TDMS Study 05004-03 Pathology Tables
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
Facility: Southern Research Institute
Chemical CAS #: 110-00-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|
| 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Developmental Malformation | X 2 X |
Eosinophilic Focus | X X X X X X |
Granuloma, Multiple | 1 2 1|
Necrosis, Focal | 2 |
Biliary Tract, Proliferation | 2 2 2 2 2 3 1 3 1 |
Centrilobular, Necrosis | 2 2 2 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic, Diffuse | |
Fat, Necrosis, Focal | 4 4 4 |
Fat, Necrosis, Multifocal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Atrophy, Multifocal | 2 |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | 3 |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|
| 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 |
Focal Cellular Change | X X X X X X |
Hypertrophy, Focal | 2 |
Necrosis, Diffuse | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Necrosis, Diffuse | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 3 3 3 2 3 3 4 3 3 3 2 2|
Pars Distalis, Cyst | X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 2 1 1 2 |
C-Cell, Hyperplasia, Multifocal | 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
Inflammation, Acute, Focal, | |
Suppurative | 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|
| 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X |
Hydrometra | |
Hyperplasia, Cystic | |
Inflammation, Acute | 2 |
Inflammation, Acute, Suppurative | |
Cervix, Cyst | |
Cervix, Cyst, Multiple | X |
Cervix, Hypertrophy | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M M + M M + + M + M + + + + + M + M + M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hyperplasia | |
Inflammation, Acute, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 3 |
Hematopoietic Cell Proliferation | 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fat, Mediastinum, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hypertrophy, Focal | 2 |
Femur, Hypertrophy, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|
| 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Degeneration, Multifocal | 4 |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | |
Granuloma, Multiple | 1 2 2 2 1 1|
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Pigmentation, Focal, Cholesterol | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Fat, Mediastinum, Necrosis, | |
Multifocal | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Subacute | |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic, Focal | 1 2 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | |
Nephropathy, Chronic | 3 2 1 3 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Parasite Metazoan | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 5 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | | 1 |
Developmental Malformation | X 2 2 2 2 X | 9 2.0|
Eosinophilic Focus | X X X X X X X X X X X | 17 |
Granuloma, Multiple | 2 2 1 1 2 2 1 | 10 1.5|
Necrosis, Focal | | 1 2.0|
Biliary Tract, Proliferation | 2 3 | 11 2.1|
Centrilobular, Necrosis | 2 2 1 2 | 8 1.9|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Inflammation, Chronic, Diffuse | 3 | 1 3.0|
Fat, Necrosis, Focal | 4 4 4 | 6 4.0|
Fat, Necrosis, Multifocal | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 2 2 | 4 2.0|
Atrophy, Multifocal | 2 2 | 3 2.0|
Hyperplasia, Focal | 2 | 4 2.0|
Hyperplasia, Multifocal | | 1 3.0|
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema, Diffuse | 2 | 1 2.0|
Ulcer | 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 | 17 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Angiectasis | 2 2| 3 2.0|
Focal Cellular Change | X X X | 9 |
Hypertrophy, Focal | | 1 2.0|
Necrosis, Diffuse | 4 | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
Necrosis, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M M + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 3 2 1 3 2 2 3 3 2 2 2 3 3 3 | 31 2.5|
Pars Distalis, Cyst | X X X X X X X X X X X| 18 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 2 2| 9 2.2|
Pars Distalis, Hyperplasia | 2 2 | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 1 2 2 2 2 | 11 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia, Focal | 2 2 2 | 7 1.7|
C-Cell, Hyperplasia, Multifocal | 2 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + M + + + + + + + M + + + M + + + + M + + + +| 43 |
Hyperplasia | 2 2 | 4 2.3|
Inflammation, Acute, Focal, | | |
Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 1.0|
Cyst | | 2 |
Hydrometra | 2 3 | 2 2.5|
Hyperplasia, Cystic | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Acute, Suppurative | 1| 1 1.0|
Cervix, Cyst | X | 1 |
Cervix, Cyst, Multiple | | 1 |
Cervix, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M + + M + + + + + + M M + M M M M + M M| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Ectasia | 3 | 3 2.3|
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + M + + + + + + + + + +| 48 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 1 | 2 1.0|
Fibrosis, Focal | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 2 3 2 3 3 | 8 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Cyst | | 1 |
Fat, Mediastinum, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X| 43 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hypertrophy, Focal | 3 | 2 2.5|
Femur, Hypertrophy, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.0|
Degeneration, Multifocal | | 1 4.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Foreign Body | 2 | 1 2.0|
Granuloma, Multiple | 2 2 1 1 2 2 | 12 1.6|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 1 2.0|
Pigmentation, Focal, Cholesterol | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 2 2 | 4 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
Fat, Mediastinum, Necrosis, | | |
Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Acute, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 3.0|
Inflammation, Subacute | 4 | 1 4.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Multilocular | X | 1 |
Nephropathy, Chronic | 1 2 1 1 1 1 2 1 | 16 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|
| 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | X X X X X X X X X|
Developmental Malformation | 2 X 2 |
Hemorrhage, Focal | 2|
Hemorrhage, Multifocal | 2 |
Hyperplasia, Multifocal, Nodular | |
Neovascularization | 2 2 2 |
Pigmentation, Hematoidin | |
Thrombosis | |
Biliary Tract, Cyst, Multiple | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4|
Biliary Tract, Fibrosis, Multifocal | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3 4 4 4 4|
Biliary Tract, Hyperplasia, | |
Multifocal | 4 4 4 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 4 4 4 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Metaplasia | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4|
Centrilobular, Necrosis | 2 3 |
Hepatocyte, Cytomegaly | 4 3 3 3 3 3 2 2 3 3 2 3 3 3 3 3 3 2 3 4 3 3 3 3 2|
Hepatocyte, Degeneration, Multifocal | 3 3 3 2 4 2 2 3 3 2 4 2 3 2 3 2 2 3 3 3 2 2 3 2|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Hepatocyte, Necrosis, Multifocal | 2 2 3 2 4 2 2 4 3 2 4 2 2 2 3 2 2 4 2 3 2 4 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 4 4 2 2 3 3 3 4 4 4 3 3 2 3 4 3 2 2 3 4|
Kupffer Cell, Pigmentation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Mineralization, Focal | 2 |
Fat, Necrosis, Focal | 4 4 4 4 2 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1|
Atrophy, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|
| 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Focal | 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperkeratosis | |
Hyperplasia | 2 2 |
Hyperplasia, Squamous | 2 |
Inflammation, Subacute | 2 2 2 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Erosion, Multiple | 3 |
Mineralization, Multifocal | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Abdominal, Hypertrophy | |
Abdominal, Inflammation, Subacute | |
Abdominal, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 1 2 3 1 2 2 1 2 1 1 2 1|
Mineralization, Multifocal | 4 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Focal Cellular Change | X X |
Hematopoietic Cell Proliferation | 2 |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 2 2 2 1 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 2 2 3 3 3 2 3 3 2 1|
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|
| 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute, Focal, | |
Suppurative | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hemorrhage | |
Cervix, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Ectasia | 3 3 4 3 2 3 3 4 3 3 2 4|
Pancreatic, Hyperplasia | 2 |
Pancreatic, Necrosis | |
Renal, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + + + + + + + + M + M + M M + + + + + M M|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + + + + + M + + + M + + + + + + +|
Ectasia | 2 |
Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 2 1 3 3|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 2 2 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|
| 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 2 2 3 4|
Inflammation, Chronic, Focal | |
Necrosis, Diffuse | |
Necrosis, Focal | 4 4 |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hypertrophy, Focal | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Foreign Body | 4 |
Granuloma, Multiple | 2 1 2 1 2 2 |
Hemorrhage, Multifocal | 2 2|
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 1 2 |
Pigmentation, Focal, Cholesterol | 1 |
Pigmentation, Multifocal, Cholesterol| 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 2 |
Fat, Mediastinum, Necrosis, | |
Multifocal | 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|
DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|
| 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Nephropathy, Chronic | 4 2 3 3 4 3 3 3 4 4 3 3 4 4 4 4 3 4 2 1 3 4 4|
Renal Tubule, Mineralization, | |
Multifocal | 3 |
Renal Tubule, Necrosis, Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| |
DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| |
| 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Multilocular | X X X | 12 |
Developmental Malformation | | 3 2.0|
Hemorrhage, Focal | 2 | 2 2.0|
Hemorrhage, Multifocal | 2 2 | 3 2.0|
Hyperplasia, Multifocal, Nodular | 4 | 1 4.0|
Neovascularization | 2 2 2 2 2 | 8 2.0|
Pigmentation, Hematoidin | 2 | 1 2.0|
Thrombosis | X | 1 |
Biliary Tract, Cyst, Multiple | 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 46 4.0|
Biliary Tract, Fibrosis, Multifocal | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
Biliary Tract, Hyperplasia, | | |
Multifocal | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 2 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
Biliary Tract, Metaplasia | 2 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
Centrilobular, Necrosis | | 2 2.5|
Hepatocyte, Cytomegaly | 2 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4| 49 3.0|
Hepatocyte, Degeneration, Multifocal | 3 4 2 2 3 3 2 3 3 4 3 3 2 3 3 3 3 2 4 2 4 3 3| 47 2.8|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 46 4.0|
Hepatocyte, Necrosis, Multifocal | 3 3 2 2 3 2 2 2 2 3 2 2 2 3 3 3 2 2 4 2 4 4 2| 47 2.6|
Hepatocyte, Vacuolization Cytoplasmic| 3 4 2 3 3 3 3 4 3 4 4 3 3 3 3 3 4 4 3 3 3 2 4| 47 3.1|
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Mineralization, Focal | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| |
DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| |
| 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis, Focal | 4 4 | 7 3.7|
Fat, Necrosis, Multifocal | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 1 | 2 1.0|
Atrophy, Multifocal | | 1 1.0|
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 2 2.5|
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia | 2 2 2 | 5 2.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Subacute | 3 2 | 6 2.2|
Ulcer | 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Erosion, Multiple | | 1 3.0|
Mineralization, Multifocal | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Abdominal, Hypertrophy | 4 | 1 4.0|
Abdominal, Inflammation, Subacute | 3 | 1 3.0|
Abdominal, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 1 2 1 2 1 2 2 1 1 1 | 32 1.6|
Mineralization, Multifocal | | 1 4.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X | 3 |
Focal Cellular Change | X | 3 |
Hematopoietic Cell Proliferation | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| |
DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| |
| 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + M + + +| 46 |
Hyperplasia | 2 2 | 9 1.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Pars Distalis, Angiectasis | 4 4 3 2 3 3 3 3 4 | 22 2.8|
Pars Distalis, Cyst | X X X X X X X X X X X X | 20 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 2 2 | 18 2.1|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | 2 2 2 3 2 2 | 8 2.1|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia | 2 2 | 2 2.0|
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 2 2.5|
Duct, Cyst | X X X X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 |
Hemorrhage | 4 | 1 4.0|
Cervix, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 2 2 2 2 2 2 2 1| 24 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Ectasia | 3 4 2 2 4 3 3 4 4 4 3| 23 3.2|
Pancreatic, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| |
DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| |
| 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Necrosis | 1 | 1 1.0|
Renal, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + M M M + M M M + + M + + + M M M +| 30 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Ectasia | 2 | 2 2.0|
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Congestion | 3 2 | 2 2.5|
Ectasia | 3 3 2 2 2 2| 10 2.3|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 2 2 2 2 2 2 2 2 2 | 23 2.0|
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 4 2 3 2 3 2 4 2 2 3 4 | 25 2.6|
Inflammation, Chronic, Focal | 4 | 1 4.0|
Necrosis, Diffuse | 1 | 1 1.0|
Necrosis, Focal | | 2 4.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + M + + M + + + + M M + + + + + +| 43 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X| 43 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hypertrophy, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 | 2 2.5|
Hemorrhage, Focal | 2 | 1 2.0|
Hemorrhage, Multifocal | 4 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| |
DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| |
| 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 4 2.3|
Foreign Body | 2 | 2 3.0|
Granuloma, Multiple | 1 1 1 2 1 | 11 1.5|
Hemorrhage, Multifocal | 2 | 3 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 | 2 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 3 1.7|
Pigmentation, Focal, Cholesterol | 2 2 | 3 1.7|
Pigmentation, Multifocal, Cholesterol| | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 4 1.8|
Fat, Mediastinum, Necrosis, | | |
Multifocal | 2 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 2 | 2 2.5|
Fungus | 3 2 | 2 2.5|
Inflammation, Acute, Suppurative | 3 4 | 2 3.5|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 3 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
Nephropathy, Chronic | 2 2 4 4 3 3 4 4 4 3 4 4 4 4 4 3 4 4 3 4 2 3 3| 46 3.4|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 3.0|
Renal Tubule, Necrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|
| 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst Multilocular | |
Developmental Malformation | 2 2 |
Granuloma, Multiple | 2 1 1|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 2 1 2 2 |
Hemorrhage, Focal | 2 |
Hemorrhage, Multifocal | 2 |
Neovascularization | 2 2 2 |
Pigmentation, Hematoidin | 2 |
Pigmentation, Hemosiderin, Multifocal| 2 |
Thrombosis | X |
Biliary Tract, Cyst, Multiple | 3 4 4 3 4 3 3 4 3 4 2 4 4 4 4 3 4 4 3 4 2 3 4 3 4|
Biliary Tract, Fibrosis, Multifocal | 4 4 4 4 3 3 4 4 4 4 2 4 4 4 4 4 4 4 4 4 2 3 4 4 4|
Biliary Tract, Hyperplasia, | |
Multifocal | 3 4 4 4 4 3 4 4 4 3 2 4 4 4 4 4 4 4 4 4 2 3 4 3 4|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 3 4 4 4 3 3 4 4 4 3 2 4 4 4 4 3 4 4 4 4 2 3 4 3 4|
Biliary Tract, Metaplasia | 3 4 4 4 4 3 4 4 4 4 3 4 4 4 4 3 4 4 4 4 3 3 4 3 4|
Centrilobular, Necrosis | 2 2 2 2 3 |
Hepatocyte, Cytomegaly | 2 2 3 2 3 3 3 2 2 2 2 2 4 2 2 3 2 3 3 2 2 2 3 2 2|
Hepatocyte, Degeneration, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 3 2 2 2 2 2 2 2|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 2 2 2 2 2 2 2 2 2 2 2 3 4 2 2 3 2 2 2 4 2 4 2 2|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 4 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 2 3 2 2 2 3 3 2 2 3 4 3 3 4 4 4 2 2 2 2 2 2|
Kupffer Cell, Pigmentation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Mineralization, Focal | |
Fat, Necrosis, Focal | 4 4 |
Fat, Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|
| 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy, Focal | 2 |
Atrophy, Multifocal | |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | 3 4 3 3 2 |
Inflammation, Subacute | 3 4 3 2 2 |
Perforation | 4 4 |
Ulcer | 2 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Diffuse | 3 2 |
Erosion | 2 |
Erosion, Multiple | 2 |
Ulcer | 3 |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Focal Cellular Change | X X X X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | X |
Necrosis, Diffuse | 2 |
Necrosis, Multifocal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 4 3 4 4 3 3 3 3 4 3|
Pars Distalis, Cyst | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|
| 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 |
C-Cell, Hyperplasia | 2 2 |
C-Cell, Hyperplasia, Multifocal | 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Acute, Focal, | |
Suppurative | 2 |
Inflammation, Chronic | |
Inflammation, Focal, Subacute | |
Duct, Cyst | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Cystic | 2 2|
Inflammation, Chronic, Focal | |
Prolapse | 3 |
Cervix, Cyst | X |
__________________________________________________________________________|
Vagina | + + |
Inflammation, Acute, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 |
Myelofibrosis | 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Ectasia | 3 4 4 3 3 3 2 |
Pancreatic, Hyperplasia | 2 |
Pancreatic, Inflammation, | |
Granulomatous | |
Renal, Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + M + + M + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|
| 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Ectasia | 2 3 2 |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 2 |
Fibrosis, Focal | 4 |
Hematopoietic Cell Proliferation | 3 2 4 2 4 2 4 2 2 2 4 4 |
Necrosis, Focal | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + M + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hypertrophy, Focal | 2 2 2 2 3|
Femur, Hypertrophy, Focal | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Multiple | 1 2 1 1 2 2 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 2 2 |
Pigmentation, Focal, Cholesterol | 2 |
Pigmentation, Multifocal, Cholesterol| 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|
| 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fat, Mediastinum, Necrosis, | |
Multifocal | 3 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 3 |
Inflammation, Acute, Suppurative | 2 3 3 |
Mucosa, Cyst | |
Nasolacrimal Duct, Hyperkeratosis | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Hemorrhage | 3 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic, Suppurative | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 4 1 2 2 2 3 3 2 2 3 4 3 3 3 3 1 2 3 3 4 4|
Cortex, Fibrosis, Focal | 2 |
Papilla, Necrosis | |
Pelvis, Inflammation, Acute, | |
Suppurative | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Calculus Gross Observation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Cyst Multilocular | X X | 2 |
Developmental Malformation | 2 | 3 2.0|
Granuloma, Multiple | 2 2 2 2 2 | 8 1.8|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 7 1.9|
Hemorrhage, Focal | | 1 2.0|
Hemorrhage, Multifocal | | 1 2.0|
Neovascularization | 2 | 4 2.0|
Pigmentation, Hematoidin | | 1 2.0|
Pigmentation, Hemosiderin, Multifocal| | 1 2.0|
Thrombosis | | 1 |
Biliary Tract, Cyst, Multiple | 4 4 4 3 3 3 4 4 4 4 3 4 3 4 4 3 4 4 4 3 4 4 3 4 4| 50 3.6|
Biliary Tract, Fibrosis, Multifocal | 4 4 4 3 3 3 4 4 4 4 3 4 3 4 4 3 4 4 4 4 4 4 4 4 4| 50 3.7|
Biliary Tract, Hyperplasia, | | |
Multifocal | 4 4 4 3 3 3 4 4 3 4 3 4 3 4 4 3 4 4 4 4 4 4 4 4 4| 50 3.7|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 4 4 4 3 3 3 4 4 3 3 3 4 3 4 3 3 4 4 4 4 4 4 4 4 4| 50 3.6|
Biliary Tract, Metaplasia | 4 4 4 3 3 3 4 4 3 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4| 50 3.8|
Centrilobular, Necrosis | 2 2 2 2 2 | 10 2.1|
Hepatocyte, Cytomegaly | 2 2 3 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 3 2 2 3 2 2 2| 50 2.3|
Hepatocyte, Degeneration, Multifocal | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 3| 49 2.1|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2| 47 2.2|
Hepatocyte, Necrosis, Multifocal | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 3| 46 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 4 4 4 2 2 3 2 3 3 3 3 3 4 2 4 2 2 2 3 3 4 3| 49 2.8|
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Mineralization, Focal | 2 | 1 2.0|
Fat, Necrosis, Focal | 4 3 3 | 5 3.6|
Fat, Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 2 2 1 2 | 6 1.8|
Atrophy, Multifocal | 2 | 1 2.0|
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Hyperplasia | | 5 3.0|
Inflammation, Subacute | | 5 2.8|
Perforation | | 2 4.0|
Ulcer | 4 | 2 3.0|
Ulcer, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema, Diffuse | | 2 2.5|
Erosion | 2 | 2 2.0|
Erosion, Multiple | | 1 2.0|
Ulcer | | 1 3.0|
Ulcer, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 1 2| 11 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Focal Cellular Change | X X X | 7 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Necrosis, Diffuse | | 1 2.0|
Necrosis, Multifocal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 2 3 3 3 2 3 2 2 2 2 3 3 2 3 2| 29 2.9|
Pars Distalis, Cyst | X X X X X X X X | 16 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 2 2 | 12 2.1|
Pars Distalis, Hyperplasia | 2 3 | 4 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 3 2 2 2 2 2 2 2| 17 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 | 4 2.0|
C-Cell, Hyperplasia | | 2 2.0|
C-Cell, Hyperplasia, Multifocal | 2 2 | 4 2.0|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Acute, Focal, | | |
Suppurative | | 1 2.0|
Inflammation, Chronic | 4| 1 4.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
Duct, Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 3.0|
Hyperplasia, Cystic | | 2 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Prolapse | | 1 3.0|
Cervix, Cyst | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | | 2 |
Inflammation, Acute, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 | 11 2.1|
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Ectasia | 4 3 3 3 2 3 2 3 3| 16 3.0|
Pancreatic, Hyperplasia | 2| 2 2.0|
Pancreatic, Inflammation, | | |
Granulomatous | 2| 1 2.0|
Renal, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + M + + M + + + + M + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Ectasia | | 3 2.3|
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Ectasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 1 2 2 2 2 2 2 1 2 1 2 | 17 1.8|
Fibrosis, Focal | 3 | 2 3.5|
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 1 2 2 4 1 2 2 2 2 | 27 2.4|
Necrosis, Focal | 2 4 | 2 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hypertrophy, Focal | 2| 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Femur, Hypertrophy, Focal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma, Multiple | 2 2 1 2 2 2 2 2 | 14 1.7|
Hemorrhage, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 1 | 4 1.8|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 3 2 2 | 8 2.1|
Pigmentation, Focal, Cholesterol | 2 1 | 3 1.7|
Pigmentation, Multifocal, Cholesterol| 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Fat, Mediastinum, Necrosis, | | |
Multifocal | 2 3 3 1 2 | 11 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 2 2.0|
Fungus | 3 | 3 3.0|
Inflammation, Acute, Suppurative | 3 3 | 5 2.8|
Mucosa, Cyst | X | 1 |
Nasolacrimal Duct, Hyperkeratosis | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 1 1 2 | 10 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 4.0|
Hemorrhage | | 2 2.5|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| |
| 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Inflammation, Chronic, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 3 3 2 4 2 3 3 2 2 2 2 2 3 4 3 4 3 3 2 2 3 3 3| 47 2.7|
Cortex, Fibrosis, Focal | | 1 2.0|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Inflammation, Acute, | | |
Suppurative | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | X | 1 |
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Cyst Multilocular | X X X |
Developmental Malformation | 2 |
Granuloma, Multiple | 2 2 1 2 1 2 1 3 2 2 1 2 2 2|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 |
Biliary Tract, Cyst, Multiple | 3 3 4 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Biliary Tract, Fibrosis, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Biliary Tract, Hyperplasia, | |
Multifocal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Biliary Tract, Metaplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1|
Hepatocyte, Degeneration, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 2 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 1|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Kupffer Cell, Pigmentation, | |
Multifocal | 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis, Focal | 4 3 3 3 4 3 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Atrophy, Multifocal | 2 2 2 |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 2 |
Inflammation, Subacute | |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Subacute | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 1 2 2 1 2 1 1|
Granuloma | |
Pericardium, Fibrosis | |
Pericardium, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Focal Cellular Change | X X X X|
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 3 2 3 3 3 3 2 4 2 3 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 2|
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2 |
C-Cell, Hyperplasia | |
C-Cell, Hyperplasia, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Acute, Focal, | |
Suppurative | |
Duct, Cyst | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Hyperplasia, Cystic | 2 2|
Prolapse | X |
Cervix, Cyst | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2|
Infiltration Cellular, Histiocyte | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Ectasia | 3 4|
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + M + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + M + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Hypertrophy, Focal | 2 2 |
Femur, Hypertrophy, Focal | 2 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Granuloma, Multiple | 2 2 2 2 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Pigmentation, Focal, Cholesterol | 2 |
Pigmentation, Multifocal, Cholesterol| 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Fat, Mediastinum, Necrosis, | |
Multifocal | 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 2|
Inflammation, Acute, Suppurative | 2 2|
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2 |
Nasopharyngeal Duct, Foreign Body | |
Nasopharyngeal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Hemorrhage | |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 3 2 2 2 1 2 2 1 3 2 1 3 1 2 2 2 2 2 2 2 2|
Cortex, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| |
| 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 2 2 2 2 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 38 |
Cyst Multilocular | X X X | 6 |
Developmental Malformation | | 1 2.0|
Granuloma, Multiple | 2 2 2 1 2| 19 1.8|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 2 2 2 2 | 7 1.9|
Biliary Tract, Cyst, Multiple | 2 3 3 3 3 2 3 3 3 3 3 3 3 3 2 2 2 3 3 3 2 3 3 3 3| 49 2.9|
Biliary Tract, Fibrosis, Multifocal | 3 3 3 3 3 2 3 3 3 3 4 3 3 3 2 2 3 3 3 3 2 3 3 3 4| 49 3.0|
Biliary Tract, Hyperplasia, | | |
Multifocal | 3 3 3 2 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3| 49 2.9|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 3 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3| 49 2.9|
Biliary Tract, Metaplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3| 49 3.0|
Centrilobular, Necrosis | 2 2 | 2 2.0|
Hepatocyte, Cytomegaly | 2 1 1 1 2 2 2 2 2 2 2 2 1 1 3 3 2 2 2 2 2 2 2| 44 1.9|
Hepatocyte, Degeneration, Multifocal | 2 2 1 1 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2| 35 1.9|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 2 2 2 1 2 2 2 2 2 2 2 2| 32 2.0|
Hepatocyte, Necrosis, Multifocal | 2 2 1 1 2 2 2 2 2 | 18 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 2 2 1 3 2 2 3 2 2 2 3 2 2 2 2 2 2 3 2| 43 2.1|
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 2 1 1 1 2 1 1 1 1 2 2 2 1 2 2 1 1 2 1 2 1 2 2 2| 49 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Fat, Necrosis, Focal | 3 2 2 4 3 | 11 3.1|
Fat, Necrosis, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| |
| 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Focal | 2 1 2 1 | 6 1.3|
Atrophy, Multifocal | 1 1 | 5 1.6|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Hyperplasia | 2 | 2 2.0|
Inflammation, Subacute | 2 | 1 2.0|
Artery, Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation, Subacute | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 1 1 1 2 2 1 2| 25 1.6|
Granuloma | 4 | 1 4.0|
Pericardium, Fibrosis | 3 | 1 3.0|
Pericardium, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Focal Cellular Change | X X X X X | 9 |
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 1 4 3 2 4 1 3 3 3 4 4 3 3 2 3 4 3 3 | 30 2.9|
Pars Distalis, Cyst | X X X X | 9 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 | 11 1.9|
Pars Distalis, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| |
| 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 1 1 2 1 2 2 2 2 1 2 1 2 | 19 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 2 | 6 2.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
C-Cell, Hyperplasia, Multifocal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 1 2.0|
Duct, Cyst | X X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X| 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 2 2| 3 2.0|
Hyperplasia, Cystic | 2 2| 4 2.0|
Prolapse | | 1 |
Cervix, Cyst | X| 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1| 8 1.9|
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Ectasia | 3 2 2 4 | 6 3.0|
Pancreatic, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M + + + M + + + + + + + + + + + + + M| 43 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 2 2 2 | 4 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Ectasia | 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| |
| 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 6 2.0|
Hematopoietic Cell Proliferation | 2 2 2 4 1 4 | 14 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + M + + + + + + + + + + + + + +| 46 |
Cyst | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X| 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hypertrophy, Focal | 2 2 | 4 2.0|
Femur, Hypertrophy, Focal | 3 | 5 2.4|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 2 4 | 3 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hemorrhage, Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Granuloma, Multiple | 1 1 1 2 1 2 2 2 2 | 14 1.7|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 1 2 1 | 5 1.6|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 2 | 4 2.0|
Pigmentation, Focal, Cholesterol | 1 1 | 3 1.3|
Pigmentation, Multifocal, Cholesterol| 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| |
| 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fat, Mediastinum, Necrosis, | | |
Multifocal | 2 1 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 2 2.0|
Fungus | | 1 2.0|
Inflammation, Acute, Suppurative | 1 2 | 4 1.8|
Nasolacrimal Duct, Foreign Body | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 3 2.0|
Nasopharyngeal Duct, Foreign Body | 2 | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Subacute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 4 | 3 3.0|
Hemorrhage | 3 | 1 3.0|
Retina, Degeneration | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 3 2 1 3 3 2 1 2 2 3 1 2 1 3 2 2 3 2 2 2| 47 2.0|
Cortex, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|
| 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic, Focal | 2 |
Degeneration, Cystic | 2 |
Degeneration, Cystic, Multifocal | |
Developmental Malformation | |
Eosinophilic Focus | X X X X X X |
Granuloma, Multiple | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Necrosis, Focal | 2 |
Biliary Tract, Ectasia, Focal | |
Biliary Tract, Proliferation | 2 2 2 2 2 2 2 2 1 2 1 2 2 1 2 2 1|
Centrilobular, Necrosis | 2 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 1 1 2 |
Atrophy, Multifocal | 2 4 2 |
Hyperplasia, Focal | 2 3|
Hyperplasia | 2 |
Hyperplasia, Multifocal | 2 3 3 2 3 2 2 2 |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Subacute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|
| 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | |
__________________________________________________________________________|
Tongue | |
Foreign Body | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 1 1 2 2 2 1 1 2 2|
Inflammation, Acute, Multifocal, | |
Suppurative | 3 |
Thrombosis | X |
Valve, Embolus Bacterial | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 3 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 3 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia | |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|
| 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Granuloma | |
Hyperplasia | 2 |
Inflammation, Acute, Focal, | |
Suppurative | 4 2 |
Inflammation, Chronic | 1 |
Inflammation, Focal, Subacute | |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 3 3 2 3 3 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + M + + + + M M M M M +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + +|
Ectasia | 2 2 2 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A M + M + + + + + +|
Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Fibrosis, Focal | 2 3 3 |
Hematopoietic Cell Proliferation | 1 1 1 1 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|
| 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage, Multifocal | |
Inflammation, Acute, Multifocal, | |
Suppurative | 2 |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 3 2 |
Foreign Body | 3 3 4 3 |
Granuloma, Multiple | 2 2 2 2 3 |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 3 2 |
Fat, Mediastinum, Necrosis, | |
Multifocal | |
Mediastinum, Inflammation, Chronic, | |
Multifocal | |
Pleura, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 3 2 |
Fungus | 2 |
Inflammation, Acute, Suppurative | 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
Nasopharyngeal Duct, Cyst | |
Nasopharyngeal Duct, Foreign Body | |
Nasopharyngeal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
Retina, Degeneration | 3|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|
| 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 2 2 2 2 1 1 1 3 1 1 2 2 1 1 2 1 4|
Cortex, Cyst | X |
Cortex, Embolus Bacterial | 2 |
Cortex, Fibrosis, Focal | 2 |
Cortex, Inflammation, Acute, | |
Multifocal, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| |
| 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 2 2.0|
Ulcer, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | X X X X X | 8 |
Degeneration, Cystic, Focal | 2 2| 3 2.0|
Degeneration, Cystic | 1 | 2 1.5|
Degeneration, Cystic, Multifocal | 2 | 1 2.0|
Developmental Malformation | X X X | 3 |
Eosinophilic Focus | X X X X X X X X | 14 |
Granuloma, Multiple | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Necrosis, Focal | | 1 2.0|
Biliary Tract, Ectasia, Focal | 2 | 1 2.0|
Biliary Tract, Proliferation | 1 1 1 1 2 2 1 1 2 1 1 1 1 3 2 1 3 1 2 1 2 2| 39 1.6|
Centrilobular, Necrosis | 2 2 | 5 1.8|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis, Focal | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 1 2 1 | 9 1.4|
Atrophy, Multifocal | 3 2 2| 6 2.5|
Hyperplasia, Focal | 2 2 2 2 2 2 | 8 2.1|
Hyperplasia | 2 | 2 2.0|
Hyperplasia, Multifocal | 2 3 3 3 3| 13 2.5|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| |
| 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Foreign Body | 2 | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 2 2 2 1 2 1 2 2 2 2 2 1 | 29 1.7|
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 3.0|
Thrombosis | | 1 |
Valve, Embolus Bacterial | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X | 2 |
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 2 3 | 10 2.5|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2| 10 2.1|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| |
| 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia, Focal | 2 2| 3 2.0|
C-Cell, Hyperplasia | 2 2 | 2 2.0|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 | 1 2.0|
Granuloma | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 3 2.7|
Inflammation, Chronic | | 1 1.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 2| 8 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M M M + + + + + M + + M + + + M + + M + + M| 34 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 3 2 3 2 2 | 10 2.2|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + M + + + + + + + + + +| 48 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 46 |
Ectasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| |
| 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2| 5 2.0|
Fibrosis, Focal | 3 | 4 2.8|
Hematopoietic Cell Proliferation | 3 2 1 2| 9 1.6|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Duct, Cyst | X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Multifocal, Subacute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hemorrhage, Multifocal | 4 | 1 4.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 6 2.5|
Foreign Body | 3 | 5 3.2|
Granuloma, Multiple | 2 2 1 2 | 9 2.0|
Hyperplasia | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Fat, Mediastinum, Necrosis, | | |
Multifocal | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| |
| 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal | 2 | 1 2.0|
Pleura, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2 2 2 2 2 2 2 2 2 | 16 2.1|
Fungus | 3 2 3 2 | 5 2.4|
Inflammation, Acute, Suppurative | 3 2 2 3 2 3 2 | 11 2.2|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 4 | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 2.0|
Nasopharyngeal Duct, Cyst | X | 1 |
Nasopharyngeal Duct, Foreign Body | 4 | 1 4.0|
Nasopharyngeal Duct, Inflammation, | | |
Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 2 2 2 2 2 2 2 4 3 2 2 2 1 1 2 2 1 1 1 3| 45 1.7|
Cortex, Cyst | | 1 |
Cortex, Embolus Bacterial | | 1 2.0|
Cortex, Fibrosis, Focal | | 1 2.0|
Cortex, Inflammation, Acute, | | |
Multifocal, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|
| 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst Multilocular | X X X X X X X X X X X X X X X |
Developmental Malformation | |
Granuloma, Multiple | 2 |
Hemorrhage, Multifocal | 2 |
Neovascularization | 1 2 2 2 2 2 3 2 2|
Thrombosis | X X |
Biliary Tract, Cyst, Multiple | 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Fibrosis, Multifocal | 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Hyperplasia, | |
Multifocal | 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Biliary Tract, Metaplasia | 4 3 4 4 4 4 4 4 4 4 3 3 4 4 4 4 3 4 4 4 4 4 4 4 4|
Centrilobular, Necrosis | 2 2 2 2 2 |
Hepatocyte, Cytomegaly | 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 3 4 4|
Hepatocyte, Degeneration, Multifocal | 2 3 3 3 4 4 4 3 3 4 3 4 3 3 3 3 3 3 3 3 3 4 3 3 3|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 3 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 4 3 3 3 3 3 4 3 2 2 4 2 2 2 2 2 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 3 4 4 3 3 4 2 4 3 4 3 4 3 4 4 3 3 4 3 3 3|
Kupffer Cell, Pigmentation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Pigmentation, Hemosiderin, Multifocal| 2 2 |
Fat, Hemorrhage | |
Fat, Necrosis, Focal | 4 4 4 4 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 2 1 2 |
Atrophy, Multifocal | 1 2 1 |
Hyperplasia, Focal | 2 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|
| 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia | 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | |
Hyperplasia, Squamous | 3 |
Inflammation, Subacute | |
Ulcer | |
Ulcer, Multiple | 2 2 4 |
Serosa, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Erosion, Multiple | |
Mineralization, Multifocal | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 1 2 2 3 2 3 2 2 1 1 2 3 3 2|
Mineralization, Multifocal | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Focal Cellular Change | X |
Capsule, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + M + + + + + + M + + + +|
Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 4|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 3|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|
| 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia | |
Follicle, Cyst | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
Suppurative | 2 4 |
Duct, Cyst | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Inflammation, Subacute | 2 4 2 2 1 |
__________________________________________________________________________|
Seminal Vesicle | |
Inflammation, Acute, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 1 1 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Ectasia | 3 3 3 2 3 3 3 4 2 4 4 |
Pancreatic, Hyperplasia | 3 2 3 4 |
Renal, Ectasia | 4 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + M M M M M + + + + M M M M + M + +|
Congestion | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Congestion | |
Ectasia | 4 2 2 2 2|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + M M + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 2 2 3 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|
| 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 1 2 2 2 2 2 2 2 2 1 3 2 2|
Degeneration, Fatty, Multifocal | 2 |
Fibrosis, Focal | 4 2 3 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 1 3 2 4 2 2 2 1 3 3|
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + + + + + + M + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X|
Duct, Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema, Focal | 4 4 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 2 |
Fungus | |
Granuloma, Multiple | 1 1 1 1 1 2|
Hemorrhage, Focal | 2 2 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|
| 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation, Focal, Cholesterol | 2 |
Pigmentation, Multifocal, Cholesterol| |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Fat, Mediastinum, Necrosis, | |
Multifocal | 2 2 |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2|
Fungus | 2 2 3|
Inflammation, Acute, Suppurative | 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2|
Submucosa, Foreign Body | 2 |
Submucosa, Inflammation, Chronic, | |
Focal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Cornea, Cyst | X |
Retina, Degeneration | 4 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 4 4 3 4 2 3 3 3 2 2 2 4 3 4 4 3 3 4 3 4 3 3 4 4|
Cortex, Cyst, Multiple | |
Cortex, Fibrosis, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Cyst Multilocular | X X X X X X X X X | 24 |
Developmental Malformation | 2 | 1 2.0|
Granuloma, Multiple | | 1 2.0|
Hemorrhage, Multifocal | 2 2 3 2 | 5 2.2|
Neovascularization | 2 2 2 2 2 3 | 15 2.1|
Thrombosis | X X | 4 |
Biliary Tract, Cyst, Multiple | 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Biliary Tract, Fibrosis, Multifocal | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Biliary Tract, Hyperplasia, | | |
Multifocal | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Biliary Tract, Metaplasia | 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Centrilobular, Necrosis | 2 2 2 2 | 9 2.0|
Hepatocyte, Cytomegaly | 3 4 4 4 4 3 4 4 4 4 3 4 4 3 4 3 3 4 4 4 3 4 3 4| 49 3.8|
Hepatocyte, Degeneration, Multifocal | 2 3 3 4 4 3 4 3 3 3 4 3 4 3 3 3 3 3 4 4 2 3 3 3| 49 3.2|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 49 3.9|
Hepatocyte, Necrosis, Multifocal | 2 3 2 3 2 2 4 3 4 3 4 3 4 2 2 2 2 2 4 4 2 3 2 3| 49 2.6|
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 4 3 3 4 4 3 3 4 4 4 2 3 3 3 3 4 4 2 4 3 3| 49 3.3|
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2| 49 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 14 |
Pigmentation, Hemosiderin, Multifocal| 4 | 3 2.7|
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 4 | 6 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Focal | 2| 6 1.5|
Atrophy, Multifocal | 1 2 | 5 1.4|
Hyperplasia, Focal | 2 2 2 2 2 2 | 12 2.1|
Hyperplasia | | 1 2.0|
Hyperplasia, Multifocal | 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 2 3 | 3 2.3|
Hyperplasia | 2 2 2 2 2 2 | 6 2.0|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Subacute | 2 3 | 2 2.5|
Ulcer | 4 3 4 | 3 3.7|
Ulcer, Multiple | | 3 2.7|
Serosa, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 2 | 2 2.0|
Erosion | | 1 2.0|
Erosion, Multiple | 2 | 1 2.0|
Mineralization, Multifocal | 2 2 | 2 2.0|
Ulcer | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 2 2 2 3 2 2 1 2 3 2 3 2 2 2 2| 39 2.1|
Mineralization, Multifocal | | 1 2.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 2 2.0|
Focal Cellular Change | X | 2 |
Capsule, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 2 | 3 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + M + M| 43 |
Hyperplasia | 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 4 2 4 | 8 3.3|
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia, Focal | 1 2 | 6 2.0|
Pars Distalis, Hyperplasia | 2 3 | 2 2.5|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 3 2 2 | 6 2.3|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | X X X | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 3 2.7|
Duct, Cyst | X | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Suppurative | 4 | 1 4.0|
Inflammation, Subacute | 2 3 2 2 4 2| 11 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Inflammation, Acute, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 2 | 3 3.0|
Interstitial Cell, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Polychromasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 | 28 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Ectasia | 2 2 3 3 4 4 3 3 4 3 4 3 4| 24 3.2|
Pancreatic, Hyperplasia | 2 2 3 2 3 2 | 10 2.6|
Renal, Ectasia | 4 | 3 3.7|
Renal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M + + M M + + + + M + + M + + M M M M + +| 27 |
Congestion | 2 | 1 2.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Congestion | 3 | 1 3.0|
Ectasia | 2 2 2 2 2 2 3 2| 13 2.2|
Hyperplasia | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + + + + + + + M + + + M| 45 |
Congestion | 4 2 | 2 3.0|
Ectasia | 2 3 3 4 2 2 2 2 | 16 2.3|
Hyperplasia | 2 2 3 2 | 9 2.1|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 2 2 | 7 2.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 3 1 3 2 2 2 2 2 | 25 2.0|
Degeneration, Fatty, Multifocal | | 1 2.0|
Fibrosis, Focal | 3 3 3 3| 7 3.0|
Hematopoietic Cell Proliferation | 1 4 2 2 1 3 2 1 1 2 4 2 2 3 | 30 2.1|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + + + + M + + + + + M| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X | 20 |
Duct, Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema, Focal | 4 | 3 4.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | 1 4 3 | 4 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 3 | 4 2.8|
Foreign Body | 3 | 2 2.5|
Fungus | 3| 1 3.0|
Granuloma, Multiple | 2 1 1 | 9 1.2|
Hemorrhage, Focal | | 2 2.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 3 | 4 2.0|
Inflammation, Focal, Granulomatous | 3| 1 3.0|
Pigmentation, Focal, Cholesterol | | 1 2.0|
Pigmentation, Multifocal, Cholesterol| 2 | 1 2.0|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Fat, Mediastinum, Necrosis, | | |
Multifocal | 2 4 2 | 5 2.4|
Mediastinum, Foreign Body | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 5 2.0|
Fungus | 3 | 4 2.5|
Inflammation, Acute, Suppurative | 2 2 | 7 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 3 2.0|
Submucosa, Foreign Body | | 1 2.0|
Submucosa, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| |
DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| |
| 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 4.0|
Cornea, Cyst | | 1 |
Retina, Degeneration | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
Inflammation, Subacute | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 2 4 3 4 3 3 4 4 4 4 3 4 4 3 3 3 3 4 3 3 3 3| 48 3.3|
Cortex, Cyst, Multiple | X | 1 |
Cortex, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|
| 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + M + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | |
Cyst Multilocular | X X X X X X X X X |
Developmental Malformation | X |
Granuloma, Multiple | 2 1|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hemorrhage, Multifocal | |
Necrosis, Focal | |
Neovascularization | 2 2 2 2 2 2 2 2|
Thrombosis | X X |
Biliary Tract, Cyst, Multiple | 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 2 4 4 4|
Biliary Tract, Fibrosis, Multifocal | 4 3 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 2 4 4 4|
Biliary Tract, Hyperplasia, | |
Multifocal | 4 3 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 2 4 4 4|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 4 3 4 3 4 4 4 4 4 4 3 3 3 4 4 4 4 4 4 3 4 4 4|
Biliary Tract, Metaplasia | 4 4 4 4 4 4 4 4 4 4 3 3 4 3 4 4 4 4 4 2 4 4 4|
Centrilobular, Necrosis | 2 |
Hepatocyte, Cytomegaly | 3 3 4 2 3 3 4 2 2 3 3 2 3 3 3 3 2 4 3 2 3|
Hepatocyte, Degeneration, Multifocal | 2 2 3 2 4 4 4 3 2 3 2 3 2 2 2 2 2 2 2 2 4|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 2 3 4 4 3 4 4 2 2 2 3 3 4 4 3 4 3 4 2 2 4|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 4 4 4 3 2 3 2 3 2 2 2 2 2 2 2 2 4|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 4 3 4 3 4 4 2 2 3 3 3 3 4 2 3 3 3 3 3|
Kupffer Cell, Pigmentation, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Pigmentation, Hemosiderin, Multifocal| |
Fat, Necrosis, Focal | 4 3 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|
| 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Atrophy, Multifocal | 3 |
Cyst Multilocular | X |
Hyperplasia, Focal | 3 2 2 2 |
Hyperplasia | |
Hyperplasia, Multifocal | 3 2 3|
Inflammation, Chronic, Focal | 2 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Hyperplasia | 3 4 4 |
Inflammation, Subacute | 3 3 3 |
Perforation | X 4 |
Ulcer | 4 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Erosion, Multiple | 3 |
Inflammation, Subacute | 3 |
Mineralization, Multifocal | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | |
Hemorrhage | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 2 1 2 3 2 2 2 2 1 2 1 |
Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X |
Hemorrhage | |
Necrosis, Diffuse | |
Left, Atrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|
| 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 4 4 2 2 4 4 4 2 2 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia, Focal | 3 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M M + +|
Inflammation, Acute, Focal, | |
Suppurative | 2 |
Inflammation, Focal, Subacute | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 3 2 2 2 2 3 4 3 3 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Inflammation, Subacute | 3 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Inflammation, Granulomatous| |
Pancreatic, Ectasia | 3 2 4 2 3 3 3 3 |
Pancreatic, Hyperplasia | |
Pancreatic, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|
| 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M + M + M M + + + + + + + + M M + + + +|
Ectasia | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 4 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 |
Inflammation, Granulomatous | |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 1 2 2 2 2 2 1 2 2|
Fibrosis, Focal | 3 3 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 3 1 2 1 2 4 2 1|
Inflammation, Granulomatous | |
Capsule, Fibrosis, Multifocal | 3 |
Capsule, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Foreign Body | 2 |
Inflammation, Focal, Subacute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|
| 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 3 3 3 |
Granuloma, Multiple | 2 2 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Pigmentation, Focal, Cholesterol | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Fat, Mediastinum, Necrosis, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Fungus | 2 3 |
Inflammation, Acute, Suppurative | 2 2 3 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
Nasopharyngeal Duct, Cyst | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 3 4 2 3 4 4 3 4 4 3 3 1 4 2 4 4 3 4 3 3|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia,| |
Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis, Focal | 2 | 1 2.0|
Parasite Metazoan | 2 2 2 2| 6 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 4 | 1 4.0|
Basophilic Focus | X X | 2 |
Cyst Multilocular | X X X X X X X X | 17 |
Developmental Malformation | 3 X | 3 3.0|
Granuloma, Multiple | 1 2 1 2 2 2 1 1 | 10 1.5|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 | 3 2.0|
Hemorrhage, Multifocal | 4 | 1 4.0|
Necrosis, Focal | 4 | 1 4.0|
Neovascularization | 2 2 2 2 2 2 | 14 2.0|
Thrombosis | 4 | 3 4.0|
Biliary Tract, Cyst, Multiple | 3 4 4 4 3 3 3 4 4 4 4 4 4 3 3 3 4 4 4 4 3 4 4 4 3| 47 3.7|
Biliary Tract, Fibrosis, Multifocal | 3 4 4 3 4 4 4 4 4 3 4 4 3 3 3 4 4 4 4 4 3 3 4 4 4| 48 3.7|
Biliary Tract, Hyperplasia, | | |
Multifocal | 3 4 4 3 4 3 4 3 4 3 4 4 4 3 3 4 4 4 4 4 3 3 4 4 4| 48 3.7|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 3 4 4 3 4 3 4 3 4 3 4 4 4 3 3 4 4 4 4 4 3 3 4 4 3| 48 3.7|
Biliary Tract, Metaplasia | 3 4 4 3 3 3 3 4 4 4 4 4 4 4 4 3 4 4 4 4 3 4 4 4 3| 48 3.7|
Centrilobular, Necrosis | 2 1 2 2 | 5 1.8|
Hepatocyte, Cytomegaly | 4 3 3 2 2 2 4 3 3 3 4 3 2 2 3 3 4 4 3 3 2 3 3 2 4| 46 2.9|
Hepatocyte, Degeneration, Multifocal | 3 4 2 2 2 2 4 2 4 2 3 3 2 3 2 2 3 3 4 2 3 2 4 2 2| 46 2.6|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 3 4 3 3 3 2 4 3 3 3 4 4 2 2 2 2 4 4 2 2 2 2 2 2 3| 46 3.0|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 2 4 2 4 2 3 3 2 2 2 2 3 3 4 2 2 2 3 2 2| 46 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 4 4 4 3 4 2 4 4 2 4 3 2 3 4 3 2 3 2 4 4 2 3 3 4| 45 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 12 |
Pigmentation, Hemosiderin, Multifocal| 4 | 1 4.0|
Fat, Necrosis, Focal | 4 4 3 4 4 3 | 9 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
Atrophy, Multifocal | 2 2 | 3 2.3|
Cyst Multilocular | | 1 |
Hyperplasia, Focal | 3 3 2 2 2 | 9 2.3|
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Multifocal | 2 2 2| 6 2.3|
Inflammation, Chronic, Focal | | 2 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 4.0|
Hyperplasia | 4 2 3 2 | 7 3.1|
Inflammation, Subacute | 3 2 2 | 6 2.7|
Perforation | 4 | 3 4.0|
Ulcer | 4 4 | 3 4.0|
Ulcer, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 | 2 2.0|
Erosion, Multiple | | 1 3.0|
Inflammation, Subacute | | 1 3.0|
Mineralization, Multifocal | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2| 38 1.9|
Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X X X X| 7 |
Hemorrhage | 3 | 1 3.0|
Necrosis, Diffuse | 3 | 1 3.0|
Left, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 4 3 2 2 2 3 4 2 | 18 3.0|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 5 2.2|
Pars Distalis, Hyperplasia | 2 2 | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | | 1 2.0|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicle, Cyst | X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + + + + + + M + + + + + +| 46 |
Inflammation, Acute, Focal, | | |
Suppurative | | 1 2.0|
Inflammation, Focal, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 2 3 3 2 1 1 2 2 3 1 3 1 | 26 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | 2 | 3 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 | 4 2.8|
Interstitial Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1| 9 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Inflammation, Granulomatous| 2 | 1 2.0|
Pancreatic, Ectasia | 4 2 3 3 | 12 2.9|
Pancreatic, Hyperplasia | 3 2 | 2 2.5|
Pancreatic, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M + M + + + + + + + + + + + M + + M M + + +| 35 |
Ectasia | 2 2 | 2 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Ectasia | 2 2 2 2 | 7 2.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Ectasia | 2 2 2 2 | 7 2.3|
Inflammation, Granulomatous | 2 | 1 2.0|
Pigmentation, Hemosiderin | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 | 2 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 2 2 2 2 2 2 2 2 2 2| 25 1.9|
Fibrosis, Focal | 3 2 3 2 | 7 2.6|
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2| 27 1.9|
Inflammation, Granulomatous | 2 | 1 2.0|
Capsule, Fibrosis, Multifocal | | 1 3.0|
Capsule, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + + M + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X X X X X X| 29 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 2.0|
Foreign Body | | 1 2.0|
Inflammation, Focal, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 2 2.0|
Hemorrhage, Multifocal | 4 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 3 3.3|
Foreign Body | 2 | 4 2.8|
Granuloma, Multiple | 1 | 4 1.8|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
Pigmentation, Focal, Cholesterol | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 3 2.3|
Fat, Mediastinum, Necrosis, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2 2 | 6 2.0|
Fungus | 2 3 2 3 | 6 2.5|
Inflammation, Acute, Suppurative | 2 3 2 2 2 | 8 2.3|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 | 2 2.0|
Nasopharyngeal Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| |
| 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 3 3 4 3 3 4 2 4 3 3 4 3 3 3 3 4 4 4 4 1 3 4 4 4| 48 3.3|
Cortex, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|
DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|
| 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X|
Cyst Multilocular | X |
Developmental Malformation | |
Granuloma, Multiple | 2 2 1 1 2 2 2 1 1 1|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 |
Hemorrhage, Multifocal | |
Leukocytosis | 2 |
Neovascularization | 2 2 2 2|
Biliary Tract, Cyst, Multiple | 3 3 3 4 3 3 3 3 4 3 3 4 3 3 3 3 4 3 4 3 3 3 3|
Biliary Tract, Fibrosis, Multifocal | 3 3 3 4 3 3 3 3 4 3 3 4 3 3 3 3 3 3 4 3 3 3 4|
Biliary Tract, Hyperplasia, | |
Multifocal | 3 3 3 3 3 3 3 3 4 3 3 4 3 3 3 3 3 3 4 3 3 3 3|
Biliary Tract, Inflammation, Chronic,| |
Multifocal | 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Biliary Tract, Metaplasia | 3 3 3 4 3 3 4 3 4 3 3 4 3 3 4 3 4 3 4 3 3 3 3|
Centrilobular, Necrosis | 1 2 2 2 2 |
Hepatocyte, Cytomegaly | 2 3 2 2 2 2 3 1 4 3 4 2 2 3 2 2 2 3 2 3 2 2|
Hepatocyte, Degeneration, Multifocal | 2 2 2 2 2 2 2 2 4 2 3 2 2 3 2 2 2 2 2 2 2 3 2|
Hepatocyte, Hyperplasia, Multifocal, | |
Nodular | 3 2 2 2 2 2 2 4 2 3 3 2 3 2 3 1 2 2 2 2|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 2 2 1 3 2 3 2 2 3 2 2 2 2 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 4 2 3 3 3 3 3 3 2 2 2 2 3 2 2 3 3|
Kupffer Cell, Pigmentation, | |
Multifocal | 1 2 2 2 2 2 2 1 2 2 2 2 2 2 1 1 1 1 2 2 2 1 1|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Foreign Body | |
Inflammation, Acute, Suppurative | |
Fat, Necrosis, Focal | 3 3 4 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|
DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|
| 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Atrophy, Multifocal | 2 2 2 2 2 |
Hyperplasia, Focal | 2 2 2 2 2 2 2 |
Hyperplasia | 2 |
Hyperplasia, Multifocal | 2 2 2 2 |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | |
Perforation | |
Ulcer | |
Artery, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
Mineralization, Multifocal | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X X X|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hemorrhage | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Focal | 2 2 2 1|
Necrosis, Diffuse | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 4 2 3 2 2 4 2 4|
Pars Distalis, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|
DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|
| 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
Pars Distalis, Necrosis | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia | 2 |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
Suppurative | |
Inflammation, Focal, Subacute | 2 |
Duct, Cyst | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 2 2 2 2 2 2 3 2 2 3 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Interstitial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ectasia | 4 |
Inguinal, Hyperplasia | 3 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + M + + + + + M M + + + +|
Ectasia | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M M + + + + + + + + + + + + + + M + + +|
Ectasia | 3 2 1 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|
DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|
| 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2 2 2 2 2 2 2|
Fibrosis, Focal | 3 3 |
Hematopoietic Cell Proliferation | 2 3 2 1 3 1 1 1 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Acute, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage, Multifocal | 4 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 3 |
Granuloma, Multiple | 1 1 1 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 |
Fat, Mediastinum, Necrosis, | |
Multifocal | 2 |
Smooth Muscle, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|
DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|
| 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 |
Fungus | 3 |
Hyperkeratosis, Focal | |
Hyperplasia, Squamous | |
Inflammation, Acute, Suppurative | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2 2 2 2 2 |
Nasopharyngeal Duct, Fungus | |
Nasopharyngeal Duct, Hyperplasia | |
Nasopharyngeal Duct, Inflammation, | |
Acute, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Anterior Chamber, Inflammation, | |
Acute, Suppurative | |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 3 2 2 3 2 3 2 2 2 3 3 3 2 4 3 2 3 3 4 3 2 4|
Cortex, Cyst | |
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Diverticulum | 4 | 1 4.0|
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Parasite Metazoan | 2 2 2 2| 6 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A M + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X| 20 |
Cyst Multilocular | | 1 |
Developmental Malformation | 3 X X | 3 3.0|
Granuloma, Multiple | 2 1 2 2 2 1 1 2 1 2 2 | 21 1.6|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 3 2.0|
Hemorrhage, Multifocal | 2 | 1 2.0|
Leukocytosis | | 1 2.0|
Neovascularization | 2 2 | 6 2.0|
Biliary Tract, Cyst, Multiple | 3 3 3 3 3 3 3 3 2 3 3 3 3 2 3 2 3 2 3 3 3| 44 3.0|
Biliary Tract, Fibrosis, Multifocal | 3 3 3 3 4 2 3 3 2 3 3 3 3 2 3 2 3 3 3 3 3| 44 3.0|
Biliary Tract, Hyperplasia, | | |
Multifocal | 3 3 3 3 3 2 3 3 2 3 3 3 3 2 3 2 3 3 3 2 3| 44 3.0|
Biliary Tract, Inflammation, Chronic,| | |
Multifocal | 3 3 3 3 3 2 3 3 2 3 3 3 3 2 3 2 3 3 3 3 3| 44 2.9|
Biliary Tract, Metaplasia | 3 3 3 3 4 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3| 44 3.2|
Centrilobular, Necrosis | 2 2 | 7 1.9|
Hepatocyte, Cytomegaly | 3 1 2 3 2 2 2 2 1 3 2 1 2| 35 2.3|
Hepatocyte, Degeneration, Multifocal | 2 1 2 2 2 2 1 2 2 1 | 33 2.1|
Hepatocyte, Hyperplasia, Multifocal, | | |
Nodular | 3 1 2 3 2 2 1 2 2 2| 30 2.2|
Hepatocyte, Necrosis, Multifocal | 2 1 2 2 2 2 1 2 2 1 | 32 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 1 2 3 2 2 2 1 2 2 2 2 2 3 2 2 2 2 3| 39 2.4|
Kupffer Cell, Pigmentation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Multifocal | 2 1 2 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1| 44 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 12 |
Foreign Body | 2 | 1 2.0|
Inflammation, Acute, Suppurative | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 3 3 4| 7 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 | 2 2.0|
Atrophy, Multifocal | 2 2 | 7 2.0|
Hyperplasia, Focal | 2 2 2 2 2 | 12 2.0|
Hyperplasia | | 1 2.0|
Hyperplasia, Multifocal | 2 2 2 3 2 | 9 2.1|
Artery, Inflammation, Subacute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 3 2 | 4 2.3|
Inflammation, Subacute | 2 2 | 2 2.0|
Perforation | 4 | 1 4.0|
Ulcer | 3 | 1 3.0|
Artery, Inflammation, Subacute | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 1 2 1 2 2 2 2 1 | 30 1.8|
Mineralization, Multifocal | 4 | 1 4.0|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X X | 7 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 3 | 2 2.5|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 2 1 2 | 7 1.7|
Necrosis, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + M| 47 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 3 2 4 3 2 2| 18 2.7|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 2| 12 2.0|
Pars Distalis, Necrosis | | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 1 2 2 2| 10 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 | 2 2.0|
C-Cell, Hyperplasia | | 1 2.0|
C-Cell, Hyperplasia, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal, | | |
Suppurative | 2 3 | 2 2.5|
Inflammation, Focal, Subacute | | 1 2.0|
Duct, Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 1 1 3 3 1 2 2 2 2| 22 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2| 5 2.2|
Interstitial Cell, Hyperplasia | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Ectasia | | 1 4.0|
Inguinal, Hyperplasia | | 1 3.0|
Pancreatic, Ectasia | 3 2 2 | 4 2.3|
Pancreatic, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M M + + + + M M + + + + + + + + + M M M +| 40 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
Ectasia | 2 2| 6 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + + + + + + + +| 45 |
Ectasia | 1 | 5 1.8|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Congestion | 2 1 1 2 2 2 1 2 2| 16 1.8|
Fibrosis, Focal | 3 2 | 4 2.8|
Hematopoietic Cell Proliferation | 1 2 2 1 2 1 1 2 2 2 3 1| 23 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X| 24 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Acute, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | | 1 3.0|
Hemorrhage, Multifocal | | 1 4.0|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 2 3 3 | 6 2.8|
Foreign Body | 3 3 2 3 4 | 6 3.0|
Granuloma, Multiple | 2 2 1 2 2 | 8 1.5|
Hemorrhage, Multifocal | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 1.0|
Fat, Mediastinum, Necrosis, | | |
Multifocal | | 1 2.0|
Smooth Muscle, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 2 2.0|
Fungus | 3 2 3 3| 5 2.8|
Hyperkeratosis, Focal | 2| 1 2.0|
Hyperplasia, Squamous | 4 | 1 4.0|
Inflammation, Acute, Suppurative | 1 2 2 3 2| 7 2.1|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 2 | 9 2.0|
Nasopharyngeal Duct, Fungus | 3 | 1 3.0|
Nasopharyngeal Duct, Hyperplasia | 2 | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 | 2 2.5|
Anterior Chamber, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05004-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURAN Date: 04/29/97
Route: GAVAGE Time: 08:02:07
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| |
| 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Acute, Suppurative | 2 | 1 2.0|
Retina, Degeneration | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 4 3 2 3 3 3 3 1 3 3 2 3 1 3 2 4 3 3 2 2| 44 2.7|
Cortex, Cyst | X | 1 |
Renal Tubule, Mineralization, | | |
Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
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