TDMS Study 05006-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BENZALDEHYDE
NTP Experiment-Test: 05006-06 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 10:23:52
Facility: Southern Research Institute
Chemical CAS #: 100-52-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 11 13 7
Dead 7 8 8
Accidently Killed 1 1
Accident 1 1
Survivors
Dead 1
Terminal Sacrifice 30 27 34
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (45) (49)
Inflammation, Chronic 1 (2%)
Liver (50) (8) (49)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%) 4 (8%)
Hemorrhage, Multifocal 2 (4%)
Necrosis, Multifocal 3 (6%) 2 (4%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (13%)
Vacuolization Cytoplasmic, Focal 1 (13%)
Centrilobular, Necrosis 1 (2%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 5 (10%) 1 (2%)
Mesentery (11) (5) (6)
Abscess 1 (9%) 1 (17%)
Inflammation, Acute, Suppurative 4 (36%) 2 (33%)
Fat, Necrosis, Focal 2 (18%) 3 (60%) 1 (17%)
Fat, Necrosis, Multifocal 1 (20%)
Salivary Glands (49) (1) (49)
Hemorrhage 1 (100%)
Stomach, Forestomach (50) (50) (50)
Cyst 1 (2%)
Hyperplasia, Focal 7 (14%) 11 (22%) 13 (26%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Multifocal 1 (2%) 4 (8%) 11 (22%)
Inflammation, Acute, Focal, Suppurative 4 (8%) 7 (14%) 4 (8%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%) 3 (6%)
Inflammation, Focal, Subacute 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (4%) 1 (2%) 3 (6%)
Stomach, Glandular (50) (50) (50)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Cyst 2 (4%)
Degeneration, Fatty, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 1 (2%)
Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Medulla (50) (50)
Hyperplasia, Focal 2 (4%) 1 (2%)
Bilateral, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Parathyroid Gland (42) (47)
Cyst 1 (2%)
Pituitary Gland (47) (3) (48)
Pars Distalis, Angiectasis 1 (2%) 4 (8%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 1 (33%) 4 (8%)
Thyroid Gland (49) (49)
C-Cell, Hyperplasia, Focal 1 (2%)
Follicle, Cyst 3 (6%)
Follicle, Degeneration, Cystic 4 (8%)
Follicular Cell, Hyperplasia, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (47) (14) (44)
Abscess 4 (9%) 6 (43%) 1 (2%)
Abscess, Multiple 4 (9%) 2 (14%) 6 (14%)
Cyst 10 (21%) 6 (43%) 9 (20%)
Inflammation, Chronic 1 (2%)
Uterus (50) (29) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hydrometra 6 (12%) 6 (21%) 4 (8%)
Hyperplasia, Cystic 45 (90%) 27 (93%) 39 (78%)
Inflammation, Acute, Suppurative 6 (12%) 2 (7%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (4) (4) (2)
Leukocytosis 1 (25%)
Polychromasia 3 (75%)
Bone Marrow (50) (50)
Myelofibrosis 2 (4%) 2 (4%)
Myeloid Cell, Hyperplasia 2 (4%)
Lymph Node (50) (10) (50)
Bronchial, Inflammation, Acute, Suppurative 1 (2%)
Deep Cervical, Hyperplasia 1 (2%)
Iliac, Ectasia 1 (2%)
Iliac, Hyperplasia 3 (30%) 1 (2%)
Iliac, Inflammation, Acute, Suppurative 1 (10%)
Mediastinal, Hyperplasia 1 (2%) 1 (10%)
Mediastinal, Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Renal, Hyperplasia 4 (8%) 2 (20%) 2 (4%)
Lymph Node, Mandibular (48) (3) (47)
Angiectasis 1 (2%)
Hyperplasia 4 (8%) 1 (2%)
Lymph Node, Mesenteric (47) (5) (45)
Angiectasis 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 2 (4%)
Spleen (50) (18) (49)
Atrophy 1 (6%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 13 (26%) 8 (44%) 7 (14%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (6%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Necrosis, Focal 1 (2%) 1 (2%)
Thymus (47) (47)
Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (2) (49)
Duct, Cyst 4 (8%) 3 (6%)
Skin (50) (48) (50)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (1) (50)
Cranium, Hypertrophy, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
Compression 1 (2%) 1 (100%)
Hemorrhage, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (4) (50)
Congestion 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%)
Mediastinum, Inflammation, Acute, Suppurative 3 (6%) 1 (2%)
Nose (50) (50)
Foreign Body 1 (2%) 2 (4%)
Fungus 1 (2%)
Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (2) (49)
Hydronephrosis 2 (4%)
Metaplasia, Focal, Osseous 1 (2%)
Capsule, Inflammation, Acute, Suppurative 1 (2%)
Glomerulus, Inflammation, Chronic 2 (4%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy, Multifocal 1 (2%)
Renal Tubule, Degeneration, Multifocal 2 (4%)
Renal Tubule, Dilatation, Multifocal 3 (6%) 1 (2%)
Renal Tubule, Nuclear Alteration, Multifocal 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Regeneration, Multifocal 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 5 4 3
Moribund 9 11 13
Gavage Death 3 2 1
Dosing Accident 1 1
Natural Death 1
Survivors
Terminal Sacrifice 32 33 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (2) (50)
Inflammation, Chronic 1 (2%)
Muscularis, Degeneration 1 (2%)
Gallbladder (45) (46)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Small, Jejunum (50) (2) (49)
Diverticulum 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Liver (50) (18) (50)
Angiectasis, Focal 1 (2%)
Cyst 2 (4%)
Focal Cellular Change 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 1 (6%)
Hyperplasia, Focal, Lymphoid 1 (6%)
Necrosis, Focal 1 (2%) 2 (4%)
Necrosis, Multifocal 1 (2%) 2 (4%)
Vacuolization Cytoplasmic, Diffuse 1 (6%)
Vacuolization Cytoplasmic, Focal 3 (17%)
Mesentery (5) (5) (2)
Hemorrhage, Focal 1 (50%)
Fat, Necrosis, Focal 4 (80%) 3 (60%) 1 (50%)
Fat, Necrosis, Multifocal 1 (20%)
Pancreas (50) (2) (49)
Atrophy, Focal 2 (4%) 1 (2%)
Cyst 2 (4%)
Stomach, Forestomach (50) (49) (50)
Cyst 2 (4%) 4 (8%)
Hyperplasia, Focal 7 (14%) 6 (12%) 15 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia, Multifocal 2 (4%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute, Focal, Suppurative 3 (6%) 5 (10%) 7 (14%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%) 4 (8%)
Stomach, Glandular (50) (49) (50)
Inflammation, Acute, Focal, Suppurative 1 (2%)
Tongue (1)
Ectopic Tissue 1 (100%)
Tooth (20) (1) (14)
Dysplasia 20 (100%) 1 (100%) 14 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Artery, Inflammation, Subacute 1 (2%)
Valve, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Hemorrhage 1 (2%)
Hyperplasia, Focal 2 (4%) 3 (6%)
Necrosis 1 (2%)
Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Medulla (49) (50)
Hemorrhage 1 (2%)
Hyperplasia, Focal 2 (4%)
Necrosis 1 (2%)
Pituitary Gland (44) (47)
Pars Distalis, Cyst 1 (2%)
Thyroid Gland (49) (49)
Follicle, Cyst 1 (2%)
Follicle, Degeneration, Cystic 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Dilatation 1 (100%)
Epididymis (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Penis (1)
Hemorrhage 1 (100%)
Inflammation, Acute, Suppurative 1 (100%)
Necrosis 1 (100%)
Preputial Gland (2) (5) (7)
Inflammation, Acute, Suppurative 2 (40%) 4 (57%)
Duct, Cyst 2 (100%) 4 (80%) 4 (57%)
Seminal Vesicle (2) (5) (5)
Dilatation 2 (100%) 5 (100%) 3 (60%)
Inflammation, Chronic 1 (20%)
Testes (50) (50)
Atrophy 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2) (2)
Leukocytosis 1 (50%)
Polychromasia 1 (50%) 2 (100%)
Bone Marrow (50) (50)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node, Mesenteric (46) (5) (48)
Angiectasis 6 (13%) 2 (40%) 6 (13%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (20%)
Spleen (50) (7) (50)
Atrophy 1 (2%) 1 (14%) 2 (4%)
Congestion 1 (14%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 9 (18%) 2 (29%) 10 (20%)
Hyperplasia, Lymphoid 1 (2%)
Thymus (41) (45)
Cyst 2 (5%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (26) (50)
Abscess 1 (2%)
Alopecia 1 (2%)
Cyst Epithelial Inclusion 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Developmental Malformation 2 (4%)
Edema, Focal 1 (2%)
Fibrosis, Focal 2 (4%) 2 (8%) 7 (14%)
Fibrosis, Multifocal 1 (2%)
Foreign Body, Focal 1 (2%)
Inflammation, Acute, Focal, Suppurative 1 (4%)
Inflammation, Focal, Subacute 1 (2%) 2 (4%)
Mineralization, Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (2)
Hemorrhage 1 (100%)
Artery, Inflammation, Subacute 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (14) (50)
Congestion 2 (4%)
Foreign Body 1 (7%) 1 (2%)
Hemorrhage, Focal 1 (7%)
Hemorrhage, Multifocal 1 (7%)
Infiltration Cellular, Histiocyte 1 (2%) 2 (14%) 3 (6%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 3 (21%) 4 (8%)
Fat, Mediastinum, Necrosis, Focal 1 (2%)
Mediastinum, Foreign Body 4 (8%) 1 (2%)
Mediastinum, Hemorrhage 1 (2%)
Mediastinum, Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Nose (50) (50)
Foreign Body 10 (20%) 13 (26%)
Fungus 1 (2%)
Inflammation, Acute, Suppurative 11 (22%) 14 (28%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 3 (6%)
Trachea (50) (1) (50)
Perforation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Cornea, Fibrosis 1 (50%)
Cornea, Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (2) (50)
Fibrosis, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 3 (6%)
Mineralization, Multifocal 1 (2%)
Cortex, Cyst 3 (6%)
Glomerulus, Amyloid Deposition 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Degeneration, Multifocal 3 (6%) 4 (8%)
Renal Tubule, Dilatation, Multifocal 1 (50%) 2 (4%)
Renal Tubule, Necrosis, Multifocal 1 (50%) 1 (2%)
Renal Tubule, Regeneration, Multifocal 1 (50%) 1 (2%)
Urinary Bladder (50) (2) (50)
Hemorrhage, Focal 1 (50%)
Inflammation, Subacute 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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