TDMS Study 05006-05 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BENZALDEHYDE
NTP Experiment-Test: 05006-05 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 08:49:08
Facility: Southern Research Institute
Chemical CAS #: 000100527
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 13 16 12
Dead 4 1 9
Survivors
Terminal Sacrifice 33 33 29
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (1) (50)
Intestine Large, Colon (49) (1) (50)
Intestine Small, Duodenum (49) (1) (46)
Intestine Small, Ileum (48) (1) (44)
Intestine Small, Jejunum (48) (2) (47)
Schwannoma Malignant 1 (50%)
Liver (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Neoplastic Nodule 5 (10%) 1 (2%)
Schwannoma Malignant 1 (2%)
Mesentery (9) (5) (6)
Sarcoma, Metastatic, Vagina 1 (11%)
Pancreas (48) (2) (50)
Adenoma 1 (2%)
Fibrous Histiocytoma 1 (50%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50)
Stomach, Forestomach (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 2 (4%) 2 (4%)
Adrenal Gland, Medulla (49) (49) (47)
Pheochromocytoma Malignant 2 (4%) 2 (4%)
Pheochromocytoma Benign 5 (10%) 2 (4%) 3 (6%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (48) (2) (50)
Adenoma 1 (2%) 2 (100%)
Pituitary Gland (49) (49) (49)
Adenoma 23 (47%) 31 (63%) 15 (31%)
Carcinoma 3 (6%) 2 (4%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (4) (50)
C-Cell, Adenoma 2 (4%) 1 (25%) 3 (6%)
C-Cell, Carcinoma 1 (25%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (50%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (50) (48)
Adenoma 1 (2%) 3 (6%) 1 (2%)
Basosquamous Tumor Malignant 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Ovary (49) (3) (50)
Uterus (49) (12) (50)
Adenoma 1 (2%)
Polyp Stromal 12 (24%) 8 (67%) 14 (28%)
Sarcoma Stromal 1 (2%)
Vagina (7) (4) (2)
Sarcoma 1 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (1) (2)
Bone Marrow (50) (5) (50)
Fibrous Histiocytoma 1 (20%)
Lymph Node (50) (1) (50)
Mediastinal, Fibrous Histiocytoma 1 (100%)
Page 3
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mandibular (46) (47)
Lymph Node, Mesenteric (48) (1) (50)
Fibrous Histiocytoma 1 (100%)
Spleen (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (47) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%) 2 (4%)
Fibroadenoma 28 (56%) 28 (56%) 22 (44%)
Skin (50) (29) (50)
Papilloma 2 (4%)
Subcutaneous Tissue, Fibroma 3 (10%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Meningioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (50) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrous Histiocytoma 1 (2%)
Nose (50) (50)
Trachea (50) (50)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (49)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (49) (49)
Sarcoma, Metastatic, Vagina 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 15 (30%) 20 (40%) 18 (36%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 48 43
Total Primary Neoplasms 111 119 97
Total Animals with Benign Neoplasms 42 46 37
Total Benign Neoplasms 81 83 69
Total Animals with Malignant Neoplasms 25 27 24
Total Malignant Neoplasms 30 36 28
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 3 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 10 12 17
Dead 3 9 12
Survivors
Terminal Sacrifice 37 29 21
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (47) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Intestine Large, Cecum (49) (48) (47)
Fibrosarcoma 1 (2%)
Intestine Small, Jejunum (49) (50) (48)
Schwannoma Malignant 1 (2%)
Liver (50) (50) (50)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 2 (4%) 1 (2%)
Mesentery (16) (22) (19)
Carcinoma, Metastatic, Uncertain Primary Site 1 (5%)
Liposarcoma 1 (6%)
Pancreas (49) (49) (48)
Adenoma 3 (6%) 2 (4%) 7 (15%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50)
Stomach, Glandular (50) (50) (50)
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Squamous Cell Carcinoma, Metastatic,
Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (49) (50) (49)
Pheochromocytoma Malignant 2 (4%) 5 (10%) 5 (10%)
Pheochromocytoma Benign 14 (29%) 16 (32%) 13 (27%)
Bilateral, Pheochromocytoma Benign 3 (6%) 3 (6%) 1 (2%)
Islets, Pancreatic (49) (48) (48)
Adenoma 4 (8%) 8 (17%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (49)
Adenoma 15 (31%) 22 (44%) 11 (22%)
Carcinoma 3 (6%) 3 (6%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Thyroid Gland (50) (50) (49)
C-Cell, Adenoma 4 (8%) 8 (16%) 7 (14%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (50) (50)
Adenoma 1 (2%) 3 (6%) 3 (6%)
Carcinoma 1 (2%) 4 (8%) 4 (8%)
Prostate (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Seminal Vesicle (2) (2)
Carcinoma, Metastatic, Uncertain Primary Site 1 (50%)
Testes (50) (50) (49)
Bilateral, Interstitial Cell, Adenoma 40 (80%) 38 (76%) 24 (49%)
Interstitial Cell, Adenoma 6 (12%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Bone Marrow (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (49) (48) (46)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (49) (48)
Spleen (50) (50) (50)
Hemangiosarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Thymus (47) (30) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (47) (44)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Fibroadenoma 3 (6%) 2 (4%) 1 (2%)
Skin (50) (49) (50)
Basal Cell Carcinoma 2 (4%)
Keratoacanthoma 1 (2%) 4 (8%)
Papilloma 1 (2%) 3 (6%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 3 (6%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Myxosarcoma 2 (4%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (4) (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Carcinoma, Metastatic, Thyroid Gland 1 (25%)
Hemangiosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Granular Cell Tumor Benign 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Zymbal's Gland 1 (2%)
Nose (50) (50) (50)
Trachea (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Squamous Cell Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (49) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 10 (20%) 17 (34%) 16 (32%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Malignant 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05006-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZALDEHYDE Date: 09/03/94
Route: GAVAGE Time: 08:49:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 200. 400.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 42
Total Primary Neoplasms 133 170 133
Total Animals with Benign Neoplasms 48 49 38
Total Benign Neoplasms 104 121 90
Total Animals with Malignant Neoplasms 24 34 33
Total Malignant Neoplasms 29 49 43
Total Animals with Metastatic Neoplasms 3 4 4
Total Metastatic Neoplasm 5 12 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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