TDMS Study 05006-05 Pathology Tables
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
Facility: Southern Research Institute
Chemical CAS #: 000100527
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|
| 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Developmental Malformation | X |
Focal Cellular Change | |
Granuloma | 1 3 2 2 1 2 |
Hematopoietic Cell Proliferation | 1 2 |
Inflammation, Chronic | 2 2 1 |
Mixed Cell Focus | X |
Bile Duct, Cyst Multilocular | X |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 |
Centrilobular, Atrophy | |
Hepatocyte, Hyperplasia, Nodular | 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Histiocyte | 3 |
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 4 2 |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Ectopic Tissue | X |
Hyperplasia, Nodular | 1 3 2|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 3 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|
| 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 |
Mineralization | 2 |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Granulomatous | |
Mineralization | 2 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 2 2 1 1 3|
Myocardium, Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X |
Angiectasis | 2 2 2|
Clear Cell Focus | X X X X X |
Hyperplasia | 1 3 |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 3 3 |
Pars Distalis, Pigmentation | |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 3 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|
| 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ectasia | 4 |
Hyperplasia | 2 3 |
Inflammation, Chronic | 2 2 2 3 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 2 |
Hyperplasia, Cystic | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Anemia | 3 |
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
Myelofibrosis | |
Proliferation | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Depletion Cellular | |
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 4 3 3 |
Hyperplasia, Re Cell | |
Pigmentation, Hemosiderin | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | X |
Fibrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|
| 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 3 3 4 4 3 2 2 2 2 3 3 3 3 3 3 2 3 3 2 2|
Hyperplasia, Lobular | 3 4 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Fibrosis | |
Inflammation, Suppurative | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | X X |
Femur, Hyperostosis | X X X |
Sternum, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + M + + + + + + + M +|
Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Axon, White Matter, Degeneration | |
Gray Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 3 |
Mediastinum, Inflammation, Chronic | |
Active | |
Subpleura, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Fungus | X |
Inflammation, Chronic | 2 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|
| 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 1 1 1 1 1 1 1 1 2 1|
Retina, Atrophy | 2 3 3 3 2 3 3 3 3 2 3 1 3 2 3 2 2 3 2 3 3 3|
Sclera, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Inflammation, Chronic | |
Mineralization | 2 2 2 2 2 2 2 1 1 3 2 2 2 1 2 3 2 1 1 2 3|
Nephropathy | 1 2 2 1 2 1 1 1 1 1 1 1 1 1|
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Degeneration | |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3| |
| 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3| 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X | 2 |
Developmental Malformation | X X X | 4 |
Focal Cellular Change | X X X | 3 |
Granuloma | 4 3 3 2 1 2 1 | 13 2.1|
Hematopoietic Cell Proliferation | | 2 1.5|
Inflammation, Chronic | 1 | 4 1.5|
Mixed Cell Focus | | 1 |
Bile Duct, Cyst Multilocular | | 1 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 25 1.1|
Centrilobular, Atrophy | 2 | 1 2.0|
Hepatocyte, Hyperplasia, Nodular | 2 | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 4 | 3 2.7|
Kupffer Cell, Pigmentation | 3 | 2 2.5|
Lobules, Necrosis | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Fat, Inflammation, Granulomatous | 3 3 | 2 3.0|
Fat, Necrosis | 3 3 4 3 | 6 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Atrophy | 1 1 | 4 1.5|
Ectopic Tissue | | 1 |
Hyperplasia, Nodular | 1 2 | 5 1.8|
__________________________________________________________________________|____________|
Pharynx | +| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3| |
| 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.5|
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | | 1 3.0|
Mucosa, Hyperplasia | 1 1 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Mineralization | 2 2 1 | 5 1.8|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 1 1 3 2 2 2 1| 20 1.8|
Myocardium, Inflammation, Chronic | 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X | 8 |
Angiectasis | 2 2 | 5 2.0|
Clear Cell Focus | X X X X | 9 |
Hyperplasia | 1 3 2 2 | 6 2.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Fibrosis | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 3 | 3 3.3|
Pars Distalis, Cyst | X X X X X X X| 14 |
Pars Distalis, Hyperplasia | 2 | 4 2.5|
Pars Distalis, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3| |
| 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Nervosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 3 1 2 | 7 1.7|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + M + + + + M + + + + M + +| 45 |
Ectasia | 2 4 3 2 2| 6 2.8|
Hyperplasia | 2| 3 2.3|
Inflammation, Chronic | 2 2| 6 2.2|
Inflammation, Suppurative | 1 2 4 2 | 6 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Cyst | X X | 4 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydrometra | | 2 3.0|
Hyperplasia, Cystic | 2 1 | 4 1.8|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Anemia | | 1 3.0|
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2 2 | 3 2.3|
Myelofibrosis | 2 | 1 2.0|
Proliferation | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + + + + + + + + + + + I| 46 |
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Lymphatic, Dilatation | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3| |
| 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Cellular | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 | 6 2.7|
Hyperplasia, Re Cell | 3 | 1 3.0|
Pigmentation, Hemosiderin | 3 2 | 3 2.7|
Red Pulp, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + M + + + +| 47 |
Cyst | | 1 |
Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 4 4 3 2 2 2 4 4 3 3 2 1 2 1 2 4 3 2 2 3| 43 2.7|
Hyperplasia, Lobular | 3 2 4 3 | 8 2.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 4 | 1 4.0|
Fibrosis | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | X X X X | 6 |
Femur, Hyperostosis | X X X X | 7 |
Sternum, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 7 |
Hydrocephalus | 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Axon, White Matter, Degeneration | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3| |
| 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Gray Matter, Degeneration | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 2.5|
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 3| 26 1.2|
Inflammation, Chronic | 3| 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
Mediastinum, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
Subpleura, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X | 4 |
Fungus | | 1 |
Inflammation, Chronic | 2 | 2 2.0|
Mucosa, Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 1 1 2 1 1 1 1 1 1 | 21 1.1|
Retina, Atrophy | 2 2 3 3 2 3 3 3 2 3 3 3 2 1 3 2 3 1 3 3 3| 43 2.6|
Sclera, Mineralization | 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Inflammation, Chronic | 1 1 1| 3 1.0|
Mineralization | 1 2 1 2 2 1 1 1 3 1 2 1 1 3 1 2 1 2 1 2 2 2| 43 1.7|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 33 1.2|
Renal Tubule, Cytoplasmic Alteration | 3 | 1 3.0|
Renal Tubule, Degeneration | 3 2 | 2 2.5|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|
| 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + M + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Developmental Malformation | X X |
Focal Cellular Change | X X |
Granuloma | 1 4 3 2 1 2 1 3 3 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 1 1 |
Bile Duct, Hyperplasia | 3 1 2 1 1 1 2|
Centrilobular, Atrophy | 2 2 2 |
Hepatocyte, Hyperplasia, Nodular | 2 2 2 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 3 2|
Lobules, Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | |
Artery, Hypertrophy | 4 |
Artery, Inflammation, Chronic Active | 4 |
Fat, Inflammation, Granulomatous | 3 |
Fat, Inflammation, Suppurative | 3 |
Fat, Mineralization | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Hyperplasia, Nodular | 2 2 2 |
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|
| 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | 2 |
Inflammation, Chronic | 2 |
Ulcer | 2 |
Mucosa, Hyperplasia | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 |
Inflammation, Granulomatous | |
Mineralization | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 2 1 2 1 1 1|
Thrombosis | X |
Epicardium, Inflammation, Chronic | |
Active | 2 |
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Angiectasis | 2 3 2 |
Basophilic Focus | |
Clear Cell Focus | X X X X |
Hemorrhage | 2 3 |
Hyperplasia | 1 2 2 2 |
Necrosis | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | 2 2 3 3 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 2 2 1 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 2|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|
| 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Ectasia | 3 3 4 3|
Hyperplasia | 2 2 3 2|
Inflammation, Chronic | 3 3 |
Inflammation, Suppurative | 3 3 2 4 3 4 4 2|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X |
Hemorrhage | 3 |
Hydrometra | 3 |
Hyperplasia, Cystic | 2 2 3 |
Inflammation, Suppurative | 4 |
Necrosis | 3 |
Endometrium, Dysplasia | |
__________________________________________________________________________|
Vagina | + M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Anemia | 3 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Re Cell | 4 |
Pigmentation, Hemosiderin | 4 3 3 3 |
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|
| 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Lobular | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | X |
Femur, Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 3 |
Hydrocephalus | |
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gray Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Inflammation, Chronic | 3 |
Mucosa, Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|
| 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + I + + + + + + + + + + + + + +|
Cataract | 3 2 2 1 1 1 4 1 1 1 1|
Cornea, Inflammation, Chronic | |
Cornea, Neovascularization | |
Retina, Atrophy | 1 3 3 2 3 2 3 3 3 2 3 3 1 3 3 2 3 3 3 3|
Sclera, Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hemorrhage | 3 |
Infarct | 3 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 3 |
Mineralization | 2 2 2 1 2 1 2 1 1 2 2 1 3 2 2 3 1 2 1|
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 2 3 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
Mineralization | 2 |
Ulcer | |
Mucosa, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + M +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X| 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Erosion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X | 3 |
Developmental Malformation | X X X X X | 7 |
Focal Cellular Change | | 2 |
Granuloma | 1 2 1 3 1 1 2 3 1 1 1 | 21 1.9|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic | | 3 1.3|
Bile Duct, Hyperplasia | 1 1 1 1 1 | 12 1.3|
Centrilobular, Atrophy | 2 | 4 2.0|
Hepatocyte, Hyperplasia, Nodular | 3 | 7 2.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0|
Kupffer Cell, Pigmentation | 2 | 3 2.3|
Lobules, Necrosis | 2 | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Accessory Spleen | X | 1 |
Artery, Hypertrophy | 2 | 2 3.0|
Artery, Inflammation, Chronic Active | 2 | 2 3.0|
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Inflammation, Suppurative | | 1 3.0|
Fat, Mineralization | 4 | 1 4.0|
Fat, Necrosis | 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.0|
Hyperplasia, Nodular | 2 2 | 5 2.0|
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 3 1.7|
Inflammation, Granulomatous | 1 | 1 1.0|
Mineralization | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 2 2 2 2| 19 1.5|
Thrombosis | | 1 |
Epicardium, Inflammation, Chronic | | |
Active | | 1 2.0|
Myocardium, Inflammation, Chronic | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 3 |
Angiectasis | 2 3 2 3 2 | 8 2.4|
Basophilic Focus | X | 1 |
Clear Cell Focus | X X X X | 8 |
Hemorrhage | | 2 2.5|
Hyperplasia | 2| 5 1.8|
Necrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M M + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | 2 4 2 2 | 8 2.5|
Pars Distalis, Cyst | X X X X X | 9 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 | 10 2.0|
Pars Distalis, Pigmentation | 2 2 | 2 2.0|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | | 1 2.0|
Pars Nervosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 1 1 2 | 7 1.4|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Ectasia | 3 3 3| 7 3.1|
Hyperplasia | 3 2 2| 7 2.3|
Inflammation, Chronic | 2 2| 4 2.5|
Inflammation, Suppurative | 4 3 3 2| 12 3.1|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Cyst | | 1 |
Hemorrhage | 4 | 2 3.5|
Hydrometra | | 1 3.0|
Hyperplasia, Cystic | 3 | 4 2.5|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 3.0|
Endometrium, Dysplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + M | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Anemia | | 2 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Reticulum Cell | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + M + + + + +| 47 |
Hyperplasia, Plasma Cell | 3 3 | 2 3.0|
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 2.5|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 | 4 2.0|
Hyperplasia, Re Cell | | 1 4.0|
Pigmentation, Hemosiderin | 3 2 4 | 7 3.1|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
Red Pulp, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M M + M + + + + + + + +| 46 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 2 2 2 1 2 3 2 1 3 3 3 2 2 2 | 32 2.3|
Hyperplasia, Lobular | 3 3 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | | 1 |
Femur, Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 3 |
Hemorrhage | 1 | 2 2.0|
Hydrocephalus | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gray Matter, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 4 3.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1| 14 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X | 6 |
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 1 |
Inflammation, Chronic | | 1 3.0|
Mucosa, Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 1 2 1 1 2 4 1 1 3 1 1 1 1 1| 25 1.6|
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Cornea, Neovascularization | 2 | 1 2.0|
Retina, Atrophy | 3 3 3 3 2 3 4 2 2 3 2 3 3 3 3 3 3 3 3 3| 40 2.7|
Sclera, Mineralization | 2 1 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 3.0|
Infarct | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | 2 | 3 2.0|
Mineralization | 2 1 2 2 1 2 2 2 1 2 1 2 1 2 2 1 1 1 2 2 1 2| 41 1.7|
Nephropathy | 1 1 1 1 1 1 1 3 1 2 1 1 1 1 1 1 1 1 1 1| 34 1.1|
Renal Tubule, Dilatation | 2 | 2 2.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3| |
| 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, Hyperplasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
Mucosa, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | 4 | 1 4.0|
Mucosa, Hyperplasia | 4 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|
| 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Developmental Malformation | X X X|
Granuloma | 1 1 2 1 2 1 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 2 2 1 1 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 1 1 2 3 3 2 2 3 |
Centrilobular, Atrophy | 2 2 3 2 |
Hepatocyte, Hyperplasia, Nodular | 3 3 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic | 3 |
Fat, Inflammation, Granulomatous | 2 2 |
Fat, Mineralization | 1 3 2 |
Fat, Necrosis | 3 3 3 3 4 |
__________________________________________________________________________|
Pancreas | + |
Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Dysplasia | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 3 |
Mineralization | 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 |
Myocardium, Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|
| 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X|
Angiectasis | 3 2 2 2 2 |
Basophilic Focus | |
Clear Cell Focus | X X X X X |
Cyst Multilocular | |
Hyperplasia | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + +|
Cyst | |
Hemorrhage | |
Hydrometra | |
Hyperplasia, Cystic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|
| 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
__________________________________________________________________________|
Bone Marrow | + |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 4 2 3 2 2|
Necrosis | 4 3 |
Pigmentation, Hemosiderin | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 1 2 3 4 2 2 1 2 3 2 3 2 3 3 1 2 2 2 1 2 4|
Hyperplasia, Lobular | 3 3 2 4 4 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | 1 |
Nipple, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | X X X |
Femur, Hyperostosis | X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Gray Matter, Degeneration | 1 |
Parenchyma, White Matter, | |
Degeneration, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|
| 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 1 2 3 1 1 2|
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 1 1 3 1 1 1 1|
Hemorrhage | |
Retina, Atrophy | 2 3 3 2 2 2 4 2 2 1 2 3 1 3 2 3 3 3 3|
Sclera, Mineralization | 1 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X |
Hydronephrosis | 2 |
Infarct | 2 |
Inflammation, Chronic | 1 2 2 1 1 |
Inflammation, Suppurative | 1 |
Mineralization | 2 2 2 1 1 1 1 2 2 2 1 1 2 2 1 2 1 1 1 2 1 3 2|
Nephropathy | 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2|
Papilla, Necrosis | |
Renal Tubule, Degeneration | 3 3 4 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.8|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | X X | 4 |
Developmental Malformation | X X X X X X X | 10 |
Granuloma | 3 2 1 1 3 4 3 3 2| 15 2.0|
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Inflammation, Chronic | 1 1 1 2 | 9 1.3|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 2 1 1| 19 1.6|
Centrilobular, Atrophy | 3 | 5 2.4|
Hepatocyte, Hyperplasia, Nodular | 2 | 5 2.6|
Hepatocyte, Vacuolization Cytoplasmic| 1 4 | 4 2.0|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
Lobules, Necrosis | 2 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Inflammation, Granulomatous | | 2 2.0|
Fat, Mineralization | | 3 2.0|
Fat, Necrosis | | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + | 2 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
Mucosa, Dysplasia | 4 | 1 4.0|
Mucosa, Hyperplasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Erosion | | 1 3.0|
Mineralization | 2 1 2 | 8 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 2 1 2| 15 1.3|
Myocardium, Inflammation, Chronic | 1 1 1 1 1 1 | 8 1.1|
Myocardium, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X | 8 |
Angiectasis | 2 3 | 7 2.3|
Basophilic Focus | X | 1 |
Clear Cell Focus | X X X X X | 10 |
Cyst Multilocular | X| 1 |
Hyperplasia | 2 3 2 3 | 5 2.6|
Vacuolization Cytoplasmic, Diffuse | 3 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | 1 | 4 1.3|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 4 3| 4 3.3|
Pars Distalis, Cyst | X X X X X X | 15 |
Pars Distalis, Hyperplasia | 2 | 4 1.8|
Pars Distalis, Pigmentation | 3 | 1 3.0|
Pars Intermedia, Angiectasis | 2 | 1 2.0|
Pars Intermedia, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 4 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 2 2.5|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 2 1 2 3 | 6 1.7|
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + | 3 |
Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 12 |
Cyst | X X X | 3 |
Hemorrhage | 4 | 1 4.0|
Hydrometra | 4 | 1 4.0|
Hyperplasia, Cystic | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Anemia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 5 |
Hyperplasia, Reticulum Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 3 2 3 | 10 2.5|
Necrosis | | 2 3.5|
Pigmentation, Hemosiderin | 3 2 3 3 | 7 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 3 3 2 2 2 2 3 3 3 1 2 3 3 4 3 1 2 3 1 2| 45 2.3|
Hyperplasia, Lobular | 3 3 2 | 10 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 29 |
Acanthosis | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Nipple, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | X X X X| 7 |
Femur, Hyperostosis | X X X X| 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X X | 16 |
Hydrocephalus | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Gray Matter, Degeneration | | 1 1.0|
Parenchyma, White Matter, | | |
Degeneration, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 3 1 1 1 1 1| 14 1.4|
Inflammation, Chronic | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 2 3 1 3 3 1 1 1 2 1 2| 19 1.6|
Hemorrhage | 2 | 1 2.0|
Retina, Atrophy | 3 2 3 3 1 1 3 3 3 4 3 3 3 2 3 3 2 3 3 3 3 3 3| 42 2.6|
Sclera, Mineralization | 1 1 2 1 3 3 2 1 | 11 1.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Cyst | | 2 |
Hydronephrosis | 3 | 2 2.5|
Infarct | | 1 2.0|
Inflammation, Chronic | 2 2 | 7 1.6|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 2 2 2 2 2 1 1 1 3 2 2 1 1 2 1 2 2 2 2 2 1 2 | 45 1.6|
Nephropathy | 1 2 3 1 1 1 1 1 3 1 1 1 1 1 2 1 1 2 1 1 1 1| 41 1.3|
Papilla, Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Degeneration | | 3 3.3|
Transitional Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|
| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + M|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X |
Developmental Malformation | X X X X X |
Focal Cellular Change | X X X X |
Granuloma | 2 2 2 2 2 2 1 3 2 2 2 1 |
Hemorrhage | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Bile Duct, Cyst Multilocular | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 3 1 2 3 3 3 2 2 3 2 1 2 2 4 2 2 1 2 2|
Centrilobular, Atrophy | 3 |
Hepatocyte, Hyperplasia, Nodular | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 2 2 2 2 2|
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + +|
Artery, Hypertrophy | |
Artery, Inflammation, Chronic Active | 3|
Fat, Inflammation, Granulomatous | 3 |
Fat, Mineralization | 3 3 2 |
Fat, Necrosis | 3 2 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 1 2 1 1 1 |
Hyperplasia, Nodular | 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Granulomatous | 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|
| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perforation | |
Mucosa, Dysplasia | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
Inflammation, Chronic Active | 2 |
Mineralization | |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 3 2 1 2 2 1 2 2 3 3 3 2 2 2 2|
Thrombosis | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | 2 3 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Hyperplasia | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 1 2 2 1 1 1 1 1 |
C-Cell, Hyperplasia | 2 1 1 2 2 1 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|
| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Chronic | 3 3 2 2 2 2 2 3 2 3 2 2 2 2 2 3 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 1 |
Ectasia | |
Fibrosis | 2 |
Inflammation, Chronic | 1 1 1 1 2 |
Inflammation, Suppurative | 2 1 1 2 2 2 3 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 2 2 3 2 3 2 1|
Spermatocele | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anemia | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Erythrophagocytosis | 3 |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pigmentation | 2 2 2 2 2 1 1 2 2 2 2 2 2 2 1 1 2 3 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 3 |
Hyperplasia, Re Cell | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + + + + + + + + + + + +|
Cyst | X X |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|
| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + M + + + + + +|
Hyperplasia, Cystic | 1 4 1 1 2 2 2 |
Hyperplasia, Lobular | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis | |
Hemorrhage | |
Inflammation, Suppurative | |
Sebaceous Gland, Ectasia | |
Subcutaneous Tissue, Fibrosis | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 2 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + I + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gray Matter, Degeneration | |
Gray Matter, Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Congestion | |
Foreign Body | 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Edema | |
Artery, Mediastinum, Hypertrophy | |
Artery, Mediastinum, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X|
Foreign Body | 2|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|
| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X X X |
Inflammation, Chronic | 3 3 2 |
Mucosa, Hyperplasia | 3 |
Mucosa, Metaplasia, Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 1 3 4 |
Cornea, Mineralization | 1 |
Retina, Atrophy | 2 2 1 2 3 1 3 2 3 2 3 2 2 3 |
Sclera, Mineralization | 3 1 1 2 2 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 2 2 3 2 2 2 1 1 1 2 2 1 1 1 |
Inflammation, Suppurative | 1 1 1 |
Mineralization | 1 1 1 1 |
Nephropathy | 2 2 3 2 3 2 2 1 2 2 2 1 2 1 2 2 1 1 1 1 2 2 1 1 1|
Capsule, Fibrosis | 2 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X X X X X | 15 |
Developmental Malformation | X X| 7 |
Focal Cellular Change | | 4 |
Granuloma | 1 1 2 1 1 1 1 1 2 2 4| 23 1.7|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Chronic Active | 3 2 1 | 3 2.0|
Bile Duct, Cyst Multilocular | X | 1 |
Bile Duct, Hyperplasia | 1 1 2 2 1 2 3 3 2 2 1 1 3 1 1 1 1 1 2 2 1 1| 47 1.9|
Centrilobular, Atrophy | 2 | 2 2.5|
Hepatocyte, Hyperplasia, Nodular | 2 2 | 3 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 2 2 3 | 15 2.3|
Lobules, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + +| 16 |
Artery, Hypertrophy | 3 2| 2 2.5|
Artery, Inflammation, Chronic Active | 3 2| 3 2.7|
Fat, Inflammation, Granulomatous | 3 3 | 3 3.0|
Fat, Mineralization | 2 4 3 3 3 | 8 2.9|
Fat, Necrosis | 4 4 4 1 4 4 3 | 12 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 2 1| 10 1.2|
Hyperplasia, Nodular | 2 3 3 2 2 | 6 2.2|
Inflammation, Chronic | 1 | 4 1.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Perforation | X | 1 |
Mucosa, Dysplasia | 3 | 1 3.0|
Mucosa, Hyperplasia | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 | 1 4.0|
Erosion | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 2 | 1 2.0|
Ulcer | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperkeratosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 1 2 1 3 2 1 3 3 2 2 1 2 2 2 1 | 37 2.1|
Thrombosis | X X | 2 |
Epicardium, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 4 |
Angiectasis | 2 2 3 | 5 2.4|
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X X X | 7 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3| 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 2| 4 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | 1 1 1 1 1 2 1 1 | 18 1.2|
C-Cell, Hyperplasia | 1 | 7 1.4|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
Inflammation, Chronic | 2 2 3 2 3 3 2 2 2 2 2 2 3 2 3 2 3 2| 35 2.3|
Inflammation, Suppurative | 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 | 2 1.5|
Ectasia | 3| 1 3.0|
Fibrosis | 1 2 3| 4 2.0|
Inflammation, Chronic | 1 1 2 1 2| 10 1.3|
Inflammation, Suppurative | 1 2 2 1 2 3 3 1 2 2 2 | 20 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 3 2 1 2 3 1 2 2 2 2 1 1 3 | 24 2.0|
Spermatocele | X | 1 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Anemia | X | 1 |
Leukocytosis | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Erythrophagocytosis | 3 | 2 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Erythrophagocytosis | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 3 3 2 | 3 2.7|
Lymphatic, Dilatation | 3 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Pigmentation | 3 1 1 1 1 1 2 2 2 2 1 3 2 3 1 2 1 1| 38 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 3 2 2 | 6 2.3|
Hyperplasia, Re Cell | | 1 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + I + + + + + + + + +| 47 |
Cyst | | 2 |
Epithelial Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Hyperplasia, Cystic | 1 1 1 3 4 4 1 2 2 | 16 2.0|
Hyperplasia, Lobular | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Fibrosis | 4 3 | 2 3.5|
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Sebaceous Gland, Ectasia | 3 | 1 3.0|
Subcutaneous Tissue, Fibrosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 2 |
Hydrocephalus | | 2 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Gray Matter, Degeneration | 1| 1 1.0|
Gray Matter, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 3 | 1 3.0|
Congestion | 3 | 1 3.0|
Foreign Body | | 1 1.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1| 18 1.1|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Edema | 2 | 1 2.0|
Artery, Mediastinum, Hypertrophy | 3 | 1 3.0|
Artery, Mediastinum, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X X X | 14 |
Foreign Body | | 1 2.0|
Fungus | X X X X X X X | 10 |
Inflammation, Chronic | 2 2 2 3 | 7 2.4|
Mucosa, Hyperplasia | 2 2 | 3 2.3|
Mucosa, Metaplasia, Squamous | 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | M | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 3 2 2 3 1 | 9 2.2|
Cornea, Mineralization | | 1 1.0|
Retina, Atrophy | 1 3 2 1 2 3 3 3 1 1 2 3 2 2 3 2 1 | 31 2.1|
Sclera, Mineralization | 2 2 3 2 2 2 2 2 2 1 2 2 1 2 1 1 3 2 1| 25 1.8|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 1 3 2 2 2 2| 29 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3| |
| 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 1 1 1 1 1 | 9 1.0|
Mineralization | 1 1 1 1 | 8 1.0|
Nephropathy | 1 2 2 2 2 1 3 1 2 2 3 1 2 2 2 2 1 2 2 2 1 3 2 2 2| 50 1.8|
Capsule, Fibrosis | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Inflammation, Suppurative | 3 |
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X X |
Congestion | 2 |
Degeneration, Cystic | |
Developmental Malformation | X X X X X |
Focal Cellular Change | X X |
Granuloma | |
Hematopoietic Cell Proliferation | 1 2 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 3 2 2 2 3 1 2 2 3 3 2 1|
Centrilobular, Atrophy | 2 2 2 2 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Hyperplasia, Nodular | 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Hyperplasia | |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Accessory Spleen | |
Artery, Hypertrophy | 2 |
Artery, Inflammation, Chronic Active | 2 2 2 3 |
Fat, Inflammation, Granulomatous | 4 3 |
Fat, Mineralization | 3 3 2 3 3 |
Fat, Necrosis | 4 4 3 3 3 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | 3 4 2 |
Basophilic Focus | X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Nodular | 2 3 3 2 3 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation, Chronic | |
Mineralization | |
Ulcer | |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | |
Mucosa, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Fibrosis | |
Aorta, Hemorrhage | |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 3 2 2 2 2 1 2 3 1 1 1 3 3|
Thrombosis | |
Epicardium, Fibrosis | |
Epicardium, Inflammation, Chronic | |
Myocardium, Inflammation, Chronic | 3 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | |
Clear Cell Focus | X X |
Cyst | |
Fibrosis | |
Hyperplasia | 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic, Diffuse | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 1 |
Pars Intermedia, Cyst | |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pigmentation | 2 1 1 1 2 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 3|
Hyperplasia | |
Inflammation, Chronic | 2 2 3 2 2 2 3 2 2 2 3 2 2 2 2|
Inflammation, Suppurative | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | |
Inflammation, Chronic | 1 1|
Inflammation, Suppurative | 3 2 1 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 3 2 2 |
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Reticulum Cell | |
Myelofibrosis | 2 |
Proliferation | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + + + + +|
Hyperplasia, Plasma Cell | 3 3 |
Lymphatic, Dilatation | 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Mast Cell | |
Pigmentation | 1 2 1 1 1 2 2 1 3 1 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 4 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 |
Lymphoid Follicle, Atrophy | 2 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +|
Hyperplasia, Cystic | 2 2|
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Suppurative | 2 |
Mineralization | 4 2 |
Ulcer | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemorrhage | 4 |
Inflammation, Chronic | 4 |
Mineralization | 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Corpora Amylacea | |
Hemorrhage | 3 |
Inflammation, Chronic | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | M + + + + M + + + + M + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gray Matter, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Congestion | 4 3 3 4 |
Infiltration Cellular, Histiocyte | 1 1 4 1 1 |
Inflammation, Chronic | 1 2 |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Edema | 3 3 |
Artery, Mediastinum, Hypertrophy | |
Artery, Mediastinum, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X |
Foreign Body | 2 2 |
Fungus | X X |
Inflammation, Chronic | 2 2 2 |
Mucosa, Hyperplasia | 2 3 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + M + + + + I + + A + + + + + + + + +|
Cataract | 2 2 2 1 1 1 |
Retina, Atrophy | 2 3 2 3 2 3 3 1 3 3 1 3 2 3 1 2 2 3|
Sclera, Mineralization | 1 2 3 2 2 1 1 1 2 1|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infarct | 2 2 2 |
Inflammation, Chronic | 4 2 4 2 2 3 2 2 3 2 3 3 2 4 4|
Inflammation, Suppurative | 1 1 1 1 |
Mineralization | 1 1 |
Nephropathy | 1 3 2 3 2 1 2 2 2 2 3 2 2 3 1 2 2 1 3 3 3 3 3|
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia | 2 3|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|
DAY ON TEST | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|
| 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Edema | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Granulomatous | 1 | 1 1.0|
Parasite Metazoan | X X X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + A + + + +| 45 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + M +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 | 4 2.0|
Basophilic Focus | X X X X X X X X X X| 20 |
Clear Cell Focus | X X X | 5 |
Congestion | | 1 2.0|
Degeneration, Cystic | 2 | 1 2.0|
Developmental Malformation | X | 6 |
Focal Cellular Change | X X | 4 |
Granuloma | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 2 3 2 3 2 2 3 3 2 1 2 1 2 2 2 3| 37 2.1|
Centrilobular, Atrophy | | 4 2.0|
Centrilobular, Necrosis | 4 3 | 3 3.0|
Hepatocyte, Hyperplasia, Nodular | 2 2 2| 5 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 2 3.0|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
Lobules, Necrosis | 3 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 19 |
Accessory Spleen | X | 1 |
Artery, Hypertrophy | 3 3 | 3 2.7|
Artery, Inflammation, Chronic Active | 3 3 | 6 2.5|
Fat, Inflammation, Granulomatous | 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Mineralization | 2 3 2 3 | 9 2.7|
Fat, Necrosis | 2 3 4 3 | 12 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Atrophy | 1 2 | 5 2.4|
Basophilic Focus | X| 2 |
Hyperplasia, Nodular | 3 3 3 2 3 3| 12 2.7|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Ulcer | 4 | 1 4.0|
Mucosa, Hyperplasia | 4 1 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 3 3 3 | 3 3.0|
Ulcer | 3 2 | 2 2.5|
Mucosa, Dysplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Fibrosis | 3 | 1 3.0|
Aorta, Hemorrhage | 2 | 1 2.0|
Aorta, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 1 3 2 3 2 2 1 3 1 3 2 3 1 1 2 3 2 2 3| 40 2.1|
Thrombosis | X | 1 |
Epicardium, Fibrosis | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | 3 | 1 3.0|
Myocardium, Inflammation, Chronic | 1 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X | 8 |
Angiectasis | 4 | 1 4.0|
Clear Cell Focus | X X X X X| 7 |
Cyst | X | 1 |
Fibrosis | 3 | 1 3.0|
Hyperplasia | 2 2 | 3 1.7|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 4 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 |
Hyperplasia | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 | 8 1.6|
Pars Intermedia, Cyst | X | 1 |
Pars Nervosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pigmentation | 1 1 1 2 1| 10 1.3|
Ultimobranchial Cyst | X| 1 |
C-Cell, Hyperplasia | 2 | 4 1.3|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 5 2.8|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 2 3 2 2 2 2 2 2 4 | 25 2.2|
Inflammation, Suppurative | 2 4 3 2 2 | 6 2.5|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 2 1 | 5 1.6|
Inflammation, Suppurative | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 2 3 3 1 1 | 11 2.1|
Interstitial Cell, Hyperplasia | | 2 2.0|
Seminiferous Tubule, Atrophy | 3 4 2 2 | 7 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
Myelofibrosis | | 1 2.0|
Proliferation | 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Hyperplasia, Plasma Cell | 2 3 2| 5 2.6|
Lymphatic, Dilatation | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 2 | 3 2.0|
Infiltration Cellular, Mast Cell | 3 | 1 3.0|
Pigmentation | 2 2 3 2 3 1 2 2 1 1 3 2| 26 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 1 | 3 2.3|
Hematopoietic Cell Proliferation | 2 2 2 | 6 2.8|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 3 | 2 3.0|
Lymphoid Follicle, Atrophy | 2 | 2 2.0|
Red Pulp, Atrophy | 2 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + + + + M + + M + + + M| 44 |
Hyperplasia, Cystic | 2 1 2 2 2 | 7 1.9|
Hyperplasia, Lobular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 2 2.5|
Mineralization | | 2 3.0|
Ulcer | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
Mineralization | | 1 2.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
Corpora Amylacea | 2| 1 2.0|
Hemorrhage | 1| 2 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gray Matter, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 3 | 1 3.0|
Congestion | 3 2 4 2 | 8 3.1|
Infiltration Cellular, Histiocyte | 1 3 1 1 | 9 1.6|
Inflammation, Chronic | | 2 1.5|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 | 4 2.0|
Alveolus, Edema | 2 | 3 2.7|
Artery, Mediastinum, Hypertrophy | 2 | 1 2.0|
Artery, Mediastinum, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X | 8 |
Foreign Body | 2 | 3 2.0|
Fungus | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7| |
DAY ON TEST | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3| |
| 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
400. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 4 2.0|
Mucosa, Hyperplasia | | 2 2.5|
Mucosa, Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + M + + + + + + + + + + + + + + + + + + I + + + +| 45 |
Cataract | 2 2 1 2 | 10 1.6|
Retina, Atrophy | 3 3 3 2 3 3 3 3 3 3 3 3 1 3 3 3 3| 35 2.6|
Sclera, Mineralization | 3 2 1 2 2 2 3 2 2 2| 20 1.9|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Infarct | | 3 2.0|
Inflammation, Chronic | 3 2 2 3 2 3 2 4 4 4 4 3 4 4 4 4 4| 32 3.1|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1| 13 1.0|
Mineralization | 1 1 1 1 2 1 3 1 | 10 1.3|
Nephropathy | 4 2 2 3 2 2 3 3 3 1 3 3 2 3 1 3 3 2 4 3 3| 44 2.4|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Necrosis | 2 | 2 2.5|
Renal Tubule, Pigmentation | 3 2 | 3 2.3|
Transitional Epithelium, Hyperplasia | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Inflammation, Suppurative | 2 |
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +|
Mineralization | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X|
Congestion | |
Degeneration, Cystic | 2 1 |
Developmental Malformation | X X X X |
Eosinophilic Focus | |
Granuloma | 1 2 3 1 2 2 2|
Hematopoietic Cell Proliferation | 2 2 2 3 3 |
Hemorrhage | |
Inflammation, Chronic | 2 |
Bile Duct, Cyst Multilocular | X |
Bile Duct, Hyperplasia | 1 2 3 2 2 2 2 2 3 2 3 2 2 3 3 2 2 3 1 2 1 2|
Centrilobular, Atrophy | |
Centrilobular, Necrosis | 1 2 2 |
Hepatocyte, Hyperplasia, Nodular | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 2 2 2 3 2 |
Kupffer Cell, Hyperplasia | 2 3 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | M + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | |
Fat, Inflammation, Granulomatous | 2 2 2 2 |
Fat, Mineralization | 2 3 2 3 2 |
Fat, Necrosis | 4 4 4 3 4 |
Fat, Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 2 3 2 1 1 1 |
Hyperplasia, Nodular | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 2 2 |
Inflammation, Chronic | 2 |
Mineralization | |
Ulcer | 4 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | |
Inflammation, Chronic | |
Mineralization | 4 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 3 2 2 2 2 3 3 3 3 3 3 2 1 3 3 1|
Thrombosis | X X X |
Myocardium, Inflammation, Chronic | 3 |
Myocardium, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X |
Angiectasis | 2 2 2 2 |
Clear Cell Focus | X X X |
Hematopoietic Cell Proliferation | 2 3 3 2 |
Hyperplasia | 4 2 2 2 |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 2 1 3 3 1 3 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Mineralization | 2 |
Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 1 2 2 1 2 2|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
Infiltration Cellular, Mononuclear | |
Cell | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 |
Hyperplasia | 3 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 3 3 2 |
Inflammation, Suppurative | 2 2 2 2 |
Metaplasia, Squamous | 4 2 |
Necrosis | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 |
Fibrosis | |
Inflammation, Chronic | 2 2 2 1 1 1 1 2|
Inflammation, Suppurative | 2 3 2 3 2 2 1 1 2 2|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 3 3 3 2 3 2 2 2 3 2 1 1 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Cellular | |
Proliferation | 2 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Erythrophagocytosis | 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Reticulum | |
Cell | 3 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 3 |
Mediastinal, Pigmentation | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Erythrophagocytosis | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Hyperplasia, Reticulum Cell | 3 |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Erythrophagocytosis | 2 |
Hemorrhage | |
Infiltration Cellular, Mast Cell | 3 |
Pigmentation | 1 2 2 1 1 3 2 1 3 3 2 1 2 1 3 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Fibrosis | 3|
Hematopoietic Cell Proliferation | 2 3 4 3 4 2 3 2 3 |
Hyperplasia, Re Cell | |
Pigmentation, Hemosiderin | 2 3 3 3 |
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Atrophy | 2 3|
__________________________________________________________________________|
Thymus | + M + M M M + M M + M + M M M + M + M + M + + M M|
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + M|
Hyperplasia, Cystic | 4 2 2 3 1 3 |
Hyperplasia, Lobular | 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X X |
Cyst Multilocular | |
Foreign Body | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Hair Follicle, Atrophy | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Edema | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X 2 |
Developmental Malformation | |
Hemorrhage | |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Inflammation, Chronic | |
Axon, Hypertrophy | 3 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gray Matter, Cytoplasmic Alteration | 2 |
Gray Matter, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Congestion | 2 |
Foreign Body | 2 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 2 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolus, Edema | |
Lymphatic, Dilatation | 3 |
Mediastinum, Edema | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X|
Foreign Body | |
Fungus | X X |
Inflammation, Chronic | 3 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|
| 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200. | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 |
Hemorrhage | 3 |
Cornea, Inflammation, Chronic | 2 |
Retina, Atrophy | 2 3 1 1 1 1 1 3 2 2 3 2|
Sclera, Mineralization | 2 2 3 1 1 2 1 2 3 1 2 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis | 2 |
Glomerulosclerosis | 2 |
Hydronephrosis | |
Inflammation, Chronic | 2 2 2 1 2 3 3 3 2 2 3 2 2|
Inflammation, Suppurative | 1 1 1 1 1 1 |
Mineralization | 4 1 2 2 1 1 |
Nephropathy | 3 1 2 3 2 2 1 2 1 2 2 3 3 2 3 3 3 2 2 2 1 3 3 2|
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation | 2 3 |
Venule, Infiltration Cellular, | |
Histiocyte | 2 |
Venule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Edema | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
Parasite Metazoan | X X X X X| 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 4 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X X X X X| 11 |
Congestion | 3 3 | 2 3.0|
Degeneration, Cystic | | 2 1.5|
Developmental Malformation | X X | 6 |
Eosinophilic Focus | X | 1 |
Granuloma | 1 1 1 1 2| 12 1.6|
Hematopoietic Cell Proliferation | 3 | 6 2.5|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Bile Duct, Cyst Multilocular | | 1 |
Bile Duct, Hyperplasia | 2 3 2 2 2 2 3 4 2 1 3 1 2 1 3 2 2 2 1 2 2 2 3| 45 2.1|
Centrilobular, Atrophy | 2 | 1 2.0|
Centrilobular, Necrosis | 1 | 4 1.5|
Hepatocyte, Hyperplasia, Nodular | 3 2 | 3 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 2 2 3| 14 2.3|
Kupffer Cell, Hyperplasia | 2 2 | 4 2.3|
Kupffer Cell, Pigmentation | 3 | 2 3.0|
Lobules, Necrosis | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + +| 22 |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Inflammation, Granulomatous | 2 3 3 4 3 2| 10 2.5|
Fat, Mineralization | 3 2 3 3 2 3 2 3| 13 2.5|
Fat, Necrosis | 4 3 4 4 4 4 3 4 4 4| 15 3.8|
Fat, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 2| 9 1.6|
Hyperplasia, Nodular | 2 2 3 3| 6 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 3 2.7|
Inflammation, Chronic | | 1 2.0|
Mineralization | 4 3 | 2 3.5|
Ulcer | 4 4 | 3 4.0|
Mucosa, Hyperplasia | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Erosion | 2 2 | 2 2.0|
Inflammation, Chronic | 3 3 | 2 3.0|
Mineralization | 3 4 3 | 6 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 3 2 3 2 2 2 2 2 2 3 2 2 2 3 3 1 3 1 2 3 2| 42 2.3|
Thrombosis | X | 4 |
Myocardium, Inflammation, Chronic | 1| 2 2.0|
Myocardium, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X X| 10 |
Angiectasis | 2 3 | 6 2.2|
Clear Cell Focus | X X X | 6 |
Hematopoietic Cell Proliferation | | 4 2.5|
Hyperplasia | 4 2 1 2 2 | 9 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic, Diffuse | 4 3 2 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 | 6 1.7|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + M + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X X X X | 6 |
Pars Distalis, Hyperplasia | 3 1 2 | 10 2.1|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | | 1 2.0|
Mineralization | | 1 2.0|
Pigmentation | 2 1 1 1 1 1 1 1| 19 1.1|
Ultimobranchial Cyst | X| 1 |
C-Cell, Hyperplasia | 2 3 3 1 1 2 2| 15 1.9|
Follicle, Cyst | X X | 2 |
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 4 2.8|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 2 2 2 2 2| 25 2.1|
Inflammation, Suppurative | 4 2 1 1 2 | 9 2.0|
Metaplasia, Squamous | | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 2 2 2 | 6 2.0|
Fibrosis | 3 2 2 2 | 4 2.3|
Inflammation, Chronic | 2 2 2 2 3 1 1 1 1 2 1 3 1| 21 1.6|
Inflammation, Suppurative | 2 2 3 2 1 2 2 2 2 3 2 3 3 2 1 2 1| 27 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 1 1 1 1 2 3 2 1| 23 2.0|
Seminiferous Tubule, Atrophy | 1 4 4 3 2 4 | 7 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Depletion Cellular | 3 | 1 3.0|
Proliferation | 2 3 3 | 9 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Erythrophagocytosis | | 1 3.0|
Mediastinal, Hemorrhage | 4 | 2 3.5|
Mediastinal, Hyperplasia, Reticulum | | |
Cell | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
Mediastinal, Pigmentation | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + M + + + +| 48 |
Depletion Cellular | 3 | 1 3.0|
Erythrophagocytosis | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 2 | 2 2.5|
Hyperplasia, Reticulum Cell | | 1 3.0|
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Cellular | 3 | 1 3.0|
Erythrophagocytosis | 3 | 2 2.5|
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, Mast Cell | 3 | 2 3.0|
Pigmentation | 1 2 2 2 2 1 1 1 2 2 2 3 2 2 2| 33 1.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 | 11 2.9|
Hyperplasia, Re Cell | 4 | 1 4.0|
Pigmentation, Hemosiderin | 3 | 5 2.8|
Lymphoid Follicle, Atrophy | 2 | 2 2.5|
Red Pulp, Atrophy | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + M + + M + + + + + + + + M + + + +| 30 |
Epithelial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Hyperplasia, Cystic | 2 4 1 2 2 3 2 4 2 1 | 16 2.4|
Hyperplasia, Lobular | 2 1 3 2 | 5 2.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
Cyst Epithelial Inclusion | X X X X | 6 |
Cyst Multilocular | X | 1 |
Foreign Body | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Granulomatous | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Hair Follicle, Atrophy | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Granuloma | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Edema | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.0|
Developmental Malformation | X | 1 |
Hemorrhage | 4 1 | 2 2.5|
Hydrocephalus | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mast Cell | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Axon, Hypertrophy | 1 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gray Matter, Cytoplasmic Alteration | | 1 2.0|
Gray Matter, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | | 1 2.0|
Congestion | 3 3 3 | 4 2.8|
Foreign Body | | 1 2.0|
Infiltration Cellular, Histiocyte | 4 1 1 1 2 2 1 | 14 1.5|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
Alveolus, Edema | 4 | 1 4.0|
Lymphatic, Dilatation | | 1 3.0|
Mediastinum, Edema | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X | 9 |
Foreign Body | 2 3 2 | 3 2.3|
Fungus | X X | 4 |
Inflammation, Chronic | 3 3 | 3 3.0|
Mucosa, Hyperplasia | 3 | 2 3.0|
Mucosa, Metaplasia, Squamous | 2 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 1 | 3 1.7|
Hemorrhage | | 1 3.0|
Cornea, Inflammation, Chronic | | 1 2.0|
Retina, Atrophy | 2 1 2 1 3 1 1 2 3 3 2 2 1 1 1 2 | 28 1.8|
Sclera, Mineralization | 2 1 3 2 1 2 2 1 1 1 2 3 2 1| 26 1.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05006-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZALDEHYDE Date: 04/30/97
Route: GAVAGE Time: 09:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3| |
| 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200. | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Fibrosis | | 1 2.0|
Glomerulosclerosis | | 1 2.0|
Hydronephrosis | 4 | 1 4.0|
Inflammation, Chronic | 2 2 3 3 3 2 2 2 2 3 2 3 3 1 2 3 2| 30 2.3|
Inflammation, Suppurative | 2 1 1 1 1 1 2 | 13 1.2|
Mineralization | 3 1 1 1 3 1 1 1 1 | 15 1.6|
Nephropathy | 2 4 3 3 3 1 3 3 1 3 2 2 3 3 3 4 2 2 3 3 3 1 2 3 2| 49 2.4|
Renal Tubule, Degeneration | 4 | 1 4.0|
Renal Tubule, Pigmentation | | 2 2.5|
Venule, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Venule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
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