TDMS Study 05006-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05006 BENZALDEHYDE TIME: 09:00:54
TEST: 05 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56133
CONT: NO1CP9565101 CAS: 000100527
PATHOLOGIST: J. HEATH S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05006 BENZALDEHYDE TIME: 09:00:54
TEST: 05 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56133
CONT: NO1CP9565101 CAS: 000100527
PATHOLOGIST: J. HEATH S. EUSTIS
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 479 507 508 585 588 593 593 600 610 696 |
| 722 724 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 235 495 561 564 617 632 652 668 668 676 |
| 682 692 697 708 710 711 714 714 719 722 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 154 202 264 299 373 373 375 388 427 446 |
| 499 506 512 558 558 558 573 585 593 605 |
| 626 680 680 697 705 712 715 718 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 84.0 82.0 74.0 |
|CONTROL | |
| | |
|200. | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 92.0 86.0 58.0 |
|MG/KG | |
| | |
|400. | 100.0 98.0 94.0 92.0 84.0 80.0 74.0 60.0 58.0 42.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 200. 400. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 58.0% 42.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.176 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 610.1 646.0 520.7 |
|NATURAL DEATHS (C) | (23.5) (24.6) (30.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.1 694.1 608.2 |
|(STANDARD ERROR) | ( 9.5) (11.7) (22.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 364 463 520 534 578 579 602 620 674 674 |
| 681 695 698 701 711 715 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 491 495 542 583 613 620 628 652 668 669 |
| 682 684 696 697 697 702 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 138 151 159 231 250 275 485 520 521 554 |
| 561 570 613 629 652 659 676 692 695 698 |
| 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZALDEHYDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 98.0 96.0 92.0 86.0 84.0 66.0 |
|CONTROL | |
| | |
|200. | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 84.0 66.0 |
|MG/KG | |
| | |
|400. | 100.0 94.0 90.0 88.0 88.0 86.0 82.0 76.0 68.0 58.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 200. 400. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 66.0% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.302 P=1.000N P=0.352 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 619.3 637.5 497.1 |
|NATURAL DEATHS (C) | (24.7) (17.4) (44.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 692.4 698.5 632.2 |
|(STANDARD ERROR) | (11.1) ( 8.5) (24.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
200. MG/KG = 2
400. MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 1 2 1
| 3 3 3 2 1 2 1
| 3 3 2 2
P 90 + 1 1 2 2
E | 2 2
R | 3 3 3 11 1 2 2
C | 3 3 1 22 1
E 80 + 3 3 22 1 1
N | 33 22
T | 33 3 22 2 1 1
|
S 70 +
U | 3 3
R | 3 3 3 22
V | 3 3 22
I 60 + 3 3
V | 3 3 2 2
A | 3 3
L | 33
50 + 33
| 33
|
| 3 3
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
BENZALDEHYDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
200. MG/KG = 2
400. MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
| 3 3 1 1
| 33 1 2 1 2
95 +
| 3 3 1 12 2
| 3 3 1 12 2
|
90 + 3 3 22
|
P | 3 3 1 1 22
E | 3 3 1 12 2
R 85 +
C | 1 2 21
E | 3 3
N |
T 80 + 33 211
|
S | 33 1 1
U | 3 3 2 2
R 75 +
V | 3 3 11
I | 3 3 11
V |
A 70 + 3 3 2211
L |
| 3 3 2 2
| 3 3 1 1
65 +
| 33
|
|
60 + 3 3
|
| 3 3
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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