TDMS Study 05004-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FURAN
NTP Experiment-Test: 05004-03 Report: PEIRPT03
Study Type: CHRONIC Date: 09/02/94
Route: GAVAGE Time: 23:55:48
Facility: Southern Research Institute
Chemical CAS #: 110-00-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund 12 17 17 19
Dead 4 1 5 10
Dosing Accident 2
Survivors
Terminal Sacrifice 34 32 28 19
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (50) (49)
Parasite Metazoan 3 (6%) 2 (4%) 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Parasite Metazoan 2 (4%) 6 (12%) 6 (12%)
Intestine Large, Rectum (49) (50) (50) (50)
Parasite Metazoan 5 (10%) 12 (24%) 7 (14%) 4 (8%)
Liver (50) (50) (50) (50)
Basophilic Focus 43 (86%) 38 (76%) 1 (2%)
Clear Cell Focus 1 (2%)
Cyst Multilocular 6 (12%) 2 (4%) 12 (24%)
Developmental Malformation 9 (18%) 1 (2%) 3 (6%) 3 (6%)
Eosinophilic Focus 17 (34%)
Granuloma, Multiple 10 (20%) 19 (38%) 8 (16%)
Hematopoietic Cell Proliferation, Multifocal 7 (14%) 7 (14%)
Hemorrhage, Focal 1 (2%) 2 (4%)
Hemorrhage, Multifocal 1 (2%) 3 (6%)
Hyperplasia, Multifocal, Nodular 1 (2%)
Necrosis, Focal 1 (2%)
Neovascularization 4 (8%) 8 (16%)
Pigmentation, Hematoidin 1 (2%) 1 (2%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Biliary Tract, Cyst, Multiple 49 (98%) 50 (100%) 46 (92%)
Biliary Tract, Fibrosis, Multifocal 49 (98%) 50 (100%) 49 (98%)
Biliary Tract, Hyperplasia, Multifocal 49 (98%) 50 (100%) 49 (98%)
Biliary Tract, Inflammation, Chronic,
Multifocal 49 (98%) 50 (100%) 49 (98%)
Biliary Tract, Metaplasia 49 (98%) 50 (100%) 49 (98%)
Biliary Tract, Proliferation 11 (22%)
Centrilobular, Necrosis 8 (16%) 2 (4%) 10 (20%) 2 (4%)
Hepatocyte, Cytomegaly 44 (88%) 50 (100%) 49 (98%)
Hepatocyte, Degeneration, Multifocal 35 (70%) 49 (98%) 47 (94%)
Hepatocyte, Hyperplasia, Multifocal, Nodular 32 (64%) 47 (94%) 46 (92%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis, Multifocal 18 (36%) 46 (92%) 47 (94%)
Hepatocyte, Vacuolization Cytoplasmic 43 (86%) 49 (98%) 47 (94%)
Kupffer Cell, Pigmentation, Multifocal 49 (98%) 50 (100%) 48 (96%)
Serosa, Inflammation, Chronic 1 (2%)
Mesentery (8) (12) (9) (13)
Inflammation, Chronic, Diffuse 1 (13%)
Mineralization, Focal 1 (11%) 2 (15%)
Fat, Necrosis, Focal 6 (75%) 11 (92%) 5 (56%) 7 (54%)
Fat, Necrosis, Multifocal 2 (25%) 1 (8%) 1 (11%) 2 (15%)
Pancreas (50) (49) (50) (50)
Atrophy, Focal 4 (8%) 6 (12%) 6 (12%) 2 (4%)
Atrophy, Multifocal 3 (6%) 5 (10%) 1 (2%) 1 (2%)
Hyperplasia, Focal 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Acinus, Atrophy 1 (2%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy, Multifocal 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema, Diffuse 1 (2%)
Erosion 1 (2%) 1 (2%) 2 (4%)
Hyperkeratosis 1 (2%)
Hyperplasia 2 (4%) 5 (10%) 5 (10%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Subacute 1 (2%) 5 (10%) 6 (12%)
Perforation 2 (4%)
Ulcer 2 (4%) 2 (4%) 3 (6%)
Ulcer, Multiple 1 (2%)
Artery, Inflammation, Subacute 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Edema, Diffuse 2 (4%)
Erosion 1 (2%) 2 (4%) 1 (2%)
Erosion, Multiple 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Mineralization 1 (2%)
Mineralization, Multifocal 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Ulcer, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Abdominal, Hypertrophy 1 (100%)
Abdominal, Inflammation, Subacute 1 (100%)
Abdominal, Thrombosis 1 (100%)
Aorta, Inflammation, Chronic 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Heart (50) (50) (50) (50)
Cardiomyopathy 17 (34%) 25 (50%) 11 (22%) 32 (64%)
Granuloma 1 (2%)
Mineralization, Multifocal 1 (2%)
Thrombosis 1 (2%)
Pericardium, Fibrosis 1 (2%)
Pericardium, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Angiectasis 3 (6%)
Focal Cellular Change 9 (18%) 9 (18%) 7 (14%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hypertrophy, Focal 1 (2%)
Necrosis, Diffuse 1 (2%) 1 (2%)
Necrosis, Multifocal 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%)
Adrenal Gland, Medulla (50) (49) (50) (49)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Multifocal 1 (2%) 1 (2%)
Necrosis, Diffuse 1 (2%)
Parathyroid Gland (48) (50) (49) (46)
Hyperplasia 2 (4%) 9 (20%)
Pituitary Gland (50) (50) (49) (49)
Pars Distalis, Angiectasis 31 (62%) 30 (60%) 29 (59%) 22 (45%)
Pars Distalis, Cyst 18 (36%) 9 (18%) 16 (33%) 20 (41%)
Pars Distalis, Hyperplasia 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Pars Distalis, Hyperplasia, Focal 9 (18%) 11 (22%) 12 (24%) 18 (37%)
Pars Distalis, Pigmentation, Hemosiderin 11 (22%) 19 (38%) 17 (35%) 10 (20%)
Thyroid Gland (50) (50) (50) (49)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 1 (2%) 2 (4%)
C-Cell, Hyperplasia, Focal 7 (14%) 6 (12%) 4 (8%) 8 (16%)
C-Cell, Hyperplasia, Multifocal 5 (10%) 2 (4%) 4 (8%)
Follicle, Cyst 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (48) (50) (47)
Hyperplasia 4 (9%) 2 (4%)
Hyperplasia, Focal 1 (2%)
Inflammation, Acute, Focal, Suppurative 2 (5%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Duct, Cyst 5 (10%) 5 (10%) 5 (11%)
Ovary (50) (50) (50) (50)
Cyst 12 (24%) 3 (6%) 3 (6%) 6 (12%)
Uterus (50) (50) (50) (50)
Abscess 1 (2%)
Cyst 2 (4%) 2 (4%)
Hemorrhage 2 (4%) 1 (2%)
Hydrometra 2 (4%) 3 (6%)
Hyperplasia, Cystic 1 (2%) 4 (8%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Prolapse 1 (2%) 1 (2%)
Cervix, Cyst 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Cervix, Cyst, Multiple 1 (2%)
Cervix, Hypertrophy 1 (2%)
Vagina (2) (1) (2)
Inflammation, Acute, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 8 (16%) 11 (22%) 24 (48%)
Infiltration Cellular, Histiocyte 1 (2%)
Myelofibrosis 1 (2%) 2 (4%)
Lymph Node (50) (50) (50) (50)
Pancreatic, Ectasia 6 (12%) 16 (32%) 23 (46%)
Pancreatic, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Pancreatic, Inflammation, Granulomatous 1 (2%)
Pancreatic, Necrosis 1 (2%)
Renal, Ectasia 1 (2%) 1 (2%)
Lymph Node, Bronchial (27) (43) (42) (30)
Ectasia 1 (2%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (47) (48) (47) (46)
Ectasia 3 (6%) 4 (8%) 3 (6%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 3 (7%)
Inflammation, Acute, Suppurative 1 (2%)
Lymph Node, Mediastinal (48) (48) (49) (49)
Congestion 1 (2%) 2 (4%)
Ectasia 3 (6%) 4 (8%) 10 (20%)
Hyperplasia 1 (2%)
Lymph Node, Mesenteric (48) (50) (50) (48)
Ectasia 1 (2%) 1 (2%)
Hyperplasia 2 (4%)
Spleen (50) (50) (50) (50)
Congestion 2 (4%) 6 (12%) 17 (34%) 23 (46%)
Fibrosis, Focal 3 (6%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 14 (28%) 27 (54%) 25 (50%)
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Diffuse 1 (2%)
Necrosis, Focal 2 (4%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Thymus (47) (46) (47) (43)
Cyst 1 (2%) 3 (7%) 1 (2%)
Hemorrhage 1 (2%)
Fat, Mediastinum, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Duct, Cyst 43 (86%) 44 (88%) 45 (92%) 43 (86%)
Skin (50) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Hypertrophy, Focal 2 (4%) 4 (8%) 6 (12%) 2 (4%)
Femur, Hypertrophy, Focal 1 (2%) 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Degeneration, Multifocal 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Abscess 1 (2%)
Congestion 1 (2%) 4 (8%)
Foreign Body 1 (2%) 2 (4%)
Granuloma, Multiple 12 (24%) 14 (28%) 14 (28%) 11 (22%)
Hemorrhage, Multifocal 1 (2%) 3 (6%)
Infiltration Cellular, Focal, Histiocyte 1 (2%) 5 (10%) 4 (8%) 2 (4%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%) 4 (8%) 8 (16%) 3 (6%)
Pigmentation, Focal, Cholesterol 1 (2%) 3 (6%) 3 (6%) 3 (6%)
Pigmentation, Multifocal, Cholesterol 2 (4%) 2 (4%) 2 (4%)
Alveolar Epithelium, Hyperplasia, Focal 4 (8%) 2 (4%) 1 (2%) 4 (8%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Fat, Mediastinum, Necrosis, Multifocal 2 (4%) 10 (20%) 11 (22%) 4 (8%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 2 (4%) 2 (4%)
Fungus 1 (2%) 3 (6%) 2 (4%)
Inflammation, Acute, Suppurative 4 (8%) 5 (10%) 2 (4%)
Mucosa, Cyst 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Hyperkeratosis 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 1 (2%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 4 (8%) 3 (6%) 10 (20%) 3 (6%)
Nasopharyngeal Duct, Foreign Body 1 (2%)
Nasopharyngeal Duct, Inflammation, Subacute 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3) (2)
Cataract 1 (50%) 3 (100%) 1 (50%)
Hemorrhage 1 (33%) 2 (100%)
Inflammation, Subacute 1 (50%)
Retina, Degeneration 1 (50%) 2 (67%) 1 (50%)
Harderian Gland (2) (1) (1)
Inflammation, Chronic, Focal 2 (100%) 1 (100%)
Lacrimal Gland (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Inflammation, Chronic, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst Multilocular 1 (2%)
Developmental Malformation 1 (2%)
Nephropathy, Chronic 16 (32%) 47 (94%) 47 (94%) 46 (92%)
Cortex, Fibrosis, Focal 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute, Suppurative 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Renal Tubule, Necrosis, Multifocal 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (49) (50) (49) (50)
Calculus Gross Observation 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Dosing Accident 6 5 4 1
Dead 1 4 3 5
Moribund 10 13 17 28
Survivors
Terminal Sacrifice 33 28 26 16
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (50) (50) (49)
Hemorrhage, Focal 1 (2%)
Intestine Large, Cecum (49) (50) (50) (50)
Parasite Metazoan 2 (4%) 1 (2%) 4 (8%)
Ulcer, Multiple 1 (2%)
Intestine Large, Colon (49) (49) (50) (50)
Diverticulum 1 (2%)
Parasite Metazoan 4 (8%) 2 (4%) 3 (6%) 6 (12%)
Intestine Large, Rectum (50) (49) (48) (50)
Fibrosis, Focal 1 (2%)
Parasite Metazoan 5 (10%) 6 (12%) 6 (13%) 2 (4%)
Liver (50) (50) (50) (50)
Angiectasis, Focal 1 (2%)
Basophilic Focus 32 (64%) 20 (40%) 2 (4%) 1 (2%)
Clear Cell Focus 8 (16%)
Cyst Multilocular 1 (2%) 17 (34%) 24 (48%)
Degeneration, Cystic 2 (4%)
Degeneration, Cystic, Focal 3 (6%)
Degeneration, Cystic, Multifocal 1 (2%)
Developmental Malformation 3 (6%) 3 (6%) 3 (6%) 1 (2%)
Eosinophilic Focus 14 (28%)
Granuloma, Multiple 1 (2%) 21 (42%) 10 (20%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 3 (6%) 3 (6%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 5 (10%)
Leukocytosis 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Neovascularization 6 (12%) 14 (28%) 15 (30%)
Thrombosis 3 (6%) 4 (8%)
Biliary Tract, Cyst, Multiple 44 (88%) 47 (94%) 49 (98%)
Biliary Tract, Ectasia, Focal 1 (2%)
Biliary Tract, Fibrosis, Multifocal 44 (88%) 48 (96%) 49 (98%)
Biliary Tract, Hyperplasia, Multifocal 44 (88%) 48 (96%) 49 (98%)
Biliary Tract, Inflammation, Chronic,
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Multifocal 44 (88%) 48 (96%) 49 (98%)
Biliary Tract, Metaplasia 44 (88%) 48 (96%) 49 (98%)
Biliary Tract, Proliferation 39 (78%)
Centrilobular, Necrosis 5 (10%) 7 (14%) 5 (10%) 9 (18%)
Hepatocyte, Cytomegaly 35 (70%) 46 (92%) 49 (98%)
Hepatocyte, Degeneration, Multifocal 33 (66%) 46 (92%) 49 (98%)
Hepatocyte, Hyperplasia, Multifocal, Nodular 30 (60%) 46 (92%) 49 (98%)
Hepatocyte, Necrosis, Multifocal 32 (64%) 46 (92%) 49 (98%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 39 (78%) 45 (90%) 49 (98%)
Kupffer Cell, Pigmentation, Multifocal 44 (88%) 48 (96%) 49 (98%)
Mesentery (5) (12) (12) (14)
Foreign Body 1 (8%)
Inflammation, Acute, Suppurative 1 (8%)
Pigmentation, Hemosiderin, Multifocal 1 (8%) 3 (21%)
Fat, Hemorrhage 1 (7%)
Fat, Necrosis, Focal 3 (60%) 7 (58%) 9 (75%) 6 (43%)
Fat, Necrosis, Multifocal 1 (7%)
Pancreas (50) (50) (50) (49)
Atrophy, Focal 9 (18%) 2 (4%) 1 (2%) 6 (12%)
Atrophy, Multifocal 6 (12%) 7 (14%) 3 (6%) 5 (10%)
Cyst Multilocular 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Focal 8 (16%) 12 (24%) 9 (18%) 12 (24%)
Hyperplasia, Multifocal 13 (26%) 9 (18%) 6 (12%) 10 (20%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%)
Inflammation, Focal, Subacute 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Artery, Inflammation, Subacute 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Edema 3 (6%)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%) 4 (8%) 7 (14%) 6 (12%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Subacute 1 (2%) 2 (4%) 6 (12%) 2 (4%)
Perforation 1 (2%) 3 (6%)
Ulcer 1 (2%) 3 (6%) 3 (6%)
Ulcer, Multiple 1 (2%) 3 (6%)
Artery, Inflammation, Subacute 2 (4%)
Serosa, Fibrosis, Focal 1 (2%)
Stomach, Glandular (50) (49) (50) (50)
Edema 2 (4%)
Erosion 2 (4%) 1 (2%)
Erosion, Multiple 1 (2%) 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Mineralization, Multifocal 1 (2%) 2 (4%)
Ulcer 1 (2%) 2 (4%)
Tongue (1) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Foreign Body 1 (100%)
Hemorrhage 1 (50%)
Inflammation, Granulomatous 1 (100%)
Tooth (1) (1) (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 29 (58%) 30 (60%) 38 (76%) 39 (78%)
Fibrosis, Focal 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Mineralization, Multifocal 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Valve, Embolus Bacterial 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%)
Focal Cellular Change 2 (4%) 7 (14%) 7 (14%) 2 (4%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis, Diffuse 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Left, Atrophy 1 (2%)
Adrenal Gland, Medulla (50) (47) (48) (49)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 7 (15%) 1 (2%) 3 (6%)
Hyperplasia, Multifocal 1 (2%) 1 (2%)
Necrosis, Diffuse 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (46) (47) (49) (43)
Hyperplasia 2 (4%) 10 (20%) 6 (14%)
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Angiectasis 10 (20%) 18 (36%) 18 (37%) 8 (16%)
Pars Distalis, Cyst 2 (4%) 2 (4%) 4 (8%) 4 (8%)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Pars Distalis, Hyperplasia, Focal 10 (20%) 12 (24%) 5 (10%) 6 (12%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation, Hemosiderin 7 (14%) 10 (20%) 3 (6%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (48) (50) (50) (48)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia, Focal 3 (6%) 2 (4%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 4 (8%) 6 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (50) (46) (48)
Foreign Body 1 (2%)
Granuloma 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Acute, Focal, Suppurative 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Subacute 1 (2%) 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 5 (10%) 4 (8%)
Prostate (50) (50) (50) (49)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Subacute 8 (16%) 22 (44%) 26 (52%) 11 (22%)
Seminal Vesicle (1) (4) (1)
Inflammation, Acute, Suppurative 1 (100%)
Inflammation, Subacute 3 (75%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 5 (10%) 4 (8%) 3 (6%)
Interstitial Cell, Hyperplasia 4 (8%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1)
Polychromasia 1 (100%)
Bone Marrow (50) (50) (50) (50)
Hyperplasia 8 (16%) 9 (18%) 28 (56%)
Necrosis 1 (2%)
Lymph Node (50) (50) (50) (50)
Inguinal, Ectasia 1 (2%)
Inguinal, Hyperplasia 1 (2%)
Inguinal, Inflammation, Granulomatous 1 (2%)
Pancreatic, Ectasia 4 (8%) 12 (24%) 24 (48%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Hyperplasia 3 (6%) 2 (4%) 10 (20%)
Pancreatic, Inflammation, Granulomatous 1 (2%)
Renal, Ectasia 3 (6%)
Renal, Hyperplasia 1 (2%)
Lymph Node, Bronchial (34) (40) (35) (27)
Congestion 1 (4%)
Ectasia 1 (3%) 2 (6%)
Hyperplasia 2 (7%)
Inflammation, Granulomatous 1 (3%)
Lymph Node, Mandibular (48) (45) (48) (48)
Congestion 1 (2%)
Ectasia 10 (21%) 6 (13%) 7 (15%) 13 (27%)
Hyperplasia 1 (2%) 2 (4%) 1 (2%) 6 (13%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mediastinal (48) (45) (48) (45)
Congestion 1 (2%) 2 (4%)
Ectasia 5 (11%) 7 (15%) 16 (36%)
Hyperplasia 1 (2%) 9 (20%)
Inflammation, Granulomatous 1 (2%)
Pigmentation, Hemosiderin 2 (4%) 1 (2%)
Lymph Node, Mesenteric (46) (50) (49) (49)
Congestion 1 (2%)
Ectasia 2 (4%) 2 (4%) 7 (14%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (50) (50) (50)
Atrophy 1 (2%)
Congestion 5 (10%) 16 (32%) 25 (50%) 25 (50%)
Degeneration, Fatty, Multifocal 1 (2%)
Fibrosis, Focal 4 (8%) 4 (8%) 7 (14%) 7 (14%)
Hematopoietic Cell Proliferation 9 (18%) 23 (46%) 27 (54%) 30 (60%)
Inflammation, Granulomatous 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Capsule, Fibrosis, Multifocal 1 (2%)
Capsule, Pigmentation, Hemosiderin 1 (2%)
Thymus (48) (49) (46) (42)
Cyst 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50) (50)
Duct, Cyst 20 (42%) 24 (48%) 29 (58%) 20 (40%)
Duct, Hemorrhage, Focal 1 (2%)
Skin (50) (50) (50) (50)
Bacterium 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Foreign Body 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%)
Subcutaneous Tissue, Edema, Focal 1 (2%) 3 (6%)
Subcutaneous Tissue, Inflammation, Focal,
Subacute 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%) 4 (8%)
Skeletal Muscle (1) (1)
Inflammation, Acute, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 3 (6%)
Hydrocephalus 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 6 (12%) 6 (12%) 3 (6%) 4 (8%)
Foreign Body 5 (10%) 6 (12%) 4 (8%) 2 (4%)
Fungus 1 (2%)
Granuloma, Multiple 9 (18%) 8 (16%) 4 (8%) 9 (18%)
Hemorrhage, Focal 2 (4%)
Hemorrhage, Multifocal 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Infiltration Cellular, Focal, Histiocyte 1 (2%) 3 (6%)
Infiltration Cellular, Multifocal, Histiocyte 2 (4%) 4 (8%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Subacute 1 (2%)
Pigmentation, Focal, Cholesterol 1 (2%) 1 (2%)
Pigmentation, Multifocal, Cholesterol 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Fat, Mediastinum, Necrosis, Multifocal 1 (2%) 1 (2%) 1 (2%) 5 (10%)
Mediastinum, Foreign Body 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Mediastinum, Inflammation, Chronic,
Multifocal 1 (2%)
Pleura, Fibrosis, Focal 1 (2%)
Smooth Muscle, Hyperplasia, Focal 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 16 (32%) 2 (4%) 6 (12%) 5 (10%)
Fungus 5 (10%) 5 (10%) 6 (12%) 4 (8%)
Hyperkeratosis, Focal 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute, Suppurative 11 (22%) 7 (14%) 8 (16%) 7 (14%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 4 (8%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%) 9 (18%) 2 (4%) 3 (6%)
Nasopharyngeal Duct, Cyst 1 (2%) 1 (2%)
Nasopharyngeal Duct, Foreign Body 1 (2%)
Nasopharyngeal Duct, Fungus 1 (2%)
Nasopharyngeal Duct, Hyperplasia 1 (2%)
Nasopharyngeal Duct, Inflammation, Acute,
Suppurative 1 (2%)
Nasopharyngeal Duct, Inflammation, Subacute 1 (2%)
Submucosa, Foreign Body 1 (2%)
Submucosa, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (1) (2)
Cataract 1 (100%) 2 (67%) 1 (50%)
Anterior Chamber, Inflammation, Acute,
Suppurative 1 (33%)
Cornea, Cyst 1 (50%)
Retina, Degeneration 1 (100%) 2 (67%) 2 (100%)
Harderian Gland (1)
Inflammation, Chronic, Focal 1 (100%)
Zymbal's Gland (1) (1)
Inflammation, Subacute 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:55:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Nephropathy, Chronic 45 (90%) 44 (88%) 48 (96%) 48 (96%)
Cortex, Cyst 1 (2%) 1 (2%) 2 (4%)
Cortex, Cyst, Multiple 1 (2%)
Cortex, Embolus Bacterial 1 (2%)
Cortex, Fibrosis, Focal 1 (2%) 1 (2%)
Cortex, Inflammation, Acute, Multifocal,
Suppurative 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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