TDMS Study 05006-06 Pathology Tables
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
Facility: Southern Research Institute
Chemical CAS #: 100-52-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|
DAY ON TEST | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|
| 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + M + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + M + + + M + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Adenocarcinoma, Metastatic, Uterus | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|
DAY ON TEST | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|
| 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M + + + + + + + + + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Lymphocytic | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Adenocarcinoma, Metastatic,| |
Mammary Gland | X |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant Lymphocytic| X |
Mediastinal, Adenocarcinoma, | |
Metastatic, Uterus | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|
DAY ON TEST | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|
| 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | M + M + + + M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Adenocarcinoma, Metastatic, Uterus | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|
DAY ON TEST | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|
| 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3| |
| 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
VEHICLE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + M| 45 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + | 11 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + A + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3| |
| 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
VEHICLE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M M + + M + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X X| 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Adenocarcinoma, Metastatic,| | |
Mammary Gland | | 1 |
Iliac, Histiocytic Sarcoma | X | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Mediastinal, Adenocarcinoma, | | |
Metastatic, Uterus | | 1 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3| |
| 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
VEHICLE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + M +| 47 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X X X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3| |
| 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
VEHICLE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X | 2 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X X X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
600. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
600. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + M + + + M + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant | |
Iliac, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
600. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed, Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
600. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3| |
| 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
600. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A M + + + + + + + + + + + + + M + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X X | 4 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3| |
| 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
600. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + M + + + + + + + + + + M + + + + + + +| 44 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + M + + + + M + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + M + + + + + + + M +| 45 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3| |
| 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
600. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X X | 8 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3| |
| 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
600. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | +| 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant Mixed | X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 2| 2| 7| 1| 2| 2| 2| 0| 0| 1| 2| 2| 9| 2| 2| 2| 5| 3| 3| 3| 3| 3|
| 4| 2| 7| 9| 9| 3| 2| 9| 9| 9| 5| 2| 1| 9| 9| 9| 9| 9| 9| 7| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Leiomyoma | X |
Lymphoma Malignant Mixed | X |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Lymphoma Malignant Mixed | X X |
Bronchial, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Mixed | X X |
Inguinal, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant Mixed| X X X |
Pancreatic, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 2| 2| 7| 1| 2| 2| 2| 0| 0| 1| 2| 2| 9| 2| 2| 2| 5| 3| 3| 3| 3| 3|
| 4| 2| 7| 9| 9| 3| 2| 9| 9| 9| 5| 2| 1| 9| 9| 9| 9| 9| 9| 7| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300. | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Alveolar/Bronchiolar Adenoma | X |
Lymphoma Malignant Mixed | X X |
Mediastinum, Lymphoma Malignant Mixed| X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3| |
| 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
300. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + | 8 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X | 1 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Squamous Cell Papilloma | X X X X | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 3 |
Pars Distalis, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + +| 29 |
Leiomyoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Axillary, Lymphoma Malignant Mixed | X | 3 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3| |
| 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
300. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Lymphoma Malignant Mixed | X | 3 |
Inguinal, Lymphoma Malignant Mixed | X | 3 |
Mediastinal, Lymphoma Malignant Mixed| X | 4 |
Pancreatic, Lymphoma Malignant Mixed | | 2 |
Renal, Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 3 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 5 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 18 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 2 |
Adenocarcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 4 |
Alveolar/Bronchiolar Adenoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
Mediastinum, Lymphoma Malignant Mixed| | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3| |
| 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
300. | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Hemangiosarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + M + + + + + + M + + + M + + + + + + M M +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + + + + + + + + + + M + + M +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X|
Subcutaneous Tissue, Fibrosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma, Metastatic, | |
Mesentery | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|
| 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M M + + + + + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | X X X X X X X X X | 12 |
Hepatocellular Adenoma | X X| 8 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + + + M + M + + + + + + M + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + M + + + + + + + + + + + + + + + + + + M| 46 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M M M + + M + + + + + + + M + + +| 41 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M + M M M M M M M M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3| |
| 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 6 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
Adenoma | X X | 2 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|
| 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|
| 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Renal, Lymphoma Malignant Histiocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + M + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M + M M M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|
| 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3| |
| 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | | 1 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X X | 7 |
Hepatocellular Adenoma | X X X X X | 13 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X| 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + +| 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3| |
| 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + +| 5 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Lymphoma Malignant Mixed | X | 2 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Renal, Lymphoma Malignant Histiocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + M + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3| |
| 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M + + + M M M + M + M M + + M M M +| 12 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | X X X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X X X X | 4 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X | 5 |
Fibrosarcoma, Metastatic, Skin | X X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3| |
| 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 9| 1| 3| 3| 3| 7| 3| 3| 3| 1| 4| 3| 3| 3| 2| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 2| 7| 7| 6| 6| 7| 1| 6| 6| 6| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | M |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Adenocarcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Spleen | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Mesentery | + + |
Fibrosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Pancreas | + |
Fibrosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + M |
__________________________________________________________________________|
Seminal Vesicle | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Fibrosarcoma, Metastatic, Spleen | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 9| 1| 3| 3| 3| 7| 3| 3| 3| 1| 4| 3| 3| 3| 2| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 2| 7| 7| 6| 6| 7| 1| 6| 6| 6| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + |
Fibrosarcoma | X |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Mediastinum, Fibrosarcoma, | |
Metastatic, Spleen | X |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3| |
| 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 2 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 18 |
Fibrosarcoma, Metastatic, Spleen | | 1 |
Hepatocellular Carcinoma | X X X | 6 |
Hepatocellular Adenoma | X | 6 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fibrosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 2 |
Fibrosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3| |
| 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 5 |
Fibrosarcoma, Metastatic, Spleen | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 7 |
Fibrosarcoma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 26 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 3 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 14 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Mediastinum, Fibrosarcoma, | | |
Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Trachea | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05006-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 10:35:06
__________________________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3| |
| 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
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