TDMS Study 05004-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
FURAN
NTP Experiment-Test: 05004-03 Report: PEIRPT05
Study Type: CHRONIC Date: 09/02/94
Route: GAVAGE Time: 23:57:13
Facility: Southern Research Institute
Chemical CAS #: 110-00-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund 12 17 17 19
Dead 4 1 5 10
Dosing Accident 2
Survivors
Terminal Sacrifice 34 32 28 19
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Intestine Large, Rectum (49) (50) (50) (50)
Intestine Small, Duodenum (49) (50) (50) (50)
Serosa, Fibrous Histiocytoma 1 (2%)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 2 (4%) 2 (4%)
Cholangiocarcinoma, Multiple 49 (98%) 48 (96%) 46 (92%)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 4 (8%) 6 (12%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
Mesentery (8) (12) (9) (13)
Fibrous Histiocytoma, Multiple 1 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (8%)
Pancreas (50) (49) (50) (50)
Adenoma 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Fibrous Histiocytoma 1 (2%)
Pharynx (1)
Squamous Cell Carcinoma 1 (100%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Abdominal, Cholangiocarcinoma, Metastatic,
Liver 1 (100%)
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Adrenal Gland, Medulla (50) (49) (50) (49)
Pheochromocytoma Malignant 1 (2%) 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (49) (49) (49) (50)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (49) (49)
Pars Distalis, Adenoma 26 (52%) 26 (52%) 25 (51%) 19 (39%)
Pars Distalis, Adenoma, Multiple 2 (4%) 1 (2%)
Thyroid Gland (50) (50) (50) (49)
C-Cell, Adenoma 8 (16%) 4 (8%) 5 (10%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenocarcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abdominal, Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (48) (50) (47)
Adenoma 3 (7%) 7 (15%) 5 (10%) 2 (4%)
Carcinoma 2 (4%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Ovary (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Granulosa Cell Tumor Malignant 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Uterus (50) (50) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Adenoma 1 (2%) 2 (4%)
Polyp Stromal 9 (18%) 12 (24%) 13 (26%) 7 (14%)
Page 3
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Polyp Stromal, Multiple 1 (2%) 1 (2%) 2 (4%)
Sarcoma Stromal 1 (2%) 1 (2%)
Cervix, Sarcoma 1 (2%)
Vagina (2) (1) (2)
Polyp 2 (100%)
Sarcoma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2)
Bone Marrow (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Lymph Node (50) (50) (50) (50)
Axillary, Adenocarcinoma, Metastatic,
Mammary Gland 1 (2%)
Lymph Node, Bronchial (27) (43) (42) (30)
Fibrous Histiocytoma 1 (3%)
Lymph Node, Mandibular (47) (48) (47) (46)
Fibrous Histiocytoma 1 (2%)
Lymph Node, Mediastinal (48) (48) (49) (49)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Pancreatic, Cholangiocarcinoma, Metastatic,
Liver 1 (2%)
Lymph Node, Mesenteric (48) (50) (50) (48)
Fibrous Histiocytoma 1 (2%)
Spleen (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Thymus (47) (46) (47) (43)
Fibrous Histiocytoma 1 (2%)
Mediastinum, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Adenocarcinoma 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 14 (28%) 13 (26%) 16 (33%) 12 (24%)
Fibroadenoma, Multiple 1 (2%) 4 (8%) 2 (4%) 2 (4%)
Skin (50) (50) (50) (50)
Fibroma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Page 4
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Rhabdomyosarcoma 1 (100%)
Diaphragm, Hepatocellular Carcinoma,
Metastatic, Liver 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Fibrous Histiocytoma 1 (2%)
Glioma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrous Histiocytoma 1 (2%)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mediastinum, Fibrous Histiocytoma 1 (2%)
Venule, Mediastinum, Cholangiocarcinoma,
Metastatic, Liver 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trachea (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Fibrosarcoma 1 (50%)
Pinna, Sarcoma 1 (50%)
Harderian Gland (2) (1) (1)
Lacrimal Gland (1) (1)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (100%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
Page 5
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Sarcoma 1 (2%)
Urinary Bladder (49) (50) (49) (50)
Transitional Epithelium, Papilloma 3 (6%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 8 (16%) 9 (18%) 17 (34%) 21 (42%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 50 50 50
Total Primary Neoplasms 86 149 157 156
Total Animals with Benign Neoplasms 42 41 41 37
Total Benign Neoplasms 69 76 78 64
Total Animals with Malignant Neoplasms 16 50 50 50
Total Malignant Neoplasms 17 73 79 92
Total Animals with Metastatic Neoplasms 3 1 1 3
Total Metastatic Neoplasm 4 1 2 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Dosing Accident 6 5 4 1
Dead 1 4 3 5
Moribund 10 13 17 28
Survivors
Terminal Sacrifice 33 28 26 16
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (50) (50)
Liver (50) (50) (50) (50)
Cholangiocarcinoma, Multiple 43 (86%) 48 (96%) 49 (98%)
Hepatocellular Carcinoma 1 (2%) 6 (12%) 17 (34%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 16 (32%) 17 (34%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) 10 (20%)
Mesentery (5) (12) (12) (14)
Cholangiocarcinoma, Metastatic, Liver 2 (14%)
Pancreas (50) (50) (50) (49)
Adenocarcinoma 1 (2%)
Adenoma 4 (8%) 6 (12%) 9 (18%) 4 (8%)
Adenoma, Multiple 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Mixed Tumor Benign 1 (2%)
Pharynx (1) (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (49) (50) (50) (49)
Stomach, Forestomach (50) (49) (50) (50)
Stomach, Glandular (50) (49) (50) (50)
Tongue (1) (2)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (47) (48) (49)
Pheochromocytoma Malignant 1 (2%) 3 (6%)
Pheochromocytoma Benign 7 (14%) 4 (9%) 8 (17%) 8 (16%)
Pheochromocytoma Benign, Multiple 1 (2%) 1 (2%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Adenoma, Multiple 3 (6%)
Carcinoma 1 (2%)
Parathyroid Gland (46) (47) (49) (43)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Adenoma 11 (22%) 11 (22%) 17 (35%) 11 (22%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (48) (50) (50) (48)
C-Cell, Adenoma 6 (13%) 6 (12%) 1 (2%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (49) (50) (46) (48)
Adenoma 1 (2%) 2 (4%) 4 (9%) 3 (6%)
Carcinoma 4 (8%)
Squamous Cell Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Prostate (50) (50) (50) (49)
Seminal Vesicle (1) (4) (1)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Interstitial Cell, Adenoma, Multiple 41 (82%) 36 (72%) 39 (78%) 43 (86%)
Interstitial Tissue, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1)
Bone Marrow (50) (50) (50) (50)
Lymph Node (50) (50) (50) (50)
Lymph Node, Bronchial (34) (40) (35) (27)
Lymph Node, Mandibular (48) (45) (48) (48)
Lymph Node, Mediastinal (48) (45) (48) (45)
Lymph Node, Mesenteric (46) (50) (49) (49)
Spleen (50) (50) (50) (50)
Sarcoma 2 (4%)
Thymus (48) (49) (46) (42)
Mediastinum, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50) (50)
Adenocarcinoma 1 (2%)
Fibroadenoma 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Fibroma 1 (2%)
Keratoacanthoma 3 (6%) 5 (10%) 2 (4%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 4 (8%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Preputial Gland 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (50) (50) (50)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 8 (16%) 11 (22%) 17 (34%) 25 (50%)
Mesothelioma Malignant 1 (2%) 1 (2%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05004-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURAN Date: 09/02/94
Route: GAVAGE Time: 23:57:13
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 45 48 49
Total Primary Neoplasms 108 156 198 217
Total Animals with Benign Neoplasms 46 42 46 47
Total Benign Neoplasms 94 90 112 116
Total Animals with Malignant Neoplasms 14 44 48 49
Total Malignant Neoplasms 14 66 86 101
Total Animals with Metastatic Neoplasms 1 3 3
Total Metastatic Neoplasm 1 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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