TDMS Study 05007-05 Pathology Tables
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
Facility: Southern Research Institute
Chemical CAS #: 9005-65-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + M + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 1 |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + A + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Fatty Change | |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 4 1 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 2 |
Inflammation, Acute | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Hyperplasia | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + A + + + + + + + + + |
Abscess | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + |
Hyperplasia, Squamous | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Chronic Active | |
Mineralization | 2 2 |
Mucosa, Ectasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 2 2 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Ventricle, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | X |
Degeneration, Fatty | 2 |
Hyperplasia | 2 |
Inflammation, Acute | |
Pigmentation | 1 2 2 2 1 2 2 2 2 2 2 2 1 2 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + A + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M + + + M + + + + M + + + M + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 |
Follicle, Ectasia | 3 2 2 |
Follicle, Hyperplasia | 1 |
Follicular Cell, Ectasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + M |
Abscess | 4 4 4 4 |
Angiectasis | 2 |
Hemorrhage | 3 |
Mineralization | |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Angiectasis | |
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 3 3 4 3 3 3 3 3 3 3 3 3 3 2 3 3 3 |
Endometrium, Inflammation, Acute | 3 4 3 3 |
Endometrium, Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Infiltration Cellular, Lymphocyte | |
Myelofibrosis | 2 2 3 3 2 2 3 3 3 |
Myeloid Cell, Hyperplasia | 4 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M M + + + + + + + + |
Angiectasis | |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 3 2 3 |
Inflammation, Acute | 2 3 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 4 2 2 2 3 2 2 3 2 3 2 3 2 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 |
Inflammation, Acute | 3 3 |
Pigmentation | 2 2 1 1 2 2 2 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Edema | |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Acinus, Ectasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 2 3 2 1 1 1 2 1 1 |
Inflammation, Chronic Active | |
Inflammation, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Congestion | 2 3 |
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Arteriole, Inflammation, Chronic | |
Active | |
Interstitium, Inflammation, Acute | 2 2 |
Mediastinum, Atypia Cellular | |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + |
Lumen, Hemorrhage | 2 1 2 2 2 2 2 1 1 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | 2 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|
| 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Capsule, Inflammation, Chronic Active| |
Renal Tubule, Casts Protein | 1 2 1 2 |
Renal Tubule, Ectasia | 1 2 1 1 1 1 2 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 1 1 2 2 1 |
Renal Tubule, Regeneration | 1 2 2 2 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Serosa, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Fatty Change | 2 |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 1 2 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 1 2 2 |
Inflammation, Acute | 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Hepatocyte, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Acute | 3 4 4 |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 2 1 |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + M + + + M + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Squamous | 3 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
Mucosa, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic Active | |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Cyst | |
Degeneration, Fatty | |
Hyperplasia | 2 |
Inflammation, Acute | 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 |
Spindle Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M M M M + M + + + + M M M M |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + M + + + + + + + + + + M + |
Congestion | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 |
Follicle, Ectasia | 2 2 2 |
Follicle, Hyperplasia | 2 |
Follicular Cell, Ectasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 4 4 4 |
Angiectasis | |
Hemorrhage | 3 |
Mineralization | 3 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Angiectasis | 2 |
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 3 3 4 2 3 4 2 3 3 4 3 |
Endometrium, Inflammation, Acute | 3 2 3 4 4 |
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Infiltration Cellular, Lymphocyte | |
Myelofibrosis | 2 3 2 3 1 2 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 4 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + + M + + + + |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 2 2 3 2 2 1 |
Pigmentation | 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Congestion | 3 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 3 3 2 3 2 |
Inflammation, Acute | 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 2 4 2 2 3 3 2 3 2 4 2 1 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
Inflammation, Acute | 3 3 |
Pigmentation | 2 1 1 1 2 2 2 1 2 2 2 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + |
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Edema | |
Hyperplasia, Lymphoid | 3 3 2 2 2 2 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + |
Acinus, Ectasia | 2 2 3 2 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | |
Inflammation, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 2 1 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Congestion | |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Arteriole, Inflammation, Chronic | |
Active | 2 |
Interstitium, Inflammation, Acute | |
Mediastinum, Atypia Cellular | X |
Mediastinum, Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 1 1 1 |
Mucosa, Inflammation, Acute | 1 |
Nasolacrimal Duct, Hemorrhage | 2 2 2 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|
| 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 3 |
Capsule, Inflammation, Chronic Active| |
Renal Tubule, Casts Protein | 3 2 2 2 |
Renal Tubule, Ectasia | 3 2 1 2 1 2 1 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | 3 1 1 1 |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | 3 |
Serosa, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + | 46 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 | 20 1.9|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 48 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 48 |
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + M + | 47 |
Serosa, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
Serosa, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Fatty Change | 2 | 2 2.0|
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 2 2 2 2 1 | 20 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 | 23 1.8|
Inflammation, Acute | | 3 2.0|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Inflammation, Acute | | 4 3.5|
Inflammation, Chronic Active | 4 | 2 3.5|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + M | 47 |
Abscess | | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 2 2 2 | 21 1.8|
Inflammation, Chronic Active | 4 | 1 4.0|
Acinus, Atrophy | | 2 3.0|
Duct, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 46 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 1 2 2 | 40 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | 2 | 4 2.3|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic Active | 2 | 2 2.5|
Mineralization | | 2 1.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 | 15 2.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 3 2.0|
Mucosa, Ectasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 9 1.6|
Inflammation, Acute | | 3 1.7|
Inflammation, Chronic Active | 2 | 1 2.0|
Ventricle, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
Capsule, Inflammation, Chronic Active| 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Cyst | | 1 |
Degeneration, Fatty | 3 3 | 3 2.7|
Hyperplasia | | 2 2.0|
Inflammation, Acute | 3 | 2 2.0|
Pigmentation | 2 2 2 1 1 1 2 1 | 35 1.8|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 50 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M | 47 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + M M M M | 26 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 46 |
Congestion | | 1 2.0|
Pars Distalis, Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 | 8 1.8|
Follicle, Ectasia | 2 2 | 8 2.1|
Follicle, Hyperplasia | 2 | 3 1.7|
Follicular Cell, Ectasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 48 |
Abscess | 4 | 9 4.0|
Angiectasis | | 1 2.0|
Hemorrhage | | 2 3.0|
Mineralization | | 1 3.0|
Follicle, Cyst | X | 3 |
Periovarian Tissue, Cyst | X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Abscess | | 2 4.0|
Angiectasis | | 1 2.0|
Hydrometra | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 4 3 3 2 3 3 3 2 3 | 44 3.0|
Endometrium, Inflammation, Acute | | 9 3.2|
Endometrium, Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Angiectasis | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Myelofibrosis | 1 3 2 2 2 | 21 2.3|
Myeloid Cell, Hyperplasia | 2 2 2 2 | 34 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Iliac, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 2.0|
Renal, Hyperplasia, Lymphoid | | 2 3.0|
Renal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 46 |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 3 2 2 | 39 2.1|
Pigmentation | 2 2 2 2 2 2 2 2 | 24 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Angiectasis | | 1 2.0|
Congestion | 4 | 4 3.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 | 24 2.3|
Inflammation, Acute | 3 | 4 2.5|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 4 3 2 3 2 | 46 2.4|
Hyperplasia, Lymphoid | 2 2 2 2 2 | 19 2.0|
Inflammation, Acute | | 4 3.0|
Pigmentation | 2 1 2 2 2 2 2 2 | 28 1.8|
Capsule, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Cyst | X | 6 |
Edema | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 3 3 | 18 2.3|
Inflammation, Acute | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 49 |
Acinus, Ectasia | 2 2 1 2 1 | 9 1.9|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Inflammation, Chronic | 2 2 1 1 | 18 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Mineralization | 2 2 2 2 1 2 2 2 | 26 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Congestion | | 2 2.5|
Hemorrhage | | 2 1.5|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 1 2 2 | 48 1.9|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 4 2.0|
Arteriole, Inflammation, Chronic | | |
Active | | 1 2.0|
Interstitium, Inflammation, Acute | | 2 2.0|
Mediastinum, Atypia Cellular | | 1 |
Mediastinum, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
Lumen, Hemorrhage | 1 2 1 2 2 1 | 20 1.6|
Mucosa, Inflammation, Acute | | 1 1.0|
Nasolacrimal Duct, Hemorrhage | 2 | 7 1.9|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 1 | 48 2.0|
Respiratory Epithelium, Degeneration | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 3 2 2 2 2 | 43 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Metaplasia, Osseous | 3 3 | 3 3.0|
Capsule, Inflammation, Chronic Active| 2 | 1 2.0|
Renal Tubule, Casts Protein | 1 1 1 1 | 12 1.6|
Renal Tubule, Ectasia | 1 1 2 1 2 | 20 1.5|
Renal Tubule, Mineralization | 1 | 2 1.5|
Renal Tubule, Necrosis | 1 2 1 1 3 1 1 | 16 1.4|
Renal Tubule, Regeneration | 2 1 1 3 2 | 15 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 32 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 3.0|
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + M + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + M + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + +|
Cytomegaly | 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 1 1 1 3 2 3 4 1 2|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 1 1 2 2 |
Inflammation, Acute | 2 |
Necrosis | |
Serosa, Inflammation, Acute | 3 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Acute | 3 3 4 4|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 |
Inflammation, Acute | 2|
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | 2 2 3 3 2 2 2 2 2 2 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Acute | 2 2 2 |
Inflammation, Chronic Active | 2 2 2 3 2 |
Inflammation, Subacute | |
Ulcer | 4 3 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | 4 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 |
Inflammation, Acute | 2 3 |
Inflammation, Chronic | |
Epicardium, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Acute | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Degeneration, Fatty | |
Inflammation, Acute | 2 |
Pigmentation | 2 2 2 2 1 1 2 2 2 1 2 2 1|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + M M M + + + M + M + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 2 1 2|
Inflammation, Chronic | |
Follicle, Ectasia | 2 2|
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4|
Hemorrhage | 4 |
Mineralization | |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | 2 |
Hydrometra | |
Endometrium, Abscess | 4|
Endometrium, Hyperplasia, Cystic | 2 4 3 4 3 2 2 2 4 2 2 2 3 3 4 3 3 3|
Endometrium, Inflammation, Acute | 2 4 2 2 4 |
Endometrium, Metaplasia, Squamous | |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 2 4 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 4 3 2 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 2 3|
Mediastinal, Inflammation, Acute | 4 |
Renal, Hyperplasia, Lymphoid | 3 3 3 |
Renal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + M + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | |
Pigmentation | 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 2 2 3 2 2 2 2 2 2|
Inflammation, Acute | 3 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation | 4 2 2 2 4 4 3 2 2 3 4 4 2 3 4|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 |
Inflammation, Acute | 3 2 3 |
Pigmentation | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M M + +|
Cyst | X X X |
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M M + + +|
Acinus, Ectasia | 1 2 2 2 2 |
Duct, Ectasia | 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 2 2 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Gliosis | 2 |
Hemorrhage | |
Hydrocephalus | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 2 2 1 2 2 2 2 2 2 2 2|
Meninges, Hemorrhage | |
Meninges, Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Inflammation, Acute | 2 |
Interstitium, Inflammation, Acute | 2 3 2 |
Interstitium, Inflammation, Chronic | |
Interstitium, Inflammation, Chronic | |
Active | |
Mediastinum, Inflammation, Acute | 4 |
Peribronchial, Inflammation, Acute | 4 |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 3 2 |
Nasolacrimal Duct, Hemorrhage | 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|
| 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 |
Metaplasia, Osseous | |
Mineralization | |
Renal Tubule, Casts Protein | 2 2 2 2 1 |
Renal Tubule, Ectasia | 2 2 2 3 1 |
Renal Tubule, Necrosis | 2 1 2 1|
Renal Tubule, Regeneration | 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + M + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + A + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 2 2 3 1 1 1 2|
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 1 2 2 1 |
Inflammation, Acute | 2 3 |
Necrosis | 2 3 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Acute | 3 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | 2 2 3 2 2 1 2 3 2|
Infiltration Cellular, Lymphocyte | 2 2 2|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 |
Inflammation, Subacute | 1 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2|
Inflammation, Acute | 2|
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Inflammation, Acute | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Epicardium, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Acute | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Fatty | 3 |
Inflammation, Acute | |
Pigmentation | 2 2 1 2 2 2 2 2 2 2 2|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Parathyroid Gland | + M M + M + + M M + M + + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Follicle, Ectasia | 3 2 |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4 |
Hemorrhage | |
Mineralization | 2 |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | |
Hydrometra | |
Endometrium, Abscess | |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 3 3 3 4 2 3 4 3 3 2 3 3|
Endometrium, Inflammation, Acute | 2 3 2 3 2 2 2 3|
Endometrium, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 2 2 |
Myeloid Cell, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Inflammation, Acute | 4 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
Inflammation, Acute | |
Pigmentation | 2 2 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 1 3|
Inflammation, Acute | |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 2 2 1 2 3 2 3 2 2 2 2 2 2 3 2 2 2 4|
Hyperplasia, Lymphoid | 2 2 3 |
Inflammation, Acute | |
Pigmentation | 1 2 1 2 1 2 2 2 1 2 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
Hyperplasia, Lymphoid | 2 2 2 2 2 2|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 1 2 2 2 |
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 2 2 2 1|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | |
Gliosis | |
Hemorrhage | |
Hydrocephalus | |
Infiltration Cellular, Lymphocyte | |
Mineralization | 2 2 2 2 1 2 2 2 1 2 2|
Meninges, Hemorrhage | 2 |
Meninges, Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 2 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 1 |
Bronchiole, Inflammation, Acute | |
Interstitium, Inflammation, Acute | 2 |
Interstitium, Inflammation, Chronic | 3|
Interstitium, Inflammation, Chronic | |
Active | |
Mediastinum, Inflammation, Acute | 2 |
Peribronchial, Inflammation, Acute | |
Pleura, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 1 2 2|
Nasolacrimal Duct, Hemorrhage | 2 2 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|
DAY ON TEST | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|
| 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 4 |
Metaplasia, Osseous | |
Mineralization | 1 |
Renal Tubule, Casts Protein | 2 1 1 2 |
Renal Tubule, Ectasia | 2 1 1 2 1 2 |
Renal Tubule, Necrosis | 2 1 1 2 1 |
Renal Tubule, Regeneration | 2 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 2 2 2 | 17 1.9|
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 49 |
Cytomegaly | | 1 3.0|
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 2 2 1 2 | 21 1.9|
Infiltration Cellular, Lymphocyte | 2 2 2 2 | 23 1.7|
Inflammation, Acute | 2 1 | 5 2.0|
Necrosis | | 2 2.5|
Serosa, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 13 |
Inflammation, Acute | 3 | 8 3.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 3 2 2 2 | 15 1.9|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | M M + + + + + + + + | 46 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 | 31 2.0|
Acinus, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Erosion | 2 | 1 2.0|
Hyperplasia, Squamous | 1 3 2 4 2 2 | 26 2.2|
Infiltration Cellular, Lymphocyte | 2 | 6 2.0|
Inflammation, Acute | | 3 2.0|
Inflammation, Chronic Active | 2 4 3 1 1 | 13 2.2|
Inflammation, Subacute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 1 | 7 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 2 | 13 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 3 2.0|
Mucosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Embolus Bacterial | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 1 | 8 1.3|
Inflammation, Acute | | 3 2.3|
Inflammation, Chronic | | 1 2.0|
Epicardium, Inflammation, Acute | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
Capsule, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Congestion | | 2 2.5|
Degeneration, Fatty | 2 2 3 | 4 2.5|
Inflammation, Acute | | 1 2.0|
Pigmentation | 2 2 1 2 2 2 2 2 | 32 1.8|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 49 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + | 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + M M + + | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 48 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 8 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | M M + + + + + M + + | 46 |
Infiltration Cellular, Lymphocyte | 1 2 | 5 1.6|
Inflammation, Chronic | | 1 2.0|
Follicle, Ectasia | 2 | 5 2.2|
Follicle, Hyperplasia | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Abscess | 4 4 4 4 | 16 4.0|
Hemorrhage | | 1 4.0|
Mineralization | | 1 2.0|
Follicle, Cyst | | 3 |
Periovarian Tissue, Cyst | X X X X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Angiectasis | | 1 2.0|
Hydrometra | 3 | 1 3.0|
Endometrium, Abscess | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 4 3 2 3 3 3 | 45 2.8|
Endometrium, Inflammation, Acute | 3 2 2 1 | 17 2.4|
Endometrium, Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Vagina | + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Myelofibrosis | 2 1 1 2 1 | 13 1.8|
Myeloid Cell, Hyperplasia | 2 3 2 3 2 2 2 2 | 38 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 6 2.2|
Mediastinal, Inflammation, Acute | | 2 4.0|
Renal, Hyperplasia, Lymphoid | 2 4 | 6 3.0|
Renal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + | 46 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 | 39 2.1|
Inflammation, Acute | 3 | 1 3.0|
Pigmentation | 2 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 3 2 2 | 32 2.1|
Inflammation, Acute | 3 | 3 2.7|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 3 3 3 2 4 3 3 2 2 | 44 2.7|
Hyperplasia, Lymphoid | 2 | 11 2.1|
Inflammation, Acute | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 2 2 1 1 2 1 | 26 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Cyst | | 7 |
Hyperplasia, Lymphoid | 2 3 2 | 12 2.1|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 48 |
Acinus, Ectasia | 2 2 2 2 | 13 1.8|
Duct, Ectasia | | 4 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Inflammation, Chronic | 2 2 2 1 | 15 1.7|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cranium, Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | | 1 |
Gliosis | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 2 2 2 2 2 | 27 1.9|
Meninges, Hemorrhage | | 1 2.0|
Meninges, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 2 | 4 2.5|
Hemorrhage | | 3 1.7|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 42 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3| | |
| 9| 4| 9| 4| 4| 7| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Inflammation, Acute | | 1 2.0|
Interstitium, Inflammation, Acute | 2 | 5 2.2|
Interstitium, Inflammation, Chronic | | 1 3.0|
Interstitium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Mediastinum, Inflammation, Acute | 2 | 3 2.7|
Peribronchial, Inflammation, Acute | | 1 4.0|
Pleura, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lumen, Hemorrhage | 1 2 2 1 | 13 1.8|
Nasolacrimal Duct, Hemorrhage | 1 2 | 11 1.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 | 49 2.0|
__________________________________________________________________________|____________|
Trachea | M M + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 | 40 2.0|
Inflammation, Acute | | 2 3.5|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | | 1 1.0|
Renal Tubule, Casts Protein | 2 1 | 11 1.6|
Renal Tubule, Ectasia | 1 2 2 1 | 15 1.7|
Renal Tubule, Necrosis | 1 2 | 11 1.5|
Renal Tubule, Regeneration | 2 1 | 11 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 | 35 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M |
Infiltration Cellular, Lymphocyte | 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 1 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + M + M + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Erosion | |
Hyperplasia, Squamous | 2 2 2 |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | 2|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Pigmentation | 1 1 2 |
Spindle Cell, Hyperplasia | 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + M + |
Follicle, Ectasia | |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Abscess | 4 4 4 4 4 |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | 2 2 2 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Abscess | 3 4 |
Hydrometra | |
Endometrium, Angiectasis | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 2 2 3 2 2 2 4 3 |
Endometrium, Inflammation, Acute | 2 2 |
Endometrium, Metaplasia, Squamous | |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + A + |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 |
Mediastinal, Inflammation, Acute | 4 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 3 |
Renal, Inflammation, Acute | 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + |
Hyperplasia, Lymphoid | 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + |
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + |
Hematopoietic Cell Proliferation | 3 4 2 3 2 3 2 3 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Pigmentation | |
Capsule, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + |
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + |
Acinus, Ectasia | |
Duct, Ectasia | 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 |
Head, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Hydrocephalus | |
Mineralization | 1 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Acute | 3 2 |
Mediastinum, Inflammation, Acute | 3 |
Peribronchial, Inflammation, Acute | |
Pleura, Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + |
Lumen, Hemorrhage | 2 |
Nasolacrimal Duct, Hemorrhage | 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|
| 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Amyloid Deposition | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Ectasia | 2 1 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + M + + + M + + + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + A + |
__________________________________________________________________________|
Intestine Small | M + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Lymphocyte | 1 2 1 |
Inflammation, Acute | |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Cyst | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Erosion | 2 |
Hyperplasia, Squamous | 2 2 1 1 2 |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Pigmentation | 1 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M M M + + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
Follicle, Ectasia | 2 |
Follicle, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + |
Abscess | 4 4 4 4 4 4 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | 2 2 X 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hydrometra | 3 |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 1 3 3 2 4 3 2 4 4 2 3 3 3 3 2 3 3 3 3|
Endometrium, Inflammation, Acute | 4 2 2 3 4 2 2|
Endometrium, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Inflammation, Acute | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 3 3 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + + M + |
Hyperplasia, Lymphoid | 2 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | M + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 2 3 2 3 3 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Acute | 4 |
Pigmentation | 2 2 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + M + |
Acinus, Ectasia | 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Head, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Hydrocephalus | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Congestion | 4 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Acute | |
Mediastinum, Inflammation, Acute | |
Peribronchial, Inflammation, Acute | |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 2 |
Nasolacrimal Duct, Hemorrhage | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|
DAY ON TEST | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|
| 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
Amyloid Deposition | 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 3 |
Renal Tubule, Casts Protein | |
Renal Tubule, Ectasia | |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + M + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 18 |
Infiltration Cellular, Lymphocyte | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + | 17 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + | 25 |
Hematopoietic Cell Proliferation | 2 2 | 6 1.8|
Infiltration Cellular, Lymphocyte | | 4 1.5|
Inflammation, Acute | 2 | 1 2.0|
Necrosis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Cyst | X | 1 |
Inflammation, Acute | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 22 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | M + + | 18 |
Infiltration Cellular, Lymphocyte | 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Erosion | | 1 2.0|
Hyperplasia, Squamous | | 8 1.8|
Inflammation, Acute | | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 | 9 2.0|
Mineralization | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 22 |
Infiltration Cellular, Lymphocyte | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 22 |
Pigmentation | | 5 1.4|
Spindle Cell, Hyperplasia | 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 22 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + | 20 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | M + + | 19 |
Follicle, Ectasia | 2 | 2 2.0|
Follicle, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 36 |
Abscess | 4 4 | 13 4.0|
Follicle, Cyst | | 1 2.0|
Periovarian Tissue, Cyst | 2 2 2 | 13 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + | 42 |
Abscess | 4 | 3 3.7|
Hydrometra | | 1 3.0|
Endometrium, Angiectasis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 2 | 37 2.6|
Endometrium, Inflammation, Acute | 4 | 10 2.7|
Endometrium, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 22 |
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 2 | 14 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + | 26 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Inflammation, Acute | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 3 | 6 3.0|
Renal, Inflammation, Acute | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + | 16 |
Hyperplasia, Lymphoid | 2 2 | 9 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + | 23 |
Congestion | | 2 2.5|
Hyperplasia, Lymphoid | 3 | 9 2.2|
__________________________________________________________________________|____________|
Spleen | + + + | 25 |
Hematopoietic Cell Proliferation | 2 2 3 | 18 2.7|
Hyperplasia, Lymphoid | 2 | 5 2.0|
Inflammation, Acute | | 1 4.0|
Pigmentation | 2 | 4 2.0|
Capsule, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + | 20 |
Hyperplasia, Lymphoid | 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 19 |
Acinus, Ectasia | | 1 1.0|
Duct, Ectasia | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Skin | + + + | 38 |
Inflammation, Chronic | 2 | 6 2.0|
Head, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 22 |
Hydrocephalus | 3 | 1 3.0|
Mineralization | 2 2 | 9 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 22 |
Congestion | 3 | 4 2.8|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| | |
DAY ON TEST | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3| | |
| 8| 8| 8| 8| 8| 7| 9| 7| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 2 2 2 | 18 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Interstitium, Inflammation, Acute | | 2 2.5|
Mediastinum, Inflammation, Acute | | 1 3.0|
Peribronchial, Inflammation, Acute | 2 | 1 2.0|
Pleura, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + | 22 |
Lumen, Hemorrhage | 2 | 5 2.0|
Nasolacrimal Duct, Hemorrhage | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 2 | 19 1.9|
__________________________________________________________________________|____________|
Trachea | M + + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 23 |
Amyloid Deposition | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 2 | 14 1.9|
Inflammation, Acute | | 2 4.0|
Inflammation, Chronic Active | | 1 3.0|
Renal Tubule, Casts Protein | | 1 2.0|
Renal Tubule, Ectasia | | 2 1.5|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + | 18 |
Infiltration Cellular, Lymphocyte | 2 2 | 11 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + M + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Cytomegaly | |
Fatty Change | 2 |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 2 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 |
Necrosis | 2 4 |
Vacuolization Cytoplasmic | |
Portal, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Squamous | 2 3 |
Infiltration Cellular, Lymphocyte | 1 2 |
Mineralization | 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | |
Mineralization | 2 2 |
Mucosa, Ectasia | |
Mucosa, Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Pulp, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hypertrophy | 2 |
Spindle Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + M M M + M M M + M M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | |
Follicle, Ectasia | |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 4 3 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Ectasia | |
Infiltration Cellular, Lymphocyte | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Atypia Cellular | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 |
Pigmentation | 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 2 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 3 3 2 2 3 2 2 2 2 2 |
Hyperplasia | |
Inflammation, Acute | 2 3 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 4 2 2 4 4 4 2 4 2 3 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Inflammation, Chronic | 3 3 3 2 1 3 2 2 2 3 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Ulcer | 4 4 |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 2 |
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 2 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 |
Alveolus, Inflammation, Acute | |
Bronchiole, Inflammation, Acute | 1 1 |
Bronchiole, Inflammation, Chronic | |
Active | 2 |
Interstitium, Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 3 2 2 2 2 2 2 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 |
Metaplasia, Osseous | |
Glomerulus, Ectasia | 2 |
Renal Tubule, Casts Protein | 1 2 1 2 |
Renal Tubule, Ectasia | 1 2 2 2 |
Renal Tubule, Mineralization | 1 2 2 2 |
Renal Tubule, Necrosis | 1 2 2 1 1 2 1 |
Renal Tubule, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|
DAY ON TEST | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|
| 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 2 1 2 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + M + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Cytomegaly | 3 |
Fatty Change | 1 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 3 2 1 1 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
Necrosis | 4 |
Vacuolization Cytoplasmic | |
Portal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + |
Infiltration Cellular | |
Infiltration Cellular, Lymphocyte | 2 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + |
Hyperplasia, Squamous | |
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | 1 3 2 2 |
Inflammation, Chronic Active | 1 |
Mineralization | |
Mucosa, Ectasia | 2 2 |
Mucosa, Erosion | 2 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hypertrophy | 2 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M M + + + + + + M M + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Ectasia | 2 |
Follicle, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 3 |
Inflammation, Chronic Active | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + |
Ectasia | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Atypia Cellular | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + |
Congestion | 3 3 2 3 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 3 4 1 3 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
Pigmentation | 2 2 2 1 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Erosion | |
Inflammation, Chronic | 3 3 3 3 3 2 2 |
Inflammation, Chronic Active | 3 3 3 4 |
Metaplasia, Osseous | 4 |
Ulcer | 3 3 4 4 4 |
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Alveolus, Inflammation, Acute | |
Bronchiole, Inflammation, Acute | 1 |
Bronchiole, Inflammation, Chronic | |
Active | |
Interstitium, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 2 2 2 1 1 2 2 2 |
Mucosa, Inflammation, Acute | 2 |
Nasolacrimal Duct, Hemorrhage | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 1 1 2 2 2 |
Respiratory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Osseous | 2 2 |
Glomerulus, Ectasia | |
Renal Tubule, Casts Protein | |
Renal Tubule, Ectasia | 2 |
Renal Tubule, Mineralization | 2 2 1 1 1 |
Renal Tubule, Necrosis | 1 2 |
Renal Tubule, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|
DAY ON TEST | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|
| 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 2 2 2 1 2 2 2 1 2 1 2 2 2 |
__________________________________________________________________________|
Urethra | + + + + |
Calculus Micro Observation Only | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 44 |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 | 15 1.9|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 46 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 49 |
Cytomegaly | | 1 3.0|
Fatty Change | | 3 1.7|
Focal Cellular Change | X | 2 |
Hematopoietic Cell Proliferation | 2 1 | 9 1.6|
Infiltration Cellular, Lymphocyte | 2 2 | 12 1.8|
Necrosis | | 3 3.3|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Portal, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
Infiltration Cellular | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 1 | 7 1.9|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 38 2.0|
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 48 |
Hyperplasia, Squamous | 2 | 3 2.3|
Infiltration Cellular, Lymphocyte | | 3 1.7|
Mineralization | | 1 2.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 | 13 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 5 2.2|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 2 2.0|
Mucosa, Ectasia | 2 1 | 4 1.8|
Mucosa, Erosion | | 3 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Cyst | X | 1 |
Hypertrophy | 2 2 2 2 | 7 2.0|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 48 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + + + + + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 47 |
Pars Distalis, Hyperplasia | | 2 2.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Ectasia | | 1 2.0|
Follicle, Hyperplasia | | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 19 1.8|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 13 |
Abscess | 4 | 4 4.0|
Inflammation, Chronic | 3 | 3 2.7|
Inflammation, Chronic Active | | 4 3.3|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 49 |
Ectasia | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 49 |
Ectasia | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 | 16 2.0|
Seminiferous Tubule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Atypia Cellular | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Myelofibrosis | | 2 2.0|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 35 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 3 2 | 40 2.0|
Pigmentation | 2 | 10 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Congestion | 2 2 2 2 | 12 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 | 33 2.1|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 5 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 48 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 1 | 26 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 7 2.0|
Pigmentation | 1 1 | 11 1.5|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 47 |
Cyst | X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Erosion | | 1 2.0|
Inflammation, Chronic | 2 | 18 2.5|
Inflammation, Chronic Active | | 4 3.3|
Metaplasia, Osseous | | 1 4.0|
Ulcer | 3 | 8 3.6|
Subcutaneous Tissue, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 49 |
Mineralization | 2 1 2 2 2 2 2 2 | 40 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 49 |
Congestion | 2 | 4 2.3|
Hemorrhage | 2 | 5 1.6|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 1 2 2 2 | 42 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 6 2.2|
Alveolus, Inflammation, Acute | 1 | 1 1.0|
Bronchiole, Inflammation, Acute | 1 | 4 1.0|
Bronchiole, Inflammation, Chronic | | |
Active | | 1 2.0|
Interstitium, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
Lumen, Hemorrhage | 2 2 2 1 2 2 | 24 1.9|
Mucosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Hemorrhage | 2 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 1 2 2 2 2 2 | 26 1.9|
Respiratory Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 | 43 2.0|
Metaplasia, Osseous | 2 | 3 2.0|
Glomerulus, Ectasia | | 1 2.0|
Renal Tubule, Casts Protein | | 4 1.5|
Renal Tubule, Ectasia | 3 1 2 | 8 1.9|
Renal Tubule, Mineralization | 2 2 2 | 12 1.7|
Renal Tubule, Necrosis | 2 2 1 2 2 | 14 1.6|
Renal Tubule, Pigmentation | 1 | 1 1.0|
Renal Tubule, Regeneration | 2 2 2 2 2 2 1 | 33 1.8|
__________________________________________________________________________|____________|
Urethra | + + + + | 9 |
Calculus Micro Observation Only | X X X X | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + | 47 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 20 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2|
Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 3 1 1 1 |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 2 2 |
Necrosis | 2 1 |
Bile Duct, Cyst | X |
Hepatocyte, Hypertrophy | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 |
Acinus, Atrophy | |
Duct, Cyst | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Squamous | 3 2 1 2 3 1 3|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 1 3 |
Inflammation, Chronic Active | 2|
Mineralization | 1 1 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Mineralization | 1 2 2 3 3 |
Mucosa, Ectasia | 2 2 |
Mucosa, Inflammation, Acute | |
Mucosa, Ulcer | |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 2 2 2 2 |
Spindle Cell, Hyperplasia, Lymphoid | 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M M M M M M M M M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
C-Cell, Hyperplasia | |
Follicle, Ectasia | 2 |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + +|
Abscess | |
Infiltration Cellular, Lymphocyte | 3|
Inflammation, Chronic | 3 2 |
Inflammation, Chronic Active | |
Duct, Cyst | X |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Infiltration Cellular, Lymphocyte | 2 1|
Inflammation, Chronic | 3 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Granuloma Sperm | |
Mineralization | |
Spermatogenic Arrest | X |
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Reticulum Cell | |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hyperplasia | 2 |
Pigmentation | 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + M + +|
Angiectasis | |
Congestion | 2 2 2 3 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 3 1 2 2 2 2 2 3 2 2 2 3|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 4 4 2 3 2 3 2 4 2 2|
Hyperplasia, Glandular | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 1 2 |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + +|
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Fibrosis, Focal | |
Inflammation, Chronic | 3 2 2 3 2 2 2 4 2|
Inflammation, Chronic Active | 3 4 |
Ulcer | 4 |
Epithelium, Hyperplasia | 2 |
Prepuce, Inflammation, Acute | |
Prepuce, Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abscess | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 1 2 2 1 3 1 2 2 2 2 2 2|
Mucosa, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 1 1 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Osseous | 2 |
Pelvis, Inflammation, Acute | |
Renal Tubule, Casts Protein | 1 |
Renal Tubule, Ectasia | 3 1 |
Renal Tubule, Mineralization | 1 1 |
Renal Tubule, Necrosis | 1 2 2 2 1 1 1 1 1 2 1|
Renal Tubule, Regeneration | 2 2 1 2 1 1 1 1 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Urethra | + + + + +|
Calculus Micro Observation Only | X X X X X|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 1|
Epithelium, Degeneration | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 3 |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 |
Necrosis | 4 2 |
Bile Duct, Cyst | |
Hepatocyte, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 |
Acinus, Atrophy | 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | 1 3 1 1 2 2 2|
Infiltration Cellular, Lymphocyte | 1 2 2 2 |
Inflammation, Acute | 2|
Inflammation, Chronic Active | 2 3 2 2 |
Mineralization | 1 1|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Mineralization | 2|
Mucosa, Ectasia | 2 |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Ulcer | 2 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 1 2|
Spindle Cell, Hyperplasia, Lymphoid | |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M M M M + M M M M M M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 1|
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
C-Cell, Hyperplasia | 2 |
Follicle, Ectasia | |
Follicle, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 1 1 2 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Abscess | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 3 4 3 3 |
Duct, Cyst | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Chronic | 2 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Granuloma Sperm | 3 |
Mineralization | 2 3 |
Spermatogenic Arrest | |
Interstitial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Reticulum Cell | 3 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia | |
Pigmentation | 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 |
Congestion | 2 3 3 |
Hyperplasia, Lymphoid | 4 2 2 3 2 2 2 3 2 3 2 3 2 2|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 4 3 2 2 4 2 2 2 2|
Hyperplasia, Glandular | |
Hyperplasia, Lymphoid | 2 2 3 2 2 3 2|
Pigmentation | 1 2 1 2 2 1|
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Fibrosis, Focal | 2 |
Inflammation, Chronic | 4 4 3 3 3 2 2 3 3 2|
Inflammation, Chronic Active | 3 |
Ulcer | 3 3 |
Epithelium, Hyperplasia | |
Prepuce, Inflammation, Acute | |
Prepuce, Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 2|
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + M + + +|
Lumen, Hemorrhage | 2 1 2 3 3 3 2 2 1 1|
Mucosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2|
Metaplasia, Osseous | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Casts Protein | 2 2 |
Renal Tubule, Ectasia | 3 2 |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Necrosis | 1 3 1 2 1 1 1 2 |
Renal Tubule, Regeneration | 1 1 1 3 2 2 2 2 1 2 1 1 2 2|
__________________________________________________________________________|
Urethra | + + + + + + |
Calculus Micro Observation Only | X X X X X |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 1 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 1 2 | 18 1.8|
Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + M + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + | 49 |
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | 3 | 1 3.0|
Focal Cellular Change | | 2 |
Hematopoietic Cell Proliferation | 1 1 | 7 1.6|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 | 7 1.9|
Necrosis | | 4 2.3|
Bile Duct, Cyst | | 1 |
Hepatocyte, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 10 1.8|
Acinus, Atrophy | | 1 4.0|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 | 42 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Erosion | | 1 2.0|
Hyperplasia, Squamous | 3 2 2 2 3 | 19 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 2 | 6 1.8|
Inflammation, Acute | 1 2 | 5 1.8|
Inflammation, Chronic Active | 3 2 | 7 2.3|
Mineralization | 1 | 6 1.3|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Erosion | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 | 22 1.9|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 1 2 | 9 2.0|
Mucosa, Ectasia | | 3 2.0|
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Pulp, Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 | 7 1.9|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 2 2 | 11 1.8|
Spindle Cell, Hyperplasia, Lymphoid | | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 | 46 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + M | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | | 4 1.8|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 4 2.0|
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Ectasia | | 1 2.0|
Follicle, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 | 25 1.8|
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | + + + | 3 |
Inflammation, Acute | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 11 |
Abscess | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic | | 4 2.3|
Inflammation, Chronic Active | 3 | 5 3.2|
Duct, Cyst | | 1 |
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | M + + + + + + + + + | 49 |
Ectasia | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 4 1.8|
Inflammation, Chronic | 3 | 3 2.7|
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Atrophy | | 2 2.0|
Granuloma Sperm | | 1 3.0|
Mineralization | | 2 2.5|
Spermatogenic Arrest | | 1 |
Interstitial Cell, Hyperplasia | 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Reticulum Cell | | 1 3.0|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 | 36 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 2 2 2 2 | 37 2.0|
Hyperplasia | | 1 2.0|
Pigmentation | 2 1 2 | 9 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 46 |
Angiectasis | | 3 3.0|
Congestion | 3 | 10 2.5|
Hyperplasia, Lymphoid | 2 2 2 3 3 | 35 2.3|
Inflammation, Acute | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + M + | 49 |
Atrophy | 3 2 | 2 2.5|
Hematopoietic Cell Proliferation | 2 4 3 2 | 35 2.5|
Hyperplasia, Glandular | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 10 2.2|
Pigmentation | 2 | 9 1.6|
Capsule, Inflammation, Chronic Active| 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Cyst | X X X X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Erosion | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Inflammation, Chronic | 3 2 2 2 1 | 24 2.5|
Inflammation, Chronic Active | | 3 3.3|
Ulcer | 4 4 | 5 3.6|
Epithelium, Hyperplasia | | 1 2.0|
Prepuce, Inflammation, Acute | 2 | 1 2.0|
Prepuce, Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Mineralization | 2 1 2 2 1 | 29 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 4 2.5|
Hemorrhage | 2 | 4 1.8|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 43 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
Lumen, Hemorrhage | 2 2 1 2 2 2 | 29 1.9|
Mucosa, Inflammation, Acute | 2 2 | 3 1.7|
Nasolacrimal Duct, Hemorrhage | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Olfactory Epithelium, Degeneration | 2 2 2 1 2 | 23 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 | 46 1.9|
Metaplasia, Osseous | | 1 2.0|
Pelvis, Inflammation, Acute | 3 2 | 2 2.5|
Renal Tubule, Casts Protein | 2 | 4 1.8|
Renal Tubule, Ectasia | 2 2 2 | 7 2.1|
Renal Tubule, Mineralization | 1 2 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 2| 6| 6| 7| 7| 1| 1| 1| 7| 7| | |
DAY ON TEST | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3| | |
| 0| 5| 4| 8| 4| 7| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Necrosis | 1 2 1 1 | 23 1.4|
Renal Tubule, Regeneration | 2 1 2 2 | 36 1.7|
__________________________________________________________________________|____________|
Urethra | + + + + | 15 |
Calculus Micro Observation Only | X X X X | 14 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 | 25 1.9|
Inflammation, Chronic | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + |
Ectasia | 3 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Developmental Malformation | X |
Focal Cellular Change | |
Infiltration Cellular, Lymphocyte | 2 2 1 2 |
Necrosis | 3 2 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 |
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Mineralization | 1 1 |
Glandular, Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Mineralization | 2 |
Mucosa, Dilatation | |
Mucosa, Ectasia | 2 |
Mucosa, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Spindle Cell, Hyperplasia, Lymphoid | 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Follicle, Ectasia | 2 |
Follicle, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 |
__________________________________________________________________________|
Preputial Gland | + M + +|
Abscess | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 4|
Duct, Cyst | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
Mineralization | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | 4 3 2 3 3 3|
Hemorrhage | 4 4 |
Hyperplasia, Lymphoid | 2 3 3 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + |
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Alopecia | |
Angiectasis | |
Erosion | 2 |
Hyperplasia | |
Inflammation, Chronic | 2 3 2 3 3 3 |
Inflammation, Chronic Active | |
Ulcer | 4 3 |
Prepuce, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Mineralization | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|
| 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2 |
Olfactory Epithelium, Degeneration | 1 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Congestion | 3 |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 2 2 2 2 |
Inflammation, Chronic | 2 |
Glomerulus, Renal Tubule, | |
Mineralization | 4 |
Renal Tubule, Ectasia | 2 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + |
Ectasia | |
Infiltration Cellular, Lymphocyte | 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Developmental Malformation | |
Focal Cellular Change | X |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis | 4 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
Acinus, Atrophy | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 2 2 2 1 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic Active | 2 |
Mineralization | |
Glandular, Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 |
Mineralization | 2 |
Mucosa, Dilatation | |
Mucosa, Ectasia | |
Mucosa, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Spindle Cell, Hyperplasia, Lymphoid | |
Spindle Cell, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M M M + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
Follicle, Ectasia | |
Follicle, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Abscess | 3 4 4 4 |
Infiltration Cellular, Lymphocyte | 2 3 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + |
Mineralization | 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Myeloid Cell, Hyperplasia | 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + |
Angiectasis | 3 |
Congestion | 3 3 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 2 2 2 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 3 2 3 2 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + |
Cyst | X |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Angiectasis | 3 |
Erosion | |
Hyperplasia | 2 |
Inflammation, Chronic | 3 3 3 2|
Inflammation, Chronic Active | 3 |
Ulcer | 3 3 4 |
Prepuce, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Mineralization | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + |
Lumen, Hemorrhage | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|
| 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Olfactory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Chronic | 3 |
Glomerulus, Renal Tubule, | |
Mineralization | |
Renal Tubule, Ectasia | |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 15 |
__________________________________________________________________________|____________|
Gallbladder | | 15 |
Ectasia | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 16 |
__________________________________________________________________________|____________|
Intestine Small | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 16 |
__________________________________________________________________________|____________|
Liver | | 23 |
Developmental Malformation | | 1 |
Focal Cellular Change | | 1 |
Infiltration Cellular, Lymphocyte | | 5 1.6|
Necrosis | | 3 3.0|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis | | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + | 17 |
Infiltration Cellular, Lymphocyte | | 3 2.0|
Acinus, Atrophy | 4 | 2 3.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 16 |
Infiltration Cellular, Lymphocyte | | 9 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | | 4 1.8|
Inflammation, Acute | | 3 2.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 2 1.0|
Glandular, Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 10 2.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Dilatation | 2 | 1 2.0|
Mucosa, Ectasia | | 1 2.0|
Mucosa, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 16 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 16 |
Spindle Cell, Hyperplasia, Lymphoid | | 1 2.0|
Spindle Cell, Hyperplasia | | 14 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 16 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | | 16 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Follicle, Ectasia | | 1 2.0|
Follicle, Hyperplasia, Cystic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 16 |
Infiltration Cellular, Lymphocyte | | 4 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 14 |
Abscess | | 5 3.8|
Infiltration Cellular, Lymphocyte | | 3 2.3|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | | 3 3.0|
Duct, Cyst | X | 2 2.0|
__________________________________________________________________________|____________|
Prostate | | 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 16 |
__________________________________________________________________________|____________|
Testes | + | 17 |
Mineralization | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 17 |
Myeloid Cell, Hyperplasia | | 12 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + | 28 |
Inguinal, Hyperplasia, Lymphoid | | 3 2.7|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 14 |
Hyperplasia, Lymphoid | | 4 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 28 |
Angiectasis | | 2 3.0|
Congestion | 2 3 | 11 2.8|
Hemorrhage | | 2 4.0|
Hyperplasia, Lymphoid | 2 3 | 15 2.3|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 21 |
Hematopoietic Cell Proliferation | | 13 2.5|
Hyperplasia, Lymphoid | | 2 2.0|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | | 16 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + + | 42 |
Alopecia | | 1 2.0|
Angiectasis | | 1 3.0|
Erosion | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 4 4 3 3 | 15 2.9|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | 4 | 6 3.5|
Prepuce, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | | 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 16 |
Mineralization | | 9 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 21 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 12 1.9|
__________________________________________________________________________|____________|
Nose | | 16 |
Lumen, Hemorrhage | | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 4 1.8|
Olfactory Epithelium, Degeneration | | 6 1.5|
__________________________________________________________________________|____________|
Trachea | | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 16 |
Congestion | | 1 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 12 1.8|
Inflammation, Chronic | | 2 2.5|
Glomerulus, Renal Tubule, | | |
Mineralization | | 1 4.0|
Renal Tubule, Ectasia | | 1 2.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Regeneration | | 3 1.3|
__________________________________________________________________________|____________|
Urethra | | 5 |
Calculus Micro Observation Only | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 08:05:11
__________________________________________________________________________________________________________________________________
| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3| | |
| 0| 7| 7| 7| 7| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Ectasia | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
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