TDMS Study 05019-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CI PIGMENT RED 3
NTP Experiment-Test: 05019-04 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
Facility: Southern Research Institute
Chemical CAS #: 2425-85-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 9 10 10 10
Early Deaths
Moribund 8 9 11 20
Accident 2
Dead 2 4 8 5
Survivors
Terminal Sacrifice 39 37 31 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (12) (17) (48)
Intestine Large, Rectum (48) (12) (18) (49)
Wall, Fibrosarcoma, Metastatic, Skin 1 (2%)
Intestine Small, Ileum (49) (13) (19) (48)
Intestine Small, Jejunum (49) (13) (17) (48)
Liver (50) (50) (49) (50)
Fibrosarcoma, Multiple, Metastatic, Three,
Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 4 (8%) 6 (12%) 2 (4%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Multiple, Two 1 (2%)
Hepatocellular Adenoma 7 (14%) 8 (16%) 2 (4%) 7 (14%)
Hepatocellular Adenoma, Multiple, Two 1 (2%)
Histiocytic Sarcoma 2 (4%) 2 (4%) 2 (4%)
Mast Cell Tumor Malignant 1 (2%)
Mesentery (8) (4) (4) (6)
Fibrosarcoma, Multiple, Metastatic, Greater
Than Five, Skin 1 (13%)
Fibrous Histiocytoma, Multiple, Greater Than
Five 1 (17%)
Pancreas (50) (12) (19) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Salivary Glands (50) (13) (18) (50)
Stomach, Forestomach (50) (16) (24) (49)
Hemangioma 1 (2%)
Squamous Cell Papilloma 1 (4%) 1 (2%)
Page 2
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Glandular (50) (12) (18) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (19) (50)
Histiocytic Sarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (15) (18) (50)
Adenoma 1 (7%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (50) (14) (18) (50)
Pheochromocytoma Malignant 1 (7%)
Pheochromocytoma Benign 1 (2%) 1 (7%)
Islets, Pancreatic (50) (12) (18) (50)
Carcinoma 1 (2%)
Pituitary Gland (49) (14) (17) (50)
Pars Distalis, Adenoma 8 (16%) 2 (14%) 2 (4%)
Thyroid Gland (50) (50) (49) (50)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma, Multiple 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (49) (50) (50)
Cystadenoma 1 (2%)
Cystadenoma, Papillary 1 (2%)
Histiocytic Sarcoma 1 (2%)
Granulosa Cell, Adenoma 1 (2%) 2 (4%)
Uterus (50) (38) (43) (50)
Adenoma, Cystic 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (3%) 1 (2%)
Polyp Stromal 2 (4%) 1 (3%)
Sarcoma 1 (3%) 1 (2%) 1 (2%)
Cervix, Histiocytic Sarcoma 1 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Mast Cell Tumor Malignant 1 (2%)
Lymph Node (50) (20) (23) (50)
Axillary, Fibrosarcoma, Metastatic, Skin 1 (4%)
Axillary, Histiocytic Sarcoma 1 (2%)
Deep Cervical, Histiocytic Sarcoma 1 (2%)
Iliac, Histiocytic Sarcoma 2 (4%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (4%) 1 (2%)
Inguinal, Histiocytic Sarcoma 1 (2%)
Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (2%)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Mesentery 1 (2%)
Mesenteric, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 2 (4%)
Lymph Node, Mandibular (50) (15) (18) (49)
Spleen (50) (49) (49) (50)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Hemangioma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%) 2 (4%)
Histiocytic Sarcoma 2 (4%)
Mast Cell Tumor Malignant 1 (2%)
Thymus (50) (13) (19) (50)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (29) (33) (50)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (3%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (3%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (3%)
Subcutaneous Tissue, Hemangiosarcoma 1 (3%)
Subcutaneous Tissue, Osteosarcoma,
Metastatic, Bone 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma, Multiple 1 (3%)
Subcutaneous Tissue, Schwannoma Benign 1 (3%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (13) (19) (50)
Osteosarcoma 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (13) (21) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (5%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Greater Than Five, Liver 1 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (8%)
Osteosarcoma, Multiple, Metastatic, Greater
Than Five, Bone 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (1) (1)
Adenoma 3 (100%) 1 (50%) 1 (100%) 1 (100%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mast Cell Tumor Malignant 1 (2%)
Osteosarcoma, Multiple, Metastatic, Two, Bone 1 (2%)
Urinary Bladder (50) (12) (18) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 2 (4%) 3 (6%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Mixed 14 (28%) 9 (18%) 8 (16%) 6 (12%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 29 23 33
Total Primary Neoplasms 58 44 27 43
Total Animals with Benign Neoplasms 21 15 6 23
Total Benign Neoplasms 30 17 6 25
Total Animals with Malignant Neoplasms 21 20 19 15
Total Malignant Neoplasms 28 27 21 18
Total Animals with Metastatic Neoplasms 3 1 2 2
Total Metastatic Neoplasm 10 1 3 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 9 8
Early Deaths
Moribund 8 13 10 10
Dead 8 9 10 9
Natural Death 1
Survivors
Terminal Sacrifice 33 28 31 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (46) (18) (16) (45)
Polyp Adenomatous 1 (6%)
Intestine Small, Ileum (45) (18) (16) (44)
Intestine Small, Jejunum (46) (19) (14) (46)
Liver (50) (48) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 4 (8%) 7 (15%) 8 (16%) 4 (8%)
Hepatocellular Carcinoma, Multiple 3 (6%)
Hepatocellular Carcinoma, Multiple, Three 1 (2%)
Hepatocellular Adenoma 6 (12%) 11 (23%) 9 (18%) 13 (27%)
Hepatocellular Adenoma, Multiple 2 (4%) 2 (4%)
Hepatocellular Adenoma, Multiple, Two 2 (4%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (49) (21) (22) (50)
Squamous Cell Papilloma 1 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (23) (19) (50)
Adrenal Gland, Medulla (50) (21) (18) (50)
Pheochromocytoma Malignant 1 (5%)
Pituitary Gland (46) (20) (18) (49)
Thyroid Gland (50) (49) (50) (50)
Follicular Cell, Adenoma 1 (2%) 5 (10%)
Page 8
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (22) (19) (50)
Fibrosarcoma, Metastatic, Skin 1 (5%)
Prostate (50) (22) (19) (50)
Testes (50) (22) (19) (50)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (22) (19) (49)
Lymph Node (49) (27) (26) (50)
Axillary, Fibrosarcoma, Metastatic, Skin 1 (4%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (4%)
Lymph Node, Mandibular (46) (18) (17) (48)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Spleen (48) (47) (49) (48)
Hemangiosarcoma 1 (2%)
Thymus (46) (18) (19) (45)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (39) (45) (50)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (3%) 3 (7%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 11 (22%) 7 (18%) 8 (18%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%) 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (3%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Rhabdomyosarcoma,
Metastatic, Skeletal Muscle 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (5%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (22) (19) (50)
Histiocytic Sarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (25) (26) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 5 (20%) 7 (27%) 5 (10%)
Alveolar/Bronchiolar Carcinoma 2 (8%)
Fibrosarcoma, Metastatic, Skin 1 (4%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Greater Than Five, Liver 1 (2%) 1 (4%)
Nose (50) (21) (20) (50)
Sarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (3) (1) (1)
Adenoma 2 (100%) 2 (67%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cortex, Adenoma 5 (10%)
Cortex, Adenoma, Multiple 1 (2%)
Urethra (1) (2) (3) (2)
Transitional Epithelium, Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Mixed 2 (4%) 2 (4%) 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05019-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 16:33:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 1.25% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 25 27 33 35
Total Primary Neoplasms 37 47 53 51
Total Animals with Benign Neoplasms 16 17 20 28
Total Benign Neoplasms 18 22 24 34
Total Animals with Malignant Neoplasms 18 23 25 17
Total Malignant Neoplasms 19 25 29 17
Total Animals with Metastatic Neoplasms 2 2 3
Total Metastatic Neoplasm 2 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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