TDMS Study 05006-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BENZALDEHYDE
NTP Experiment-Test: 05006-05 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 08:49:07
Facility: Southern Research Institute
Chemical CAS #: 000100527
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 13 16 12
Dead 4 1 9
Survivors
Terminal Sacrifice 33 33 29
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (1) (50)
Parasite Metazoan 1 (2%) 5 (10%)
Intestine Large, Colon (49) (1) (50)
Parasite Metazoan 3 (6%) 1 (2%)
Intestine Large, Rectum (48) (1) (50)
Parasite Metazoan 4 (8%) 5 (10%)
Intestine Small, Duodenum (49) (1) (46)
Erosion 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 4 (8%)
Basophilic Focus 41 (82%) 43 (86%) 36 (72%)
Clear Cell Focus 2 (4%) 4 (8%) 3 (6%)
Developmental Malformation 4 (8%) 10 (20%) 7 (14%)
Focal Cellular Change 3 (6%) 2 (4%)
Granuloma 13 (26%) 15 (30%) 21 (42%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic 4 (8%) 9 (18%) 3 (6%)
Mixed Cell Focus 1 (2%) 1 (2%)
Bile Duct, Cyst Multilocular 1 (2%)
Bile Duct, Hyperplasia 25 (50%) 19 (38%) 12 (24%)
Centrilobular, Atrophy 1 (2%) 5 (10%) 4 (8%)
Hepatocyte, Hyperplasia, Nodular 2 (4%) 5 (10%) 7 (14%)
Hepatocyte, Vacuolization Cytoplasmic 3 (6%) 4 (8%) 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 2 (4%) 3 (6%)
Lobules, Necrosis 3 (6%) 6 (12%) 4 (8%)
Mesentery (9) (5) (6)
Accessory Spleen 1 (17%)
Infiltration Cellular, Histiocyte 1 (11%)
Artery, Hypertrophy 2 (33%)
Artery, Inflammation, Chronic Active 2 (33%)
Fat, Inflammation, Chronic 1 (20%)
Fat, Inflammation, Granulomatous 2 (22%) 2 (40%) 1 (17%)
Fat, Inflammation, Suppurative 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Mineralization 3 (60%) 1 (17%)
Fat, Necrosis 6 (67%) 5 (100%) 3 (50%)
Pancreas (48) (2) (50)
Atrophy 4 (8%) 1 (50%) 2 (4%)
Ectopic Tissue 1 (2%)
Hyperplasia, Nodular 5 (10%) 5 (10%)
Inflammation, Chronic 2 (4%)
Salivary Glands (50) (50)
Ectasia 1 (2%)
Inflammation, Chronic 2 (4%)
Stomach, Forestomach (50) (50) (50)
Edema 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Mucosa, Dysplasia 1 (2%)
Mucosa, Hyperplasia 5 (10%) 2 (4%) 3 (6%)
Stomach, Glandular (50) (50) (50)
Cyst 1 (2%)
Edema 1 (2%)
Erosion 1 (2%) 3 (6%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mineralization 5 (10%) 8 (16%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 20 (40%) 15 (30%) 19 (38%)
Thrombosis 1 (2%)
Epicardium, Inflammation, Chronic Active 1 (2%)
Myocardium, Inflammation, Chronic 7 (14%) 8 (16%) 1 (2%)
Myocardium, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 8 (16%) 8 (16%) 3 (6%)
Angiectasis 5 (10%) 7 (14%) 8 (16%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 9 (18%) 10 (20%) 8 (16%)
Cyst Multilocular 1 (2%)
Hemorrhage 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 6 (12%) 5 (10%) 5 (10%)
Necrosis 3 (6%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 3 (6%)
Adrenal Gland, Medulla (49) (49) (47)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 4 (8%) 1 (2%)
Inflammation, Chronic 1 (2%)
Islets, Pancreatic (48) (2) (50)
Hyperplasia 1 (2%)
Pituitary Gland (49) (49) (49)
Pars Distalis, Angiectasis 3 (6%) 4 (8%) 8 (16%)
Pars Distalis, Cyst 14 (29%) 15 (31%) 9 (18%)
Pars Distalis, Hyperplasia 4 (8%) 4 (8%) 10 (20%)
Pars Distalis, Pigmentation 1 (2%) 1 (2%) 2 (4%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (4) (50)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 7 (14%) 1 (25%) 7 (14%)
Follicle, Cyst 1 (2%) 1 (25%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (50) (48)
Ectasia 6 (13%) 2 (4%) 7 (15%)
Hyperplasia 3 (7%) 1 (2%) 7 (15%)
Inflammation, Chronic 6 (13%) 6 (12%) 4 (8%)
Inflammation, Suppurative 6 (13%) 2 (4%) 12 (25%)
Metaplasia, Squamous 1 (2%)
Ovary (49) (3) (50)
Atrophy 1 (2%)
Cyst 4 (8%) 2 (67%) 7 (14%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Uterus (49) (12) (50)
Angiectasis 1 (2%)
Cyst 3 (25%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 1 (8%) 2 (4%)
Hydrometra 2 (4%) 1 (8%) 1 (2%)
Hyperplasia, Cystic 4 (8%) 1 (8%) 4 (8%)
Inflammation, Suppurative 1 (2%) 1 (8%) 1 (2%)
Necrosis 1 (2%)
Endometrium, Dysplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (1) (2)
Anemia 1 (50%) 1 (100%) 2 (100%)
Leukocytosis 1 (50%)
Bone Marrow (50) (5) (50)
Hyperplasia, Reticulum Cell 3 (6%) 1 (20%) 5 (10%)
Myelofibrosis 1 (2%)
Proliferation 3 (6%)
Lymph Node (50) (1) (50)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (46) (47)
Hyperplasia, Plasma Cell 1 (2%) 2 (4%)
Lymphatic, Dilatation 2 (4%) 1 (2%)
Lymph Node, Mesenteric (48) (1) (50)
Depletion Cellular 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Spleen (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 10 (20%) 4 (8%)
Hyperplasia, Re Cell 1 (2%) 1 (2%)
Necrosis 2 (4%)
Pigmentation, Hemosiderin 3 (6%) 7 (14%) 7 (14%)
Lymphoid Follicle, Atrophy 1 (2%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
Thymus (47) (46)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Hyperplasia, Cystic 43 (86%) 45 (90%) 32 (64%)
Hyperplasia, Lobular 8 (16%) 10 (20%) 3 (6%)
Skin (50) (29) (50)
Acanthosis 1 (2%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Fibrosis 1 (2%)
Inflammation, Chronic 1 (3%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Nipple, Hypertrophy 1 (3%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Hyperostosis 6 (12%) 7 (14%) 1 (2%)
Femur, Hyperostosis 7 (14%) 7 (14%) 1 (2%)
Sternum, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 7 (14%) 16 (32%) 3 (6%)
Hemorrhage 2 (4%)
Hydrocephalus 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%)
Vacuolization Cytoplasmic 1 (2%)
Peripheral Nerve (47) (50) (49)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Spinal Cord (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Axon, White Matter, Degeneration 1 (2%)
Gray Matter, Degeneration 2 (4%) 1 (2%) 1 (2%)
Parenchyma, White Matter, Degeneration,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 2 (4%) 2 (4%) 4 (8%)
Fibrosis 1 (2%)
Infiltration Cellular, Histiocyte 26 (52%) 14 (28%) 14 (28%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Subpleura, Inflammation, Chronic Active 1 (2%)
Nose (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Exudate 4 (8%) 6 (12%)
Fungus 1 (2%)
Inflammation, Chronic 2 (4%)
Mucosa, Hyperplasia 1 (2%)
Mucosa, Metaplasia, Squamous 2 (4%)
Trachea (50) (50)
Exudate 1 (2%)
Inflammation, Chronic 1 (2%)
Mucosa, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (49)
Cataract 21 (42%) 19 (38%) 25 (51%)
Hemorrhage 1 (2%)
Cornea, Inflammation, Chronic 1 (2%)
Cornea, Neovascularization 1 (2%)
Retina, Atrophy 43 (86%) 42 (84%) 40 (82%)
Sclera, Mineralization 5 (10%) 11 (22%) 6 (12%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Angiectasis 1 (2%)
Cyst 2 (4%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hydronephrosis 2 (4%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 3 (6%) 7 (14%) 1 (2%)
Inflammation, Suppurative 1 (2%) 3 (6%)
Mineralization 43 (86%) 45 (90%) 41 (82%)
Nephropathy 33 (66%) 41 (82%) 34 (68%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Degeneration 2 (4%) 3 (6%)
Renal Tubule, Dilatation 2 (4%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 2 (4%)
Transitional Epithelium, Hyperplasia 2 (4%) 2 (4%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Inflammation, Suppurative 1 (100%)
Mucosa, Hyperplasia 1 (100%)
Urinary Bladder (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 10 12 17
Dead 3 9 12
Survivors
Terminal Sacrifice 37 29 21
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (47)
Edema 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Parasite Metazoan 5 (10%) 4 (8%) 3 (6%)
Intestine Large, Colon (50) (49) (48)
Inflammation, Granulomatous 1 (2%)
Parasite Metazoan 5 (10%) 3 (6%) 3 (6%)
Intestine Large, Rectum (49) (49) (45)
Mineralization 1 (2%)
Parasite Metazoan 9 (18%) 7 (14%) 4 (9%)
Liver (50) (50) (50)
Angiectasis 4 (8%) 4 (8%)
Basophilic Focus 37 (74%) 31 (62%) 20 (40%)
Clear Cell Focus 15 (30%) 11 (22%) 5 (10%)
Congestion 2 (4%) 1 (2%)
Degeneration, Cystic 2 (4%) 1 (2%)
Developmental Malformation 7 (14%) 6 (12%) 6 (12%)
Eosinophilic Focus 1 (2%)
Focal Cellular Change 4 (8%) 4 (8%)
Granuloma 23 (46%) 12 (24%) 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Bile Duct, Cyst Multilocular 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 47 (94%) 45 (90%) 37 (74%)
Centrilobular, Atrophy 2 (4%) 1 (2%) 4 (8%)
Centrilobular, Necrosis 4 (8%) 3 (6%)
Hepatocyte, Hyperplasia, Nodular 3 (6%) 3 (6%) 5 (10%)
Hepatocyte, Vacuolization Cytoplasmic 15 (30%) 14 (28%) 2 (4%)
Kupffer Cell, Hyperplasia 4 (8%) 1 (2%)
Kupffer Cell, Pigmentation 2 (4%)
Lobules, Necrosis 1 (2%) 3 (6%) 2 (4%)
Mesentery (16) (22) (19)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Accessory Spleen 1 (5%)
Artery, Hypertrophy 2 (13%) 3 (16%)
Artery, Inflammation, Chronic Active 3 (19%) 1 (5%) 6 (32%)
Artery, Mineralization 1 (5%)
Fat, Inflammation, Granulomatous 3 (19%) 10 (45%) 3 (16%)
Fat, Mineralization 8 (50%) 13 (59%) 9 (47%)
Fat, Necrosis 12 (75%) 15 (68%) 12 (63%)
Fat, Pigmentation 1 (5%)
Pancreas (49) (49) (48)
Atrophy 10 (20%) 9 (18%) 5 (10%)
Basophilic Focus 2 (4%)
Hyperplasia, Nodular 6 (12%) 6 (12%) 12 (25%)
Inflammation, Chronic 4 (8%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Salivary Glands (50) (50) (49)
Atrophy 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Stomach, Forestomach (50) (50) (50)
Edema 1 (2%) 3 (6%)
Erosion 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%) 1 (2%)
Perforation 1 (2%)
Ulcer 3 (6%) 1 (2%)
Mucosa, Dysplasia 1 (2%)
Mucosa, Hyperplasia 2 (4%) 3 (6%) 3 (6%)
Stomach, Glandular (50) (50) (50)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 6 (12%) 3 (6%)
Ulcer 2 (4%) 2 (4%)
Mucosa, Dysplasia 1 (2%)
Tongue (1)
Hyperkeratosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Aorta, Fibrosis 1 (100%)
Aorta, Hemorrhage 1 (100%)
Aorta, Inflammation, Chronic 1 (100%)
Aorta, Mineralization 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Heart (50) (50) (50)
Cardiomyopathy 37 (74%) 42 (84%) 40 (80%)
Thrombosis 2 (4%) 4 (8%) 1 (2%)
Epicardium, Fibrosis 1 (2%)
Epicardium, Inflammation, Chronic 1 (2%) 1 (2%)
Myocardium, Inflammation, Chronic 2 (4%) 5 (10%)
Myocardium, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 4 (8%) 10 (20%) 8 (16%)
Angiectasis 5 (10%) 6 (12%) 1 (2%)
Basophilic Focus 2 (4%)
Clear Cell Focus 7 (14%) 6 (12%) 7 (14%)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 4 (8%)
Hyperplasia 2 (4%) 9 (18%) 3 (6%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic, Diffuse 6 (12%) 4 (8%)
Adrenal Gland, Medulla (49) (50) (49)
Hyperplasia 2 (4%) 6 (12%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Islets, Pancreatic (49) (48) (48)
Hyperplasia 3 (6%)
Parathyroid Gland (48) (46) (46)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (49)
Pars Distalis, Angiectasis 4 (8%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 6 (12%) 2 (4%)
Pars Distalis, Hyperplasia 4 (8%) 10 (20%) 8 (16%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49)
Concretion 1 (2%)
Mineralization 1 (2%)
Pigmentation 18 (36%) 19 (38%) 10 (20%)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 7 (14%) 15 (30%) 4 (8%)
Follicle, Cyst 2 (4%) 2 (4%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage 1 (100%)
Infiltration Cellular, Mononuclear Cell 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (49)
Fibrosis 1 (2%)
Pigmentation 1 (2%)
Preputial Gland (50) (50) (50)
Ectasia 1 (2%) 4 (8%) 5 (10%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 35 (70%) 25 (50%) 25 (50%)
Inflammation, Suppurative 4 (8%) 9 (18%) 6 (12%)
Metaplasia, Squamous 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Prostate (50) (50) (50)
Corpora Amylacea 2 (4%) 6 (12%) 1 (2%)
Ectasia 1 (2%)
Fibrosis 4 (8%) 4 (8%)
Inflammation, Chronic 10 (20%) 21 (42%) 5 (10%)
Inflammation, Suppurative 20 (40%) 27 (54%) 6 (12%)
Testes (50) (50) (49)
Mineralization 24 (48%) 23 (46%) 11 (22%)
Spermatocele 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 2 (4%)
Seminiferous Tubule, Atrophy 2 (4%) 7 (14%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Anemia 1 (100%)
Leukocytosis 1 (100%)
Bone Marrow (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Depletion Cellular 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Myelofibrosis 1 (2%)
Proliferation 9 (18%) 3 (6%)
Lymph Node (50) (50) (50)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Erythrophagocytosis 2 (4%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Hyperplasia, Reticulum Cell 1 (2%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Pigmentation 3 (6%)
Lymph Node, Mandibular (49) (48) (46)
Depletion Cellular 1 (2%)
Erythrophagocytosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 3 (6%) 2 (4%) 5 (11%)
Hyperplasia, Reticulum Cell 1 (2%)
Lymphatic, Dilatation 5 (10%) 1 (2%) 3 (7%)
Lymph Node, Mesenteric (50) (49) (48)
Depletion Cellular 1 (2%)
Erythrophagocytosis 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 3 (6%)
Infiltration Cellular, Mast Cell 2 (4%) 1 (2%)
Pigmentation 38 (76%) 33 (67%) 26 (54%)
Spleen (50) (50) (50)
Congestion 1 (2%)
Fibrosis 2 (4%) 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 6 (12%) 11 (22%) 6 (12%)
Hyperplasia, Re Cell 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 5 (10%) 2 (4%)
Lymphoid Follicle, Atrophy 2 (4%) 2 (4%)
Red Pulp, Atrophy 3 (6%) 4 (8%)
Thymus (47) (30) (49)
Cyst 2 (4%)
Hemorrhage 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%) 2 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (47) (44)
Hyperplasia, Cystic 16 (34%) 16 (34%) 7 (16%)
Hyperplasia, Lobular 2 (4%) 5 (11%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Skin (50) (49) (50)
Acanthosis 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 6 (12%) 2 (4%)
Cyst Multilocular 1 (2%)
Fibrosis 2 (4%)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
Mineralization 2 (4%)
Ulcer 2 (4%)
Hair Follicle, Atrophy 1 (2%)
Sebaceous Gland, Ectasia 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Fibrosis 2 (4%)
Subcutaneous Tissue, Granuloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Hyperostosis 1 (2%)
Skeletal Muscle (1) (4) (3)
Edema 1 (25%)
Hemorrhage 1 (33%)
Inflammation, Chronic 1 (33%)
Inflammation, Chronic Active 1 (25%)
Mineralization 1 (33%)
Necrosis 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 2 (4%) 2 (4%) 1 (2%)
Corpora Amylacea 1 (2%)
Developmental Malformation 1 (2%)
Hemorrhage 2 (4%) 2 (4%)
Hydrocephalus 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Peripheral Nerve (49) (49) (46)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Axon, Hypertrophy 2 (4%)
Spinal Cord (50) (50) (50)
Gray Matter, Cytoplasmic Alteration 1 (2%)
Gray Matter, Degeneration 1 (2%) 1 (2%) 1 (2%)
Gray Matter, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenomatosis 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%) 4 (8%) 8 (16%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 18 (36%) 14 (28%) 9 (18%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Leukocytosis 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 4 (8%)
Alveolus, Edema 1 (2%) 1 (2%) 3 (6%)
Artery, Mediastinum, Hypertrophy 1 (2%) 1 (2%)
Artery, Mediastinum, Inflammation, Chronic
Active 1 (2%) 1 (2%)
Lymphatic, Dilatation 1 (2%)
Mediastinum, Edema 1 (2%)
Nose (50) (50) (50)
Exudate 14 (28%) 9 (18%) 8 (16%)
Foreign Body 1 (2%) 3 (6%) 3 (6%)
Fungus 10 (20%) 4 (8%) 2 (4%)
Inflammation, Chronic 7 (14%) 3 (6%) 4 (8%)
Mucosa, Hyperplasia 3 (6%) 2 (4%) 2 (4%)
Mucosa, Metaplasia, Squamous 5 (10%) 5 (10%) 2 (4%)
Trachea (50) (50) (50)
Inflammation, Chronic 2 (4%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (45)
Cataract 9 (18%) 3 (6%) 10 (22%)
Hemorrhage 1 (2%)
Cornea, Inflammation, Chronic 1 (2%)
Cornea, Mineralization 1 (2%)
Retina, Atrophy 31 (62%) 28 (56%) 35 (78%)
Sclera, Mineralization 25 (50%) 26 (52%) 20 (44%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%)
Fibrosis 1 (2%)
Glomerulosclerosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 1 (2%) 1 (2%)
Infarct 3 (6%)
Inflammation, Chronic 29 (58%) 30 (60%) 32 (64%)
Inflammation, Suppurative 9 (18%) 13 (26%) 13 (26%)
Mineralization 8 (16%) 15 (30%) 10 (20%)
Nephropathy 50 (100%) 49 (98%) 44 (88%)
Capsule, Fibrosis 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Necrosis 2 (4%)
Renal Tubule, Pigmentation 2 (4%) 3 (6%)
Transitional Epithelium, Hyperplasia 1 (2%) 5 (10%)
Venule, Infiltration Cellular, Histiocyte 1 (2%)
Venule, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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