TDMS Study 05006-06 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BENZALDEHYDE
NTP Experiment-Test: 05006-06 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 10:23:53
Facility: Southern Research Institute
Chemical CAS #: 100-52-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 11 13 7
Dead 7 8 8
Accidently Killed 1 1
Accident 1 1
Survivors
Dead 1
Terminal Sacrifice 30 27 34
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (45) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Intestine Small, Jejunum (48) (1) (49)
Polyp Adenomatous 1 (100%)
Liver (50) (8) (49)
Hepatocellular Carcinoma 1 (2%) 2 (25%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (13%) 4 (8%)
Hepatocellular Adenoma, Multiple 1 (13%)
Histiocytic Sarcoma 2 (4%)
Mesentery (11) (5) (6)
Adenocarcinoma, Metastatic, Uterus 1 (9%)
Histiocytic Sarcoma 1 (9%)
Pancreas (48) (48)
Salivary Glands (49) (1) (49)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 5 (10%) 4 (8%)
Stomach, Glandular (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50)
Pheochromocytoma Benign 1 (2%)
Pituitary Gland (47) (3) (48)
Pars Distalis, Adenoma 5 (11%) 1 (33%) 2 (4%)
Thyroid Gland (49) (49)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (47) (14) (44)
Adenoma 1 (2%)
Uterus (50) (29) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (3%)
Polyp Stromal 1 (2%) 1 (2%)
Sarcoma Stromal 2 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (4) (4) (2)
Bone Marrow (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (10) (50)
Axillary, Adenocarcinoma, Metastatic,
Mammary Gland 1 (2%)
Iliac, Histiocytic Sarcoma 1 (2%)
Mediastinal, Adenocarcinoma, Metastatic,
Uterus 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (48) (3) (47)
Lymph Node, Mesenteric (47) (5) (45)
Histiocytic Sarcoma 2 (4%)
Spleen (50) (18) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Page 3
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (47) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (2) (49)
Adenocarcinoma 2 (4%) 2 (100%) 2 (4%)
Skin (50) (48) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (4) (50)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%) 1 (2%)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (25%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Histiocytic Sarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (1) (2)
Adenoma 1 (50%) 1 (100%) 1 (50%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (2) (49)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (50) (48)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Page 4
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 4 (8%) 2 (4%) 6 (12%)
Lymphoma Malignant Mixed 8 (16%) 7 (14%) 8 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 300. 600.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 29 23 27
Total Primary Neoplasms 35 29 36
Total Animals with Benign Neoplasms 12 10 10
Total Benign Neoplasms 12 13 13
Total Animals with Malignant Neoplasms 21 16 21
Total Malignant Neoplasms 23 16 23
Total Animals with Metastatic Neoplasms 4 2
Total Metastatic Neoplasm 8 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 5 4 3
Moribund 9 11 13
Gavage Death 3 2 1
Dosing Accident 1 1
Natural Death 1
Survivors
Terminal Sacrifice 32 33 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (2) (49)
Adenocarcinoma 1 (2%) 1 (50%) 1 (2%)
Polyp Adenomatous 1 (2%)
Liver (50) (18) (50)
Fibrosarcoma, Metastatic, Spleen 1 (6%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 12 (24%) 6 (33%) 7 (14%)
Hepatocellular Adenoma 8 (16%) 6 (33%) 13 (26%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (6%)
Mesentery (5) (5) (2)
Fibrosarcoma, Metastatic, Spleen 1 (20%)
Hemangiosarcoma 1 (20%)
Pancreas (50) (2) (49)
Fibrosarcoma, Metastatic, Spleen 1 (50%)
Stomach, Forestomach (50) (49) (50)
Squamous Cell Papilloma 1 (2%) 2 (4%) 5 (10%)
Stomach, Glandular (50) (49) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Spindle Cell, Adenoma 2 (4%)
Adrenal Gland, Medulla (49) (50)
Pheochromocytoma Benign 2 (4%) 2 (4%)
Islets, Pancreatic (50) (49)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (44) (47)
Pars Distalis, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (49) (49)
Follicular Cell, Adenoma 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (49) (50)
Testes (50) (50)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (5) (50)
Lymph Node, Mandibular (46) (47)
Lymph Node, Mesenteric (46) (5) (48)
Fibrosarcoma, Metastatic, Spleen 1 (20%)
Histiocytic Sarcoma 1 (20%)
Spleen (50) (7) (50)
Fibrosarcoma 1 (14%)
Hemangiosarcoma 1 (14%) 1 (2%)
Hemangiosarcoma, Metastatic, Mesentery 1 (2%)
Thymus (41) (45)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (26) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (4%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%) 3 (12%) 4 (8%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Page 8
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Sarcoma, Multiple 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (50%)
Hemangiosarcoma, Metastatic, Mesentery 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (14) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 2 (14%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 2 (14%) 5 (10%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Fibrosarcoma, Metastatic, Spleen 1 (7%)
Nose (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (2)
Adenoma 2 (67%) 2 (100%) 2 (100%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Urinary Bladder (50) (2) (50)
Papilloma 1 (2%)
Page 9
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Histiocytic 2 (4%)
Lymphoma Malignant Lymphocytic 2 (4%)
Lymphoma Malignant Mixed 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05006-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 10:23:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 26 40
Total Primary Neoplasms 50 31 62
Total Animals with Benign Neoplasms 21 13 28
Total Benign Neoplasms 27 13 35
Total Animals with Malignant Neoplasms 20 17 25
Total Malignant Neoplasms 23 18 27
Total Animals with Metastatic Neoplasms 4 1 3
Total Metastatic Neoplasm 8 5 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 60071-60071/60071
--multipart-boundary--