TDMS Study 05006-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05006 BENZALDEHYDE TIME: 10:32:53
TEST: 06 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56133
CONT: NO1CP9565101 CAS: 100-52-7
PATHOLOGIST: H. GILES S.EUSTIS
--------------------------------------------------------------------------------
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05006 BENZALDEHYDE TIME: 10:32:53
TEST: 06 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56133
CONT: NO1CP9565101 CAS: 100-52-7
PATHOLOGIST: H. GILES S.EUSTIS
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 4 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 448 451 556 576 576 609 638 659 661 675 |
| 697 713 715 734 |
| CENSORED DEATHS |
| 2 5 10 11 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 2 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 219 313 498 504 527 541 571 577 577 627 |
| 697 697 700 717 727 |
| CENSORED DEATHS |
| 2 3 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 2 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 293 345 471 477 529 535 568 569 571 575 |
| 576 640 654 659 693 717 718 |
| CENSORED DEATHS |
| 14 682 |
| |
==================================================================================
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 95.7 95.7 89.1 80.4 69.6 |
|CONTROL | |
| | |
|200. | 100.0 100.0 97.9 95.8 95.8 95.8 87.5 81.3 79.2 68.8 |
|MG/KG | |
| | |
|400. | 100.0 100.0 100.0 95.9 95.9 91.8 87.8 77.6 71.4 65.1 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 200. 400. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 69.6% 68.8% 65.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.592 P=1.000 P=0.654 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.0 566.1 564.1 |
|NATURAL DEATHS (C) | (24.5) (37.8) (28.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.8 655.7 662.0 |
|(STANDARD ERROR) | (28.6) (24.6) (20.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 2 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 445 478 504 504 520 521 531 541 568 603 |
| 624 637 645 667 672 697 702 714 |
| CENSORED DEATHS |
| 9 638 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 2 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 399 431 473 486 535 545 557 591 612 614 |
| 624 624 641 661 661 671 673 702 711 712 |
| 717 |
| CENSORED DEATHS |
| 105 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 344 437 456 486 500 526 535 604 618 623 |
| 684 688 702 711 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 95.9 83.7 79.6 73.4 62.9 |
|CONTROL | |
| | |
|300. | 100.0 100.0 100.0 100.0 98.0 93.8 87.6 83.4 68.8 56.3 |
|MG/KG | |
| | |
|600. | 100.0 100.0 100.0 98.0 98.0 94.0 86.0 84.0 80.0 70.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 300. 600. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.9% 56.3% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.521N P=0.695 P=0.589N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 587.4 601.9 575.5 |
|NATURAL DEATHS (C) | (20.0) (20.5) (30.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 661.8 657.7 682.9 |
|(STANDARD ERROR) | (17.9) (17.2) (13.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
200. MG/KG = 2
400. MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 2 3 1 1
| 2 3 1 3 2 1
95 +
| 33 1 1
P |
E | 3 2 2
R 90 + 232
C | 1 1
E | 32 2 1 1
N |
T 85 + 22 1 1
|
S |
U | 32 2
R 80 + 1 1
V | 2 1 1
I | 3 3
V | 1 1
A 75 + 3 3
L | 3 3 11
| 2 2
| 3 3 12 1
70 + 11
| 3 32 2
|
|
65 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
BENZALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
300. MG/KG = 2
600. MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
| 3 2 231 1
| 23 3 21 1
95 +
| 3 2 2
| 3 3
| 2 1 1 2
90 + 3 322
|
P | 1132 2
E | 131 3
R 85 + 2 2
C | 1 1 2 323
E |
N | 1 1
T 80 + 1 31 3
| 2 2
S | 11 33
U | 3 3
R 75 + 2121
V | 1 1 33
I | 2 2 33
V |
A 70 + 3 3
L | 21 1
| 11
| 22
65 + 2 11
|
| 21 1
|
60 +
| 22
|
| 2 2
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
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