TDMS Study 05007-05 Pathology Tables
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
Facility: Southern Research Institute
Chemical CAS #: 9005-65-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + A + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + A + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M + + + M + + + + M + + + M + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + M |
Adenoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
Endometrium, Polyp Stromal | X |
Endometrium, Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M M + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Sternum, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + |
Hemangioma | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + M + + + M + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M M M M + M + + + + M M M M |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + M + + + + + + + + + + M + |
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
Endometrium, Polyp Stromal | |
Endometrium, Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | X X |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + M + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Sternum, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Hemangioma | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + M + | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + M | 47 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 46 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + M M M M | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 46 |
Pars Distalis, Adenoma | X X X X | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
Follicle, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 48 |
Adenoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Endometrium, Polyp Stromal | X X | 3 |
Endometrium, Sarcoma Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 4 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 5 |
Lymphoma Malignant Mixed | X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X | 5 |
Lymphoma Malignant Mixed | | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Subcutaneous Tissue, Fibrosarcoma | | 4 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Sternum, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Hemangioma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 5 |
Lymphoma Malignant Mixed | X | 12 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + +|
Leiomyoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + M + + + + + A + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + +|
Fibrosarcoma, Metastatic, Mesentery | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + +|
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fibrosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + +|
Fibrosarcoma, Metastatic, Mesentery | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Glandular, Fibrosarcoma, Metastatic, | |
Mesentery | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | |
Pulp, Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + M M M + + + M + M + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Luteoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + +|
Axillary, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + M + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M M + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma, Metastatic, Spleen | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Turbinate, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Harderian Gland | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + A + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + +|
Leiomyoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Mesentery | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Mesentery | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Glandular, Fibrosarcoma, Metastatic, | |
Mesentery | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Tooth | |
Pulp, Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Pheochromocytoma NOS | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Parathyroid Gland | + M M + M + + M M + M + + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Luteoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | X X |
Lumbar, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Carcinoma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma, Metastatic, Spleen | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spinal Cord | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Turbinate, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Harderian Gland | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 47 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 47 |
Leiomyoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 45 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 47 |
Fibrosarcoma, Metastatic, Mesentery | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 49 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Mesentery | + + | 13 |
Fibrosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + | 48 |
Fibrosarcoma, Metastatic, Mesentery | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | M M + + + + + + + + | 46 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Glandular, Fibrosarcoma, Metastatic, | | |
Mesentery | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Pulp, Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Pheochromocytoma NOS | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + | 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + M M + + | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 48 |
Pars Distalis, Adenoma | X X X X | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | M M + + + + + M + + | 46 |
Lymphoma Malignant Mixed | | 1 |
Follicle, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Luteoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Leiomyoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Mixed | | 3 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 3 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + | 46 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 49 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 48 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Sebaceous Gland, Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Turbinate, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | M M + + + + + + + + | 47 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + M + M + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + +|
Pars Distalis, Adenoma | X|
__________________________________________________________________________|
Thyroid Gland | + + + + + M + M + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + A + |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + M + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + M + + + M + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + A + |
__________________________________________________________________________|
Intestine Small | M + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + A + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + A + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M M M + + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + |
Granulosa Cell Tumor Benign | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Iliac, Lymphoma Malignant Lymphocytic| X |
Iliac, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + + M + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | M + + + + + + + + + + + + |
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + M + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + M + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + | 17 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + | 18 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + | 19 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Liver | + + + | 25 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | M + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + | 20 |
Pars Distalis, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + | 19 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 36 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + | 42 |
Lymphoma Malignant Lymphocytic | | 1 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 26 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + | 16 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + | 23 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + | 25 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | M + + | 20 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 19 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 38 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 22 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 22 |
__________________________________________________________________________|____________|
Trachea | M + + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 23 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + M + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X |
Neoplasm NOS | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + M M M + M M M + M M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X X X X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Neoplasm NOS | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Pheochromocytoma NOS | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M M + + + + + + M M + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 46 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 49 |
Hepatocellular Carcinoma | X X | 11 |
Hepatocellular Adenoma | X | 5 |
Neoplasm NOS | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 48 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Pheochromocytoma NOS | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + + + + + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
Follicle, Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 13 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 47 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 5 |
Subcutaneous Tissue, Fibrosarcoma | | 4 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 49 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Urethra | + + + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X|
Leukemia Granulocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Pheochromocytoma NOS | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M M M M M M M M M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + M + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leukemia Granulocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urethra | + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Leukemia Granulocytic | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M M M M + M M M M M M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leukemia Granulocytic | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Subcutaneous Tissue, Fibroma | X X|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leukemia Granulocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urethra | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + M + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + | 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Carcinoma | | 5 |
Hepatocellular Adenoma | | 6 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Adenoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Pheochromocytoma NOS | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + M | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Penis | + + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + | 11 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | M + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 46 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + M + | 49 |
Hemangioma | | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X | 5 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 2 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 5 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urethra | + + + + | 15 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + |
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Pheochromocytoma NOS | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Preputial Gland | + M + +|
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach | |
__________________________________________________________________________|
Pancreas | + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M M M + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X X X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 15 |
__________________________________________________________________________|____________|
Gallbladder | | 15 |
__________________________________________________________________________|____________|
Intestine Large | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 16 |
__________________________________________________________________________|____________|
Intestine Small | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 16 |
__________________________________________________________________________|____________|
Liver | | 23 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 7 |
Hepatocellular Adenoma | | 7 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 17 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 16 |
Pheochromocytoma NOS | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | | 15 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 16 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 14 |
Squamous Cell Carcinoma | | 2 |
__________________________________________________________________________|____________|
Prostate | | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 16 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + | 17 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + | 28 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 28 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 21 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + + | 42 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 5 |
Subcutaneous Tissue, Fibrosarcoma | | 5 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 3 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 21 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | | 16 |
__________________________________________________________________________|____________|
Trachea | | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05007-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:18:15
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urethra | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
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