TDMS Study 05007-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst POLYSORBATE 80 DATE: 09/03/94
EXPERIMENT: 05007 TEST: 05 TIME: 11:42:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9565102 ROUTE: DOSED FEED NTP C#: 60286
PATHOLOGIST: J. SAGARTZ S. EUSTIS CAS: 9005-65-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst POLYSORBATE 80 DATE: 09/03/94
EXPERIMENT: 05007 TEST: 05 TIME: 11:42:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565102 ROUTE: DOSED FEED NTP C#: 60286
PATHOLOGIST: J. SAGARTZ S. EUSTIS CAS: 9005-65-6
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst POLYSORBATE 80 DATE: 09/03/94
EXPERIMENT: 05007 TEST: 05 TIME: 11:42:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9565102 ROUTE: DOSED FEED NTP C#: 60286
PATHOLOGIST: J. SAGARTZ S. EUSTIS CAS: 9005-65-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF POLYSORBATE 80
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/16 (0%) 2/50 (4%) | 0/50 (0%) 0/22 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/0 2/32 (6%) | 0/30 (0%) 0/0 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138 (e) P=0.231 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.138 (e) P=0.231 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.138 (e) P=0.231 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.127 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/16 (6%) 2/50 (4%) | 0/50 (0%) 0/22 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.0% 0.0% 5.2% | 0.0% 0.0% 7.7% |
|TERMINAL (d) | 1/33 (3%) 0/0 1/32 (3%) | 0/30 (0%) 0/0 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 651 561 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 P=0.535 P=0.503 | P=0.120 (e) P=0.207 |
|INCIDENTAL TUMOR | P=0.442 P=0.739 P=0.526 | P=0.120 (e) P=0.207 |
|LOGISTIC REGRESSION | P=0.399 P=0.469 P=0.507 | P=0.120 (e) P=0.207 |
|COCHRAN-ARMITAGE | P=0.399 | P=0.119 |
|FISHER EXACT | P=0.435 P=0.508 | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | 0/13 (0%) 2/14 (14%) 0/11 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 18.2% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/7 (0%) 2/11 (18%) 0/9 (0%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.630N P=0.339 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.630N P=0.339 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.630N P=0.339 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.641 | (e) |
|FISHER EXACT | P=0.259 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 8.8% 3.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 3/34 (9%) 1/32 (3%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.367 P=0.126 P=0.494 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.367 P=0.126 P=0.494 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.367 P=0.126 P=0.494 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.384 | (e) |
|FISHER EXACT | P=0.125 P=0.505 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 7/23 (30%) 6/50 (12%) | 2/50 (4%) 1/25 (4%) 2/49 (4%) |
|ADJUSTED (b) | 14.6% 47.9% 18.8% | 6.7% 2.4% 6.4% |
|TERMINAL (d) | 4/33 (12%) 3/7 (43%) 6/32 (19%) | 2/30 (7%) 0/3 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 707 533 729 (T) | 729 (T) 588 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.433 P=0.035 * P=0.482 | P=0.533 P=0.601 P=0.637 |
|INCIDENTAL TUMOR | P=0.403 P=0.024 * P=0.523 | P=0.493 P=0.578 P=0.608 |
|LOGISTIC REGRESSION | P=0.466 P=0.034 * P=0.509 | P=0.572 P=0.675 P=0.662 |
|COCHRAN-ARMITAGE | P=0.460 | P=0.593 |
|FISHER EXACT | P=0.038 * P=0.514 | P=0.744N P=0.684 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/49 (22%) 7/23 (30%) 5/50 (10%) | 1/50 (2%) 1/25 (4%) 0/49 (0%) |
|ADJUSTED (b) | 31.3% 47.9% 13.3% | 3.3% 33.3% 0.0% |
|TERMINAL (d) | 9/33 (27%) 3/7 (43%) 2/32 (6%) | 1/30 (3%) 1/3 (33%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 640 533 608 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.087N P=0.235 P=0.096N | P=0.395N P=0.213 P=0.529N |
|INCIDENTAL TUMOR | P=0.099N P=0.228 P=0.052N | P=0.395N P=0.213 P=0.529N |
|LOGISTIC REGRESSION | P=0.070N P=0.315 P=0.075N | P=0.395N P=0.213 P=0.529N |
|COCHRAN-ARMITAGE | P=0.072N | P=0.350N |
|FISHER EXACT | P=0.326 P=0.079N | P=0.559 P=0.505N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 13/23 (57%) 11/50 (22%) | 3/50 (6%) 2/25 (8%) 2/49 (4%) |
|ADJUSTED (b) | 42.7% 87.9% 30.7% | 10.0% 35.0% 6.4% |
|TERMINAL (d) | 13/33 (39%) 6/7 (86%) 8/32 (25%) | 3/30 (10%) 1/3 (33%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 640 533 608 | 729 (T) 588 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246N P=0.011 * P=0.264N | P=0.495N P=0.189 P=0.569N |
|INCIDENTAL TUMOR | P=0.251N P=0.006 ** P=0.190N | P=0.529N P=0.175 P=0.598N |
|LOGISTIC REGRESSION | P=0.194N P=0.026 * P=0.208N | P=0.471N P=0.327 P=0.555N |
|COCHRAN-ARMITAGE | P=0.205N | P=0.423N |
|FISHER EXACT | P=0.033 * P=0.228N | P=0.544 P=0.510N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 13/23 (57%) 11/50 (22%) | 3/50 (6%) 2/25 (8%) 2/49 (4%) |
|ADJUSTED (b) | 42.7% 87.9% 30.7% | 10.0% 35.0% 6.4% |
|TERMINAL (d) | 13/33 (39%) 6/7 (86%) 8/32 (25%) | 3/30 (10%) 1/3 (33%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 640 533 608 | 729 (T) 588 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246N P=0.011 * P=0.264N | P=0.495N P=0.189 P=0.569N |
|INCIDENTAL TUMOR | P=0.251N P=0.006 ** P=0.190N | P=0.529N P=0.175 P=0.598N |
|LOGISTIC REGRESSION | P=0.194N P=0.026 * P=0.208N | P=0.471N P=0.327 P=0.555N |
|COCHRAN-ARMITAGE | P=0.205N | P=0.423N |
|FISHER EXACT | P=0.033 * P=0.228N | P=0.544 P=0.510N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 5/21 (24%) 5/50 (10%) | 3/50 (6%) 1/22 (5%) 2/50 (4%) |
|ADJUSTED (b) | 15.2% 61.9% 14.5% | 10.0% 0.0% 7.7% |
|TERMINAL (d) | 5/33 (15%) 3/5 (60%) 4/32 (13%) | 3/30 (10%) 0/0 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 598 604 | 729 (T) 707 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.547 P=0.016 * P=0.620 | P=0.487N P=0.475 P=0.566N |
|INCIDENTAL TUMOR | P=0.535N P=0.017 * P=0.631N | P=0.483N P=0.419 P=0.566N |
|LOGISTIC REGRESSION | P=0.536N P=0.063 P=0.611N | P=0.484N P=0.286 P=0.566N |
|COCHRAN-ARMITAGE | P=0.545N | P=0.409N |
|FISHER EXACT | P=0.133 P=0.617N | P=0.643N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 6/21 (29%) 5/50 (10%) | 3/50 (6%) 2/22 (9%) 3/50 (6%) |
|ADJUSTED (b) | 18.2% 80.9% 14.5% | 10.0% 0.0% 11.5% |
|TERMINAL (d) | 6/33 (18%) 4/5 (80%) 4/32 (13%) | 3/30 (10%) 0/0 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 598 604 | 729 (T) 651 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.458N P=0.004 ** P=0.514N | P=0.492 P=0.211 P=0.597 |
|INCIDENTAL TUMOR | P=0.424N P=0.004 ** P=0.501N | P=0.498 P=0.147 P=0.597 |
|LOGISTIC REGRESSION | P=0.415N P=0.030 * P=0.477N | P=0.489 P=0.118 P=0.597 |
|COCHRAN-ARMITAGE | P=0.427N | P=0.580 |
|FISHER EXACT | P=0.097 P=0.486N | P=0.486 P=0.661N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/15 (0%) 0/49 (0%) | 11/46 (24%) 2/20 (10%) 15/48 (31%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 39.1% 100.0% 47.5% |
|TERMINAL (d) | 0/33 (0%) 0/0 0/31 (0%) | 10/27 (37%) 2/2 (100%) 10/26 (38%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 708 729 (T) 581 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.157 P=0.408 P=0.192 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.130 P=0.373 P=0.148 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.125 P=0.340 P=0.151 |
|COCHRAN-ARMITAGE | (e) | P=0.235 |
|FISHER EXACT | (e) (e) | P=0.167N P=0.287 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 5.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 2/34 (6%) 0/32 (0%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.355N | (e) |
|FISHER EXACT | P=0.508 P=0.495N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 5.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 2/34 (6%) 0/32 (0%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.368N P=0.510 P=0.506N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.355N | (e) |
|FISHER EXACT | P=0.508 P=0.495N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 5/50 (10%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.5% 14.3% 9.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/33 (9%) 4/34 (12%) 3/32 (9%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 538 709 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.305N P=0.598N P=0.364N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.363N P=0.630N P=0.492N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.280N P=0.584N P=0.344N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.286N | (e) |
|FISHER EXACT | P=0.617N P=0.346N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 5/50 (10%) 5/50 (10%) | 4/50 (8%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 10.2% 12.6% 12.3% | 10.5% 0.0% 7.7% |
|TERMINAL (d) | 0/33 (0%) 2/34 (6%) 1/32 (3%) | 0/30 (0%) 0/28 (0%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 580 581 561 | 637 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.454 P=0.558 P=0.524 | P=0.273N P=0.085N P=0.407N |
|INCIDENTAL TUMOR | P=0.511N P=0.632 P=0.547N | P=0.289N P=0.109N P=0.427N |
|LOGISTIC REGRESSION | P=0.544 P=0.615 P=0.626 | P=0.249N P=0.060N P=0.374N |
|COCHRAN-ARMITAGE | P=0.444 | P=0.222N |
|FISHER EXACT | P=0.513 P=0.513 | P=0.059N P=0.339N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.8% 7.6% 5.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/34 (3%) 0/32 (0%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 654 596 637 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411 P=0.347 P=0.506 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.541 P=0.476 P=0.694 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.408 P=0.290 P=0.507 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.407 | (e) |
|FISHER EXACT | P=0.316 P=0.508 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 9/50 (18%) 10/50 (20%) | 4/50 (8%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 22.9% 23.5% 26.5% | 10.5% 0.0% 7.7% |
|TERMINAL (d) | 4/33 (12%) 6/34 (18%) 6/32 (19%) | 0/30 (0%) 0/28 (0%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 538 581 561 | 637 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.456 P=0.537N P=0.507 | P=0.273N P=0.085N P=0.407N |
|INCIDENTAL TUMOR | P=0.509 P=0.550N P=0.560 | P=0.289N P=0.109N P=0.427N |
|LOGISTIC REGRESSION | P=0.467 P=0.577N P=0.519 | P=0.249N P=0.060N P=0.374N |
|COCHRAN-ARMITAGE | P=0.468 | P=0.222N |
|FISHER EXACT | P=0.584N P=0.520 | P=0.059N P=0.339N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 6/50 (12%) 7/50 (14%) | 4/50 (8%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 12.9% 15.3% 18.0% | 10.5% 0.0% 7.7% |
|TERMINAL (d) | 1/33 (3%) 3/34 (9%) 3/32 (9%) | 0/30 (0%) 0/28 (0%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 580 581 561 | 637 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.341 P=0.557 P=0.401 | P=0.273N P=0.085N P=0.407N |
|INCIDENTAL TUMOR | P=0.485 P=0.620 P=0.585 | P=0.289N P=0.109N P=0.427N |
|LOGISTIC REGRESSION | P=0.336 P=0.495 P=0.393 | P=0.249N P=0.060N P=0.374N |
|COCHRAN-ARMITAGE | P=0.335 | P=0.222N |
|FISHER EXACT | P=0.514 P=0.394 | P=0.059N P=0.339N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.9% 6.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/34 (3%) 2/32 (6%) | 0/30 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 P=0.506 P=0.231 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.135 P=0.506 P=0.231 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.135 P=0.506 P=0.231 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.145 | (e) |
|FISHER EXACT | P=0.505 P=0.253 | (e) (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 10.0% 0.0% 0.0% |
|TERMINAL (d) | | 3/30 (10%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.046N* P=0.132N P=0.146N |
|INCIDENTAL TUMOR | | P=0.046N* P=0.132N P=0.146N |
|LOGISTIC REGRESSION | | P=0.046N* P=0.132N P=0.146N |
|COCHRAN-ARMITAGE | | P=0.037N* |
|FISHER EXACT | | P=0.121N P=0.121N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | | 12.6% 3.6% 0.0% |
|TERMINAL (d) | | 3/30 (10%) 1/28 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | | 707 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.036N* P=0.205N P=0.086N |
|INCIDENTAL TUMOR | | P=0.036N* P=0.223N P=0.083N |
|LOGISTIC REGRESSION | | P=0.035N* P=0.211N P=0.081N |
|COCHRAN-ARMITAGE | | P=0.026N* |
|FISHER EXACT | | P=0.181N P=0.059N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.6% 6.3% | 3.3% 0.0% 2.3% |
|TERMINAL (d) | 0/33 (0%) 0/34 (0%) 2/32 (6%) | 1/30 (3%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 707 729 (T) | 729 (T) --- 474 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140 P=0.516 P=0.231 | P=0.638 P=0.514N P=0.730 |
|INCIDENTAL TUMOR | P=0.151 P=0.739 P=0.231 | P=0.506N P=0.514N P=0.592N |
|LOGISTIC REGRESSION | P=0.142 P=0.520 P=0.231 | P=0.638N P=0.514N P=0.697N |
|COCHRAN-ARMITAGE | P=0.145 | P=0.669N |
|FISHER EXACT | P=0.505 P=0.253 | P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 5.1% 6.3% | 3.3% 2.3% 5.5% |
|TERMINAL (d) | 0/33 (0%) 0/34 (0%) 2/32 (6%) | 1/30 (3%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- 705 729 (T) | 729 (T) 499 474 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175 P=0.264 P=0.231 | P=0.332 P=0.741 P=0.448 |
|INCIDENTAL TUMOR | P=0.206 P=0.527 P=0.231 | P=0.628 P=0.616N P=0.669 |
|LOGISTIC REGRESSION | P=0.178 P=0.258 P=0.231 | P=0.431 P=0.729N P=0.565 |
|COCHRAN-ARMITAGE | P=0.180 | P=0.378 |
|FISHER EXACT | P=0.253 P=0.253 | P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 4/50 (8%) 6/50 (12%) | 18/50 (36%) 9/50 (18%) 11/50 (22%) |
|ADJUSTED (b) | 8.3% 11.0% 16.6% | 49.6% 26.6% 32.9% |
|TERMINAL (d) | 2/33 (6%) 3/34 (9%) 3/32 (9%) | 12/30 (40%) 5/28 (18%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 575 678 608 | 653 585 409 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.188 P=0.534 P=0.248 | P=0.162N P=0.073N P=0.213N |
|INCIDENTAL TUMOR | P=0.246 P=0.565 P=0.346 | P=0.127N P=0.094N P=0.129N |
|LOGISTIC REGRESSION | P=0.193 P=0.542 P=0.253 | P=0.125N P=0.065N P=0.177N |
|COCHRAN-ARMITAGE | P=0.195 | P=0.068N |
|FISHER EXACT | P=0.511 P=0.254 | P=0.035N* P=0.093N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 4/50 (8%) 6/50 (12%) | 18/50 (36%) 9/50 (18%) 11/50 (22%) |
|ADJUSTED (b) | 8.3% 11.0% 16.6% | 49.6% 26.6% 32.9% |
|TERMINAL (d) | 2/33 (6%) 3/34 (9%) 3/32 (9%) | 12/30 (40%) 5/28 (18%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 575 678 608 | 653 585 409 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.188 P=0.534 P=0.248 | P=0.162N P=0.073N P=0.213N |
|INCIDENTAL TUMOR | P=0.246 P=0.565 P=0.346 | P=0.127N P=0.094N P=0.129N |
|LOGISTIC REGRESSION | P=0.193 P=0.542 P=0.253 | P=0.125N P=0.065N P=0.177N |
|COCHRAN-ARMITAGE | P=0.195 | P=0.068N |
|FISHER EXACT | P=0.511 P=0.254 | P=0.035N* P=0.093N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 20/50 (40%) 15/50 (30%) | 17/50 (34%) 5/50 (10%) 19/50 (38%) |
|ADJUSTED (b) | 41.2% 46.5% 45.0% | 52.9% 15.8% 58.4% |
|TERMINAL (d) | 12/33 (36%) 12/34 (35%) 14/32 (44%) | 15/30 (50%) 3/28 (11%) 13/26 (50%) |
|FIRST INCIDENCE (DAYS) | 538 533 604 | 696 588 474 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.525 P=0.281 P=0.563 | P=0.218 P=0.006N** P=0.225 |
|INCIDENTAL TUMOR | P=0.503 P=0.289 P=0.520 | P=0.229 P=0.008N** P=0.252 |
|LOGISTIC REGRESSION | P=0.506N P=0.288 P=0.543N | P=0.207 P=0.007N** P=0.204 |
|COCHRAN-ARMITAGE | P=0.514N | P=0.368 |
|FISHER EXACT | P=0.222 P=0.560N | P=0.004N** P=0.418 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 2.5% 5.0% | UNTREATD 2.5% 5.0% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 21/49 (43%) 23/50 (46%) 17/50 (34%) | 22/50 (44%) 11/50 (22%) 17/50 (34%) |
|ADJUSTED (b) | 51.2% 48.2% 39.9% | 55.9% 30.4% 50.0% |
|TERMINAL (d) | 13/33 (39%) 10/34 (29%) 7/32 (22%) | 13/30 (43%) 5/28 (18%) 10/26 (38%) |
|FIRST INCIDENCE (DAYS) | 575 533 561 | 609 499 409 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264N P=0.546 P=0.295N | P=0.352N P=0.053N P=0.415N |
|INCIDENTAL TUMOR | P=0.091N P=0.494N P=0.055N | P=0.242N P=0.045N* P=0.288N |
|LOGISTIC REGRESSION | P=0.096N P=0.393N P=0.116N | P=0.261N P=0.029N* P=0.347N |
|COCHRAN-ARMITAGE | P=0.212N | P=0.170N |
|FISHER EXACT | P=0.455 P=0.242N | P=0.016N* P=0.206N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 32/49 (65%) 34/50 (68%) 31/50 (62%) | 30/50 (60%) 16/50 (32%) 29/50 (58%) |
|ADJUSTED (b) | 74.3% 69.3% 71.8% | 76.6% 42.9% 77.8% |
|TERMINAL (d) | 22/33 (67%) 19/34 (56%) 20/32 (63%) | 21/30 (70%) 8/28 (29%) 18/26 (69%) |
|FIRST INCIDENCE (DAYS) | 440 533 561 | 609 499 409 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.473N P=0.551N P=0.513N | P=0.349 P=0.025N* P=0.346 |
|INCIDENTAL TUMOR | P=0.375N P=0.450N P=0.356N | P=0.447 P=0.018N* P=0.486 |
|LOGISTIC REGRESSION | P=0.377N P=0.424N P=0.445N | P=0.399 P=0.012N* P=0.353 |
|COCHRAN-ARMITAGE | P=0.404N | P=0.460N |
|FISHER EXACT | P=0.472 P=0.447N | P=0.004N** P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05007 TEST: 05 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- POLYSORBATE 80
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).