TDMS Study 05007-06 Pathology Tables
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
Facility: Southern Research Institute
Chemical CAS #: 9005-65-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma NOS | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + M + + M + + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | X |
Pars Intermedia, Carcinoma | |
Pars Intermedia, Leukemia Mononuclear| X |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + |
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + + + + + M + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Fibroadenoma | X X X X X X X X X X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Deep Invasion, Metastatic,| |
Pituitary Gland | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Pheochromocytoma NOS | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | |
Pars Intermedia, Carcinoma | X |
Pars Intermedia, Leukemia Mononuclear| X |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Carcinoma | X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Endometrium, Polyp Stromal | X X X X X |
__________________________________________________________________________|
Vagina | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Fibroadenoma | X X X X X X X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Rhabdomyosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Deep Invasion, Metastatic,| |
Pituitary Gland | X X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 7 |
Pheochromocytoma NOS | X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X | 37 |
Pars Distalis, Carcinoma | | 1 |
Pars Distalis, Leukemia Mononuclear | | 3 |
Pars Intermedia, Adenoma | X | 2 |
Pars Intermedia, Carcinoma | | 1 |
Pars Intermedia, Leukemia Mononuclear| | 2 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 48 |
Adenoma | X | 3 |
Carcinoma | X X | 7 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Endometrium, Polyp Stromal | | 9 |
__________________________________________________________________________|____________|
Vagina | | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Adenoma | | 1 |
Fibroadenoma | X X X X | 28 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Rhabdomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Carcinoma, Deep Invasion, Metastatic,| | |
Pituitary Gland | | 2 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 24 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 26 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma NOS | X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + M + + M + + M + + M +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Thymoma Malignant, Metastatic, Thymus| |
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Endometrium, Polyp Stromal | X X X X X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Lipoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Leukemia Mononuclear | |
Nasolacrimal Duct, Squamous Cell | |
Carcinoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Thymoma Malignant, Metastatic, Thymus| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + I + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma NOS | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Malignant, Metastatic, Thymus| X |
C-Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X X X X X X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + I + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
Thymoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lipoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Leukemia Mononuclear | X |
Nasolacrimal Duct, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Malignant, Metastatic, Thymus| X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Adenoma | X | 3 |
Leukemia Mononuclear | X X X | 13 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma NOS | X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 41 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X X X X | 36 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
Pars Intermedia, Leukemia Mononuclear| X | 1 |
Pars Nervosa, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Thymoma Malignant, Metastatic, Thymus| | 1 |
C-Cell, Adenoma | X X X | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 50 |
Adenoma | X X | 3 |
Carcinoma | X | 4 |
Leukemia Mononuclear | X | 2 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Endometrium, Polyp Stromal | X | 12 |
Endometrium, Sarcoma Stromal | X | 1 |
__________________________________________________________________________|____________|
Vagina | | 5 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Leukemia Mononuclear | X X | 4 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
Leukemia Mononuclear | X X | 7 |
Thymoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X | 26 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Lipoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Mucosa, Leukemia Mononuclear | | 1 |
Nasolacrimal Duct, Squamous Cell | | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Thymoma Malignant, Metastatic, Thymus| | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 10 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
Adenoma | | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + +|
Adenocarcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma NOS | X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + A + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X|
Pars Distalis, Histiocytic Sarcoma | X |
Pars Distalis, Leukemia Mononuclear | X X |
Pars Intermedia, Leukemia Mononuclear| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + +|
Adenoma | X |
Carcinoma | X X X X X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X X X X X X|
__________________________________________________________________________|
Vagina | + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + M M M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X X X X X X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Head, Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma NOS | X X X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Histiocytic Sarcoma | |
Pars Distalis, Leukemia Mononuclear | X X |
Pars Intermedia, Leukemia Mononuclear| X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X|
Carcinoma | |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X X X X X |
__________________________________________________________________________|
Vagina | + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X X X|
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Head, Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Oligodendroglioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 48 |
Adenocarcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 47 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 2 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma NOS | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 47 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Pars Distalis, Adenoma | X X X | 30 |
Pars Distalis, Histiocytic Sarcoma | | 1 |
Pars Distalis, Leukemia Mononuclear | | 4 |
Pars Intermedia, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
C-Cell, Adenoma | | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 49 |
Adenoma | | 3 |
Carcinoma | | 5 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Endometrium, Polyp Stromal | | 11 |
__________________________________________________________________________|____________|
Vagina | | 9 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 4 |
Pancreatic, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Thymus | + + + M + | 46 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 48 |
Adenocarcinoma | | 2 |
Fibroadenoma | X X X X | 27 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Head, Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Oligodendroglioma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 9 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + M + + M + M + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X X X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + M + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Thymoma NOS | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + M + + + + + + + + |
Fibroadenoma | X |
Neurofibrosarcoma, Deep Invasion, | |
Metastatic, Skin | |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Osteosarcoma | |
Femur, Lymphoma Malignant Lymphocytic| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hemangioma | X |
Leukemia Mononuclear | |
Neuroblastoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Lids, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + M + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Lymphoma Malignant Lymphocytic | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + M + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + M + |
Adenoma | X |
Carcinoma | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + M + |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | |
Thymoma NOS | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + |
Fibroadenoma | |
Neurofibrosarcoma, Deep Invasion, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Osteosarcoma | |
Femur, Lymphoma Malignant Lymphocytic| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hemangioma | |
Leukemia Mononuclear | X |
Neuroblastoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + |
Lids, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urethra | + + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X | 22 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + M + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 6 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 9 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 17 |
Bilateral, Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X | 30 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Adenoma | X X | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 48 |
Adenoma | | 5 |
Carcinoma | X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Interstitial Cell, Adenoma | X X X X X X X | 39 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + | 49 |
Mediastinal, Leukemia Mononuclear | X X | 5 |
Pancreatic, Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 11 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
Leukemia Mononuclear | X X | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
Thymoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 47 |
Fibroadenoma | | 1 |
Neurofibrosarcoma, Deep Invasion, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cranium, Osteosarcoma | X | 1 |
Femur, Lymphoma Malignant Lymphocytic| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hemangioma | | 1 |
Leukemia Mononuclear | X | 2 |
Neuroblastoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 20 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 10 |
Lids, Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Carcinoma | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Urethra | + | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 23 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + +|
Acinus, Adenoma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicle, Adenocarcinoma | |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X|
Tunic, Mesothelioma Benign | X|
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Keratoacanthoma | X X X X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X X X X |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Neurofibroma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Canal, Squamous Cell Carcinoma | X X |
__________________________________________________________________________|
Eye | + + + + |
Retina, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X|
Mesothelioma Benign | X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenocarcinoma | X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X|
Tunic, Mesothelioma Benign | |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Sarcoma | X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Keratoacanthoma | X |
Squamous Cell Papilloma | X|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Neurofibroma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Eye | + + + + + +|
Retina, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 49 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X X | 22 |
__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Carcinoma | | 1 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 9 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, Pheochromocytoma Benign | X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 48 |
Adenoma | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + M + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X | 26 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 2 |
Follicle, Adenocarcinoma | | 1 |
Follicle, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Adenoma | | 2 |
Carcinoma | X X | 5 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Interstitial Cell, Adenoma | X X X X X X X X X | 41 |
Tunic, Mesothelioma Benign | | 1 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + | 49 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 22 |
Sarcoma | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Basal Cell Carcinoma | | 1 |
Keratoacanthoma | | 5 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 4 |
Subcutaneous Tissue, Lipoma | | 2 |
Subcutaneous Tissue, Neurofibroma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Astrocytoma NOS | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X | 26 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Mucosa, Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Canal, Squamous Cell Carcinoma | | 2 |
__________________________________________________________________________|____________|
Eye | + + + + | 14 |
Retina, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Urethra | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X | 26 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + I + + M +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
Acinus, Adenoma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X X|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X|
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + M + + + + + M M M + M + + + + + M|
Leukemia Mononuclear | X X X X X X |
Neoplasm NOS | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + + + + M +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Neurofibroma | |
__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Lymphoma Malignant Mixed | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + + |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + M + +|
Adenoma | X X X X |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X X X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Neoplasm NOS | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + M M + + M + + + + + + + + + + + + M|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Keratoacanthoma | X X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Pinna, Neurofibroma | X |
__________________________________________________________________________|
Eye | + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant Mixed | X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 47 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Leukemia Mononuclear | X | 21 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Leukemia Mononuclear | | 7 |
Mesothelioma Malignant | | 2 |
Acinus, Adenoma | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Leukemia Mononuclear | | 14 |
Pheochromocytoma Malignant | | 4 |
Pheochromocytoma Benign | X X X | 12 |
Bilateral, Pheochromocytoma Benign | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 48 |
Adenoma | X | 5 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Adenoma | X | 23 |
Pars Distalis, Leukemia Mononuclear | | 8 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Adenoma | | 2 |
Follicle, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Adenoma | | 1 |
Carcinoma | X | 6 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Interstitial Cell, Adenoma | X X X X | 35 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 12 |
Pancreatic, Leukemia Mononuclear | | 5 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Leukemia Mononuclear | | 15 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Leukemia Mononuclear | X | 21 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M M | 40 |
Leukemia Mononuclear | | 13 |
Neoplasm NOS | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + | 39 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Basal Cell Carcinoma | | 2 |
Keratoacanthoma | | 2 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Lipoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05007-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC POLYSORBATE 80 Date: 04/09/97
Route: DOSED FEED Time: 07:32:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Leukemia Mononuclear | X | 18 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Pinna, Neurofibroma | | 1 |
__________________________________________________________________________|____________|
Eye | + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Leukemia Mononuclear | X | 21 |
Lymphoma Malignant Mixed | | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
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