TDMS Study 05019-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
CI PIGMENT RED 3
NTP Experiment-Test: 05019-04 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
Facility: Southern Research Institute
Chemical CAS #: 2425-85-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 9 10 10 10
Early Deaths
Moribund 8 9 11 20
Accident 2
Dead 2 4 8 5
Survivors
Terminal Sacrifice 39 37 31 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%) 2 (4%)
Cytologic Alterations 1 (2%) 1 (2%) 15 (30%)
Eosinophilic Focus 3 (6%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 7 (14%) 15 (30%)
Inflammation, Granulomatous 1 (2%) 2 (4%) 2 (4%) 11 (22%)
Mixed Cell Focus 1 (2%) 2 (4%)
Necrosis, Focal 4 (8%) 3 (6%) 1 (2%) 6 (12%)
Necrosis, Multifocal 2 (4%) 4 (8%)
Kupffer Cell, Pigmentation 2 (4%) 1 (2%) 1 (2%) 29 (58%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 4 (8%) 2 (4%) 10 (20%) 18 (36%)
Mesentery (8) (4) (4) (6)
Inflammation, Acute, Suppurative 2 (25%) 1 (25%) 2 (50%) 3 (50%)
Inflammation, Chronic 1 (13%)
Artery, Inflammation 1 (17%)
Fat, Necrosis, Focal 4 (50%) 3 (75%) 2 (50%) 1 (17%)
Pancreas (50) (12) (19) (50)
Cyst, Multiple 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Acute, Suppurative 1 (2%) 1 (5%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 2 (4%) 3 (6%)
Acinus, Atrophy, Multifocal 3 (6%) 1 (8%) 5 (26%) 3 (6%)
Acinus, Hyperplasia, Focal 1 (2%)
Acinus, Necrosis, Multifocal 1 (2%)
Duct, Dilatation 2 (11%) 1 (2%)
Stomach, Forestomach (50) (16) (24) (49)
Erosion 6 (12%) 5 (31%) 4 (17%) 4 (8%)
Hyperplasia 11 (22%) 5 (31%) 5 (21%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hypertrophy 1 (2%)
Ulcer 1 (4%) 1 (2%)
Stomach, Glandular (50) (12) (18) (49)
Erosion, Multiple 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Tooth (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (19) (50)
Inflammation, Focal, Subacute 1 (8%) 1 (5%) 1 (2%)
Inflammation, Multifocal, Subacute 1 (8%) 2 (11%) 2 (4%)
Artery, Inflammation, Subacute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (15) (18) (50)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Hyperplasia, Multifocal 1 (2%)
Hypertrophy, Diffuse 1 (2%)
Hypertrophy, Focal 2 (4%)
Capsule, Accessory Adrenal Cortical Nodule 1 (2%) 1 (6%)
X-Zone, Degeneration, Fatty 2 (4%)
Adrenal Gland, Medulla (50) (14) (18) (50)
Hyperplasia, Focal 1 (2%) 1 (2%)
Islets, Pancreatic (50) (12) (18) (50)
Hyperplasia 1 (6%)
Pituitary Gland (49) (14) (17) (50)
Pars Distalis, Angiectasis 10 (20%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 16 (33%) 2 (14%) 3 (18%) 12 (24%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Ultimobranchial Cyst 1 (2%)
Artery, Inflammation 1 (2%)
Follicle, Cyst 7 (14%) 12 (24%) 11 (22%) 21 (42%)
Follicle, Hyperplasia, Cystic 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 11 (22%) 11 (22%) 24 (49%) 38 (76%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (49) (50) (50)
Abscess 2 (4%) 6 (12%) 9 (18%)
Abscess, Multiple 2 (4%) 6 (12%) 10 (20%)
Angiectasis 1 (2%)
Cyst 18 (36%) 14 (29%) 13 (26%) 16 (32%)
Cyst, Multiple 2 (4%) 4 (8%) 4 (8%)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Cystic 2 (4%) 1 (2%)
Inflammation, Chronic 2 (4%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Fat, Necrosis, Focal 1 (2%)
Uterus (50) (38) (43) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 5 (10%) 3 (8%) 4 (9%)
Inflammation, Acute, Suppurative 3 (6%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia 1 (2%)
Endometrium, Hyperplasia, Cystic 47 (94%) 33 (87%) 39 (91%) 48 (96%)
Serosa, Inflammation, Acute, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (1)
Leukocytosis 1 (100%)
Bone Marrow (50) (50) (49) (50)
Fibrosis 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Myeloid Cell, Hypercellularity 1 (2%) 2 (4%) 11 (22%) 15 (30%)
Lymph Node (50) (20) (23) (50)
Deep Cervical, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%) 1 (5%) 4 (17%) 9 (18%)
Inguinal, Hyperplasia, Lymphoid 1 (5%) 1 (4%) 1 (2%)
Inguinal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Mediastinal, Abscess 1 (2%) 1 (4%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 3 (6%) 2 (10%) 3 (13%) 11 (22%)
Mesenteric, Angiectasis 5 (10%) 1 (5%) 2 (9%) 5 (10%)
Mesenteric, Hyperplasia, Lymphoid 4 (8%) 2 (10%) 1 (4%) 6 (12%)
Mesenteric, Infiltration Cellular,
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Polymorphonuclear 3 (6%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%) 1 (5%) 1 (4%) 2 (4%)
Renal, Hyperplasia, Lymphoid 1 (2%) 1 (5%) 6 (26%) 12 (24%)
Lymph Node, Mandibular (50) (15) (18) (49)
Hyperplasia, Lymphoid 1 (7%)
Spleen (50) (49) (49) (50)
Fibrosis, Focal 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 16 (32%) 14 (29%) 18 (37%) 21 (42%)
Pigmentation 4 (8%) 10 (20%)
Thrombosis 1 (2%)
Thymus (50) (13) (19) (50)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (14) (19) (50)
Inflammation, Subacute 1 (2%)
Duct, Cyst 2 (4%) 3 (6%)
Skin (50) (29) (33) (50)
Cyst Epithelial Inclusion 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 2 (4%)
Subcutaneous Tissue, Inflammation, Focal,
Subacute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (14) (18) (50)
Compression 3 (6%) 1 (7%)
Hemorrhage 1 (2%) 1 (2%)
Mineralization, Multifocal 39 (78%) 6 (43%) 12 (67%) 30 (60%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (13) (21) (50)
Hemorrhage 2 (4%) 1 (5%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Acute, Suppurative 1 (5%)
Alveolar Epithelium, Hyperplasia, Focal 1 (5%)
Nose (50) (13) (19) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Subacute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Fibrosis 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hydronephrosis 1 (2%)
Nephropathy, Chronic 33 (66%) 45 (92%) 46 (94%) 45 (90%)
Capsule, Inflammation, Subacute 1 (2%)
Cortex, Cyst 1 (2%) 1 (2%)
Cortex, Fibrosis, Focal 2 (4%)
Cortex, Metaplasia, Focal, Osseous 1 (2%) 3 (6%)
Glomerulus, Inflammation 2 (4%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute, Suppurative 1 (2%)
Renal Tubule, Degeneration, Multifocal 2 (4%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Renal Tubule, Necrosis, Multifocal 1 (2%)
Urinary Bladder (50) (12) (18) (50)
Inflammation, Subacute 1 (2%)
Serosa, Inflammation, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 9 8
Early Deaths
Moribund 8 13 10 10
Dead 8 9 10 9
Natural Death 1
Survivors
Terminal Sacrifice 33 28 31 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (15) (15) (48)
Mineralization, Focal 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (46) (18) (16) (45)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (6%)
Liver (50) (48) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 3 (6%) 2 (4%) 3 (6%) 8 (16%)
Clear Cell Focus 1 (2%)
Cytologic Alterations 21 (44%) 41 (82%) 43 (88%)
Eosinophilic Focus 4 (8%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%) 10 (20%) 38 (78%)
Inflammation, Multifocal, Subacute 2 (4%) 1 (2%)
Mixed Cell Focus 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Necrosis, Focal 4 (8%) 3 (6%) 2 (4%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation 5 (10%) 30 (60%) 41 (84%)
Sinusoid, Amyloid Deposition 1 (2%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 1 (2%) 1 (2%)
Mesentery (2) (3) (2) (1)
Cyst 1 (33%)
Fat, Mineralization, Focal 1 (100%)
Fat, Necrosis, Focal 2 (100%) 2 (67%) 2 (100%) 1 (100%)
Pancreas (50) (20) (18) (50)
Inflammation, Acute, Suppurative 1 (2%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Acinus, Atrophy, Multifocal 1 (5%)
Acinus, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Inflammation, Focal, Subacute 1 (2%)
Acinus, Necrosis 1 (2%)
Stomach, Forestomach (49) (21) (22) (50)
Erosion 3 (14%)
Hyperplasia 1 (5%) 5 (23%) 2 (4%)
Inflammation, Subacute 2 (10%)
Ulcer 1 (5%)
Stomach, Glandular (49) (20) (18) (50)
Erosion 1 (5%)
Inflammation, Subacute 1 (5%)
Mineralization 1 (2%)
Tooth (16) (3) (4) (24)
Dysplasia 15 (94%) 3 (100%) 4 (100%) 24 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Abdominal, Inflammation, Subacute 1 (100%)
Heart (50) (22) (19) (50)
Fibrosis, Focal 1 (2%)
Inflammation, Subacute 1 (5%)
Atrium, Thrombosis 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (23) (19) (50)
Capsule, Hyperplasia 1 (2%) 1 (2%)
Adrenal Gland, Cortex (50) (23) (19) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 1 (4%)
Fibrosis, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 5 (10%) 8 (16%)
Hypertrophy, Multifocal 1 (2%)
Mineralization, Focal 1 (2%)
Necrosis 1 (2%)
Pigmentation, Focal, Hematoidin 1 (2%)
Capsule, Accessory Adrenal Cortical Nodule 2 (4%) 1 (4%) 1 (2%)
Spindle Cell, Hyperplasia 4 (8%) 1 (5%) 2 (4%)
Adrenal Gland, Medulla (50) (21) (18) (50)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (50) (22) (17) (50)
Hyperplasia 1 (2%) 1 (5%) 2 (12%) 1 (2%)
Necrosis 1 (2%)
Pituitary Gland (46) (20) (18) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 3 (7%) 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Follicle, Cyst 3 (6%) 4 (8%) 19 (38%) 38 (76%)
Follicle, Degeneration, Cystic 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 10 (20%) 24 (48%) 41 (82%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (22) (19) (50)
Granuloma Sperm 1 (5%) 2 (4%)
Inflammation, Subacute 3 (6%) 2 (11%) 4 (8%)
Penis (3)
Developmental Malformation 1 (33%)
Preputial Gland (16) (14) (7) (4)
Inflammation, Subacute 9 (56%) 10 (71%) 4 (57%) 2 (50%)
Duct, Cyst 3 (19%) 6 (43%) 2 (29%) 2 (50%)
Prostate (50) (22) (19) (50)
Hemorrhage 1 (2%) 1 (5%)
Inflammation, Subacute 6 (12%) 7 (32%) 2 (11%) 8 (16%)
Seminal Vesicle (50) (21) (18) (50)
Dilatation 1 (6%)
Fibrosis 1 (2%)
Inflammation, Subacute 2 (4%) 1 (5%) 2 (11%) 2 (4%)
Testes (50) (22) (19) (50)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Degeneration 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1) (1) (3)
Leukocytosis 1 (100%) 1 (100%) 1 (100%) 1 (33%)
Bone Marrow (50) (22) (19) (49)
Hyperplasia, Histiocytic 1 (5%)
Myeloid Cell, Hypercellularity 9 (18%) 2 (9%) 5 (26%) 6 (12%)
Lymph Node (49) (27) (26) (50)
Axillary, Hyperplasia, Lymphoid 1 (4%) 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (4%)
Inguinal, Ectasia 1 (2%)
Inguinal, Hyperplasia, Lymphoid 6 (12%) 4 (15%) 3 (12%) 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia, Lymphoid 1 (4%)
Mesenteric, Angiectasis 14 (29%) 7 (26%) 4 (15%) 14 (28%)
Mesenteric, Hyperplasia, Lymphoid 4 (8%)
Renal, Hyperplasia, Lymphoid 1 (4%)
Spleen (48) (47) (49) (48)
Atrophy 2 (4%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 12 (25%) 9 (19%) 11 (22%) 5 (10%)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Pigmentation 6 (13%) 23 (47%) 39 (81%)
Thymus (46) (18) (19) (45)
Atrophy 1 (2%) 1 (6%) 2 (4%)
Cyst 4 (9%)
Necrosis 1 (6%) 1 (5%) 3 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (39) (45) (50)
Inflammation, Focal, Subacute 6 (12%) 8 (21%) 5 (11%) 1 (2%)
Inflammation, Multifocal, Subacute 3 (6%)
Ulcer 3 (6%) 6 (15%) 4 (9%)
Epidermis, Hyperplasia 1 (3%)
Epidermis, Hyperplasia, Focal 5 (10%) 4 (10%) 3 (7%) 4 (8%)
Epidermis, Hyperplasia, Multifocal 3 (6%)
Subcutaneous Tissue, Edema, Focal 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 6 (12%) 6 (15%) 8 (18%) 7 (14%)
Subcutaneous Tissue, Fibrosis, Multifocal 3 (6%) 1 (3%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Focal,
Subacute 1 (2%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Mineralization, Focal 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (22) (19) (50)
Hemorrhage 1 (2%) 1 (5%)
Mineralization, Multifocal 31 (62%) 11 (50%) 15 (79%) 36 (72%)
Necrosis, Multifocal 1 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (25) (26) (50)
Congestion 1 (2%) 1 (4%) 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 2 (8%)
Alveolar Epithelium, Hyperplasia 4 (15%)
Nose (50) (21) (20) (50)
Foreign Body 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Cataract 1 (50%)
Conjunctiva, Inflammation, Subacute 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Bacterium 1 (2%)
Hydronephrosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Nephropathy, Chronic 34 (68%) 39 (78%) 42 (84%) 45 (90%)
Artery, Inflammation 1 (2%) 1 (2%)
Cortex, Cyst 2 (4%) 4 (8%) 9 (18%)
Glomerulus, Amyloid Deposition 1 (2%)
Left, Fibrosis, Focal 1 (2%)
Papilla, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 7 (14%) 7 (14%)
Renal Tubule, Hyperplasia, Cystic 4 (8%)
Renal Tubule, Mineralization, Multifocal 1 (2%) 6 (12%) 5 (10%) 4 (8%)
Renal Tubule, Epithelium, Cytomegaly 40 (80%) 47 (94%) 46 (92%)
Right, Atrophy 1 (2%)
Urethra (1) (2) (3) (2)
Dilatation 1 (50%) 1 (50%)
Inflammation, Suppurative 1 (100%) 1 (50%) 1 (50%)
Bulbourethral Gland, Cyst 1 (50%)
Bulbourethral Gland, Hemorrhage 2 (67%)
Bulbourethral Gland, Inflammation, Subacute 1 (50%)
Urinary Bladder (49) (22) (18) (50)
Hemorrhage 2 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia 1 (2%)
Inflammation, Subacute 2 (4%) 2 (9%) 1 (6%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (5%)
Mineralization 1 (2%)
Wall, Mineralization, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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