TDMS Study 05006-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 06 TIME: 10:32:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: H. GILES S.EUSTIS CAS: 100-52-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 06 TIME: 10:32:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: H. GILES S.EUSTIS CAS: 100-52-7
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 06 TIME: 10:32:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: H. GILES S.EUSTIS CAS: 100-52-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BENZALDEHYDE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/0 (0%) 2/50 (4%) | 1/50 (2%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.5% | 3.3% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/0 2/31 (6%) | 1/30 (3%) 0/0 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138 (e) P=0.231 | P=0.282N (e) P=0.469N |
|INCIDENTAL TUMOR | P=0.138 (e) P=0.231 | P=0.282N (e) P=0.469N |
|LOGISTIC REGRESSION | P=0.138 (e) P=0.231 | P=0.282N (e) P=0.469N |
|COCHRAN-ARMITAGE | P=0.142 | P=0.308N |
|FISHER EXACT | (e) P=0.247 | P=1.000N P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/0 (0%) 2/50 (4%) | 1/50 (2%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.7% 0.0% 6.5% | 3.3% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/0 2/31 (6%) | 1/30 (3%) 0/0 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 576 --- 736 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590 P=0.251N P=0.671 | P=0.282N (e) P=0.469N |
|INCIDENTAL TUMOR | P=0.572N (e) P=0.670N | P=0.282N (e) P=0.469N |
|LOGISTIC REGRESSION | P=0.572N (e) P=0.670N | P=0.282N (e) P=0.469N |
|COCHRAN-ARMITAGE | P=0.593N | P=0.308N |
|FISHER EXACT | P=1.000N P=0.684N | P=1.000N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 5.4% 6.1% 6.2% | 3.3% 2.2% 2.9% |
|TERMINAL (d) | 1/32 (3%) 2/33 (6%) 1/31 (3%) | 1/30 (3%) 0/27 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 576 736 (T) 717 | 729 (T) 473 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586 P=0.690N P=0.678 | P=0.609N P=0.744 P=0.727N |
|INCIDENTAL TUMOR | P=0.593 P=0.682 P=0.689 | P=0.633N P=0.734 P=0.727N |
|LOGISTIC REGRESSION | P=0.600 P=0.693N P=0.693N | P=0.630 P=0.763N P=0.727N |
|COCHRAN-ARMITAGE | P=0.601 | P=0.640 |
|FISHER EXACT | P=0.691N P=0.691N | P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 8.2% 6.1% 6.2% | 6.7% 2.2% 2.9% |
|TERMINAL (d) | 1/32 (3%) 2/33 (6%) 1/31 (3%) | 2/30 (7%) 0/27 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 576 736 (T) 717 | 729 (T) 473 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.422N P=0.493N P=0.517N | P=0.346N P=0.529N P=0.446N |
|INCIDENTAL TUMOR | P=0.424N P=0.542N P=0.517N | P=0.366N P=0.540N P=0.446N |
|LOGISTIC REGRESSION | P=0.408N P=0.497N P=0.498N | P=0.379N P=0.499N P=0.446N |
|COCHRAN-ARMITAGE | P=0.406N | P=0.378N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 6/18 (33%) 14/50 (28%) | 1/50 (2%) 2/8 (25%) 4/49 (8%) |
|ADJUSTED (b) | 22.2% 43.2% 39.9% | 3.3% 35.2% 11.4% |
|TERMINAL (d) | 5/32 (16%) 5/12 (42%) 11/31 (35%) | 1/30 (3%) 1/3 (33%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 576 697 293 | 729 (T) 641 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.079 P=0.315 P=0.102 | P=0.204 P=0.101 P=0.227 |
|INCIDENTAL TUMOR | P=0.083 P=0.108 P=0.102 | P=0.180 P=0.085 P=0.227 |
|LOGISTIC REGRESSION | P=0.097 P=0.128 P=0.116 | P=0.188 P=0.028 * P=0.227 |
|COCHRAN-ARMITAGE | P=0.098 | P=0.149 |
|FISHER EXACT | P=0.113 P=0.114 | P=0.047 * P=0.175 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 6/18 (33%) 7/50 (14%) | 1/50 (2%) 2/8 (25%) 1/49 (2%) |
|ADJUSTED (b) | 29.4% 30.2% 17.0% | 2.9% 66.7% 2.9% |
|TERMINAL (d) | 5/32 (16%) 3/12 (25%) 2/31 (6%) | 0/30 (0%) 2/3 (67%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 448 527 471 | 667 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.374N P=0.199N | P=0.550N P=0.097 P=0.728N |
|INCIDENTAL TUMOR | P=0.064N P=0.443 P=0.084N | P=0.575N P=0.014 * P=0.758 |
|LOGISTIC REGRESSION | P=0.044N* P=0.321 P=0.053N | P=0.570N P=0.024 * P=0.756N |
|COCHRAN-ARMITAGE | P=0.136N | P=0.598 |
|FISHER EXACT | P=0.317 P=0.154N | P=0.047 * P=0.747 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 12/18 (67%) 20/50 (40%) | 2/50 (4%) 4/8 (50%) 5/49 (10%) |
|ADJUSTED (b) | 45.6% 69.8% 50.8% | 6.1% 100.0% 14.3% |
|TERMINAL (d) | 10/32 (31%) 8/12 (67%) 13/31 (42%) | 1/30 (3%) 3/3 (100%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 448 527 293 | 667 641 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410 P=0.477 P=0.448 | P=0.279 P=0.008 ** P=0.282 |
|INCIDENTAL TUMOR | P=0.505 P=0.057 P=0.542 | P=0.245 P<0.001 ** P=0.261 |
|LOGISTIC REGRESSION | P=0.474 P=0.045 * P=0.514 | P=0.251 P<0.001 ** P=0.261 |
|COCHRAN-ARMITAGE | P=0.459 | P=0.195 |
|FISHER EXACT | P=0.034 * P=0.500 | P=0.002 ** P=0.210 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 12/18 (67%) 20/50 (40%) | 2/50 (4%) 4/8 (50%) 5/49 (10%) |
|ADJUSTED (b) | 45.6% 69.8% 50.8% | 6.1% 100.0% 14.3% |
|TERMINAL (d) | 10/32 (31%) 8/12 (67%) 13/31 (42%) | 1/30 (3%) 3/3 (100%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | 448 527 293 | 667 641 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410 P=0.477 P=0.448 | P=0.279 P=0.008 ** P=0.282 |
|INCIDENTAL TUMOR | P=0.505 P=0.057 P=0.542 | P=0.245 P<0.001 ** P=0.261 |
|LOGISTIC REGRESSION | P=0.474 P=0.045 * P=0.514 | P=0.251 P<0.001 ** P=0.261 |
|COCHRAN-ARMITAGE | P=0.459 | P=0.195 |
|FISHER EXACT | P=0.034 * P=0.500 | P=0.002 ** P=0.210 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/14 (14%) 1/50 (2%) | 0/50 (0%) 1/4 (25%) 0/50 (0%) |
|ADJUSTED (b) | 17.0% 16.7% 3.2% | 0.0% 100.0% 0.0% |
|TERMINAL (d) | 4/32 (13%) 1/7 (14%) 1/31 (3%) | 0/30 (0%) 1/1 (100%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 451 717 736 (T) | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.047N* P=0.525N P=0.064N | P=0.666N P=0.004 ** (e) |
|INCIDENTAL TUMOR | P=0.045N* P=0.499 P=0.051N | P=0.666N P=0.004 ** (e) |
|LOGISTIC REGRESSION | P=0.047N* P=0.572 P=0.057N | P=0.666N P=0.004 ** (e) |
|COCHRAN-ARMITAGE | P=0.048N* | P=0.696N |
|FISHER EXACT | P=0.563 P=0.056N | P=0.074 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/14 (14%) 5/50 (10%) | 0/50 (0%) 0/4 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.1% 16.5% 14.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/32 (6%) 1/7 (14%) 3/31 (10%) | 0/30 (0%) 0/1 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 734 697 640 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.274 P=0.522 P=0.339 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.274 P=0.342 P=0.338 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.287 P=0.282 P=0.346 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.298 | (e) |
|FISHER EXACT | P=0.299 P=0.357 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 4/14 (29%) 6/50 (12%) | 0/50 (0%) 1/4 (25%) 0/50 (0%) |
|ADJUSTED (b) | 22.4% 32.4% 17.5% | 0.0% 100.0% 0.0% |
|TERMINAL (d) | 5/32 (16%) 2/7 (29%) 4/31 (13%) | 0/30 (0%) 1/1 (100%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 451 697 640 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363N P=0.581 P=0.412N | P=0.666N P=0.004 ** (e) |
|INCIDENTAL TUMOR | P=0.346N P=0.191 P=0.382N | P=0.666N P=0.004 ** (e) |
|LOGISTIC REGRESSION | P=0.343N P=0.219 P=0.385N | P=0.666N P=0.004 ** (e) |
|COCHRAN-ARMITAGE | P=0.341N | P=0.696N |
|FISHER EXACT | P=0.241 P=0.387N | P=0.074 (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.2% 6.9% 5.3% |
|TERMINAL (d) | 0/32 (0%) 0/33 (0%) 0/31 (0%) | 0/30 (0%) 1/27 (4%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 504 711 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.542N P=0.671 P=0.649N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.555 P=0.666N P=0.625 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.596N P=0.695 P=0.684 |
|COCHRAN-ARMITAGE | (e) | P=0.601 |
|FISHER EXACT | (e) (e) | P=0.691N P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/44 (2%) 0/0 (0%) 1/47 (2%) | 5/47 (11%) 1/3 (33%) 2/48 (4%) |
|ADJUSTED (b) | 2.2% 0.0% 3.3% | 17.2% 50.0% 5.6% |
|TERMINAL (d) | 0/29 (0%) 0/0 1/30 (3%) | 5/29 (17%) 1/2 (50%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | 451 --- 736 (T) | 729 (T) 729 (T) 718 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.642N P=0.496N P=0.752N | P=0.117N P=0.419 P=0.156N |
|INCIDENTAL TUMOR | P=0.580N (e) P=0.712N | P=0.127N P=0.419 P=0.165N |
|LOGISTIC REGRESSION | P=0.580N (e) P=0.712N | P=0.115N P=0.419 P=0.151N |
|COCHRAN-ARMITAGE | P=0.622N | P=0.167N |
|FISHER EXACT | P=1.000N P=0.736N | P=0.324 P=0.209N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 3.0% 7.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/32 (6%) 1/33 (3%) 1/31 (3%) | 0/30 (0%) 0/27 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 529 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 P=0.489N P=0.489 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.420 P=0.489N P=0.538 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.403 P=0.489N P=0.504 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.400 | (e) |
|FISHER EXACT | P=0.500N P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/50 (8%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.9% 9.1% 10.2% | 0.0% 3.7% 0.0% |
|TERMINAL (d) | 1/32 (3%) 3/33 (9%) 1/31 (3%) | 0/30 (0%) 1/27 (4%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 609 736 (T) 529 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.406 P=0.659N P=0.483 | P=0.702N P=0.479 (e) |
|INCIDENTAL TUMOR | P=0.488 P=0.639 P=0.617 | P=0.702N P=0.479 (e) |
|LOGISTIC REGRESSION | P=0.424 P=0.661N P=0.495 | P=0.702N P=0.479 (e) |
|COCHRAN-ARMITAGE | P=0.421 | P=0.730N |
|FISHER EXACT | P=0.661N P=0.500 | P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 7/50 (14%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 13.8% 14.6% 18.5% | 2.9% 3.7% 0.0% |
|TERMINAL (d) | 3/32 (9%) 4/33 (12%) 3/31 (10%) | 0/30 (0%) 1/27 (4%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 609 700 529 | 672 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.302 P=0.619N P=0.362 | P=0.303N P=0.742 P=0.468N |
|INCIDENTAL TUMOR | P=0.349 P=0.594 P=0.451 | P=0.329N P=0.741N P=0.536N |
|LOGISTIC REGRESSION | P=0.323 P=0.629N P=0.384 | P=0.320N P=0.758 P=0.500N |
|COCHRAN-ARMITAGE | P=0.318 | P=0.332N |
|FISHER EXACT | P=0.630N P=0.380 | P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 5/50 (10%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.9% 11.6% 13.2% | 2.9% 3.7% 0.0% |
|TERMINAL (d) | 1/32 (3%) 3/33 (9%) 2/31 (6%) | 0/30 (0%) 1/27 (4%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 609 700 529 | 672 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278 P=0.504 P=0.344 | P=0.303N P=0.742 P=0.468N |
|INCIDENTAL TUMOR | P=0.338 P=0.449 P=0.459 | P=0.329N P=0.741N P=0.536N |
|LOGISTIC REGRESSION | P=0.294 P=0.504 P=0.355 | P=0.320N P=0.758 P=0.500N |
|COCHRAN-ARMITAGE | P=0.290 | P=0.332N |
|FISHER EXACT | P=0.500 P=0.357 | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 5/50 (10%) | 0/50 (0%) 5/50 (10%) 5/50 (10%) |
|ADJUSTED (b) | 3.1% 5.3% 16.1% | 0.0% 15.6% 13.4% |
|TERMINAL (d) | 1/32 (3%) 1/33 (3%) 5/31 (16%) | 0/30 (0%) 3/27 (11%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 541 736 (T) | --- 591 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.504 P=0.094 | P=0.057 P=0.030 * P=0.047 * |
|INCIDENTAL TUMOR | P=0.063 P=0.585 P=0.094 | P=0.036 * P=0.038 * P=0.040 * |
|LOGISTIC REGRESSION | P=0.057 P=0.502 P=0.094 | P=0.039 * P=0.032 * P=0.035 * |
|COCHRAN-ARMITAGE | P=0.060 | P=0.036 * |
|FISHER EXACT | P=0.500 P=0.102 | P=0.028 * P=0.028 * |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 5/50 (10%) | 0/50 (0%) 5/50 (10%) 4/50 (8%) |
|ADJUSTED (b) | 3.1% 5.3% 16.1% | 0.0% 15.6% 10.6% |
|TERMINAL (d) | 1/32 (3%) 1/33 (3%) 5/31 (16%) | 0/30 (0%) 3/27 (11%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 541 736 (T) | --- 591 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.504 P=0.094 | P=0.101 P=0.030 * P=0.082 |
|INCIDENTAL TUMOR | P=0.063 P=0.585 P=0.094 | P=0.068 P=0.038 * P=0.069 |
|LOGISTIC REGRESSION | P=0.057 P=0.502 P=0.094 | P=0.074 P=0.032 * P=0.063 |
|COCHRAN-ARMITAGE | P=0.060 | P=0.070 |
|FISHER EXACT | P=0.500 P=0.102 | P=0.028 * P=0.059 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/0 (0%) 1/49 (2%) | 1/49 (2%) 0/0 (0%) 1/49 (2%) |
|ADJUSTED (b) | 5.3% 0.0% 3.2% | 3.3% 0.0% 2.9% |
|TERMINAL (d) | 1/32 (3%) 0/0 1/31 (3%) | 1/30 (3%) 0/0 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 451 --- 736 (T) | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.496N P=0.502N | P=0.598N (e) P=0.727N |
|INCIDENTAL TUMOR | P=0.318N (e) P=0.429N | P=0.598N (e) P=0.727N |
|LOGISTIC REGRESSION | P=0.318N (e) P=0.429N | P=0.598N (e) P=0.727N |
|COCHRAN-ARMITAGE | P=0.385N | P=0.640 |
|FISHER EXACT | P=1.000N P=0.500N | P=1.000N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/0 (0%) 2/49 (4%) | 0/49 (0%) 0/0 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/0 2/31 (6%) | 0/30 (0%) 0/0 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138 (e) P=0.231 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.138 (e) P=0.231 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.138 (e) P=0.231 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | (e) P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/0 (0%) 3/49 (6%) | 1/49 (2%) 0/0 (0%) 1/49 (2%) |
|ADJUSTED (b) | 5.3% 0.0% 9.7% | 3.3% 0.0% 2.9% |
|TERMINAL (d) | 1/32 (3%) 0/0 3/31 (10%) | 1/30 (3%) 0/0 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 451 --- 736 (T) | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.398 P=0.496N P=0.492 | P=0.598N (e) P=0.727N |
|INCIDENTAL TUMOR | P=0.458 (e) P=0.550 | P=0.598N (e) P=0.727N |
|LOGISTIC REGRESSION | P=0.458 (e) P=0.550 | P=0.598N (e) P=0.727N |
|COCHRAN-ARMITAGE | P=0.409 | P=0.640 |
|FISHER EXACT | P=1.000N P=0.500 | P=1.000N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 6.1% 0.0% |
|TERMINAL (d) | | 0/30 (0%) 1/27 (4%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 591 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.640N P=0.231 (e) |
|INCIDENTAL TUMOR | | P=0.649 P=0.264 (e) |
|LOGISTIC REGRESSION | | P=0.668 P=0.238 (e) |
|COCHRAN-ARMITAGE | | P=0.668N |
|FISHER EXACT | | P=0.247 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 3.3% 6.1% 2.9% |
|TERMINAL (d) | | 1/30 (3%) 1/27 (4%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 591 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.575N P=0.478 P=0.727N |
|INCIDENTAL TUMOR | | P=0.615N P=0.514 P=0.727N |
|LOGISTIC REGRESSION | | P=0.607N P=0.497 P=0.727N |
|COCHRAN-ARMITAGE | | P=0.622N |
|FISHER EXACT | | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.3% 2.9% 5.9% | 3.3% 0.0% 5.7% |
|TERMINAL (d) | 0/32 (0%) 0/33 (0%) 1/31 (3%) | 1/30 (3%) 0/27 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 556 727 659 | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.365 P=0.758 P=0.484 | P=0.407 P=0.521N P=0.554 |
|INCIDENTAL TUMOR | P=0.369 P=0.697 P=0.500 | P=0.407 P=0.521N P=0.554 |
|LOGISTIC REGRESSION | P=0.381 P=0.762 P=0.499 | P=0.407 P=0.521N P=0.554 |
|COCHRAN-ARMITAGE | P=0.379 | P=0.360 |
|FISHER EXACT | P=0.753N P=0.500 | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 4.5% 2.9% 5.9% | 3.3% 0.0% 5.7% |
|TERMINAL (d) | 0/32 (0%) 0/33 (0%) 1/31 (3%) | 1/30 (3%) 0/27 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 556 727 659 | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.588 P=0.507N P=0.671 | P=0.407 P=0.521N P=0.554 |
|INCIDENTAL TUMOR | P=0.605N P=0.594N P=0.680N | P=0.407 P=0.521N P=0.554 |
|LOGISTIC REGRESSION | P=0.610 P=0.504N P=0.690 | P=0.407 P=0.521N P=0.554 |
|COCHRAN-ARMITAGE | P=0.610N | P=0.360 |
|FISHER EXACT | P=0.500N P=0.691N | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.9% 0.0% | 6.5% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/33 (0%) 0/31 (0%) | 1/30 (3%) 0/27 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 727 --- | 714 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.723 P=0.506 (e) | P=0.088N P=0.263N P=0.207N |
|INCIDENTAL TUMOR | P=0.700 P=0.433 (e) | P=0.092N P=0.219N P=0.242N |
|LOGISTIC REGRESSION | P=0.726 P=0.501 (e) | P=0.086N P=0.247N P=0.210N |
|COCHRAN-ARMITAGE | P=0.730 | P=0.096N |
|FISHER EXACT | P=0.500 (e) | P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 5/50 (10%) | 15/50 (30%) 9/50 (18%) 15/50 (30%) |
|ADJUSTED (b) | 2.7% 8.6% 15.2% | 41.9% 27.5% 37.2% |
|TERMINAL (d) | 0/32 (0%) 1/33 (3%) 3/31 (10%) | 10/30 (33%) 5/27 (19%) 10/35 (29%) |
|FIRST INCIDENCE (DAYS) | 675 717 717 | 568 612 618 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.068 P=0.321 P=0.102 | P=0.387N P=0.182N P=0.413N |
|INCIDENTAL TUMOR | P=0.048 * P=0.210 P=0.079 | P=0.545 P=0.085N P=0.563 |
|LOGISTIC REGRESSION | P=0.063 P=0.306 P=0.095 | P=0.537 P=0.127N P=0.560 |
|COCHRAN-ARMITAGE | P=0.070 | P=0.545 |
|FISHER EXACT | P=0.309 P=0.102 | P=0.121N P=0.586N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 5/50 (10%) | 13/50 (26%) 9/50 (18%) 15/50 (30%) |
|ADJUSTED (b) | 2.7% 5.8% 15.2% | 36.9% 27.5% 37.2% |
|TERMINAL (d) | 0/32 (0%) 1/33 (3%) 3/31 (10%) | 9/30 (30%) 5/27 (19%) 10/35 (29%) |
|FIRST INCIDENCE (DAYS) | 675 717 717 | 568 612 618 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058 P=0.513 P=0.102 | P=0.522 P=0.307N P=0.577 |
|INCIDENTAL TUMOR | P=0.045 * P=0.424 P=0.079 | P=0.355 P=0.185N P=0.377 |
|LOGISTIC REGRESSION | P=0.054 P=0.502 P=0.095 | P=0.341 P=0.245N P=0.366 |
|COCHRAN-ARMITAGE | P=0.060 | P=0.364 |
|FISHER EXACT | P=0.500 P=0.102 | P=0.235N P=0.412 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 13/50 (26%) 28/50 (56%) | 12/50 (24%) 10/50 (20%) 10/50 (20%) |
|ADJUSTED (b) | 53.1% 35.6% 71.0% | 38.0% 29.7% 26.7% |
|TERMINAL (d) | 14/32 (44%) 10/33 (30%) 20/31 (65%) | 11/30 (37%) 6/27 (22%) 8/35 (23%) |
|FIRST INCIDENCE (DAYS) | 451 541 293 | 504 473 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.087 P=0.071N P=0.110 | P=0.239N P=0.495N P=0.265N |
|INCIDENTAL TUMOR | P=0.097 P=0.072N P=0.122 | P=0.302N P=0.454N P=0.303N |
|LOGISTIC REGRESSION | P=0.095 P=0.063N P=0.121 | P=0.309N P=0.419N P=0.329N |
|COCHRAN-ARMITAGE | P=0.094 | P=0.357N |
|FISHER EXACT | P=0.069N P=0.115 | P=0.405N P=0.405N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 300. 600. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 17/50 (34%) 25/50 (50%) | 21/50 (42%) 16/50 (32%) 21/50 (42%) |
|ADJUSTED (b) | 45.9% 41.2% 56.3% | 51.9% 47.2% 50.0% |
|TERMINAL (d) | 9/32 (28%) 9/33 (27%) 12/31 (39%) | 11/30 (37%) 10/27 (37%) 14/35 (40%) |
|FIRST INCIDENCE (DAYS) | 448 527 471 | 504 591 618 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187 P=0.344N P=0.218 | P=0.342N P=0.313N P=0.372N |
|INCIDENTAL TUMOR | P=0.189 P=0.453N P=0.257 | P=0.530 P=0.130N P=0.519 |
|LOGISTIC REGRESSION | P=0.283 P=0.312N P=0.354 | P=0.520 P=0.165N P=0.503 |
|COCHRAN-ARMITAGE | P=0.181 | P=0.541 |
|FISHER EXACT | P=0.339N P=0.211 | P=0.204N P=0.580N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 36/50 (72%) 26/50 (52%) 40/50 (80%) | 29/50 (58%) 23/50 (46%) 27/50 (54%) |
|ADJUSTED (b) | 78.3% 61.7% 86.8% | 72.1% 62.6% 62.8% |
|TERMINAL (d) | 22/32 (69%) 17/33 (52%) 25/31 (81%) | 19/30 (63%) 14/27 (52%) 19/35 (54%) |
|FIRST INCIDENCE (DAYS) | 448 527 293 | 504 473 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.229 P=0.061N P=0.252 | P=0.186N P=0.302N P=0.201N |
|INCIDENTAL TUMOR | P=0.247 P=0.031N* P=0.290 | P=0.350N P=0.105N P=0.407N |
|LOGISTIC REGRESSION | P=0.347 P=0.022N* P=0.289 | P=0.368N P=0.166N P=0.426N |
|COCHRAN-ARMITAGE | P=0.228 | P=0.382N |
|FISHER EXACT | P=0.032N* P=0.241 | P=0.158N P=0.420N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 06 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZALDEHYDE
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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