TDMS Study 05007-06 Pathology Tables
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
Facility: Southern Research Institute
Chemical CAS #: 9005-65-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Developmental Malformation | X X X |
Fatty Change | 1 |
Granuloma | 3 2 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 2 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 3 |
Hepatocyte, Hyperplasia | |
Portal, Inflammation, Chronic | 2 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Acute | 4 |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 1 1 2 4 2 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 2 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 |
Hemorrhage | |
Coronary Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Cyst | |
Degeneration, Fatty | 3 1 3 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 |
Hypertrophy | 2 1 |
Pigmentation | 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + M + + M + + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Distalis, Metaplasia, Osseous | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 1 2 2 1 1 2 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + |
Abscess | |
Inflammation, Chronic | 1 1 2 1 3 |
Inflammation, Chronic Active | 1 3 2 |
Duct, Ectasia | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Ectasia | |
Endometrium, Hyperplasia, Cystic | 2 3 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 2 |
Mediastinal, Hyperplasia, Reticulum | |
Cell | 2 |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 3 2 2 2 |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 2 3 2 2 2 3 3 3 2 3 |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 3 3 3 2 2 2 3 3 3 3 2 3 2 2 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + + + + + M + + |
Cyst | X |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Acinus, Ectasia | 2 3 4 4 3 3 3 3 3 2 2 4 4 3 2 2 3 4 3 4 |
Acinus, Hyperplasia | 4 2 |
Duct, Ectasia | 3 3 4 3 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X X |
Inflammation, Chronic Active | 2 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | 4 |
Cranium, Osteopetrosis | 3 3 |
Femur, Fibrous Osteodystrophy | 4 |
Femur, Osteopetrosis | 3 |
Rib, Hyperplasia | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | X X X X |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 1 1 2 2 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 2 2 2 1 1 1 2 2 2 |
Arteriole, Mineralization | 2 2 1 2 2 2 2 1 2 2 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 1 2 2 1 1 1 1 2 1 |
Mucosa, Cyst | X |
Mucosa, Inflammation, Acute | 2 4 |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2 2 3 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 2 1 1 2 1 1 1 1 1 2 2 |
Vomeronasal Organ, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Hemorrhage | |
Synechia | |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|
| 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 2 3 2 3 3 2 2 2 3 4 3 2 2 2 2 2 2 3 |
Renal Tubule, Pigmentation | 1 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 4 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Developmental Malformation | X X |
Fatty Change | 2 2 3 2 |
Granuloma | |
Hematopoietic Cell Proliferation | 1 2 |
Necrosis | 3 |
Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 1 2 |
Hepatocyte, Hyperplasia | 2 3 |
Portal, Inflammation, Chronic | 1 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Acute | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 3 3 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
Mineralization | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 2 |
Mucosa, Dilatation | 2 2 2 2 1 3 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 |
Hemorrhage | 2 |
Coronary Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Angiectasis | |
Cyst | X |
Degeneration, Fatty | 2 2 2 2 1 2 2 1 1 1 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 1 1 2 |
Hypertrophy | 2 2 |
Pigmentation | 1 2 1 1 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 |
Pars Distalis, Metaplasia, Osseous | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 2 2 1 2 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + |
Abscess | 3 |
Inflammation, Chronic | 2 1 1 |
Inflammation, Chronic Active | 2 3 2 |
Duct, Ectasia | 3 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Ectasia | 3 3 |
Endometrium, Hyperplasia, Cystic | 2 1 2 |
__________________________________________________________________________|
Vagina | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 4 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Reticulum | |
Cell | |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 3 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 3 2 1 2 3 2 2 3 2 2 2 2 2 2 2 |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 3 3 2 2 3 3 3 3 2 4 3 3 2 |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Acinus, Ectasia | 2 3 4 2 4 3 4 4 3 2 2 2 4 2 2 3 |
Acinus, Hyperplasia | 3 |
Duct, Ectasia | 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | |
Cranium, Osteopetrosis | 4 4 3 |
Femur, Fibrous Osteodystrophy | |
Femur, Osteopetrosis | |
Rib, Hyperplasia | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | X X X X X X X X X X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage | 1 1 2 1 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 2 2 2 2 2 |
Arteriole, Mineralization | 2 2 2 1 2 2 2 2 2 2 2 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 1 2 2 1 2 2 2 |
Mucosa, Cyst | |
Mucosa, Inflammation, Acute | 3 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 2 2 1 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 1 1 2 2 2 2 1 2 2 2 |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Hemorrhage | |
Synechia | |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|
| 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATD | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 2 3 3 2 3 2 2 2 2 3 1 3 3 1 3 3 4 3 |
Renal Tubule, Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 4.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 3 2.0|
Basophilic Focus | X X X X X X X X X X | 42 |
Developmental Malformation | | 5 |
Fatty Change | 2 | 6 2.0|
Granuloma | 2 | 5 2.2|
Hematopoietic Cell Proliferation | 2 2 | 4 1.8|
Necrosis | | 2 2.5|
Bile Duct, Hyperplasia | 1 1 2 2 1 2 | 23 1.4|
Hepatocyte, Hyperplasia | | 2 2.5|
Portal, Inflammation, Chronic | 2 1 1 1 1 2 | 15 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Fat, Inflammation, Acute | | 1 4.0|
Fat, Necrosis | 4 4 | 7 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Acinus, Atrophy | 2 4 2 2 2 | 19 2.1|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Inflammation, Acute | | 2 2.5|
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Hyperplasia | 2 | 1 2.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Hyperkeratosis | | 1 2.0|
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
Mineralization | | 3 2.7|
Mucosa, Dilatation | 2 2 2 2 2 2 2 1 2 | 41 1.9|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 1 1 2 2 2 2 3 2 2 1 | 44 1.9|
Hemorrhage | | 1 2.0|
Coronary Artery, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | 3 | 1 3.0|
Cyst | | 1 |
Degeneration, Fatty | 3 2 1 2 2 | 26 1.9|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 | 7 1.6|
Hypertrophy | | 4 1.8|
Pigmentation | 2 1 1 1 1 1 2 1 | 28 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Cyst | X | 10 |
Pars Distalis, Hyperplasia | | 5 2.2|
Pars Distalis, Metaplasia, Osseous | | 1 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 2 1 1 2 2 1 | 33 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 48 |
Abscess | | 1 3.0|
Inflammation, Chronic | 2 1 | 10 1.5|
Inflammation, Chronic Active | | 6 2.2|
Duct, Ectasia | | 5 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Periovarian Tissue, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Ectasia | 2 | 3 2.7|
Endometrium, Hyperplasia, Cystic | 2 1 2 | 9 1.9|
__________________________________________________________________________|____________|
Vagina | | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | | 3 3.3|
Mediastinal, Hyperplasia, Lymphoid | | 4 2.3|
Mediastinal, Hyperplasia, Reticulum | | |
Cell | | 1 2.0|
Pancreatic, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 | 31 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Congestion | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 3 2 | 16 2.3|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 | 44 2.2|
Hyperplasia, Histiocytic, Lymphoid | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Pigmentation | 3 2 2 2 2 3 2 2 | 37 2.6|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X | 2 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Acinus, Ectasia | 4 3 2 4 3 2 4 2 2 | 45 3.0|
Acinus, Hyperplasia | 2 | 4 2.8|
Duct, Ectasia | 2 2 4 | 12 2.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 3 |
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Suppurative | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cranium, Fibrous Osteodystrophy | | 1 4.0|
Cranium, Osteopetrosis | | 5 3.4|
Femur, Fibrous Osteodystrophy | | 1 4.0|
Femur, Osteopetrosis | | 1 3.0|
Rib, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X X X X X | 19 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hemorrhage | 1 1 2 | 13 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 1 | 28 1.7|
Arteriole, Mineralization | 2 2 2 2 2 2 | 27 1.9|
Interstitium, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lumen, Hemorrhage | 1 2 2 1 | 22 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3| | |
| 1| 5| 0| 0| 0| 5| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Cyst | | 1 |
Mucosa, Inflammation, Acute | | 3 3.0|
Nasolacrimal Duct, Hemorrhage | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 3 2 | 14 2.0|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 1 | 46 2.0|
Respiratory Epithelium, Degeneration | 2 3 2 2 1 2 2 | 30 1.7|
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Cataract | 4 2 4 | 5 3.2|
Hemorrhage | 3 | 1 3.0|
Synechia | 4 | 1 4.0|
Retina, Degeneration | 4 3 4 | 6 3.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Nephropathy, Chronic | 3 1 4 2 3 3 3 2 3 2 | 48 2.5|
Renal Tubule, Pigmentation | 1 1 2 2 2 2 2 2 2 1 | 47 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Developmental Malformation | X X X X X X |
Fatty Change | 2 |
Granuloma | 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Mineralization | |
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 2 2 1 |
Portal, Inflammation, Chronic | 1 2 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 4 2 1 1 2 2 2 2 1 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 2 2 1|
Mucosa, Dilatation | 2 2 2 2 2 1 2 2 2 2 2 2 2|
Mucosa, Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 1 1 2 2 1 2 2 3 2 2 2 1 1 3 3 2 2 1 2|
Mineralization | |
Coronary Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 3 2 2 1 2 2 2 1 2 |
Hyperplasia | 2 2 1 2 2 2 2 2 |
Hypertrophy | 2 1 |
Mineralization | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + M + + M + + M + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 3 1 2 1 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 3 2 2 2 1 2 3 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
Inflammation, Chronic | 3 1 1 |
Inflammation, Chronic Active | 4 |
Duct, Ectasia | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 2 |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 3 2|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 2 2 3 2 2 2 1 2 2 2 2 2 3 2 2 2|
Hyperplasia, Histiocytic, Lymphoid | 4 |
Infarct | |
Pigmentation | 3 2 3 2 2 2 2 3 2 3 2 3 2 2 2 2 3|
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + +|
Congestion | 4 |
Cyst | X |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Acinus, Ectasia | 2 2 2 2 3 4 2 2 4 4 3 2|
Acinus, Hyperplasia | 2 |
Duct, Ectasia | 2 2 4 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic | |
Cranium, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|
| 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X X X|
Hemorrhage | 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2|
Hemorrhage | 1 2 2 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 2 1 2 2 1 2 2 2 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Interstitium, Inflammation, Chronic | 1 1 |
Peribronchiolar, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 1 2 2 2 2 1 2|
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 1 2 1 2 1 2 1 2 1 1 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 4 4 2 |
Hemorrhage | 4 |
Synechia | 3 3 |
Retina, Degeneration | 4 4 4 4 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Mineralization | |
Nephropathy, Chronic | 2 2 2 2 2 2 3 3 3 3 2 1 2 2 3 2 3 3 3 1|
Pelvis, Inflammation, Acute | |
Pelvis, Necrosis | |
Renal Tubule, Pigmentation | 1 1 2 1 2 2 2 2 2 1 1 1 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + I + + +|
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Developmental Malformation | X X X |
Fatty Change | 1 1 2 1 |
Granuloma | 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Mineralization | |
Bile Duct, Hyperplasia | 2 1 3 1 1 1 1 1 2 1 1|
Portal, Inflammation, Chronic | 2 1 3 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 2 3 |
Mucosa, Dilatation | 2 2 2 2 1 2 2 2 1 2 2|
Mucosa, Ulcer | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 1 1 2 2 3 2 1 2 1 3 1 1 1 1 1 2 3|
Mineralization | 2 |
Coronary Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 1 3 1 3 1 2|
Hyperplasia | 2|
Hypertrophy | 2 1 |
Mineralization | 2 |
Pigmentation | 1 1 1 2 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia | 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 1 2 2 1 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | |
Inflammation, Chronic | 2 2 2 |
Inflammation, Chronic Active | 2 3 |
Duct, Ectasia | 3 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 4 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 |
__________________________________________________________________________|
Vagina | + + + + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Histiocytic, Lymphoid | |
Infarct | 4 |
Pigmentation | 2 3 2 2 3 3 3 2 3 2 2 2 3 3 2 2 2|
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + I + + +|
Congestion | 2 2 |
Cyst | X X |
Hyperplasia, Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Acinus, Ectasia | 3 3 3 2 2 3 3 2 4 2 3 3 4 2 2|
Acinus, Hyperplasia | |
Duct, Ectasia | 2 3 4 3 3 3 3 4 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic | |
Cranium, Osteopetrosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|
| 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 3 4 3 |
Hemorrhage | 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 2 2 2 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 1|
Interstitium, Inflammation, Chronic | |
Peribronchiolar, Inflammation, Acute | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 1 2 2 1 1 1 2 2 1|
Mucosa, Inflammation, Acute | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2 1 1 3 |
Olfactory Epithelium, Degeneration | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 3 1 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Cataract | 4 4 4 4|
Hemorrhage | 4 |
Synechia | 4 |
Retina, Degeneration | 4 4 4 4|
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 3 |
Nephropathy, Chronic | 2 2 2 2 2 1 1 2 2 2 2 2 2 3 1 1 2 3|
Pelvis, Inflammation, Acute | 2 4 |
Pelvis, Necrosis | 4 |
Renal Tubule, Pigmentation | 2 2 2 2 1 2 2 2 1 2 1 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
Mineralization | 2 | 1 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Mineralization | 2 | 1 2.0|
Parasite Metazoan | X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
Parasite Metazoan | | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X | 43 |
Developmental Malformation | X | 10 |
Fatty Change | 3 2 1 | 8 1.6|
Granuloma | 2 2 | 8 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Mineralization | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 2 | 28 1.3|
Portal, Inflammation, Chronic | 2 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Acinus, Atrophy | 1 2 2 1 | 20 1.7|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Inflammation, Chronic | 3 | 2 2.5|
Mineralization | 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 4 | 8 2.3|
Mucosa, Dilatation | 2 2 2 2 2 2 2 | 31 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 1 | 45 1.8|
Mineralization | | 1 2.0|
Coronary Artery, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Degeneration, Fatty | 2 2 3 2 | 23 1.9|
Hyperplasia | | 9 1.9|
Hypertrophy | | 4 1.5|
Mineralization | | 1 2.0|
Pigmentation | 1 1 1 1 1 1 | 32 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | 2 | 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 41 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | X X | 15 |
Pars Distalis, Hyperplasia | | 7 1.9|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 1 2 2 1 1 2 2 2 | 30 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 1 | 9 1.7|
Inflammation, Chronic Active | | 3 3.0|
Duct, Ectasia | | 1 3.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Hyperplasia, Adenomatous | 2 | 1 2.0|
Follicle, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Ectasia | 2 | 2 2.0|
Hemorrhage | 4 4 | 3 3.7|
Inflammation, Acute | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Vagina | | 5 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
Myelofibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Mediastinal, Congestion | 2 3 | 5 2.4|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 50 |
Congestion | | 2 2.5|
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 2 3 3 | 25 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 | 39 2.0|
Hyperplasia, Histiocytic, Lymphoid | | 1 4.0|
Infarct | | 1 4.0|
Pigmentation | 3 2 3 3 2 4 2 2 | 42 2.4|
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
Congestion | | 3 2.7|
Cyst | X X | 5 |
Hyperplasia, Lymphoid | | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Acinus, Ectasia | 4 3 4 3 3 3 3 2 | 35 2.8|
Acinus, Hyperplasia | | 1 2.0|
Duct, Ectasia | 2 4 3 3 | 21 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cranium, Inflammation, Chronic | 3 | 1 3.0|
Cranium, Osteopetrosis | | 3 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X | 8 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 9 2.7|
Hemorrhage | 1 | 11 1.2|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 | 20 1.9|
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 | 34 2.0|
Interstitium, Inflammation, Chronic | | 2 1.0|
Peribronchiolar, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lumen, Hemorrhage | 2 2 1 | 22 1.6|
Mucosa, Inflammation, Acute | 2 | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 9 1.9|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 | 44 2.0|
Respiratory Epithelium, Degeneration | 1 1 2 2 2 1 2 1 | 28 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3| | |
| 8| 9| 1| 1| 1| 3| 4| 8| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 10 |
Cataract | 4 4 | 10 3.7|
Hemorrhage | 4 2 | 4 3.5|
Synechia | | 3 3.3|
Retina, Degeneration | 4 4 | 10 4.0|
Sclera, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Cyst | | 3 |
Mineralization | | 1 3.0|
Nephropathy, Chronic | 2 2 1 1 2 1 2 1 1 2 | 48 2.0|
Pelvis, Inflammation, Acute | | 2 3.0|
Pelvis, Necrosis | | 1 4.0|
Renal Tubule, Pigmentation | 1 1 2 2 2 1 2 2 2 2 | 45 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Developmental Malformation | X |
Fatty Change | 2 2 2 |
Granuloma | 2 2 2 2 2 2 2|
Hematopoietic Cell Proliferation | 1 2 2 2|
Bile Duct, Hyperplasia | 1 1 1 2 1 4 1 2 1 1 |
Hepatocyte, Hyperplasia | |
Portal, Inflammation, Chronic | 1 2 2 1 1 1 2 2 1|
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + A + + + + + + + + +|
Acinus, Atrophy | 2 2 3 2 2 3 2|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Chronic | 2 |
Mineralization | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 3 2 3 3 3 2 2 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty | 2 2 1 2 2 2 2 |
Hemorrhage | |
Hyperplasia | 2 2 2 2 1 |
Pigmentation | 2 1 1 1 1 2 2 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 2 1 1 1 1 2 2 2 1 1 2|
Follicle, Ectasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + +|
Abscess | |
Inflammation, Chronic | 3 2 1 1 2|
Inflammation, Chronic Active | 2 2 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Cervix, Epithelium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Congestion | 2 2 3 2 1 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Reticulum | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 3 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 3 2|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 3 2 2 3 2 2 2 3 2 2 |
Hyperplasia, Lymphoid | |
Necrosis | 2 |
Pigmentation | 2 2 3 2 2 2 2 2 2 3 2 3|
__________________________________________________________________________|
Thymus | + + + M M M + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Hyperplasia, Lymphoid | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 3 3 3 2 2 3 2 2 2 2 2 3 3 2 3 |
Acinus, Hyperplasia | 3 2 |
Duct, Ectasia | 3 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 3 3|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|
| 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Hemorrhage | 2 1 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Arteriole, Mineralization | 2 1 2 2 1 2 2 1 2 2 2 2|
Interstitium, Inflammation, Chronic | 1 |
Mediastinum, Inflammation, Acute | |
Peribronchiolar, Inflammation, | |
Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 2 2|
Lumen, Inflammation, Acute | |
Mucosa, Inflammation, Acute | 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 2 1 2 1 2 1 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 3 4 4 2 |
Hemorrhage | 3 3 |
Retina, Degeneration | 4 4 4 4 4 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Acute | 4 |
Mineralization | |
Nephropathy, Chronic | 2 2 4 2 2 3 2 2 2 2 3 2 2 2 3 2 2 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Developmental Malformation | X |
Fatty Change | 1 2 2 |
Granuloma | 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 3 1 1 1 1 1 1 1|
Hepatocyte, Hyperplasia | 3 |
Portal, Inflammation, Chronic | 2 1 1 1 2 1 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 4 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 2 |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperkeratosis | 3 |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 1 1 3 2 2 1 1 1 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 |
Degeneration, Fatty | 2 1 1 2 2 2 2 2 2 1 2 |
Hemorrhage | |
Hyperplasia | 1 2 2 2 2 2 2 2 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 |
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 1 1 2 2 1 |
Follicle, Ectasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic | 1 2 2 3 2 1 2 |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Cervix, Epithelium, Cyst | X |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 2|
__________________________________________________________________________|
Vagina | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Congestion | 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Reticulum | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 2 3 2 2|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
Necrosis | |
Pigmentation | 2 2 2 2 3 2 2 3 2 2 2 2 3 3 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 2 2 3 2 2 2 2 2 3 2|
Acinus, Hyperplasia | 3 |
Duct, Ectasia | 2 2 2 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 2 1 2 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 |
Hemorrhage | 1 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 1 3 1 1 1 1 1|
Arteriole, Mineralization | 2 2 1 2 1 2 2 2 2 2 2|
Interstitium, Inflammation, Chronic | 2 |
Mediastinum, Inflammation, Acute | 3 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 2 2 1 2 2 2 2 2 2 |
Lumen, Inflammation, Acute | 1 |
Mucosa, Inflammation, Acute | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2 1 2 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 1 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 4 4 2 3 |
Hemorrhage | |
Retina, Degeneration | 4 4 4 4 |
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Acute | |
Mineralization | 2 |
Nephropathy, Chronic | 2 3 2 1 3 3 2 3 1 1 2 2 1 2 2 2 2 4 1 2 3|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + | 48 |
Parasite Metazoan | | 5 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 49 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | X X X | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Basophilic Focus | X X X X | 37 |
Developmental Malformation | X X | 4 |
Fatty Change | | 6 1.8|
Granuloma | | 11 2.0|
Hematopoietic Cell Proliferation | 1 2 2 | 10 1.7|
Bile Duct, Hyperplasia | 1 | 24 1.3|
Hepatocyte, Hyperplasia | | 1 3.0|
Portal, Inflammation, Chronic | 2 2 2 | 21 1.5|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 47 |
Acinus, Atrophy | 1 2 | 15 2.1|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Edema | | 1 2.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mineralization | 2 | 3 1.7|
Ulcer | | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Mineralization | 2 | 6 2.0|
Mucosa, Dilatation | 2 2 | 39 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 2 1 2 | 40 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Angiectasis | 3 | 4 2.8|
Degeneration, Fatty | 2 2 2 2 | 22 1.8|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 2 2 | 16 1.9|
Pigmentation | 1 1 2 | 31 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Pars Distalis, Angiectasis | | 4 3.0|
Pars Distalis, Cyst | X X | 13 |
Pars Distalis, Hyperplasia | 1 2 | 13 1.8|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 2 2 | 23 1.6|
Follicle, Ectasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 49 |
Abscess | | 1 3.0|
Inflammation, Chronic | 3 2 | 14 1.9|
Inflammation, Chronic Active | 4 2 | 4 2.5|
Duct, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Ectasia | | 3 2.0|
Cervix, Epithelium, Cyst | | 1 |
Endometrium, Hyperplasia, Cystic | 1 | 10 1.8|
__________________________________________________________________________|____________|
Vagina | | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Mediastinal, Congestion | 2 2 | 11 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 2.0|
Mediastinal, Hyperplasia, Reticulum | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Hyperplasia, Lymphoid | 2 2 2 | 23 2.1|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Congestion | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 11 2.3|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 3 3 2 | 34 2.2|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | 2 2 2 2 | 35 2.2|
__________________________________________________________________________|____________|
Thymus | + + + M + | 46 |
Congestion | 4 | 1 4.0|
Cyst | X | 4 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 48 |
Acinus, Ectasia | 2 3 2 | 28 2.4|
Acinus, Hyperplasia | | 3 2.7|
Duct, Ectasia | 2 2 3 2 | 20 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Alopecia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Cranium, Osteopetrosis | 3 | 5 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | 2 2 | 13 2.3|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | 3 | 3 2.7|
Hemorrhage | | 5 1.6|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 14 1.3|
Arteriole, Mineralization | 1 2 | 25 1.8|
Interstitium, Inflammation, Chronic | | 2 1.5|
Mediastinum, Inflammation, Acute | | 1 3.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Lumen, Hemorrhage | 2 2 | 17 1.9|
Lumen, Inflammation, Acute | | 1 1.0|
Mucosa, Inflammation, Acute | | 4 2.5|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 9 1.9|
Olfactory Epithelium, Degeneration | 2 2 2 2 | 44 2.0|
Respiratory Epithelium, Degeneration | 1 1 | 22 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 9 |
Cataract | | 8 3.3|
Hemorrhage | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 6| 7| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Degeneration | | 9 4.0|
Sclera, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Congestion | 2 | 1 2.0|
Inflammation, Acute | | 1 4.0|
Mineralization | | 1 2.0|
Nephropathy, Chronic | 2 1 2 2 | 43 2.1|
Pelvis, Inflammation, Chronic | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 2 2 2 | 47 2.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Calculus Gross Observation | X | 2 |
Inflammation, Chronic | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Congestion | |
Developmental Malformation | X X X |
Focal Cellular Change | |
Necrosis | 2 1 |
Vacuolization Cytoplasmic | 2 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 4 2 2 2 2 2 2 2 3 |
Portal, Inflammation, Chronic | 2 2 2 1 2 2 1 2 2 2 1 3 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 3 1 1 2 2 2 2 1 2 1 |
Acinus, Hyperplasia | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Edema | |
Hyperkeratosis | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 |
Mucosa, Dilatation | 1 2 1 2 1 1 1 2 1 2 2 1 2 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Artery, Inflammation, Chronic | 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 1 3 2 2 2 2 1 2 2 2 3 3 3 2 |
Mineralization | 2 2 |
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | 1 2 2 2 2 1 2 2 2 2 3 2 2 2 2 |
Hyperplasia | 2 2 2 2 |
Infiltration Cellular, Lymphocyte | |
Necrosis | 2 |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + M + + M + M + + + + + + M |
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 |
Pars Distalis, Infarct | 4 |
Pars Distalis, Infiltration Cellular,| |
Lymphocyte | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 2 |
Follicle, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 3 2 3 3 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | 3 2 |
Inflammation, Chronic Active | 2 3 2 2 3 3 2 2 2 2 3 4 3 2 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 4 4 |
Necrosis | 4 |
Interstitial Cell, Hyperplasia | 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | X X |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 2 3 2 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 1 1 1 1 1 1 3 2 1 1 |
Necrosis | 2 |
Pigmentation | 2 2 2 3 3 3 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + M + + + + + + + |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + M + + + + + + + + |
Acinus, Ectasia | 2 2 3 2 4 2 3 1 |
Acinus, Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + |
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | 2 |
Femur, Fibrous Osteodystrophy | 2 2 |
Femur, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | 2 2 3 |
Hemorrhage | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage | 2 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Arteriole, Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 1 |
Mucosa, Inflammation, Acute | 3 3 3 4 2 |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 1 1 1 1 2 2 |
Olfactory Epithelium, Degeneration | 1 2 2 2 1 1 1 1 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Abscess | |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Hemorrhage | |
Posterior Chamber, Synechia | |
Retina, Degeneration | 3 3 |
Sclera, Mineralization | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|
| 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X |
Necrosis | |
Nephropathy, Chronic | 2 4 3 4 2 3 2 2 3 2 3 4 4 3 2 2 3 3 4 3 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 1 2 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | X |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + M + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X X X |
Congestion | |
Developmental Malformation | X |
Focal Cellular Change | X |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 3 4 2 2 1 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 |
Portal, Inflammation, Chronic | 2 2 1 1 2 2 2 2 1 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 3 2 2 3 2 2 4 2 2 |
Acinus, Hyperplasia | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Edema | 3 |
Hyperkeratosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Artery, Inflammation, Chronic | 2 4 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 3 2 3 2 2 3 3 2 1 3 1 3 3 2 2 2 3 2 |
Mineralization | |
Pigmentation, Hemosiderin | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 1 1 2 1 2 1 1 2 |
Hyperplasia | 2 2 2 2 1 2 |
Infiltration Cellular, Lymphocyte | 2 |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + M + + + M + + + |
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 1 |
Pars Distalis, Infarct | |
Pars Distalis, Infiltration Cellular,| |
Lymphocyte | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 1 2 |
Follicle, Ectasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + M + |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + M + |
Abscess | |
Inflammation, Chronic | 2 2 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 3 2 2 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | 4 2 |
Inflammation, Chronic Active | 2 2 2 3 3 3 2 2 3 3 3 3 3 3 3 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + M + |
Atrophy | 4 4 3 |
Necrosis | |
Interstitial Cell, Hyperplasia | 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | X |
Hyperplasia, Lymphoid | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 3 3 2 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 2 1 2 2 2 2 2 |
Necrosis | 3 |
Pigmentation | 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + |
Acinus, Ectasia | 3 2 4 2 2 2 2 2 2 |
Acinus, Hyperplasia | 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | 2 |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | 2 |
Hemorrhage | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 |
Arteriole, Mineralization | 2 2 1 2 1 2 2 2 2 2 2 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 1 1 2 2 |
Mucosa, Inflammation, Acute | 2 1 2 3 |
Nasolacrimal Duct, Hemorrhage | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 1 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 1 2 2 |
Respiratory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Canal, Abscess | 4 |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 2 4 4 4 4 |
Hemorrhage | 4 3 |
Posterior Chamber, Synechia | 4 |
Retina, Degeneration | 4 4 4 4 4 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|
| 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X |
Necrosis | 4 |
Nephropathy, Chronic | 2 3 2 4 4 2 3 4 4 3 4 3 2 2 4 1 2 1 2 3 |
Renal Tubule, Mineralization | 4 |
Renal Tubule, Pigmentation | 2 2 1 1 1 2 2 2 2 2 2 2 2 1 1 2 |
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 49 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | 1 | 4 1.5|
Basophilic Focus | X X X X X X | 34 |
Congestion | 3 | 1 3.0|
Developmental Malformation | X X X | 7 |
Focal Cellular Change | X | 2 |
Necrosis | | 3 1.7|
Vacuolization Cytoplasmic | 1 | 4 1.5|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 49 2.2|
Portal, Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 | 46 1.8|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Acinus, Atrophy | 2 2 2 2 3 | 25 2.1|
Acinus, Hyperplasia | | 1 2.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 5 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Edema | | 1 3.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + M + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 2 2.5|
Mucosa, Dilatation | 2 2 2 2 2 | 30 1.7|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 6 |
Artery, Inflammation, Chronic | | 6 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 3 2 3 1 2 2 3 | 47 2.2|
Mineralization | | 2 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Accessory Adrenal Cortical Nodule | X | 2 |
Degeneration, Fatty | 2 1 2 | 26 1.7|
Hyperplasia | 2 1 2 1 2 | 15 1.8|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | 2 2 1 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 39 |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia | 2 2 | 10 2.0|
Pars Distalis, Infarct | | 1 4.0|
Pars Distalis, Infiltration Cellular,| | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | | 8 1.8|
Follicle, Ectasia | 2 3 | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 49 |
Inflammation, Chronic | 2 | 4 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 48 |
Abscess | | 1 4.0|
Inflammation, Chronic | 2 2 2 2 | 19 2.1|
Inflammation, Chronic Active | 2 3 | 13 2.5|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | 1 2 | 6 2.3|
Inflammation, Chronic Active | 2 3 2 4 2 3 | 40 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Atrophy | | 6 3.7|
Necrosis | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 | 13 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + | 49 |
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 49 |
Congestion | 2 | 1 2.0|
Cyst | X | 4 |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 | 37 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 49 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Fibrosis | 2 | 6 2.5|
Hematopoietic Cell Proliferation | 2 1 1 2 2 | 30 1.6|
Necrosis | | 2 2.5|
Pigmentation | 2 3 2 3 3 2 2 | 25 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 47 |
Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 47 |
Acinus, Ectasia | 2 3 2 | 20 2.4|
Acinus, Hyperplasia | | 2 2.0|
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Abscess | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cranium, Fibrous Osteodystrophy | | 1 2.0|
Femur, Fibrous Osteodystrophy | | 3 2.0|
Femur, Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X | 5 2.3|
Hemorrhage | | 2 2.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 2 3 3 | 4 2.8|
Hemorrhage | 2 2 1 | 5 1.6|
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 6 1.8|
Arteriole, Mineralization | 2 1 2 2 2 2 | 31 1.9|
Interstitium, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lumen, Hemorrhage | 3 2 | 9 1.8|
Mucosa, Inflammation, Acute | 2 4 2 | 12 2.6|
Nasolacrimal Duct, Hemorrhage | | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 2 | 14 1.6|
Olfactory Epithelium, Degeneration | 1 2 2 1 1 1 | 32 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3| | |
| 5| 3| 0| 7| 0| 0| 2| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Degeneration | | 7 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Canal, Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + + + | 10 |
Cataract | 4 4 | 8 3.6|
Hemorrhage | 3 | 3 3.3|
Posterior Chamber, Synechia | | 1 4.0|
Retina, Degeneration | 4 4 | 9 3.8|
Sclera, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Cyst | | 2 |
Necrosis | | 1 4.0|
Nephropathy, Chronic | 2 2 2 4 3 2 4 3 3 3 | 50 2.8|
Renal Tubule, Mineralization | | 1 4.0|
Renal Tubule, Pigmentation | 2 2 2 2 1 1 1 2 | 44 1.7|
__________________________________________________________________________|____________|
Urethra | + | 3 |
Calculus Micro Observation Only | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + | 49 |
Calculus Micro Observation Only | | 1 |
Infiltration Cellular, Lymphocyte | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Arteriole, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 |
Basophilic Focus | X X X X X X X X X X X X|
Congestion | |
Developmental Malformation | |
Granuloma | 1 |
Necrosis | 1 |
Vacuolization Cytoplasmic | |
Arteriole, Inflammation, Chronic | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 4 2 2 2 2 3 1 1 2 2 2 1 2|
Portal, Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 3 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Pigmentation | |
Acinus, Atrophy | 2 1 2 2 2 2 2 2 2 2|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | |
Duct, Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 2 |
Mucosa, Erosion | 2 |
Mucosa, Ulcer | |
__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Hemorrhage | |
Peridontal Tissue, Inflammation, | |
Chronic | 3 |
Pulp, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Artery, Inflammation, Chronic | |
Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 3 2 3 4 2 2 2 2 1 3 1 3 2 3|
Mineralization | |
Artery, Inflammation, Chronic | |
Artery, Mineralization | |
Atrium Left, Thrombosis | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Degeneration, Fatty | 2 2 2 2 1 2 1 2 2 1 2 2 2 |
Hyperplasia | 2 2 2 1 2 2 2 1|
Hypertrophy | |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 1 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + +|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 2 1 1 1|
Follicle, Ectasia | 2 |
Follicle, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 1 2 2 2 2 2 2 |
Inflammation, Chronic Active | 3 2 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | 3 3 3 3 3 2 3 3 3 4 2 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Artery, Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 3 3 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 2|
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X X |
Hyperplasia, Lymphoid | 2 2 2 2 3 3 2 2 2 2 2 3 2 2 3 2 2|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 2 3 2 3 3 2 3 3 1 2 2 1 3 2|
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 3 2 2 2 3 3 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + +|
Acinus, Ectasia | 2 3 2 2 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | X 2 |
Hemorrhage | 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 1 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 2 2|
Alveolus, Mineralization | |
Arteriole, Mineralization | 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2|
Bronchiole, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|
DAY ON TEST | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|
| 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic | |
Interstitium, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, | |
Chronic Active | 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 1 1 |
Mucosa, Inflammation, Acute | 3 4 2 |
Mucosa, Inflammation, Chronic | 2 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 3 2 |
Olfactory Epithelium, Degeneration | 2 2 1 2 1 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 2 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 4 3 4 |
Hemorrhage | |
Inflammation, Chronic | |
Anterior Chamber, Hemorrhage | 3 |
Cornea, Inflammation, Acute | 4 |
Posterior Chamber, Synechia | |
Retina, Degeneration | 4 4 4 |
Sclera, Mineralization | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Infarct | |
Nephropathy, Chronic | 2 3 4 4 4 1 2 3 4 4 2 2 3 4 3 2 3 3 3 3|
Cortex, Cyst | X |
Renal Tubule, Pigmentation | 2 1 1 1 1 2 1 1 2 1 1 1 1 1 2 2 2|
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Arteriole, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Basophilic Focus | X X X X X X X X X X|
Congestion | 2 |
Developmental Malformation | X |
Granuloma | |
Necrosis | 1 |
Vacuolization Cytoplasmic | 2 |
Arteriole, Inflammation, Chronic | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 4 2 3 2 2 2 2 3 2 2 2 2 2 2 3|
Portal, Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic | 4 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
Pigmentation | 2 |
Acinus, Atrophy | 1 2 3 2 2 3 1 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | |
Duct, Mineralization | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2|
Mucosa, Erosion | |
Mucosa, Ulcer | 3 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Hemorrhage | 2 |
Peridontal Tissue, Inflammation, | |
Chronic | |
Pulp, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Artery, Inflammation, Chronic | 4 |
Artery, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 3 2 3 3 2 2 2 2 3 3 2 2 2 3|
Mineralization | 2 |
Artery, Inflammation, Chronic | |
Artery, Mineralization | 1 |
Atrium Left, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Degeneration, Fatty | 2 2 1 1 2 2 2 1 2 2 |
Hyperplasia | 2 2 2 2 2|
Hypertrophy | 2 |
Necrosis | 4 |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2|
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 2 2|
Follicle, Ectasia | 2 |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 |
Inflammation, Chronic Active | 3 3 2 3 2 3 |
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 1 2 |
Inflammation, Chronic Active | 2 2 3 4 4 2 4 2 4 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Artery, Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + +|
Congestion | |
Cyst | X|
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 2 3 2 2 2 3 3|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Edema | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 1 2 2 3 1 2 1 4 4 2 3 2 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 3 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + +|
Acinus, Ectasia | 2 2 2 2 4 4 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 2 X X |
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage | 2 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 2 2 |
Alveolus, Mineralization | 2 1 |
Arteriole, Mineralization | 2 2 2 2 2 2 1 2 2 2 2 1 2|
Bronchiole, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|
DAY ON TEST | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|
| 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic | 2 |
Interstitium, Inflammation, Chronic | |
Active | 3 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 1 2 |
Mucosa, Inflammation, Acute | 4 2 3 |
Mucosa, Inflammation, Chronic | 2 |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 4 2 2 2|
Olfactory Epithelium, Degeneration | 1 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + +|
Cataract | 2 4 4 4 4|
Hemorrhage | 4 3 |
Inflammation, Chronic | 4 |
Anterior Chamber, Hemorrhage | |
Cornea, Inflammation, Acute | |
Posterior Chamber, Synechia | 3 |
Retina, Degeneration | 4 4 4 4 4|
Sclera, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Infarct | 4 |
Nephropathy, Chronic | 2 3 3 2 4 3 4 3 3 4 2 2 1 4 3 4 2 2 4 3|
Cortex, Cyst | |
Renal Tubule, Pigmentation | 2 3 2 1 2 2 2 2 1 2 2 2 1 4 2 2|
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 48 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 49 |
Parasite Metazoan | X X | 3 |
Arteriole, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 6 1.7|
Basophilic Focus | X X X | 25 |
Congestion | | 1 2.0|
Developmental Malformation | X X | 3 |
Granuloma | | 1 1.0|
Necrosis | 2 | 3 1.3|
Vacuolization Cytoplasmic | 2 | 2 2.0|
Arteriole, Inflammation, Chronic | | 1 3.0|
Bile Duct, Hyperplasia | 2 3 2 2 2 2 2 4 2 2 | 50 2.2|
Portal, Inflammation, Chronic | 2 1 2 1 2 2 3 2 2 | 45 1.9|
__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Artery, Inflammation, Chronic | | 1 4.0|
Fat, Necrosis | 4 4 | 8 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | 4 | 1 4.0|
Pigmentation | | 1 2.0|
Acinus, Atrophy | 2 2 3 4 2 | 23 2.0|
Artery, Inflammation, Chronic | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Acinus, Atrophy | 2 | 1 2.0|
Duct, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Hyperkeratosis | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Mineralization | | 1 2.0|
Mucosa, Dilatation | 1 2 2 1 2 2 | 24 1.9|
Mucosa, Erosion | | 1 2.0|
Mucosa, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Peridontal Tissue, Hemorrhage | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Pulp, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Artery, Inflammation, Chronic | | 1 4.0|
Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 3 3 2 2 2 2 3 3 | 45 2.3|
Mineralization | | 1 2.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Artery, Mineralization | 2 | 2 1.5|
Atrium Left, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Accessory Adrenal Cortical Nodule | X | 2 |
Cyst | | 1 |
Degeneration, Fatty | 2 3 2 1 | 27 1.8|
Hyperplasia | 2 | 14 1.9|
Hypertrophy | | 1 2.0|
Necrosis | | 1 4.0|
Pigmentation | 1 2 2 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Cyst | X | 1 |
Hyperplasia | 2 | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + M + | 45 |
Hypertrophy | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 | 12 2.0|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | X | 2 |
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | | 12 1.8|
Follicle, Ectasia | | 2 2.0|
Follicle, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Inflammation, Chronic | 2 3 2 | 20 2.1|
Inflammation, Chronic Active | 3 3 2 3 3 | 14 2.6|
Duct, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 1 | 6 1.3|
Inflammation, Chronic Active | 3 2 3 4 4 3 2 | 32 2.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Mineralization | | 1 2.0|
Artery, Inflammation, Chronic | | 2 2.0|
Interstitial Cell, Hyperplasia | 1 2 | 14 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + | 49 |
Hemorrhage | 3 | 2 3.5|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Mediastinal, Congestion | 3 | 3 2.7|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 48 |
Congestion | 3 | 1 3.0|
Cyst | | 4 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 | 39 2.2|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Congestion | | 1 2.0|
Edema | | 1 3.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Fibrosis | 2 2 | 4 2.5|
Hematopoietic Cell Proliferation | 1 2 3 1 2 3 2 1 | 37 2.2|
Hyperplasia, Lymphoid | | 3 2.0|
Pigmentation | 2 2 2 2 2 2 | 23 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Congestion | | 1 2.0|
Cyst | X | 2 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 48 |
Acinus, Ectasia | 2 4 3 2 | 16 2.5|
Duct, Ectasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Alopecia | | 1 |
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | 4 | 2 4.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | X | 6 2.0|
Hemorrhage | | 1 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 2 4 2 | 5 2.8|
Hemorrhage | 1 2 2 2 1 | 12 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 13 1.8|
Alveolus, Mineralization | | 2 1.5|
Arteriole, Mineralization | 2 2 2 2 2 2 | 34 1.9|
Bronchiole, Inflammation, Acute | | 1 1.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active | | 1 3.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Lumen, Hemorrhage | 1 | 7 1.3|
Mucosa, Inflammation, Acute | 2 2 2 | 9 2.7|
Mucosa, Inflammation, Chronic | | 2 2.0|
Nasolacrimal Duct, Hemorrhage | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 8 2.4|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 | 38 1.9|
Respiratory Epithelium, Degeneration | | 7 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 6| 6| 7| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3| | |
| 7| 0| 1| 1| 1| 8| 2| 9| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + + + | 14 |
Cataract | 4 4 3 4 | 12 3.7|
Hemorrhage | 4 4 4 | 5 3.8|
Inflammation, Chronic | | 1 4.0|
Anterior Chamber, Hemorrhage | | 1 3.0|
Cornea, Inflammation, Acute | | 1 4.0|
Posterior Chamber, Synechia | 4 | 2 3.5|
Retina, Degeneration | 4 4 4 4 | 12 4.0|
Sclera, Mineralization | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Congestion | 2 | 1 2.0|
Cyst | | 1 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 3 4 3 4 4 4 3 4 3 | 49 3.0|
Cortex, Cyst | | 1 |
Renal Tubule, Pigmentation | 3 2 2 2 1 2 2 1 2 | 42 1.7|
__________________________________________________________________________|____________|
Urethra | | 3 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + | 49 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Metaplasia, Osseous | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + I + + M +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X|
Clear Cell Focus | |
Developmental Malformation | X X X X |
Hematopoietic Cell Proliferation | |
Necrosis | 2 2 2 2 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 2 2 1 3 2 2 2|
Portal, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Mesentery | + + + |
Arteriole, Inflammation, Chronic | |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinus, Atrophy | 3 2 2 2 1 3 3 2 2 3 |
Acinus, Hyperplasia | 3 2|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 3 |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Mineralization | 3 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2|
Mucosa, Erosion | 3 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 3 3 3 2 2 2 3 3 2 3 2 2 2|
Mineralization | |
Atrium Left, Thrombosis | |
Atrium Right, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 2 1 2 2 |
Hyperplasia | 2 2 2 2 2|
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 2 2 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 2 |
Follicle, Ectasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 2 2 2 2 3 2 2|
Inflammation, Chronic Active | 2 2 2 4 4 2 3 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 4 3 3 2 2 3 2 2 2 2 2 3 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Granuloma Sperm | |
Necrosis | 4 |
Artery, Inflammation, Chronic | 2 2 |
Interstitial Cell, Hyperplasia | 2 1 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Atypia Cellular | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X X X |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 2 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X |
Infiltration Cellular, Plasma Cell | |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 2|
Hematopoietic Cell Proliferation | 1 4 2 1 1 1 2 1 1 1 2 1 2 1|
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + M M M + M + + + + + M|
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + + + + M +|
Acinus, Ectasia | 2 3 2 3 2 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | |
Alopecia | |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Hemorrhage | 4 4 |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2|
Arteriole, Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 1 2 2 2 2 |
Mucosa, Inflammation, Acute | 1 3 2 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 |
Olfactory Epithelium, Degeneration | 1 2 2 2 2 2 2 1 2 2 1 2 2 2 1 1|
Respiratory Epithelium, Degeneration | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 4 4 |
Hemorrhage | |
Retina, Degeneration | 4 4 4 |
Sclera, Mineralization | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|
| 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 4 3 2 2 4 2 4 2 3 3 4 2 2 3 4 2 4|
Pelvis, Dilatation | |
Renal Tubule, Pigmentation | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Metaplasia, Osseous | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | X |
Developmental Malformation | X X X X X |
Hematopoietic Cell Proliferation | |
Necrosis | 3 2 2 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 1 3 2 2 2 3 2 2 2 2 2 2 2|
Portal, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Arteriole, Inflammation, Chronic | 3 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Acinus, Atrophy | 2 3 2 2 2 2 2 3 3 1 2 |
Acinus, Hyperplasia | 3 2 |
Artery, Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 3 |
Ulcer | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Mineralization | 3 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mucosa, Erosion | 1 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 2 1 3 3 4 3 2 1 3 3 2 3 3 2 3 3 2 3 3 3|
Mineralization | 2 |
Atrium Left, Thrombosis | 2 |
Atrium Right, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 1 1 2 2 2 2|
Hyperplasia | 2 2 2 2 2 2 2|
Pigmentation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 1 2 2 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + M + + + + + + + + + + + M +|
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 1 1 1 2 2 |
Follicle, Ectasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Chronic | 2 2 2 3 3 2 3 2 2|
Inflammation, Chronic Active | 2 3 2 2 2 3 3 3 3 3 3 2 3 |
Duct, Ectasia | 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 3 3 3 4 3 3 2 3 3 3 2 3 3 2 3 3 3 4 2 2 4 4|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 3 |
Granuloma Sperm | 2 |
Necrosis | |
Artery, Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | 2 1 1 2 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Atypia Cellular | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Cyst | |
Infiltration Cellular, Plasma Cell | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 2 4 2 1 1 3 2 1|
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Reticulum Cell | |
Pigmentation | 2 2 2 2 3 2 2 3 2 3 2|
__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + M M + + M + + + + + + + + + + + + M|
Acinus, Ectasia | 3 2 2 3 2 2 2 3 |
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abscess | 4 |
Alopecia | 2 |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 |
Hemorrhage | |
Necrosis | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 3 2 1 1 |
Mucosa, Inflammation, Acute | 2 4 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 2 1 2 2 2 2 2|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + + + |
Cataract | 4 4 4 4 2 4 4 |
Hemorrhage | 2 3 |
Retina, Degeneration | 4 4 4 4 4 4 4 |
Sclera, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|
| 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 2 2 4 2 4 2 4 4 3 4 2 4 4 2 2 3 3 4 4 2 4 3 4|
Pelvis, Dilatation | 4 |
Renal Tubule, Pigmentation | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Diverticulum | | 1 3.0|
Metaplasia, Osseous | | 1 3.0|
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 49 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 47 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Basophilic Focus | X X X | 21 |
Clear Cell Focus | | 1 |
Developmental Malformation | | 9 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis | 1 | 8 2.0|
Vacuolization Cytoplasmic | 2 | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 | 44 2.0|
Portal, Inflammation, Chronic | 1 2 2 2 | 45 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Arteriole, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 3 4 | 7 3.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | | 1 2.0|
Acinus, Atrophy | 2 | 22 2.2|
Acinus, Hyperplasia | | 4 2.5|
Artery, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | | 4 2.5|
Ulcer | | 1 4.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Dilatation | | 1 2.0|
Mineralization | | 2 3.0|
Mucosa, Dilatation | 2 2 2 2 | 29 2.0|
Mucosa, Erosion | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 3 3 3 | 46 2.5|
Mineralization | | 1 2.0|
Atrium Left, Thrombosis | | 1 2.0|
Atrium Right, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Degeneration, Fatty | 2 2 3 2 | 21 1.9|
Hyperplasia | 2 | 13 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 50 |
Hyperplasia | 3 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 48 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 47 |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Cyst | X X | 5 |
Pars Distalis, Hyperplasia | 2 | 14 1.9|
Pars Intermedia, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 12 1.8|
Follicle, Ectasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Abscess | | 1 4.0|
Inflammation, Chronic | 1 2 | 18 2.2|
Inflammation, Chronic Active | 4 | 21 2.7|
Duct, Ectasia | | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 2 2.0|
Inflammation, Chronic Active | 4 4 2 3 | 41 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Atrophy | 3 | 7 2.7|
Granuloma Sperm | | 1 2.0|
Necrosis | | 1 4.0|
Artery, Inflammation, Chronic | | 3 2.0|
Interstitial Cell, Hyperplasia | 1 1 | 15 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
Atypia Cellular | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 50 |
Mediastinal, Congestion | | 4 2.3|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Mediastinal, Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Congestion | | 1 3.0|
Cyst | | 6 |
Hyperplasia, Lymphoid | 2 2 | 31 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Congestion | 2 | 3 2.7|
Cyst | | 1 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Fibrosis | | 5 2.8|
Hematopoietic Cell Proliferation | 3 3 2 | 31 1.9|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
Pigmentation | 3 2 2 | 26 2.2|
__________________________________________________________________________|____________|
Thymus | + + + M M | 40 |
Congestion | | 1 2.0|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + | 39 |
Acinus, Ectasia | 2 | 15 2.3|
Duct, Ectasia | | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Abscess | | 1 4.0|
Alopecia | | 1 2.0|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 2 2.5|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Compression | | 5 2.4|
Hemorrhage | | 2 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | 3 | 4 2.3|
Hemorrhage | 2 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYSORBATE 80 Date: 04/28/97
Route: DOSED FEED Time: 07:49:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| | |
DAY ON TEST | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3| | |
| 2| 2| 2| 2| 2| 8| 5| 7| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | | 4 2.0|
Arteriole, Mineralization | 2 1 2 2 | 35 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Lumen, Hemorrhage | 1 | 12 1.6|
Mucosa, Inflammation, Acute | | 7 2.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 12 1.9|
Olfactory Epithelium, Degeneration | 2 2 2 2 | 34 1.9|
Respiratory Epithelium, Degeneration | | 5 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 11 |
Cataract | 4 | 11 3.8|
Hemorrhage | 3 | 3 2.7|
Retina, Degeneration | 4 | 11 4.0|
Sclera, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Nephropathy, Chronic | 2 4 2 3 4 | 49 3.0|
Pelvis, Dilatation | | 1 4.0|
Renal Tubule, Pigmentation | 1 2 2 2 2 | 48 2.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
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---------- END OF REPORT ----------
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