TDMS Study 05006-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 05 TIME: 09:00:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 000100527
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 05 TIME: 09:00:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 000100527
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZALDEHYDE DATE: 09/03/94
EXPERIMENT: 05006 TEST: 05 TIME: 09:00:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56133
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 000100527
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BENZALDEHYDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma or Adenoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Keratoacanthoma
Papilloma
Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,
Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Mesothelioma Benign, Malignant, NOS
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Carcinoma or Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Carcinoma
Carcinoma or Adenoma
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 2.2% 3.4% 2.9% | 0.0% 4.2% 6.4% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | 593 729 (T) 573 | --- 542 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.532 P=0.736 P=0.685 | P=0.148 P=0.252 P=0.208 |
|INCIDENTAL TUMOR | P=0.626N P=0.687 P=0.702N | P=0.170 P=0.240 P=0.199 |
|LOGISTIC REGRESSION | P=0.584N P=0.754N P=0.699N | P=0.206 P=0.132 P=0.207 |
|COCHRAN-ARMITAGE | P=0.640 | P=0.176 |
|FISHER EXACT | P=0.753N P=0.753N | P=0.247 P=0.247 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/49 (35%) 19/50 (38%) 14/49 (29%) | 5/49 (10%) 3/49 (6%) 3/47 (6%) |
|ADJUSTED (b) | 44.5% 50.4% 50.3% | 13.5% 9.1% 10.7% |
|TERMINAL (d) | 15/36 (42%) 11/29 (38%) 8/21 (38%) | 2/33 (6%) 3/33 (9%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | 696 564 558 | 695 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164 P=0.193 P=0.208 | P=0.366N P=0.369N P=0.455N |
|INCIDENTAL TUMOR | P=0.481 P=0.570N P=0.504 | P=0.396N P=0.332N P=0.515N |
|LOGISTIC REGRESSION | P=0.403 P=0.433 P=0.439 | P=0.382N P=0.348N P=0.474N |
|COCHRAN-ARMITAGE | P=0.297N | P=0.302N |
|FISHER EXACT | P=0.447 P=0.332N | P=0.357N P=0.381N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 5/50 (10%) 5/49 (10%) | 2/49 (4%) 0/49 (0%) 2/47 (4%) |
|ADJUSTED (b) | 5.6% 16.3% 18.2% | 5.0% 0.0% 6.3% |
|TERMINAL (d) | 2/36 (6%) 4/29 (14%) 2/21 (10%) | 1/33 (3%) 0/33 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 714 499 | 364 --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.051 P=0.142 P=0.080 | P=0.575 P=0.240N P=0.637 |
|INCIDENTAL TUMOR | P=0.121 P=0.202 P=0.219 | P=0.508N P=0.500N P=0.644N |
|LOGISTIC REGRESSION | P=0.097 P=0.177 P=0.149 | P=0.555N P=0.338N P=0.667N |
|COCHRAN-ARMITAGE | P=0.178 | P=0.609 |
|FISHER EXACT | P=0.226 P=0.218 | P=0.247N P=0.676 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/49 (39%) 23/50 (46%) 19/49 (39%) | 7/49 (14%) 3/49 (6%) 5/47 (11%) |
|ADJUSTED (b) | 49.8% 61.5% 62.1% | 18.0% 9.1% 16.7% |
|TERMINAL (d) | 17/36 (47%) 15/29 (52%) 10/21 (48%) | 3/33 (9%) 3/33 (9%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 696 564 499 | 364 730 (T) 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031 * P=0.085 P=0.046 * | P=0.409N P=0.171N P=0.499N |
|INCIDENTAL TUMOR | P=0.195 P=0.376 P=0.260 | P=0.347N P=0.223N P=0.472N |
|LOGISTIC REGRESSION | P=0.140 P=0.277 P=0.172 | P=0.386N P=0.164N P=0.468N |
|COCHRAN-ARMITAGE | P=0.541N | P=0.333N |
|FISHER EXACT | P=0.300 P=0.582N | P=0.159N P=0.410N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 3/50 (6%) | 1/45 (2%) 3/50 (6%) 1/48 (2%) |
|ADJUSTED (b) | 2.2% 9.6% 12.4% | 3.6% 9.1% 3.7% |
|TERMINAL (d) | 0/37 (0%) 2/29 (7%) 2/21 (10%) | 1/28 (4%) 3/33 (9%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 588 714 593 | 730 (T) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104 P=0.252 P=0.163 | P=0.602 P=0.365 P=0.754 |
|INCIDENTAL TUMOR | P=0.185 P=0.324 P=0.253 | P=0.602 P=0.365 P=0.754 |
|LOGISTIC REGRESSION | P=0.185 P=0.307 P=0.282 | P=0.602 P=0.365 P=0.754 |
|COCHRAN-ARMITAGE | P=0.239 | P=0.588N |
|FISHER EXACT | P=0.309 P=0.309 | P=0.349 P=0.736N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 4/50 (8%) | 1/45 (2%) 0/50 (0%) 1/48 (2%) |
|ADJUSTED (b) | 2.0% 10.2% 11.9% | 2.6% 0.0% 3.7% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 1/21 (5%) | 0/28 (0%) 0/33 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 507 495 427 | 698 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.072 P=0.161 P=0.109 | P=0.645 P=0.516N P=0.734 |
|INCIDENTAL TUMOR | P=0.389 P=0.074 P=0.372 | P=0.644 P=0.479N P=0.729 |
|LOGISTIC REGRESSION | P=0.327 P=0.095 P=0.364 | P=0.658 P=0.477N P=0.746 |
|COCHRAN-ARMITAGE | P=0.146 | P=0.658N |
|FISHER EXACT | P=0.181 P=0.181 | P=0.474N P=0.736N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 7/50 (14%) | 2/45 (4%) 3/50 (6%) 2/48 (4%) |
|ADJUSTED (b) | 4.2% 16.6% 23.2% | 6.1% 9.1% 7.4% |
|TERMINAL (d) | 0/37 (0%) 3/29 (10%) 3/21 (14%) | 1/28 (4%) 3/33 (9%) 2/27 (7%) |
|FIRST INCIDENCE (DAYS) | 507 495 427 | 698 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017 * P=0.109 P=0.028 * | P=0.571 P=0.552 P=0.666 |
|INCIDENTAL TUMOR | P=0.141 P=0.047 * P=0.137 | P=0.569 P=0.569 P=0.662 |
|LOGISTIC REGRESSION | P=0.127 P=0.151 P=0.138 | P=0.560 P=0.562 P=0.664 |
|COCHRAN-ARMITAGE | P=0.067 | P=0.567N |
|FISHER EXACT | P=0.134 P=0.080 | P=0.550 P=0.667N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 8/48 (17%) 1/48 (2%) | 1/48 (2%) 2/2 (100%) 0/50 (0%) |
|ADJUSTED (b) | 11.1% 23.5% 4.8% | 2.8% 0.0% 0.0% |
|TERMINAL (d) | 4/36 (11%) 4/29 (14%) 1/21 (5%) | 0/32 (0%) 0/0 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 692 729 (T) | 711 682 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.456N P=0.105 P=0.371N | P=0.409N P=0.496 P=0.536N |
|INCIDENTAL TUMOR | P=0.272N P=0.285 P=0.371N | P=0.415N P=0.070 P=0.527N |
|LOGISTIC REGRESSION | P=0.371N P=0.147 P=0.371N | P=0.403N P<0.001 ** P=0.519N |
|COCHRAN-ARMITAGE | P=0.195N | P=0.370N |
|FISHER EXACT | P=0.168 P=0.187N | P=0.002 ** P=0.490N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 9/48 (19%) 2/48 (4%) | 1/48 (2%) 2/2 (100%) 0/50 (0%) |
|ADJUSTED (b) | 13.9% 26.6% 8.0% | 2.8% 0.0% 0.0% |
|TERMINAL (d) | 5/36 (14%) 5/29 (17%) 1/21 (5%) | 0/32 (0%) 0/0 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 692 680 | 711 682 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520N P=0.108 P=0.460N | P=0.409N P=0.496 P=0.536N |
|INCIDENTAL TUMOR | P=0.313N P=0.276 P=0.379N | P=0.415N P=0.070 P=0.527N |
|LOGISTIC REGRESSION | P=0.417N P=0.155 P=0.387N | P=0.403N P<0.001 ** P=0.519N |
|COCHRAN-ARMITAGE | P=0.219N | P=0.370N |
|FISHER EXACT | P=0.182 P=0.226N | P=0.002 ** P=0.490N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 5/50 (10%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.4% 0.0% 4.8% | 14.6% 0.0% 2.9% |
|TERMINAL (d) | 2/37 (5%) 0/29 (0%) 1/21 (5%) | 4/33 (12%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 715 --- 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.516N P=0.293N P=0.694N | P=0.050N* P=0.035N* P=0.143N |
|INCIDENTAL TUMOR | P=0.516N P=0.293N P=0.694N | P=0.049N* P=0.032N* P=0.147N |
|LOGISTIC REGRESSION | P=0.516N P=0.293N P=0.694N | P=0.048N* P=0.033N* P=0.140N |
|COCHRAN-ARMITAGE | P=0.361N | P=0.037N* |
|FISHER EXACT | P=0.247N P=0.500N | P=0.028N* P=0.102N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 5/50 (10%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.4% 3.4% 4.8% | 14.6% 0.0% 2.9% |
|TERMINAL (d) | 2/37 (5%) 1/29 (3%) 1/21 (5%) | 4/33 (12%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 715 --- 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.585N P=0.694N | P=0.050N* P=0.035N* P=0.143N |
|INCIDENTAL TUMOR | P=0.560N P=0.585N P=0.694N | P=0.049N* P=0.032N* P=0.147N |
|LOGISTIC REGRESSION | P=0.560N P=0.585N P=0.694N | P=0.048N* P=0.033N* P=0.140N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.037N* |
|FISHER EXACT | P=0.500N P=0.500N | P=0.028N* P=0.102N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 5/50 (10%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.4% 3.4% 4.8% | 14.6% 0.0% 2.9% |
|TERMINAL (d) | 2/37 (5%) 1/29 (3%) 1/21 (5%) | 4/33 (12%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 715 --- 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.585N P=0.694N | P=0.050N* P=0.035N* P=0.143N |
|INCIDENTAL TUMOR | P=0.560N P=0.585N P=0.694N | P=0.049N* P=0.032N* P=0.147N |
|LOGISTIC REGRESSION | P=0.560N P=0.585N P=0.694N | P=0.048N* P=0.033N* P=0.140N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.037N* |
|FISHER EXACT | P=0.500N P=0.500N | P=0.028N* P=0.102N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.9% 3.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/29 (3%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 593 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.226N P=0.554N P=0.343N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.191N P=0.602N P=0.265N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.150N P=0.496N P=0.234N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.9% 6.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 2/29 (7%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 593 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.629 P=0.343N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.256N P=0.588 P=0.265N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.208N P=0.695N P=0.234N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.176N | (e) |
|FISHER EXACT | P=0.691N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% | 2.9% 4.6% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- 676 --- | 715 620 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.691 P=0.500 (e) | P=0.408N P=0.499 P=0.538N |
|INCIDENTAL TUMOR | P=0.706N P=0.761 (e) | P=0.378N P=0.525 P=0.550N |
|LOGISTIC REGRESSION | P=0.733 P=0.505 (e) | P=0.350N P=0.481 P=0.530N |
|COCHRAN-ARMITAGE | P=0.730N | P=0.360N |
|FISHER EXACT | P=0.500 (e) | P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 0.0% 0.0% | 3.0% 0.0% 6.9% |
|TERMINAL (d) | 1/37 (3%) 0/29 (0%) 0/21 (0%) | 1/33 (3%) 0/33 (0%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.346N P=0.549N P=0.613N | P=0.325 P=0.500N P=0.455 |
|INCIDENTAL TUMOR | P=0.346N P=0.549N P=0.613N | P=0.325 P=0.500N P=0.455 |
|LOGISTIC REGRESSION | P=0.346N P=0.549N P=0.613N | P=0.325 P=0.500N P=0.455 |
|COCHRAN-ARMITAGE | P=0.270N | P=0.360 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 2.4% 0.0% | 5.8% 4.6% 6.9% |
|TERMINAL (d) | 1/37 (3%) 0/29 (0%) 0/21 (0%) | 1/33 (3%) 0/33 (0%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 676 --- | 715 620 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.426N P=0.734 P=0.613N | P=0.540 P=0.691 P=0.641 |
|INCIDENTAL TUMOR | P=0.326N P=0.664N P=0.613N | P=0.561 P=0.675N P=0.635 |
|LOGISTIC REGRESSION | P=0.377N P=0.762 P=0.613N | P=0.564 P=0.689 P=0.635 |
|COCHRAN-ARMITAGE | P=0.332N | P=0.601 |
|FISHER EXACT | P=0.753N P=0.500N | P=0.691N P=0.691N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/50 (2%) | 28/50 (56%) 28/50 (56%) 22/50 (44%) |
|ADJUSTED (b) | 7.9% 5.6% 4.8% | 71.4% 64.5% 62.1% |
|TERMINAL (d) | 2/37 (5%) 1/29 (3%) 1/21 (5%) | 22/33 (67%) 18/33 (55%) 16/29 (55%) |
|FIRST INCIDENCE (DAYS) | 726 632 729 (T) | 520 495 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.578N P=0.524N | P=0.356N P=0.568N P=0.378N |
|INCIDENTAL TUMOR | P=0.296N P=0.497N P=0.394N | P=0.294N P=0.538N P=0.320N |
|LOGISTIC REGRESSION | P=0.316N P=0.503N P=0.509N | P=0.304N P=0.552N P=0.353N |
|COCHRAN-ARMITAGE | P=0.222N | P=0.135N |
|FISHER EXACT | P=0.500N P=0.309N | P=0.580N P=0.159N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 1/50 (2%) | 29/50 (58%) 30/50 (60%) 22/50 (44%) |
|ADJUSTED (b) | 7.9% 7.9% 4.8% | 72.2% 66.1% 62.1% |
|TERMINAL (d) | 2/37 (5%) 1/29 (3%) 1/21 (5%) | 22/33 (67%) 18/33 (55%) 16/29 (55%) |
|FIRST INCIDENCE (DAYS) | 726 632 729 (T) | 520 495 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.431N P=0.592 P=0.524N | P=0.307N P=0.501 P=0.316N |
|INCIDENTAL TUMOR | P=0.280N P=0.571N P=0.394N | P=0.231N P=0.551 P=0.258N |
|LOGISTIC REGRESSION | P=0.331N P=0.661 P=0.509N | P=0.235N P=0.528 P=0.282N |
|COCHRAN-ARMITAGE | P=0.238N | P=0.096N |
|FISHER EXACT | P=0.661N P=0.309N | P=0.500 P=0.115N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 1/50 (2%) | 29/50 (58%) 30/50 (60%) 22/50 (44%) |
|ADJUSTED (b) | 10.5% 7.9% 4.8% | 72.2% 66.1% 62.1% |
|TERMINAL (d) | 3/37 (8%) 1/29 (3%) 1/21 (5%) | 22/33 (67%) 18/33 (55%) 16/29 (55%) |
|FIRST INCIDENCE (DAYS) | 726 632 729 (T) | 520 495 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297N P=0.585N P=0.386N | P=0.307N P=0.501 P=0.316N |
|INCIDENTAL TUMOR | P=0.177N P=0.423N P=0.279N | P=0.231N P=0.551 P=0.258N |
|LOGISTIC REGRESSION | P=0.208N P=0.503N P=0.373N | P=0.235N P=0.528 P=0.282N |
|COCHRAN-ARMITAGE | P=0.133N | P=0.096N |
|FISHER EXACT | P=0.500N P=0.181N | P=0.500 P=0.115N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/49 (4%) 7/48 (15%) | 0/48 (0%) 0/2 (0%) 1/50 (2%) |
|ADJUSTED (b) | 8.3% 6.2% 31.2% | 0.0% 0.0% 3.4% |
|TERMINAL (d) | 3/36 (8%) 1/29 (3%) 6/21 (29%) | 0/32 (0%) 0/0 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 711 697 | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.590N P=0.026 * | P=0.291 (e) P=0.480 |
|INCIDENTAL TUMOR | P=0.026 * P=0.476N P=0.038 * | P=0.291 (e) P=0.480 |
|LOGISTIC REGRESSION | P=0.024 * P=0.532N P=0.038 * | P=0.291 (e) P=0.480 |
|COCHRAN-ARMITAGE | P=0.093 | P=0.313 |
|FISHER EXACT | P=0.500N P=0.150 | (e) P=0.510 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 22/50 (44%) 11/49 (22%) | 23/49 (47%) 31/49 (63%) 15/49 (31%) |
|ADJUSTED (b) | 35.7% 57.0% 40.1% | 59.4% 71.4% 46.7% |
|TERMINAL (d) | 10/36 (28%) 13/29 (45%) 6/21 (29%) | 17/32 (53%) 20/32 (63%) 12/29 (41%) |
|FIRST INCIDENCE (DAYS) | 585 561 506 | 463 495 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.259 P=0.045 * P=0.399 | P=0.180N P=0.115 P=0.164N |
|INCIDENTAL TUMOR | P=0.350N P=0.175 P=0.327N | P=0.132N P=0.095 P=0.131N |
|LOGISTIC REGRESSION | P=0.473N P=0.117 P=0.450N | P=0.132N P=0.081 P=0.146N |
|COCHRAN-ARMITAGE | P=0.225N | P=0.064N |
|FISHER EXACT | P=0.121 P=0.246N | P=0.077 P=0.073N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 0/50 (0%) 3/49 (6%) | 3/49 (6%) 2/49 (4%) 1/49 (2%) |
|ADJUSTED (b) | 7.8% 0.0% 11.5% | 8.5% 5.7% 2.4% |
|TERMINAL (d) | 2/36 (6%) 0/29 (0%) 1/21 (5%) | 2/32 (6%) 1/32 (3%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 610 --- 680 | 674 697 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.426 P=0.143N P=0.446 | P=0.266N P=0.507N P=0.355N |
|INCIDENTAL TUMOR | P=0.582 P=0.176N P=0.665N | P=0.248N P=0.481N P=0.327N |
|LOGISTIC REGRESSION | P=0.534 P=0.116N P=0.505N | P=0.229N P=0.495N P=0.308N |
|COCHRAN-ARMITAGE | P=0.601 | P=0.222N |
|FISHER EXACT | P=0.117N P=0.661N | P=0.500N P=0.309N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/49 (37%) 22/50 (44%) 14/49 (29%) | 26/49 (53%) 33/49 (67%) 16/49 (33%) |
|ADJUSTED (b) | 42.0% 57.0% 48.0% | 65.7% 74.5% 48.0% |
|TERMINAL (d) | 12/36 (33%) 13/29 (45%) 7/21 (33%) | 19/32 (59%) 21/32 (66%) 12/29 (41%) |
|FIRST INCIDENCE (DAYS) | 585 561 506 | 463 495 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217 P=0.128 P=0.308 | P=0.114N P=0.155 P=0.101N |
|INCIDENTAL TUMOR | P=0.363N P=0.358 P=0.332N | P=0.067N P=0.135 P=0.067N |
|LOGISTIC REGRESSION | P=0.504N P=0.292 P=0.509N | P=0.065N P=0.115 P=0.074N |
|COCHRAN-ARMITAGE | P=0.231N | P=0.027N* |
|FISHER EXACT | P=0.298 P=0.259N | P=0.108 P=0.033N* |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 2/29 (7%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.548 P=0.186 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.548 P=0.186 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.548 P=0.186 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.668N | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 0.0% 17.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 0/29 (0%) 3/21 (14%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 593 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * P=0.549N P=0.061 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.040 * P=0.549N P=0.081 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.047 * P=0.549N P=0.104 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.082 | (e) |
|FISHER EXACT | P=0.500N P=0.181 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.5% 11.1% | 0.0% 0.0% 6.1% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 1/21 (5%) | 0/33 (0%) 0/33 (0%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | --- 682 427 | --- --- 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * P=0.495 P=0.059 | P=0.082 (e) P=0.212 |
|INCIDENTAL TUMOR | P=0.095 P=0.761 P=0.184 | P=0.103 (e) P=0.249 |
|LOGISTIC REGRESSION | P=0.067 P=0.503 P=0.127 | P=0.089 (e) P=0.222 |
|COCHRAN-ARMITAGE | P=0.060 | P=0.095 |
|FISHER EXACT | P=0.500 P=0.121 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 7/50 (14%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.7% 9.2% 26.8% | 0.0% 0.0% 6.1% |
|TERMINAL (d) | 1/37 (3%) 2/29 (7%) 4/21 (19%) | 0/33 (0%) 0/33 (0%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 682 427 | --- --- 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.242 P=0.005 ** | P=0.082 (e) P=0.212 |
|INCIDENTAL TUMOR | P=0.010 ** P=0.338 P=0.020 * | P=0.103 (e) P=0.249 |
|LOGISTIC REGRESSION | P=0.009 ** P=0.299 P=0.018 * | P=0.089 (e) P=0.222 |
|COCHRAN-ARMITAGE | P=0.017 * | P=0.095 |
|FISHER EXACT | P=0.309 P=0.030 * | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 3/50 (6%) | 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 13.2% 9.2% 12.9% | 0.0% 8.7% 0.0% |
|TERMINAL (d) | 4/37 (11%) 2/29 (7%) 2/21 (10%) | 0/33 (0%) 2/33 (6%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 726 676 697 | --- 702 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562N P=0.477N P=0.628 | P=0.602 P=0.121 (e) |
|INCIDENTAL TUMOR | P=0.423N P=0.290N P=0.498N | P=0.598 P=0.129 (e) |
|LOGISTIC REGRESSION | P=0.476N P=0.375N P=0.602N | P=0.600 P=0.120 (e) |
|COCHRAN-ARMITAGE | P=0.283N | P=0.639N |
|FISHER EXACT | P=0.357N P=0.357N | P=0.121 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.7% 3.4% 7.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 585 729 (T) 680 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451 P=0.558N P=0.535 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.532N P=0.437N P=0.468N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.574 P=0.494N P=0.666 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.610 | (e) |
|FISHER EXACT | P=0.500N P=0.691N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Myxosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.5% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- 235 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.624 P=0.234 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.278N P=0.761 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.360N P=0.359 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.668N | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 4/50 (8%) | 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 15.0% 14.7% 15.9% | 0.0% 8.7% 0.0% |
|TERMINAL (d) | 4/37 (11%) 3/29 (10%) 2/21 (10%) | 0/33 (0%) 2/33 (6%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 585 676 680 | --- 702 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510 P=0.621N P=0.569 | P=0.602 P=0.121 (e) |
|INCIDENTAL TUMOR | P=0.401N P=0.409N P=0.432N | P=0.598 P=0.129 (e) |
|LOGISTIC REGRESSION | P=0.475N P=0.504N P=0.561N | P=0.600 P=0.120 (e) |
|COCHRAN-ARMITAGE | P=0.309N | P=0.639N |
|FISHER EXACT | P=0.500N P=0.370N | P=0.121 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.7% 5.9% 7.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 585 682 680 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 P=0.644 P=0.535 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.496N P=0.536N P=0.468N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.561 P=0.690N P=0.666 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.601 | (e) |
|FISHER EXACT | P=0.691N P=0.691N | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 6.9% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.081 (e) P=0.210 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.081 (e) P=0.210 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.081 (e) P=0.210 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 47/50 (94%) 31/49 (63%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | |
|TERMINAL (d) | 37/37 (100%) 29/29 (100%) 21/21 (100%) | |
|FIRST INCIDENCE (DAYS) | 507 495 558 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 P=0.045 * P=0.187 | |
|INCIDENTAL TUMOR | P=0.068N P=0.304 P=0.132N | |
|LOGISTIC REGRESSION | P=0.109N P=0.480 P=0.198N | |
|COCHRAN-ARMITAGE | P<0.001N** | |
|FISHER EXACT | P=0.500 P<0.001N** | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 8/50 (16%) 7/49 (14%) | 2/50 (4%) 1/4 (25%) 3/50 (6%) |
|ADJUSTED (b) | 10.8% 23.1% 29.0% | 6.1% 33.3% 9.4% |
|TERMINAL (d) | 4/37 (11%) 4/29 (14%) 5/21 (24%) | 2/33 (6%) 1/3 (33%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 692 605 | 730 (T) 730 (T) 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041 * P=0.103 P=0.055 | P=0.354 P=0.295 P=0.442 |
|INCIDENTAL TUMOR | P=0.094 P=0.293 P=0.088 | P=0.383 P=0.295 P=0.473 |
|LOGISTIC REGRESSION | P=0.071 P=0.160 P=0.097 | P=0.347 P=0.295 P=0.438 |
|COCHRAN-ARMITAGE | P=0.214 | P=0.415 |
|FISHER EXACT | P=0.178 P=0.251 | P=0.210 P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/49 (2%) | 0/50 (0%) 1/4 (25%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 6.5% 2.6% | 0.0% 33.3% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 0/21 (0%) | 0/33 (0%) 1/3 (33%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 726 719 506 | --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.462 P=0.419 P=0.668 | P=0.674 P=0.066 (e) |
|INCIDENTAL TUMOR | P=0.480N P=0.740N P=0.552N | P=0.674 P=0.066 (e) |
|LOGISTIC REGRESSION | P=0.616 P=0.477 P=0.742N | P=0.674 P=0.066 (e) |
|COCHRAN-ARMITAGE | P=0.616 | P=0.696N |
|FISHER EXACT | P=0.500 P=0.747 | P=0.074 (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 10/50 (20%) 8/49 (16%) | 2/50 (4%) 2/4 (50%) 3/50 (6%) |
|ADJUSTED (b) | 13.2% 28.5% 30.8% | 6.1% 66.7% 9.4% |
|TERMINAL (d) | 4/37 (11%) 5/29 (17%) 5/21 (24%) | 2/33 (6%) 2/3 (67%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 726 692 506 | 730 (T) 730 (T) 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039 * P=0.067 P=0.057 | P=0.354 P=0.014 * P=0.442 |
|INCIDENTAL TUMOR | P=0.147 P=0.310 P=0.159 | P=0.381 P=0.014 * P=0.473 |
|LOGISTIC REGRESSION | P=0.087 P=0.112 P=0.127 | P=0.344 P=0.014 * P=0.438 |
|COCHRAN-ARMITAGE | P=0.230 | P=0.421 |
|FISHER EXACT | P=0.131 P=0.264 | P=0.024 * P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/49 (2%) | 0/50 (0%) 0/4 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.9% 4.8% | 0.0% 0.0% 3.4% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 1/21 (5%) | 0/33 (0%) 0/3 (0%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | --- 682 729 (T) | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233 P=0.211 P=0.387 | P=0.282 (e) P=0.474 |
|INCIDENTAL TUMOR | P=0.289 P=0.336 P=0.387 | P=0.282 (e) P=0.474 |
|LOGISTIC REGRESSION | P=0.272 P=0.236 P=0.387 | P=0.282 (e) P=0.474 |
|COCHRAN-ARMITAGE | P=0.355 | P=0.304 |
|FISHER EXACT | P=0.247 P=0.495 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/49 (0%) | 0/50 (0%) 2/4 (50%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 34.9% 2.7% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 0/33 (0%) 1/3 (33%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 652 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.332 P=0.055 P=0.475 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.369 P<0.001 ** P=0.545 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.374 P<0.001 ** P=0.523 |
|COCHRAN-ARMITAGE | (e) | P=0.383 |
|FISHER EXACT | (e) (e) | P=0.004 ** P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/49 (2%) | 0/50 (0%) 2/4 (50%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 5.9% 4.8% | 0.0% 34.9% 6.1% |
|TERMINAL (d) | 0/37 (0%) 1/29 (3%) 1/21 (5%) | 0/33 (0%) 1/3 (33%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | --- 682 729 (T) | --- 652 629 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233 P=0.211 P=0.387 | P=0.168 P=0.055 P=0.212 |
|INCIDENTAL TUMOR | P=0.289 P=0.336 P=0.387 | P=0.202 P<0.001 ** P=0.249 |
|LOGISTIC REGRESSION | P=0.272 P=0.236 P=0.387 | P=0.196 P<0.001 ** P=0.222 |
|COCHRAN-ARMITAGE | P=0.355 | P=0.218 |
|FISHER EXACT | P=0.247 P=0.495 | P=0.004 ** P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 12/50 (24%) 8/50 (16%) 14/50 (28%) |
|ADJUSTED (b) | | 29.6% 20.6% 46.4% |
|TERMINAL (d) | | 7/33 (21%) 4/33 (12%) 13/29 (45%) |
|FIRST INCIDENCE (DAYS) | | 364 491 659 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.241 P=0.241N P=0.271 |
|INCIDENTAL TUMOR | | P=0.295 P=0.279N P=0.333 |
|LOGISTIC REGRESSION | | P=0.306 P=0.263N P=0.322 |
|COCHRAN-ARMITAGE | | P=0.360 |
|FISHER EXACT | | P=0.227N P=0.410 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 13/50 (26%) 8/50 (16%) 14/50 (28%) |
|ADJUSTED (b) | | 31.3% 20.6% 46.4% |
|TERMINAL (d) | | 7/33 (21%) 4/33 (12%) 13/29 (45%) |
|FIRST INCIDENCE (DAYS) | | 364 491 659 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.317 P=0.183N P=0.346 |
|INCIDENTAL TUMOR | | P=0.379 P=0.198N P=0.413 |
|LOGISTIC REGRESSION | | P=0.397 P=0.190N P=0.409 |
|COCHRAN-ARMITAGE | | P=0.453 |
|FISHER EXACT | | P=0.163N P=0.500 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 8.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 479 --- 712 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 P=0.504N P=0.363 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.582 P=0.718N P=0.706N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.409 P=0.350N P=0.535 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360 | (e) |
|FISHER EXACT | P=0.500N P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 17/50 (34%) 16/50 (32%) | 15/50 (30%) 20/50 (40%) 18/50 (36%) |
|ADJUSTED (b) | 24.6% 50.6% 56.7% | 37.3% 53.3% 50.9% |
|TERMINAL (d) | 7/37 (19%) 13/29 (45%) 10/21 (48%) | 9/33 (27%) 16/33 (48%) 12/29 (41%) |
|FIRST INCIDENCE (DAYS) | 508 632 373 | 534 613 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** P=0.026 * P=0.006 ** | P=0.163 P=0.217 P=0.194 |
|INCIDENTAL TUMOR | P=0.028 * P=0.072 P=0.058 | P=0.168 P=0.222 P=0.187 |
|LOGISTIC REGRESSION | P=0.023 * P=0.081 P=0.041 * | P=0.163 P=0.211 P=0.205 |
|COCHRAN-ARMITAGE | P=0.112 | P=0.301 |
|FISHER EXACT | P=0.088 P=0.127 | P=0.201 P=0.335 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 7.0% | 5.1% 0.0% 2.8% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 1/33 (3%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 680 | 578 --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.060 (e) P=0.163 | P=0.402N P=0.237N P=0.555N |
|INCIDENTAL TUMOR | P=0.091 (e) P=0.397 | P=0.372N P=0.240N P=0.518N |
|LOGISTIC REGRESSION | P=0.073 (e) P=0.189 | P=0.331N P=0.254N P=0.490N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.361N |
|FISHER EXACT | (e) P=0.247 | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 7.0% | 5.1% 0.0% 2.8% |
|TERMINAL (d) | 0/37 (0%) 0/29 (0%) 0/21 (0%) | 1/33 (3%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 680 | 578 --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.060 (e) P=0.163 | P=0.402N P=0.237N P=0.555N |
|INCIDENTAL TUMOR | P=0.091 (e) P=0.397 | P=0.372N P=0.240N P=0.518N |
|LOGISTIC REGRESSION | P=0.073 (e) P=0.189 | P=0.331N P=0.254N P=0.490N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.361N |
|FISHER EXACT | (e) P=0.247 | P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 15.9% 7.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 4/29 (14%) 1/21 (5%) | 0/33 (0%) 0/33 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | --- 676 558 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104 P=0.020 * P=0.156 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.146 P=0.032 * P=0.206 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.167 P=0.031 * P=0.233 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.239 | (e) |
|FISHER EXACT | P=0.028 * P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 49/50 (98%) 38/50 (76%) | 42/50 (84%) 46/50 (92%) 37/50 (74%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 91.2% 92.0% 97.3% |
|TERMINAL (d) | 37/37 (100%) 29/29 (100%) 21/21 (100%) | 29/33 (88%) 29/33 (88%) 28/29 (97%) |
|FIRST INCIDENCE (DAYS) | 507 495 427 | 364 491 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.054 P=0.024 * | P=0.490 P=0.317 P=0.545 |
|INCIDENTAL TUMOR | P=0.181N P=0.409 P=0.314N | P=0.412N P=0.168 P=0.463N |
|LOGISTIC REGRESSION | P=0.486N P=0.374 P=0.629N | P=0.472N P=0.173 P=0.561N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.113N |
|FISHER EXACT | P=0.500 P=0.004N** | P=0.178 P=0.163N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 34/50 (68%) 33/50 (66%) | 25/50 (50%) 27/50 (54%) 24/50 (48%) |
|ADJUSTED (b) | 51.6% 80.3% 86.4% | 56.1% 63.6% 62.6% |
|TERMINAL (d) | 15/37 (41%) 21/29 (72%) 16/21 (76%) | 14/33 (42%) 18/33 (55%) 15/29 (52%) |
|FIRST INCIDENCE (DAYS) | 479 235 373 | 364 583 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.012 * P<0.001 ** | P=0.361 P=0.433 P=0.396 |
|INCIDENTAL TUMOR | P=0.024 * P=0.025 * P=0.037 * | P=0.456 P=0.395 P=0.492 |
|LOGISTIC REGRESSION | P=0.012 * P=0.034 * P=0.013 * | P=0.447 P=0.422 P=0.498 |
|COCHRAN-ARMITAGE | P=0.041 * | P=0.460N |
|FISHER EXACT | P=0.034 * P=0.053 | P=0.421 P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05006 TEST: 05 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BENZALDEHYDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 200. 400. | VEHICLE 200. 400. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 42/50 (84%) | 46/50 (92%) 48/50 (96%) 43/50 (86%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.8% 96.0% 100.0% |
|TERMINAL (d) | 37/37 (100%) 29/29 (100%) 21/21 (100%) | 30/33 (91%) 31/33 (94%) 29/29 (100%) |
|FIRST INCIDENCE (DAYS) | 479 235 373 | 364 491 485 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.088 P=0.012 * | P=0.318 P=0.440 P=0.350 |
|INCIDENTAL TUMOR | P=0.052N (e) P=0.249N | P=0.411 P=0.329 P=0.506 |
|LOGISTIC REGRESSION | P=0.087N (e) P=0.860N | P=0.372 P=0.339 P=0.419 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.187N |
|FISHER EXACT | P=1.000N P=0.003N** | P=0.339 P=0.262N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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