TDMS Study 05004-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 03 TIME: 00:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: H. GILES S. EUSTIS CAS: 110-00-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 03 TIME: 00:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: H. GILES S. EUSTIS CAS: 110-00-9
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 03 TIME: 00:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: H. GILES S. EUSTIS CAS: 110-00-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURAN
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Liver Cholangiocarcinoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Skin Keratoacanthoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Spleen Sarcoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURAN DATE: 09/03/94
EXPERIMENT: 05004 TEST: 03 TIME: 00:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565101 ROUTE: GAVAGE NTP C#: 56202
PATHOLOGIST: H. GILES S. EUSTIS CAS: 110-00-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURAN
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Cholangiocarcinoma
Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Urinary Bladder Papilloma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 4/47 (9%) 9/48 (19%) 10/49 (20%) | 2/50 (4%) 3/49 (6%) 1/50 (2%) 3/49 (6%) |
|ADJUSTED (b) | 24.2% 14.3% 31.0% 45.1% | 5.4% 9.4% 3.6% 14.1% |
|TERMINAL (d) | 8/33 (24%) 4/28 (14%) 6/25 (24%) 5/15 (33%) | 1/34 (3%) 3/32 (9%) 1/28 (4%) 2/19 (11%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 633 624 | 687 729 (T) 729 (T) 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.259N P=0.281 P=0.036 * | P=0.250 P=0.471 P=0.557N P=0.285 |
|INCIDENTAL TUMOR | P=0.061 P=0.259N P=0.324 P=0.144 | P=0.305 P=0.446 P=0.545N P=0.362 |
|LOGISTIC REGRESSION | P=0.058 P=0.259N P=0.335 P=0.155 | P=0.302 P=0.467 P=0.539N P=0.344 |
|COCHRAN-ARMITAGE | P=0.184 | P=0.471 |
|FISHER EXACT | P=0.210N P=0.463 P=0.379 | P=0.490 P=0.500N P=0.490 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/47 (0%) 3/48 (6%) 0/49 (0%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) 2/49 (4%) |
|ADJUSTED (b) | 2.4% 0.0% 10.0% 0.0% | 0.0% 3.1% 0.0% 5.1% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 2/25 (8%) 0/15 (0%) | 0/34 (0%) 1/32 (3%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 629 --- 520 --- | --- 729 (T) --- 532 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.616N P=0.515N P=0.251 P=0.520N | P=0.094 P=0.488 (e) P=0.199 |
|INCIDENTAL TUMOR | P=0.497N P=0.557N P=0.394 P=0.419N | P=0.208 P=0.488 (e) P=0.460 |
|LOGISTIC REGRESSION | P=0.502N P=0.511N P=0.289 P=0.504N | P=0.186 P=0.488 (e) P=0.334 |
|COCHRAN-ARMITAGE | P=0.502N | P=0.137 |
|FISHER EXACT | P=0.515N P=0.293 P=0.505N | P=0.495 (e) P=0.242 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 4/47 (9%) 11/48 (23%) 10/49 (20%) | 3/50 (6%) 4/49 (8%) 1/50 (2%) 5/49 (10%) |
|ADJUSTED (b) | 26.1% 14.3% 36.1% 45.1% | 7.9% 12.5% 3.6% 18.5% |
|TERMINAL (d) | 8/33 (24%) 4/28 (14%) 7/25 (28%) 5/15 (33%) | 1/34 (3%) 4/32 (13%) 1/28 (4%) 2/19 (11%) |
|FIRST INCIDENCE (DAYS) | 629 729 (T) 520 624 | 687 729 (T) 729 (T) 532 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.182N P=0.203 P=0.070 | P=0.135 P=0.466 P=0.360N P=0.172 |
|INCIDENTAL TUMOR | P=0.106 P=0.190N P=0.302 P=0.244 | P=0.257 P=0.422 P=0.340N P=0.376 |
|LOGISTIC REGRESSION | P=0.129 P=0.162N P=0.294 P=0.284 | P=0.246 P=0.463 P=0.335N P=0.316 |
|COCHRAN-ARMITAGE | P=0.239 | P=0.324 |
|FISHER EXACT | P=0.142N P=0.362 P=0.480 | P=0.489 P=0.309N P=0.346 |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.1% 0.0% | 0.0% 5.1% 0.0% 2.2% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 0/16 (0%) | 0/34 (0%) 1/32 (3%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 394 --- | --- 364 --- 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.702 (e) P=0.504 (e) | P=0.480 P=0.233 (e) P=0.483 |
|INCIDENTAL TUMOR | P=0.713N (e) P=0.638 (e) | P=0.520N P=0.488 (e) P=0.638 |
|LOGISTIC REGRESSION | P=0.673 (e) P=0.505 (e) | P=0.500N P=0.361 (e) P=0.743 |
|COCHRAN-ARMITAGE | P=0.694 | P=0.539 |
|FISHER EXACT | (e) P=0.500 (e) | P=0.247 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 4/46 (9%) 4/48 (8%) | 3/43 (7%) 7/48 (15%) 5/50 (10%) 2/47 (4%) |
|ADJUSTED (b) | 3.1% 7.1% 14.1% 15.0% | 9.1% 21.3% 15.1% 10.1% |
|TERMINAL (d) | 1/32 (3%) 2/28 (7%) 2/24 (8%) 1/15 (7%) | 2/29 (7%) 6/31 (19%) 3/28 (11%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 633 575 | 659 639 561 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.453 P=0.120 P=0.087 | P=0.511N P=0.174 P=0.321 P=0.659 |
|INCIDENTAL TUMOR | P=0.117 P=0.453 P=0.172 P=0.222 | P=0.342N P=0.199 P=0.415 P=0.593N |
|LOGISTIC REGRESSION | P=0.092 P=0.453 P=0.146 P=0.166 | P=0.337N P=0.178 P=0.429 P=0.607N |
|COCHRAN-ARMITAGE | P=0.106 | P=0.222N |
|FISHER EXACT | P=0.508 P=0.162 P=0.175 | P=0.207 P=0.445 P=0.457N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 4/50 (8%) 0/46 (0%) 0/48 (0%) | 0/43 (0%) 0/48 (0%) 2/50 (4%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 11.8% 0.0% 0.0% | 0.0% 0.0% 5.5% 5.6% |
|TERMINAL (d) | 0/32 (0%) 1/28 (4%) 0/24 (0%) 0/15 (0%) | 0/29 (0%) 0/31 (0%) 1/28 (4%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- 660 --- --- | --- --- 388 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.316N P=0.056 (e) (e) | P=0.170 (e) P=0.236 P=0.405 |
|INCIDENTAL TUMOR | P=0.119N P=0.077 (e) (e) | P=0.239 (e) P=0.331 P=0.405 |
|LOGISTIC REGRESSION | P=0.263N P=0.059 (e) (e) | P=0.331 (e) P=0.413 P=0.405 |
|COCHRAN-ARMITAGE | P=0.256N | P=0.256 |
|FISHER EXACT | P=0.061 (e) (e) | (e) P=0.286 P=0.522 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 6/50 (12%) 4/46 (9%) 4/48 (8%) | 3/43 (7%) 7/48 (15%) 7/50 (14%) 3/47 (6%) |
|ADJUSTED (b) | 3.1% 18.4% 14.1% 15.0% | 9.1% 21.3% 20.1% 15.3% |
|TERMINAL (d) | 1/32 (3%) 3/28 (11%) 2/24 (8%) 1/15 (7%) | 2/29 (7%) 6/31 (19%) 4/28 (14%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 660 633 575 | 659 639 388 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 P=0.047 * P=0.120 P=0.087 | P=0.403 P=0.174 P=0.141 P=0.440 |
|INCIDENTAL TUMOR | P=0.432 P=0.061 P=0.172 P=0.222 | P=0.531N P=0.199 P=0.235 P=0.545 |
|LOGISTIC REGRESSION | P=0.267 P=0.049 * P=0.146 P=0.166 | P=0.478N P=0.178 P=0.266 P=0.542 |
|COCHRAN-ARMITAGE | P=0.290 | P=0.389N |
|FISHER EXACT | P=0.059 P=0.162 P=0.175 | P=0.207 P=0.227 P=0.618N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 1/50 (2%) 1/49 (2%) | 1/49 (2%) 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 18.2% 6.9% 3.8% 2.5% | 2.9% 0.0% 0.0% 5.0% |
|TERMINAL (d) | 6/33 (18%) 1/28 (4%) 1/26 (4%) 0/15 (0%) | 1/34 (3%) 0/31 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 702 729 (T) 609 | 729 (T) --- --- 718 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107N P=0.192N P=0.101N P=0.235N | P=0.485 P=0.518N P=0.539N P=0.632 |
|INCIDENTAL TUMOR | P=0.062N P=0.172N P=0.101N P=0.204N | P=0.572 P=0.518N P=0.539N P=0.723 |
|LOGISTIC REGRESSION | P=0.048N* P=0.179N P=0.101N P=0.095N | P=0.514 P=0.518N P=0.539N P=0.665 |
|COCHRAN-ARMITAGE | P=0.032N* | P=0.599 |
|FISHER EXACT | P=0.134N P=0.056N P=0.059N | P=0.500N P=0.500N P=0.747N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 2/50 (4%) 1/50 (2%) 1/49 (2%) | 1/49 (2%) 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 20.6% 6.9% 3.8% 2.5% | 2.9% 0.0% 0.0% 5.0% |
|TERMINAL (d) | 6/33 (18%) 1/28 (4%) 1/26 (4%) 0/15 (0%) | 1/34 (3%) 0/31 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 716 702 729 (T) 609 | 729 (T) --- --- 718 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066N P=0.129N P=0.065N P=0.175N | P=0.485 P=0.518N P=0.539N P=0.632 |
|INCIDENTAL TUMOR | P=0.023N* P=0.098N P=0.060N P=0.085N | P=0.572 P=0.518N P=0.539N P=0.723 |
|LOGISTIC REGRESSION | P=0.026N* P=0.112N P=0.053N P=0.058N | P=0.514 P=0.518N P=0.539N P=0.665 |
|COCHRAN-ARMITAGE | P=0.017N* | P=0.599 |
|FISHER EXACT | P=0.080N P=0.030N* P=0.032N* | P=0.500N P=0.500N P=0.747N |
|=================================================================================================================================|
| |
|Liver |
| Cholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 43/50 (86%) 48/50 (96%) 49/50 (98%) | 0/50 (0%) 49/50 (98%) 50/50 (100%) 48/50 (96%) |
|ADJUSTED (b) | 0.0% 100.0% 100.0% 100.0% | 0.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 0/33 (0%) 28/28 (100%) 26/26 (100%) 16/16 (100%)| 0/34 (0%) 32/32 (100%) 28/28 (100%) 19/19 (100%)|
|FIRST INCIDENCE (DAYS) | --- 470 254 421 | --- 436 388 143 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 18/50 (36%) 27/50 (54%) | 0/50 (0%) 2/50 (4%) 4/50 (8%) 7/50 (14%) |
|ADJUSTED (b) | 2.6% 14.3% 56.9% 74.0% | 0.0% 6.0% 13.3% 33.8% |
|TERMINAL (d) | 0/33 (0%) 4/28 (14%) 13/26 (50%) 8/16 (50%) | 0/34 (0%) 1/32 (3%) 3/28 (11%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 660 729 (T) 613 490 | --- 697 688 644 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.142 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.045 * P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.156 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.195 P=0.047 * P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.149 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.224 P=0.048 * P=0.002 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.003 ** |
|FISHER EXACT | P=0.181 P<0.001 ** P<0.001 ** | P=0.247 P=0.059 P=0.006 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 6/50 (12%) 18/50 (36%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 3.6% 22.0% 58.5% | 0.0% 0.0% 0.0% 3.4% |
|TERMINAL (d) | 0/33 (0%) 1/28 (4%) 5/26 (19%) 5/16 (31%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 703 624 | --- --- --- 664 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.467 P=0.008 ** P<0.001 ** | P=0.156 (e) (e) P=0.426 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.467 P=0.009 ** P<0.001 ** | P=0.231 (e) (e) P=0.519 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.467 P=0.009 ** P<0.001 ** | P=0.197 (e) (e) P=0.502 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.198 |
|FISHER EXACT | P=0.500 P=0.013 * P<0.001 ** | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 22/50 (44%) 35/50 (70%) | 0/50 (0%) 2/50 (4%) 4/50 (8%) 8/50 (16%) |
|ADJUSTED (b) | 2.6% 17.9% 68.0% 84.5% | 0.0% 6.0% 13.3% 36.1% |
|TERMINAL (d) | 0/33 (0%) 5/28 (18%) 16/26 (62%) 10/16 (63%) | 0/34 (0%) 1/32 (3%) 3/28 (11%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 660 729 (T) 613 490 | --- 697 688 644 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.075 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.045 * P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.083 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.195 P=0.047 * P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.079 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.224 P=0.048 * P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.102 P<0.001 ** P<0.001 ** | P=0.247 P=0.059 P=0.003 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 22/50 (44%) 35/50 (70%) | 0/50 (0%) 2/50 (4%) 4/50 (8%) 8/50 (16%) |
|ADJUSTED (b) | 2.6% 17.9% 68.0% 84.5% | 0.0% 6.0% 13.3% 36.1% |
|TERMINAL (d) | 0/33 (0%) 5/28 (18%) 16/26 (62%) 10/16 (63%) | 0/34 (0%) 1/32 (3%) 3/28 (11%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 660 729 (T) 613 490 | --- 697 688 644 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.075 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.230 P=0.045 * P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.083 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.195 P=0.047 * P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.079 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.224 P=0.048 * P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.102 P<0.001 ** P<0.001 ** | P=0.247 P=0.059 P=0.003 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 7.3% 0.0% | 2.9% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 1/26 (4%) 0/16 (0%) | 1/34 (3%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 707 --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.466 (e) P=0.194 (e) | P=0.370N P=0.512N P=0.539N P=0.616N |
|INCIDENTAL TUMOR | P=0.653 (e) P=0.214 (e) | P=0.370N P=0.512N P=0.539N P=0.616N |
|LOGISTIC REGRESSION | P=0.544 (e) P=0.210 (e) | P=0.370N P=0.512N P=0.539N P=0.616N |
|COCHRAN-ARMITAGE | P=0.594 | P=0.305N |
|FISHER EXACT | (e) P=0.247 (e) | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 5.9% 2.4% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 0/16 (0%) | 0/34 (0%) 0/32 (0%) 1/28 (4%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 627 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.177 (e) P=0.211 P=0.473 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.355 (e) P=0.303 P=0.757 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.290 (e) P=0.241 P=0.631 |
|COCHRAN-ARMITAGE | (e) | P=0.245 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% 0.0% | 2.9% 8.7% 8.9% 4.8% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 0/16 (0%) | 1/34 (3%) 2/32 (6%) 1/28 (4%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 539 --- --- | 729 (T) 659 541 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566N P=0.486 (e) (e) | P=0.502 P=0.282 P=0.257 P=0.638 |
|INCIDENTAL TUMOR | P=0.452N P=0.682 (e) (e) | P=0.541N P=0.260 P=0.316 P=0.710 |
|LOGISTIC REGRESSION | P=0.580N P=0.522 (e) (e) | P=0.564N P=0.285 P=0.312 P=0.665 |
|COCHRAN-ARMITAGE | P=0.567N | P=0.500N |
|FISHER EXACT | P=0.500 (e) (e) | P=0.309 P=0.309 P=0.753N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 5/50 (10%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% 0.0% | 2.9% 8.7% 14.4% 7.1% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 0/16 (0%) | 1/34 (3%) 2/32 (6%) 2/28 (7%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 539 --- --- | 729 (T) 659 541 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566N P=0.486 (e) (e) | P=0.240 P=0.282 P=0.078 P=0.364 |
|INCIDENTAL TUMOR | P=0.452N P=0.682 (e) (e) | P=0.472 P=0.260 P=0.133 P=0.583 |
|LOGISTIC REGRESSION | P=0.580N P=0.522 (e) (e) | P=0.416 P=0.285 P=0.106 P=0.502 |
|COCHRAN-ARMITAGE | P=0.567N | P=0.437 |
|FISHER EXACT | P=0.500 (e) (e) | P=0.309 P=0.102 P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 1/50 (2%) 1/50 (2%) | 15/50 (30%) 17/50 (34%) 18/50 (36%) 14/50 (28%) |
|ADJUSTED (b) | 11.6% 10.7% 3.8% 3.4% | 39.2% 42.5% 51.6% 48.9% |
|TERMINAL (d) | 3/33 (9%) 3/28 (11%) 1/26 (4%) 0/16 (0%) | 11/34 (32%) 10/32 (31%) 12/28 (43%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 680 729 (T) 729 (T) 688 | 665 541 549 521 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.219N P=0.586N P=0.252N P=0.355N | P=0.112 P=0.351 P=0.171 P=0.148 |
|INCIDENTAL TUMOR | P=0.129N P=0.557N P=0.242N P=0.163N | P=0.461 P=0.313 P=0.256 P=0.416 |
|LOGISTIC REGRESSION | P=0.141N P=0.568N P=0.216N P=0.233N | P=0.417 P=0.370 P=0.231 P=0.395 |
|COCHRAN-ARMITAGE | P=0.092N | P=0.419N |
|FISHER EXACT | P=0.500N P=0.181N P=0.181N | P=0.415 P=0.335 P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 1/50 (2%) 1/50 (2%) | 15/50 (30%) 17/50 (34%) 20/50 (40%) 15/50 (30%) |
|ADJUSTED (b) | 11.6% 10.7% 3.8% 3.4% | 39.2% 42.5% 55.7% 50.2% |
|TERMINAL (d) | 3/33 (9%) 3/28 (11%) 1/26 (4%) 0/16 (0%) | 11/34 (32%) 10/32 (31%) 13/28 (46%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 680 729 (T) 729 (T) 688 | 665 541 549 521 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.219N P=0.586N P=0.252N P=0.355N | P=0.065 P=0.351 P=0.089 P=0.107 |
|INCIDENTAL TUMOR | P=0.129N P=0.557N P=0.242N P=0.163N | P=0.383 P=0.313 P=0.156 P=0.379 |
|LOGISTIC REGRESSION | P=0.141N P=0.568N P=0.216N P=0.233N | P=0.325 P=0.370 P=0.125 P=0.347 |
|COCHRAN-ARMITAGE | P=0.092N | P=0.531N |
|FISHER EXACT | P=0.500N P=0.181N P=0.181N | P=0.415 P=0.201 P=0.586N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 1/50 (2%) 1/50 (2%) | 15/50 (30%) 18/50 (36%) 23/50 (46%) 15/50 (30%) |
|ADJUSTED (b) | 11.6% 12.9% 3.8% 3.4% | 39.2% 44.0% 61.0% 50.2% |
|TERMINAL (d) | 3/33 (9%) 3/28 (11%) 1/26 (4%) 0/16 (0%) | 11/34 (32%) 10/32 (31%) 14/28 (50%) 6/19 (32%) |
|FIRST INCIDENCE (DAYS) | 680 539 729 (T) 688 | 665 541 541 521 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.184N P=0.560 P=0.252N P=0.355N | P=0.061 P=0.282 P=0.029 * P=0.107 |
|INCIDENTAL TUMOR | P=0.091N P=0.636N P=0.242N P=0.163N | P=0.399 P=0.229 P=0.058 P=0.379 |
|LOGISTIC REGRESSION | P=0.089N P=0.606 P=0.216N P=0.233N | P=0.334 P=0.297 P=0.042 * P=0.347 |
|COCHRAN-ARMITAGE | P=0.077N | P=0.530N |
|FISHER EXACT | P=0.643N P=0.181N P=0.181N | P=0.335 P=0.074 P=0.586N |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 6.3% 0.0% 0.0% |
|TERMINAL (d) | | 0/34 (0%) 2/32 (6%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.520N P=0.225 (e) (e) |
|INCIDENTAL TUMOR | | P=0.520N P=0.225 (e) (e) |
|LOGISTIC REGRESSION | | P=0.520N P=0.225 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.405N |
|FISHER EXACT | | P=0.247 (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 10/50 (20%) 6/49 (12%) | 0/50 (0%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 17.0% 29.8% 33.9% 35.3% | 0.0% 0.0% 3.2% 0.0% |
|TERMINAL (d) | 4/33 (12%) 7/28 (25%) 7/26 (27%) 5/15 (33%) | 0/34 (0%) 0/31 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 680 668 665 665 | --- --- 703 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142 P=0.191 P=0.105 P=0.196 | P=0.639 (e) P=0.476 (e) |
|INCIDENTAL TUMOR | P=0.444 P=0.246 P=0.111 P=0.382 | P=0.713 (e) P=0.500 (e) |
|LOGISTIC REGRESSION | P=0.378 P=0.212 P=0.142 P=0.401 | P=0.671 (e) P=0.486 (e) |
|COCHRAN-ARMITAGE | P=0.506N | P=0.694 |
|FISHER EXACT | P=0.288 P=0.207 P=0.606 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 11/50 (22%) 6/49 (12%) | 0/50 (0%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 17.0% 29.8% 37.4% 35.3% | 0.0% 0.0% 3.2% 0.0% |
|TERMINAL (d) | 4/33 (12%) 7/28 (25%) 8/26 (31%) 5/15 (33%) | 0/34 (0%) 0/31 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 680 668 665 665 | --- --- 703 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 P=0.191 P=0.064 P=0.196 | P=0.639 (e) P=0.476 (e) |
|INCIDENTAL TUMOR | P=0.410 P=0.246 P=0.067 P=0.382 | P=0.713 (e) P=0.500 (e) |
|LOGISTIC REGRESSION | P=0.353 P=0.212 P=0.088 P=0.401 | P=0.671 (e) P=0.486 (e) |
|COCHRAN-ARMITAGE | P=0.519N | P=0.694 |
|FISHER EXACT | P=0.288 P=0.143 P=0.606 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/49 (22%) 11/50 (22%) 17/49 (35%) 11/49 (22%) | 28/50 (56%) 26/50 (52%) 25/49 (51%) 20/49 (41%) |
|ADJUSTED (b) | 30.4% 31.3% 45.2% 43.5% | 61.6% 66.1% 68.7% 69.4% |
|TERMINAL (d) | 8/33 (24%) 5/28 (18%) 7/26 (27%) 5/16 (31%) | 17/34 (50%) 19/32 (59%) 16/27 (59%) 11/19 (58%) |
|FIRST INCIDENCE (DAYS) | 659 629 394 421 | 470 436 541 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107 P=0.455 P=0.064 P=0.139 | P=0.266 P=0.546N P=0.441 P=0.365 |
|INCIDENTAL TUMOR | P=0.378N P=0.580 P=0.148 P=0.598 | P=0.273N P=0.535N P=0.423N P=0.211N |
|LOGISTIC REGRESSION | P=0.446 P=0.519 P=0.110 P=0.528 | P=0.264N P=0.449N P=0.473N P=0.241N |
|COCHRAN-ARMITAGE | P=0.469 | P=0.075N |
|FISHER EXACT | P=0.574N P=0.132 P=0.595N | P=0.421N P=0.384N P=0.095N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/49 (22%) 11/50 (22%) 17/49 (35%) 12/49 (24%) | 28/50 (56%) 26/50 (52%) 25/49 (51%) 20/49 (41%) |
|ADJUSTED (b) | 30.4% 31.3% 45.2% 45.9% | 61.6% 66.1% 68.7% 69.4% |
|TERMINAL (d) | 8/33 (24%) 5/28 (18%) 7/26 (27%) 5/16 (31%) | 17/34 (50%) 19/32 (59%) 16/27 (59%) 11/19 (58%) |
|FIRST INCIDENCE (DAYS) | 659 629 394 421 | 470 436 541 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.069 P=0.455 P=0.064 P=0.092 | P=0.266 P=0.546N P=0.441 P=0.365 |
|INCIDENTAL TUMOR | P=0.449N P=0.580 P=0.148 P=0.544 | P=0.273N P=0.535N P=0.423N P=0.211N |
|LOGISTIC REGRESSION | P=0.349 P=0.519 P=0.110 P=0.428 | P=0.264N P=0.449N P=0.473N P=0.241N |
|COCHRAN-ARMITAGE | P=0.372 | P=0.075N |
|FISHER EXACT | P=0.574N P=0.132 P=0.500 | P=0.421N P=0.384N P=0.095N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 5/50 (10%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 9.4% 18.0% 6.1% | 0.0% 0.0% 3.6% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/28 (4%) 4/26 (15%) 0/16 (0%) | 0/34 (0%) 0/32 (0%) 1/28 (4%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 660 678 665 | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 P=0.104 P=0.019 * P=0.214 | P=0.629 (e) P=0.461 (e) |
|INCIDENTAL TUMOR | P=0.425 P=0.138 P=0.020 * P=0.500 | P=0.629 (e) P=0.461 (e) |
|LOGISTIC REGRESSION | P=0.251 P=0.108 P=0.023 * P=0.233 | P=0.629 (e) P=0.461 (e) |
|COCHRAN-ARMITAGE | P=0.291 | P=0.694 |
|FISHER EXACT | P=0.121 P=0.028 * P=0.247 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 9.3% 0.0% 3.1% | 0.0% 3.1% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 2/28 (7%) 0/26 (0%) 0/16 (0%) | 0/34 (0%) 1/32 (3%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 421 --- 667 | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539N P=0.262 P=0.548N P=0.668 | P=0.656N P=0.488 (e) (e) |
|INCIDENTAL TUMOR | P=0.400N P=0.335 P=0.548N P=0.746N | P=0.656N P=0.488 (e) (e) |
|LOGISTIC REGRESSION | P=0.409N P=0.298 P=0.548N P=0.746 | P=0.656N P=0.488 (e) (e) |
|COCHRAN-ARMITAGE | P=0.409N | P=0.567N |
|FISHER EXACT | P=0.309 P=0.500N P=0.753N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 5.8% 0.0% 3.1% | 0.0% 3.1% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 1/28 (4%) 0/26 (0%) 0/16 (0%) | 0/34 (0%) 1/32 (3%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 421 --- 667 | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.598N P=0.459 P=0.548N P=0.668 | P=0.656N P=0.488 (e) (e) |
|INCIDENTAL TUMOR | P=0.444N P=0.563 P=0.548N P=0.746N | P=0.656N P=0.488 (e) (e) |
|LOGISTIC REGRESSION | P=0.500N P=0.504 P=0.548N P=0.746 | P=0.656N P=0.488 (e) (e) |
|COCHRAN-ARMITAGE | P=0.500N | P=0.567N |
|FISHER EXACT | P=0.500 P=0.500N P=0.753N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 5/50 (10%) 4/50 (8%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.1% 21.3% 18.0% 12.8% | 0.0% 3.1% 3.6% 0.0% |
|TERMINAL (d) | 2/33 (6%) 4/28 (14%) 4/26 (15%) 0/16 (0%) | 0/34 (0%) 1/32 (3%) 1/28 (4%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 421 678 665 | --- 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.207 P=0.057 P=0.137 P=0.196 | P=0.680 P=0.488 P=0.461 (e) |
|INCIDENTAL TUMOR | P=0.556N P=0.090 P=0.142 P=0.558 | P=0.680 P=0.488 P=0.461 (e) |
|LOGISTIC REGRESSION | P=0.438 P=0.069 P=0.159 P=0.303 | P=0.680 P=0.488 P=0.461 (e) |
|COCHRAN-ARMITAGE | P=0.467 | P=0.595N |
|FISHER EXACT | P=0.080 P=0.218 P=0.339 | P=0.500 P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 4/50 (8%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 9.4% 12.0% 11.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 2/28 (7%) 1/26 (4%) 1/16 (6%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- 525 541 591 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.078 P=0.102 P=0.051 P=0.073 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.273 P=0.149 P=0.074 P=0.153 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.161 P=0.115 P=0.062 P=0.118 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.162 | (e) |
|FISHER EXACT | P=0.121 P=0.059 P=0.121 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.2% 0.0% 7.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 2/26 (8%) 0/16 (0%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 464 --- 729 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.576N P=0.509N P=0.445 P=0.504N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.505N P=0.318N P=0.523 P=0.282N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.461N P=0.459N P=0.501 P=0.527N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.461N | (e) |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 6/50 (12%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.2% 9.4% 19.1% 11.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 2/28 (7%) 3/26 (12%) 1/16 (6%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 464 525 541 591 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 P=0.271 P=0.043 * P=0.227 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.364 P=0.433 P=0.068 P=0.468 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.264 P=0.313 P=0.058 P=0.304 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.264 | (e) |
|FISHER EXACT | P=0.309 P=0.056 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Spleen |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 8.6% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 1/16 (6%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 609 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027 * (e) (e) P=0.156 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.032 * (e) (e) P=0.199 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.046 * (e) (e) P=0.234 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.046 * | (e) |
|FISHER EXACT | (e) (e) P=0.247 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/50 (90%) 38/50 (76%) 40/50 (80%) 45/50 (90%) | |
|ADJUSTED (b) | 100.0% 100.0% 97.5% 100.0% | |
|TERMINAL (d) | 33/33 (100%) 28/28 (100%) 25/26 (96%) 16/16 (100%)| |
|FIRST INCIDENCE (DAYS) | 407 587 520 448 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.504N P=0.331 P<0.001 ** | |
|INCIDENTAL TUMOR | P=0.263 P=0.091N P=0.117N P=0.625N | |
|LOGISTIC REGRESSION | P=0.329 P=0.031N* P=0.054N P=0.526N | |
|COCHRAN-ARMITAGE | P=0.348 | |
|FISHER EXACT | P=0.054N P=0.131N P=0.630N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/48 (13%) 6/50 (12%) 1/50 (2%) 4/48 (8%) | 8/50 (16%) 4/50 (8%) 5/50 (10%) 2/49 (4%) |
|ADJUSTED (b) | 15.6% 18.9% 3.1% 24.4% | 22.5% 12.5% 17.9% 9.6% |
|TERMINAL (d) | 3/33 (9%) 4/28 (14%) 0/26 (0%) 3/15 (20%) | 7/34 (21%) 4/32 (13%) 5/28 (18%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 464 660 678 707 | 666 729 (T) 729 (T) 701 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.474N P=0.530 P=0.091N P=0.542 | P=0.199N P=0.208N P=0.407N P=0.213N |
|INCIDENTAL TUMOR | P=0.180N P=0.583N P=0.030N* P=0.411N | P=0.168N P=0.219N P=0.399N P=0.162N |
|LOGISTIC REGRESSION | P=0.234N P=0.607 P=0.052N P=0.395N | P=0.148N P=0.212N P=0.373N P=0.143N |
|COCHRAN-ARMITAGE | P=0.209N | P=0.050N |
|FISHER EXACT | P=0.591N P=0.050N* P=0.370N | P=0.178N P=0.277N P=0.049N* |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 1/50 (2%) 2/50 (4%) 0/48 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 3.0% 3.1% 7.4% 0.0% | 2.9% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/28 (0%) 1/26 (4%) 0/15 (0%) | 1/34 (3%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 680 725 --- | 729 (T) 575 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.526N P=0.729 P=0.422 P=0.657N | P=0.287N P=0.751 P=0.539N P=0.616N |
|INCIDENTAL TUMOR | P=0.291N P=0.752N P=0.445 P=0.657N | P=0.195N P=0.679N P=0.539N P=0.616N |
|LOGISTIC REGRESSION | P=0.436N P=0.749 P=0.432 P=0.657N | P=0.210N P=0.739N P=0.539N P=0.616N |
|COCHRAN-ARMITAGE | P=0.368N | P=0.238N |
|FISHER EXACT | P=0.742N P=0.515 P=0.500N | P=0.753N P=0.500N P=0.505N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/48 (13%) 7/50 (14%) 3/50 (6%) 4/48 (8%) | 9/50 (18%) 5/50 (10%) 5/50 (10%) 2/49 (4%) |
|ADJUSTED (b) | 15.6% 21.5% 10.3% 24.4% | 25.4% 14.4% 17.9% 9.6% |
|TERMINAL (d) | 3/33 (9%) 4/28 (14%) 1/26 (4%) 3/15 (20%) | 8/34 (24%) 4/32 (13%) 5/28 (18%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | 464 660 678 707 | 666 575 729 (T) 701 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.512N P=0.409 P=0.334N P=0.542 | P=0.122N P=0.228N P=0.309N P=0.157N |
|INCIDENTAL TUMOR | P=0.146N P=0.554 P=0.179N P=0.411N | P=0.085N P=0.202N P=0.303N P=0.117N |
|LOGISTIC REGRESSION | P=0.247N P=0.483 P=0.233N P=0.395N | P=0.070N P=0.225N P=0.278N P=0.100N |
|COCHRAN-ARMITAGE | P=0.215N | P=0.025N* |
|FISHER EXACT | P=0.532 P=0.223N P=0.370N | P=0.194N P=0.194N P=0.028N* |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/49 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 15.8% |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/26 (0%) 0/16 (0%) | 0/34 (0%) 0/32 (0%) 0/27 (0%) 3/19 (16%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.002 ** (e) (e) P=0.040 * |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.002 ** (e) (e) P=0.040 * |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.002 ** (e) (e) P=0.040 * |
|COCHRAN-ARMITAGE | (e) | P=0.012 * |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.125 |
|=================================================================================================================================|
| |
|Uterus |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 3.1% 0.0% 7.5% |
|TERMINAL (d) | | 0/34 (0%) 1/32 (3%) 0/28 (0%) 1/19 (5%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) --- 532 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.078 P=0.488 (e) P=0.165 |
|INCIDENTAL TUMOR | | P=0.116 P=0.488 (e) P=0.240 |
|LOGISTIC REGRESSION | | P=0.141 P=0.488 (e) P=0.266 |
|COCHRAN-ARMITAGE | | P=0.140 |
|FISHER EXACT | | P=0.500 (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 12/50 (24%) 14/50 (28%) 9/50 (18%) |
|ADJUSTED (b) | | 24.6% 36.1% 36.8% 30.0% |
|TERMINAL (d) | | 5/34 (15%) 11/32 (34%) 6/28 (21%) 3/19 (16%) |
|FIRST INCIDENCE (DAYS) | | 528 667 557 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.211 P=0.344 P=0.157 P=0.318 |
|INCIDENTAL TUMOR | | P=0.480N P=0.283 P=0.297 P=0.457N |
|LOGISTIC REGRESSION | | P=0.540N P=0.356 P=0.237 P=0.526N |
|COCHRAN-ARMITAGE | | P=0.421N |
|FISHER EXACT | | P=0.405 P=0.241 P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 13/50 (26%) 14/50 (28%) 9/50 (18%) |
|ADJUSTED (b) | | 24.6% 37.7% 36.8% 30.0% |
|TERMINAL (d) | | 5/34 (15%) 11/32 (34%) 6/28 (21%) 3/19 (16%) |
|FIRST INCIDENCE (DAYS) | | 528 639 557 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.233 P=0.266 P=0.157 P=0.318 |
|INCIDENTAL TUMOR | | P=0.418N P=0.241 P=0.297 P=0.457N |
|LOGISTIC REGRESSION | | P=0.499N P=0.278 P=0.237 P=0.526N |
|COCHRAN-ARMITAGE | | P=0.388N |
|FISHER EXACT | | P=0.318 P=0.241 P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Vagina |
| Polyp |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 5.9% 0.0% 0.0% 0.0% |
|TERMINAL (d) | | 2/34 (6%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.160N P=0.252N P=0.282N P=0.373N |
|INCIDENTAL TUMOR | | P=0.160N P=0.252N P=0.282N P=0.373N |
|LOGISTIC REGRESSION | | P=0.160N P=0.252N P=0.282N P=0.373N |
|COCHRAN-ARMITAGE | | P=0.115N |
|FISHER EXACT | | P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 11/50 (22%) 17/50 (34%) 25/50 (50%) | 8/50 (16%) 9/50 (18%) 17/50 (34%) 21/50 (42%) |
|ADJUSTED (b) | 21.0% 31.7% 46.5% 70.6% | 18.6% 24.1% 45.4% 59.9% |
|TERMINAL (d) | 4/33 (12%) 6/28 (21%) 8/26 (31%) 8/16 (50%) | 1/34 (3%) 5/32 (16%) 9/28 (32%) 7/19 (37%) |
|FIRST INCIDENCE (DAYS) | 645 384 520 421 | 556 602 557 238 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.227 P=0.016 * P<0.001 ** | P<0.001 ** P=0.441 P=0.022 * P<0.001 ** |
|INCIDENTAL TUMOR | P=0.002 ** P=0.385 P=0.046 * P=0.005 ** | P=0.003 ** P=0.521 P=0.050 * P=0.020 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.267 P=0.027 * P<0.001 ** | P<0.001 ** P=0.527 P=0.027 * P=0.008 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.306 P=0.032 * P<0.001 ** | P=0.500 P=0.032 * P=0.004 ** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 3/50 (6%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 3.6% 7.2% 10.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 1/28 (4%) 0/26 (0%) 1/16 (6%) | 0/34 (0%) 0/32 (0%) 0/28 (0%) 0/19 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 556 490 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104 P=0.725 P=0.279 P=0.190 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.177 P=0.725 P=0.538 P=0.296 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.163 P=0.725 P=0.307 P=0.306 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.164 | (e) |
|FISHER EXACT | P=0.753N P=0.309 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 42/50 (84%) 46/50 (92%) 47/50 (94%) | 42/50 (84%) 41/50 (82%) 41/50 (82%) 37/50 (74%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 85.7% 93.1% 95.2% 92.4% |
|TERMINAL (d) | 33/33 (100%) 28/28 (100%) 26/26 (100%) 16/16 (100%)| 27/34 (79%) 29/32 (91%) 26/28 (93%) 16/19 (84%) |
|FIRST INCIDENCE (DAYS) | 407 421 394 421 | 470 436 462 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.414 P=0.094 P<0.001 ** | P=0.012 * P=0.462 P=0.221 P=0.034 * |
|INCIDENTAL TUMOR | P=0.624 P=0.288N P=0.638N P=0.500N | P=0.536N P=0.466 P=0.557N P=0.476N |
|LOGISTIC REGRESSION | P=0.609 P=0.200N P=0.691N P=0.417N | P=0.549N P=0.609 P=0.561 P=0.549N |
|COCHRAN-ARMITAGE | P=0.244 | P=0.120N |
|FISHER EXACT | P=0.178N P=0.643N P=0.500 | P=0.500N P=0.500N P=0.163N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG | VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 44/50 (88%) 48/50 (96%) 49/50 (98%) | 16/50 (32%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|
|ADJUSTED (b) | 33.5% 100.0% 100.0% 100.0% | 35.9% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 6/33 (18%) 28/28 (100%) 26/26 (100%) 16/16 (100%)| 6/34 (18%) 32/32 (100%) 28/28 (100%) 19/19 (100%)|
|FIRST INCIDENCE (DAYS) | 464 384 254 421 | 556 364 388 143 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 45/50 (90%) 48/50 (96%) 49/50 (98%) | 45/50 (90%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 91.8% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 33/33 (100%) 28/28 (100%) 26/26 (100%) 16/16 (100%)| 30/34 (88%) 32/32 (100%) 28/28 (100%) 19/19 (100%)|
|FIRST INCIDENCE (DAYS) | 407 384 254 421 | 470 364 388 143 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.221 P=0.053 P<0.001 ** | P<0.001 ** P=0.129 P=0.036 * P<0.001 ** |
|INCIDENTAL TUMOR | P=0.555 (e) P=0.443 (e) | P=0.012 * P=0.039 * P=0.037 * P=0.063 |
|LOGISTIC REGRESSION | P=0.241 (e) P=0.268 (e) | P=0.010 ** P=0.033 * P=0.034 * P=0.043 * |
|COCHRAN-ARMITAGE | P=0.079 | P=0.009 ** |
|FISHER EXACT | P=0.500N P=0.339 P=0.181 | P=0.028 * P=0.028 * P=0.028 * |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05004 TEST: 03 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURAN
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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