 | 14 1.9|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + I + + + + M + + +| 46 |
Angiectasis | 2 | 1 2.0|
Depletion Lymphoid | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 2 1 2 1 4 1 2 | 17 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 5 1.6|
Ulcer | 3 | 1 3.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Mixed Cell | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 3 | 2 3.0|
Subcutaneous Tissue, Fat, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Distal, Joint, Femur, Arthrosis | | 1 2.0|
Trabecula, Cranium, Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Hindlimb, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 1 2 2 2 2 2 1 1 2 1 1 1 1 2| 27 1.6|
Hyperplasia, Macrophage | 4 | 2 2.5|
Infiltration Cellular, Mixed Cell | 3 3 2 2 2 | 7 2.3|
Inflammation, Suppurative | 3 | 2 3.0|
Fat, Mediastinum, Necrosis | | 1 2.0|
Mediastinum, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinum, Inflammation, | | |
Suppurative | 3 4 3 4 | 5 3.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 2 1 2 2 2 3 2 1| 18 1.7|
Lumen, Foreign Body | 1 2 1 2 2 2 2 1 2 1 2 1 1| 26 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
Acinus, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Fibrosis | 2 2 2 1 | 4 1.8|
Infiltration Cellular, Mixed Cell | 2 2 2 | 3 2.0|
Metaplasia, Osseous | 2 2 | 2 2.0|
Mineralization | | 2 2.0|
Nephropathy | 2 3 1 2 1 2 1 1 1 1 1 1 1| 21 1.4|
Renal Tubule, Bacterium | 1 | 1 1.0|
Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Vacuolization | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3| |
| 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 2 1 2 1 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|
| 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Cyst | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Depletion Glycogen | 3 |
Eosinophilic Focus | |
Fibrosis, Focal | 1 3 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Hyperplasia, Multifocal | |
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Multifocal | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic | 2 2 1 |
Centrilobular, Necrosis | 3 |
Hepatocyte, Cytomegaly | 1 1 2 2 1 1 1 |
Hepatocyte, Mitotic Alteration | 2 |
Hepatocyte, Necrosis | 1 1 |
Kupffer Cell, Pigmentation | 1 2 |
Parenchyma, Atrophy, Focal | 3 |
__________________________________________________________________________|
Mesentery | + + +|
Fibrosis | |
Inflammation, Chronic | |
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Focal | 2 1 2 2 2 |
Mucosa, Erosion | 2 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|
| 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia, Papillary | 2 1 2 2 |
Mucosa, Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Epithelium, Degeneration, Hyaline | |
Mucosa, Cyst | |
Mucosa, Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + +|
Incisor, Dysplasia | 1 2 2 2 2 4 1 1 4 4 3 4 2 1 3 3 3 4|
Incisor, Inflammation, Suppurative | 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Abdominal, Thrombosis | X |
Thoracic, Artery, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic, Focal | |
Subcapsular, Hyperplasia, Focal | 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
Dilatation | 2|
__________________________________________________________________________|
Ductus Deferens | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|
| 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Degeneration, Cystic | |
Inflammation, Suppurative | 4 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Dilatation | |
Granuloma | |
Inflammation, Chronic | 1 4 |
Artery, Media, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Mineralization | |
Germinal Epithelium, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Angiectasis | 1 2 |
Inguinal, Congestion | |
Inguinal, Hyperplasia | 4 2 |
Pancreatic, Inflammation, Chronic, | |
Focal | 2 |
Renal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M M M M M M M + M + + + M + M + M M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + M + + + + + + + M + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 1 2 2 2 2 3 2 1 1 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 2 3 3 3 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + M + + + + M + +|
Cyst | |
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|
| 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Exudate | 2 |
Inflammation, Chronic | 2 2 2 2 |
Ulcer | |
Prepuce, Inflammation, Chronic | 3 |
Prepuce, Ulcer | 2 |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
Subcutaneous Tissue, Thrombosis | X |
Subcutaneous Tissue, Fat, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 1 1 1 1 2 1 2 2 1 1 |
Hyperplasia, Macrophage | 3 1 2 2 1 1 2 1 2 3|
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | |
Bronchus, Epithelium, Hyperplasia, | |
Papillary | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 2 2 2 |
Lumen, Foreign Body | 2 3 2 2 |
Lumen, Hemorrhage | 2 2 |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|
| 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis | 2 2 |
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | |
Metaplasia, Osseous | 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Nephropathy | 1 3 1 1 1 1 1 1 1 1 1 2 1 1 2 3 2 1|
Papilla, Necrosis | |
Pelvis, Dilatation | 2 |
Renal Tubule, Cyst | 2 2|
Renal Tubule, Dilatation | 3 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 2 1 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Depletion Glycogen | 3 | 2 3.0|
Eosinophilic Focus | 2 | 1 2.0|
Fibrosis, Focal | | 3 2.0|
Hematopoietic Cell Proliferation | 1 1 1 | 4 1.3|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 1 1 2 1 1 1| 26 1.1|
Hyperplasia, Multifocal | 1 | 1 1.0|
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | 1 | 2 1.0|
Inflammation, Multifocal | 1 1 1 1 1 1 1 | 17 1.0|
Necrosis, Multifocal | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 1 1 1 2 | 8 1.4|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Cytomegaly | 1 | 8 1.3|
Hepatocyte, Mitotic Alteration | | 1 2.0|
Hepatocyte, Necrosis | | 2 1.0|
Kupffer Cell, Pigmentation | | 2 1.5|
Parenchyma, Atrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Cyst Epithelial Inclusion | 1 | 1 1.0|
Inflammation, Focal | 1 3 2 2 | 9 1.9|
Mucosa, Erosion | | 2 2.0|
Mucosa, Hyperplasia, Papillary | 1 2 2 | 7 1.7|
Mucosa, Ulcer | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Inflammation, Focal | | 1 2.0|
Epithelium, Degeneration, Hyaline | 1 | 1 1.0|
Mucosa, Cyst | 1 | 1 1.0|
Mucosa, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Incisor, Dysplasia | 1 4 3 3 2 1 1 2 3 3 2 2 2 2 2 1 3 2 2 1 1 1 1 2 4| 43 2.3|
Incisor, Inflammation, Suppurative | 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Abdominal, Thrombosis | | 1 |
Thoracic, Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 | 1 3.0|
Hyperplasia, Focal | 1 | 2 1.0|
Vacuolization Cytoplasmic, Focal | 3 | 1 3.0|
Subcapsular, Hyperplasia, Focal | 2 2 1 2 | 7 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 2 1 2 2 | 6 1.7|
Pars Distalis, Hyperplasia, Focal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 2 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 2 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 | 2 1.5|
__________________________________________________________________________|____________|
Preputial Gland | + + | 6 |
Degeneration, Cystic | 2 | 1 2.0|
Inflammation, Suppurative | 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 | 1 2.0|
Dilatation | 2 | 1 2.0|
Granuloma | 2 | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Artery, Media, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Mineralization | 2 | 1 2.0|
Germinal Epithelium, Degeneration | 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Angiectasis | | 2 1.5|
Inguinal, Congestion | 2 | 1 2.0|
Inguinal, Hyperplasia | 3 1 | 4 2.5|
Pancreatic, Inflammation, Chronic, | | |
Focal | | 1 2.0|
Renal, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M + M M M M M M M M M M M M M M M M M M M M| 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + + M + + + + + + + + + M + + + M + M M M| 38 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 1 1 2 1 2| 21 1.8|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 5 2.8|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + M + + + + + M M + + + + M +| 42 |
Cyst | 1 | 1 1.0|
Depletion Lymphoid | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Exudate | | 1 2.0|
Inflammation, Chronic | 3 3 2 2 2 2| 11 2.2|
Ulcer | 4 1 1 2 | 4 2.0|
Prepuce, Inflammation, Chronic | | 1 3.0|
Prepuce, Ulcer | | 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Subcutaneous Tissue, Thrombosis | | 1 |
Subcutaneous Tissue, Fat, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hyperplasia, Lymphoid | 1 2 1 2 1 1 1 2 1 1 1 1| 23 1.3|
Hyperplasia, Macrophage | 1 1 1 1 1 | 15 1.5|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
Bronchus, Epithelium, Hyperplasia, | | |
Papillary | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 3 1 1 2 1 2 2 1 1 1 1 2| 16 1.6|
Lumen, Foreign Body | 3 1 1 2 1 2 1 2 1 1 1 1| 16 1.6|
Lumen, Hemorrhage | | 2 2.0|
Lumen, Inflammation, Suppurative | | 2 2.0|
Mucosa, Inflammation, Suppurative | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 1 2.0|
Fibrosis | | 2 2.0|
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
Nephropathy | 3 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 3 3 1 1 2| 41 1.4|
Papilla, Necrosis | 3 | 1 3.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Cyst | 2 | 3 2.0|
Renal Tubule, Dilatation | 2 | 3 2.3|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 3 | 6 2.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3| |
| 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|
| 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + + + M A + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Mucosa, Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2|
Basophilic Focus, Multiple, Two | 2|
Clear Cell Focus | |
Clear Cell Focus, Multiple, Three | |
Cyst | 3 |
Cytoplasmic Alteration, Focal | 2 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 1 2 1 1 2 1 1 1 1 1 2 1 |
Hyperplasia, Multifocal | 2 2 4 3 2 3 3 3 3 2 3 2 2 3 3 2 3 3 2 3 3 3 3 3 3|
Infarct | 2 4 4 3 |
Infarct, Multiple, Two | 4 |
Infiltration Cellular, Mixed Cell | 2 2 3 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1|
Inflammation, Multifocal | 2 |
Mineralization | |
Mixed Cell Focus | 2 |
Necrosis, Multifocal | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 |
Artery, Inflammation, Chronic | |
Bile Duct, Dilatation | 3 2 3 |
Biliary Tract, Fibrosis | 2 3 3 3 3 4 3 3 3 2 3 2 2 3 2 2 2 3 2 3 3 3 3 2 3|
Biliary Tract, Hyperplasia | 2 2 3 3 3 4 3 3 3 3 3 2 2 2 2 2 1 3 2 3 3 3 3 2 3|
Biliary Tract, Inflammation, Chronic | 2 2 3 2 2 3 2 2 3 2 2 2 2 2 2 2 2 3 2 2 3 2 3 2 3|
Centrilobular, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|
| 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hepatocyte, Cytomegaly | 2 2 3 3 2 3 3 2 3 2 2 2 2 3 2 3 3 3 2 3 3 3 2 3 3|
Hepatocyte, Degeneration | 2 2 3 2 2 2 2 2 2 1 2 1 2 1 2 1 2 2 2 2 2 2|
Hepatocyte, Necrosis | 2 2 2 1 1 2 1 1 2 2 2 2 1 1 1 1 1 1 1 1 2 1 2 1 2|
Hepatocyte, Pigmentation | 2 |
Kupffer Cell, Pigmentation | 2 1 3 2 2 3 2 2 2 2 3 2 2 2 1 2 2 3 1 2 2 2 2 1 2|
Parenchyma, Atrophy, Multifocal | 3 3 3 3 3 4 3 3 3 4 3 2 2 3 3 2 3 3 2 2 4 2 3 3 3|
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic | |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 2 2 2 2 2 1 2 2 3 2|
Mucosa, Erosion | 1 2 2|
Mucosa, Hyperplasia, Papillary | 2 3 2 2 2 2 2 2 2 3 3 2|
Mucosa, Inflammation, Focal | |
Mucosa, Mineralization | 2 |
Mucosa, Ulcer | 3 |
Mucosa, Ulcer, Multiple, Two | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 1 2 |
Mucosa, Cyst | |
Mucosa, Dysplasia | |
Mucosa, Erosion | |
Mucosa, Hyperplasia, Papillary | |
Mucosa, Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
Hemorrhage | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + +|
Incisor, Dysplasia | 2 2 3 1 3 4 1 1 2 2 1 1 1 2 3 1 2 1 3|
Incisor, Inflammation, Suppurative | 2 3 3|
Molar, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Abdominal, Inflammation, Chronic | 2 |
Abdominal, Adventitia, Thrombosis | 4 |
Aorta, Media, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|
| 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | |
Mesenteric Artery, Media, | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Coronary Artery, Mineralization | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Subcapsular, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 3 |
Hyperplasia | 2 2 3 |
Extra Adrenal Tissue, Ectopic Tissue | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
Pars Distalis, Cyst | |
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Degeneration, Cystic | 3 3 3 3 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Edema | 2 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|
| 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Germinal Epithelium, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Angiectasis | 3 |
Inguinal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + M + + M + + + + + M + M M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M + + + + + + + M + + + + + + M M + + +|
Depletion Lymphoid | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 2 2 2 2 2 2 |
Artery, Degeneration, Hyaline | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + M +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Inflammation, Chronic | 4 1 2 2 |
Ulcer | 4 1 2 |
Hair Follicle, Atrophy | 3 |
Prepuce, Fibrosis | 2 |
Prepuce, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|
| 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
15 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Granuloma | 2 1 |
Hyperplasia, Lymphoid | 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
Hyperplasia, Macrophage | 1 2 2 1 1 1 1 1 1 1 2|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Focal, Granulomatous | |
Inflammation, Focal | |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Bronchiole, Hyperplasia | 2 |
Mediastinum, Hemorrhage | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 |
Lumen, Foreign Body | 2 2 |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Congestion | 3 |
Fibrosis | 3 |
Hydronephrosis | 3 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Nephropathy | 1 3 1 4 4 2 2 2 1 2 2 3 1 3 3 3 2 2 2|
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Ureter | + + |
Serosa, Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + M + + + + + + + + + + + + + M + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Inflammation, Chronic | 3 | 2 3.0|
Mucosa, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
Mucosa, Hyperplasia, Papillary | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 2.7|
Basophilic Focus, Multiple, Two | | 1 2.0|
Clear Cell Focus | 2 | 1 2.0|
Clear Cell Focus, Multiple, Three | 2 | 1 2.0|
Cyst | | 1 3.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Eosinophilic Focus | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | 4 | 2 4.0|
Hyperplasia, Lymphoid | 2 1 1 1 1 1 2 2 1 2 | 22 1.3|
Hyperplasia, Multifocal | 3 3 3 3 2 2 3 2 2 3 3 3 2 3 2 2 3 2 3 3 3 3 3 3| 49 2.7|
Infarct | 4 2 4 4 2 4 4 | 11 3.4|
Infarct, Multiple, Two | | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 1 2 1 1 1 1 | 29 1.3|
Inflammation, Multifocal | 2 | 2 2.0|
Mineralization | 3 3 3 | 3 3.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Multifocal | 3 3 | 3 2.7|
Thrombosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 1 2 2 3 2 2 2 2 1 2 2 2 2 2| 36 1.9|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Bile Duct, Dilatation | 3 2 3 | 6 2.7|
Biliary Tract, Fibrosis | 2 3 3 2 2 2 2 2 2 3 3 3 2 2 2 2 3 2 3 3 3 3 3 3| 49 2.6|
Biliary Tract, Hyperplasia | 2 3 3 3 2 2 2 2 2 3 3 3 2 2 2 2 3 2 3 3 3 3 3 3| 49 2.6|
Biliary Tract, Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 3 3 2 2 2 1 2 2 2 2 2 2 2 2 2| 49 2.1|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Cytomegaly | 2 3 3 3 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 3 3 2 2| 50 2.4|
Hepatocyte, Degeneration | 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 43 1.9|
Hepatocyte, Necrosis | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1| 41 1.3|
Hepatocyte, Pigmentation | | 1 2.0|
Kupffer Cell, Pigmentation | 2 2 2 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| 50 1.9|
Parenchyma, Atrophy, Multifocal | 2 4 3 2 3 3 2 3 3 2 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3| 50 2.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular, Focal | | 1 1.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + M + + +| 48 |
Hyperplasia, Lymphoid | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 2 2 2 1 2 2 2 1 2 1 | 21 1.9|
Mucosa, Erosion | 1 2 2 | 6 1.7|
Mucosa, Hyperplasia, Papillary | 1 2 2 1 2 2 2 1 2 2 2 | 23 2.0|
Mucosa, Inflammation, Focal | 2 | 1 2.0|
Mucosa, Mineralization | 2 | 2 2.0|
Mucosa, Ulcer | 2 2 | 3 2.3|
Mucosa, Ulcer, Multiple, Two | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 1 | 4 1.3|
Mucosa, Cyst | 2 | 1 2.0|
Mucosa, Dysplasia | 1 | 1 1.0|
Mucosa, Erosion | 1 | 1 1.0|
Mucosa, Hyperplasia, Papillary | 2 | 1 2.0|
Mucosa, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + +| 32 |
Incisor, Dysplasia | 4 2 1 1 1 1 1 2 1 1 1 2 1| 32 1.7|
Incisor, Inflammation, Suppurative | 2 1 | 5 2.2|
Molar, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 4 |
Abdominal, Inflammation, Chronic | | 1 2.0|
Abdominal, Adventitia, Thrombosis | | 1 4.0|
Aorta, Media, Mineralization | 4 2 | 2 3.0|
Mesenteric Artery, Inflammation, | | |
Chronic | 3 2 | 2 2.5|
Mesenteric Artery, Media, | | |
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
Coronary Artery, Mineralization | 3 | 1 3.0|
Myocardium, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 | 2 2.0|
Subcapsular, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 2 2 1 2 | 9 1.7|
Hyperplasia | | 3 2.3|
Extra Adrenal Tissue, Ectopic Tissue | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Cyst | 2 | 1 2.0|
Pars Distalis, Cyst | 1 2 2 | 3 1.7|
Pars Distalis, Focal Cellular Change | 1 | 1 1.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 | 4 1.5|
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | +| 5 |
Degeneration, Cystic | | 4 3.0|
Inflammation, Suppurative | 4| 3 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 2 2.5|
Edema | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Germinal Epithelium, Degeneration | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Focal, Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inguinal, Angiectasis | | 1 3.0|
Inguinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + M M M M + M M + M M + M M + + M + M M + M| 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + M + + + + + M + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | A + + + + M + + + + M + + + + + + + M + + + + + +| 41 |
Depletion Lymphoid | 2 | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 2 3 4 | 6 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 2 3 3 2 3 | 15 2.5|
Artery, Degeneration, Hyaline | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | A + M + M + + + + + + + M + + + + M + + M + + + +| 42 |
Depletion Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 1 1.0|
Inflammation, Chronic | 2 2 2 | 7 2.1|
Ulcer | 1 | 4 2.0|
Hair Follicle, Atrophy | | 1 3.0|
Prepuce, Fibrosis | | 1 2.0|
Prepuce, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3| 4 2.5|
Granuloma | | 2 1.5|
Hyperplasia, Lymphoid | 2 1 1 1 2 1 2 2 1 | 23 1.3|
Hyperplasia, Macrophage | 2 2 1 3 2 1 | 17 1.5|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
Inflammation, Focal | 1 | 1 1.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Bronchiole, Hyperplasia | | 1 2.0|
Mediastinum, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | | 1 2.0|
Lumen, Foreign Body | 2 1 3 1 | 6 1.8|
Lumen, Inflammation, Suppurative | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3| |
| 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
15 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Congestion | | 1 3.0|
Fibrosis | | 1 3.0|
Hydronephrosis | 3 3 | 4 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 2 1 1| 41 1.1|
Nephropathy | 3 1 1 2 1 1 1 1 2 1 1 1 4 1 2 4 4 3 1 | 38 2.1|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 2 |
Serosa, Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Clear Cell Focus | X |
Congestion | |
Cyst | 3 |
Cyst, Multiple | 3 |
Degeneration, Cystic | |
Depletion Glycogen | |
Eosinophilic Focus | |
Hyperplasia, Lymphoid | 2 1 1 1 1 2 1 2 1 2 1 2 2|
Hyperplasia, Multifocal | 2 2 1 2 1 2 1 2 1 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2|
Infarct | 3 4 2 4 3 1 3 4 2 4 1 |
Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 2 1 2 1 |
Inflammation, Multifocal | 1 1 1 |
Mixed Cell Focus | 2 2 |
Necrosis, Multifocal | |
Thrombosis | 3 3 |
Vacuolization Cytoplasmic | 2 1 1 2 2 2 3 2 2 2 2 2 2|
Biliary Tract, Fibrosis | 3 2 1 2 1 2 2 2 2 2 1 2 2 2 3 2 2 1 2 3 1 2 2|
Biliary Tract, Hyperplasia | 2 2 1 2 1 1 2 2 1 2 2 2 2 2 2 3 2 2 1 2 3 1 2 2|
Biliary Tract, Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 2 1 2 1 2 3 1 2 1 2 2 2 1|
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 2 1 2 1 2 1 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2|
Hepatocyte, Degeneration | 1 1 1 1 1 2 2 1 1 1 2 3 2 2 3 2 2 2 2 2 2 2 2|
Hepatocyte, Mitotic Alteration | 2 |
Hepatocyte, Necrosis | 1 1 1 1 2 3 1 2 1 1 1 1 3 2 1 1 1 1 1 1 1|
Kupffer Cell, Pigmentation | 1 2 2 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 2 1 1 2 1|
Parenchyma, Atrophy, Multifocal | 3 2 3 1 2 2 1 3 2 2 1 2 2 1 3 2 3 1 2 3 3 2 3|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Serosa, Fibrosis, Focal | |
Serosa, Pigmentation, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hyperplasia, Lymphoid | 3 |
Infarct | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 |
Adventitia, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 3 1 1 1 2 2 1 1 |
Mineralization, Focal | |
Mucosa, Edema | |
Mucosa, Erosion | 3 2 2 1 |
Mucosa, Hyperplasia, Papillary | 3 1 2 1 2 2 2 2 1 |
Mucosa, Ulcer | 3 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 2 |
Mineralization | 2 2|
Epithelium, Degeneration, Hyaline | 2 1 |
Epithelium, Metaplasia, Squamous | |
Mucosa, Cyst | |
Mucosa, Cyst, Multiple | |
Mucosa, Erosion | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Incisor, Dysplasia | 1 1 1 3 2 2 1 1 1 2 1 1 2 1 4 1 2 3 1 1 2|
Incisor, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Inflammation, | |
Chronic | |
Renal Artery, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia | |
Subcapsular, Hyperplasia, Focal | 1 2 |
Subcapsular, Hyperplasia | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 3 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | |
Pars Nervosa, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 1 |
Degeneration | |
Follicular Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 4 |
Hyperplasia, Adenomatous | 2 |
__________________________________________________________________________|
Ductus Deferens | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Degeneration, Cystic | 3 3 1 3 |
Fibrosis | 4 |
Inflammation, Suppurative | 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Dilatation | 2 |
Edema | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mineralization | 2 2 2 |
Germinal Epithelium, Degeneration | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M + + + + + M M M M + + M M + + M M + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 |
Hyperplasia | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 4 2 2 4 3 |
Hyperplasia, Lymphoid | 2 2 3 |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + M + + + + + + + + M + + + +|
Depletion Lymphoid | 1 2 2 |
Hyperplasia, Lymphoid | 2 3 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Ulcer | 2 |
Prepuce, Fibrosis | 3 |
Subcutaneous Tissue, Congestion | |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 |
Subcutaneous Tissue, Head, | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Mast Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | 4 3 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hyperplasia, Lymphoid | 2 2 1 1 1 1 1 1 2 1 |
Hyperplasia, Macrophage | 1 1 1 2 1 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, | |
Suppurative | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 2 2 2 |
Lumen, Foreign Body | 2 1 2 2 2 2 |
Lumen, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Congestion | 2 3 |
Cyst | |
Fibrosis | 3 3 |
Hydronephrosis | 3 2 |
Hyperplasia, Lymphoid | 3 |
Infarct | 4 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|
| 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1|
Nephropathy | 4 1 1 1 1 3 1 1 1 1 4 1 2 1 1 1 1 1|
Thrombosis | |
Renal Tubule, Dilatation | 2 3 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Ureter | + + |
Mineralization | 3 |
Necrosis | 3 |
Serosa, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Mucosa, Hyperplasia, Papillary | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 1 |
Congestion | 3 | 1 3.0|
Cyst | | 1 3.0|
Cyst, Multiple | | 1 3.0|
Degeneration, Cystic | 2 | 1 2.0|
Depletion Glycogen | 2 | 1 2.0|
Eosinophilic Focus | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 1 2 2 2 2 1 1 1 2 2| 24 1.5|
Hyperplasia, Multifocal | 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 1 2 2 2 2| 44 2.0|
Infarct | 4 4 | 13 3.0|
Infiltration Cellular, Mixed Cell | 1 2 1 1 2 1 2 1 1 1 2 2 2 | 23 1.6|
Inflammation, Multifocal | 1 1 1 1 | 7 1.0|
Mixed Cell Focus | 2 3 2 | 5 2.2|
Necrosis, Multifocal | 2 1 | 2 1.5|
Thrombosis | 4 4 | 4 3.5|
Vacuolization Cytoplasmic | 1 2 2 1 2 2 2 2 2 1 2| 24 1.8|
Biliary Tract, Fibrosis | 2 3 2 1 1 1 2 1 1 2 2 1 2 2 2 2 2 1 2 1 2 1| 45 1.8|
Biliary Tract, Hyperplasia | 2 3 2 1 1 1 2 1 1 2 2 1 2 2 2 2 2 1 3 1 2 1| 46 1.8|
Biliary Tract, Inflammation, Chronic | 1 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1| 44 1.3|
Centrilobular, Necrosis | 3 3 3 | 3 3.0|
Hepatocyte, Cytomegaly | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 45 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Degeneration | 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 43 1.9|
Hepatocyte, Mitotic Alteration | | 1 2.0|
Hepatocyte, Necrosis | 3 1 1 1 1 1 1 3 2 2 2 1 2 1 2 2 1 1| 39 1.4|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1| 43 1.2|
Parenchyma, Atrophy, Multifocal | 2 3 3 2 2 2 1 2 2 3 3 2 2 2 2 2 2 1 3 2 2 1| 45 2.1|
Serosa, Fibrosis, Focal | 2 | 1 2.0|
Serosa, Pigmentation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Hyperplasia, Lymphoid | | 1 3.0|
Infarct | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
Hyperplasia, Lymphoid | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 1| 4 1.5|
Adventitia, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 1 1 1 1 1 | 13 1.3|
Mineralization, Focal | 3 | 1 3.0|
Mucosa, Edema | 2 | 1 2.0|
Mucosa, Erosion | 1 | 5 1.8|
Mucosa, Hyperplasia, Papillary | 1 1 2 1 2 | 14 1.6|
Mucosa, Ulcer | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 1 1 2 2 | 6 1.7|
Mineralization | 1 | 3 1.7|
Epithelium, Degeneration, Hyaline | | 2 1.5|
Epithelium, Metaplasia, Squamous | 1 | 1 1.0|
Mucosa, Cyst | 2 | 1 2.0|
Mucosa, Cyst, Multiple | 2 | 1 2.0|
Mucosa, Erosion | 1 | 1 1.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + | 36 |
Incisor, Dysplasia | 1 1 1 3 1 1 1 1 1 1 3 1 2 1 | 35 1.5|
Incisor, Inflammation, Suppurative | 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | | 1 3.0|
Mesenteric Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
Renal Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | 1 | 1 1.0|
Hyperplasia | 3 | 1 3.0|
Subcapsular, Hyperplasia, Focal | | 2 1.5|
Subcapsular, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 3 2.0|
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst, Multiple | | 1 3.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + M + + M + + M I + M + +| 44 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
Pars Nervosa, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 2 | 7 1.6|
Degeneration | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1| 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Adenomatous | | 1 2.0|
__________________________________________________________________________|____________|
Ductus Deferens | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 2 | 1 2.0|
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Degeneration, Cystic | | 4 2.5|
Fibrosis | | 1 4.0|
Inflammation, Suppurative | | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Dilatation | | 1 2.0|
Edema | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 4 1.8|
Germinal Epithelium, Degeneration | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M + + + + + + M M M + + + + M + + + M M + M| 27 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + M + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 | 4 2.3|
Hyperplasia | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M + + + + + M + + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | 2 | 5 2.2|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 4 | 7 2.4|
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 2 | 11 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 2 2 2 | 7 2.1|
Red Pulp, Depletion Cellular | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + M + + +| 44 |
Depletion Lymphoid | 2 | 4 1.8|
Hyperplasia, Lymphoid | 2 | 3 2.3|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 2 | 6 2.0|
Ulcer | 3 | 2 2.5|
Prepuce, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Congestion | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 2 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
Subcutaneous Tissue, Head, | | |
Hyperplasia, Mast Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Distal, Joint, Femur, Arthrosis | 2 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 4 2.3|
Hyperplasia, Lymphoid | 2 1 2 1 1 2 1 2 1 1| 20 1.4|
Hyperplasia, Macrophage | 1 2 1 2 | 12 1.5|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Mediastinum, Foreign Body | 4 2 | 2 3.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05004-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:03:20
__________________________________________________________________________________________________________________________________
| 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7| |
DAY ON TEST | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3| |
| 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 2 1 1 1 1 | 9 1.6|
Lumen, Foreign Body | 2 2 2 1 1 2 1 | 13 1.7|
Lumen, Inflammation, Suppurative | 2 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Congestion | 3 | 3 2.7|
Cyst | X | 1 |
Fibrosis | | 2 3.0|
Hydronephrosis | 2 | 3 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
Infarct | 4 | 2 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.1|
Nephropathy | 4 2 2 1 1 1 1 3 1 2 1 1 1 4 2 1 1 1| 36 1.6|
Thrombosis | X | 1 |
Renal Tubule, Dilatation | | 2 2.5|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Ureter | | 2 |
Mineralization | | 1 3.0|
Necrosis | | 1 3.0|
Serosa, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
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