TDMS Study 05004-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05004 FURAN TIME: 00:15:07
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56202
CONT: N01CP9565101 CAS: 110-00-9
PATHOLOGIST: H. GILES S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05004 FURAN TIME: 00:15:07
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56202
CONT: N01CP9565101 CAS: 110-00-9
PATHOLOGIST: H. GILES S. EUSTIS
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 6 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 464 549 611 629 645 659 660 666 680 689 |
| 716 |
| CENSORED DEATHS |
| 53 115 188 319 407 613 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 5 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 384 421 470 525 539 587 602 629 660 660 |
| 660 660 668 680 687 694 702 |
| CENSORED DEATHS |
| 25 29 54 60 85 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 4 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 394 520 541 556 589 613 618 618 627 627 |
| 633 634 639 665 678 688 688 703 707 725 |
| CENSORED DEATHS |
| 46 70 254 410 |
| |
==================================================================================
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 8. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 1 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 421 421 443 448 456 490 575 583 591 609 |
| 617 624 645 655 656 665 666 667 680 686 |
| 688 688 694 694 694 695 695 695 695 696 |
| 698 707 723 |
| CENSORED DEATHS |
| 52 |
| |
==================================================================================
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 97.8 97.8 95.6 84.2 75.1 |
|CONTROL | |
| | |
|2. MG/KG | 100.0 100.0 100.0 100.0 95.6 93.3 88.9 84.4 73.3 62.2 |
| | |
| | |
|4. MG/KG | 100.0 100.0 100.0 100.0 97.9 97.9 93.5 89.2 69.6 56.5 |
| | |
| | |
|8. MG/KG | 100.0 100.0 100.0 100.0 95.9 89.8 87.8 81.6 67.3 32.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.1% 62.2% 56.5% 32.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.245 P=0.086 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.5 601.6 623.2 626.1 |
|NATURAL DEATHS (C) | (21.5) (24.1) (17.3) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 654.4 617.9 643.9 647.5 |
|(STANDARD ERROR) | (22.9) (29.4) (22.2) (17.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 470 528 537 556 605 605 655 659 665 666 |
| 684 687 688 688 695 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 364 436 478 541 561 575 575 602 617 639 |
| 642 659 665 667 688 689 697 703 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 388 402 421 462 541 549 557 561 591 627 |
| 627 635 654 655 666 688 688 691 702 703 |
| 708 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 8. MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 2 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 339 424 457 471 511 521 532 549 575 583 |
| 592 596 598 613 623 627 633 644 663 664 |
| 665 665 689 696 697 698 701 716 718 |
| CENSORED DEATHS |
| 143 238 |
| |
==================================================================================
FURAN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 82.0 68.0 |
|CONTROL | |
| | |
|2. MG/KG | 100.0 100.0 100.0 98.0 98.0 94.0 92.0 84.0 74.0 64.0 |
| | |
| | |
|4. MG/KG | 100.0 100.0 100.0 100.0 94.0 92.0 90.0 82.0 72.0 56.0 |
| | |
| | |
|8. MG/KG | 100.0 100.0 100.0 97.9 95.8 91.7 85.4 72.9 54.2 39.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 2. MG/KG 4. MG/KG 8. MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 64.0% 56.0% 39.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.002 P=0.732 P=0.263 P=0.006 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.4 599.9 601.4 602.1 |
|NATURAL DEATHS (C) | (18.2) (22.5) (22.2) (17.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 697.8 682.5 672.8 633.8 |
|(STANDARD ERROR) | ( 8.6) (11.9) (13.2) (18.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURAN
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
2. MG/KG = 2
4. MG/KG = 3
8. MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 4 1
| 2 3 2 1 3 1
| 2 4 2 3 31 1
| 4 4 2 2 3 3 3 1 1
90 + 4 4 2 2 2 3 3 1 1 1
| 4 42 2 33
P | 44 2 2 11
E | 4 4 4 32 21 1
R 80 + 4 4 11
C | 433 1 1
E | 4334 1 1
N | 344 22
T 70 + 4 32322
| 443 22
S | 22
U | 4 43 2 2
R 60 + 44
V | 3 3 3
I | 44
V |
A 50 +
L |
|
|
40 +
| 44
| 4 4
| 4 4
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
FURAN
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
2. MG/KG = 2
4. MG/KG = 3
8. MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
| 4 2 3 3 4 2 1 1
| 3 3 2 3 42 112 1
| 3 4 4 2 12 1
P 90 + 4 4 33 2 2
E | 44 33 1 1
R | 4 433 2 32 2 1 1
C | 4 44 3 23 2 11
E 80 + 4 4 1 1
N | 44 332 2 11
T | 3 3 22
| 4 4 3 2 11
S 70 + 444 3 31 1
U | 44 22 1 1
R | 44 322 2
V | 4 4
I 60 + 33
V |
A | 4 4 3 3
L | 44
50 +
|
| 44 4
|
40 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
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