https://ntp.niehs.nih.gov/go/2768

TDMS Study 05019-04 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          CI PIGMENT RED 3
NTP Experiment-Test: 05019-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 16:33:56
       Facility:  Southern Research Institute
       Chemical CAS #:  2425-85-6
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  9           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           8            9           11           20                                     
    Accident                                           2                                                                            
    Dead                                               2            4            8            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           37           31           25                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (48)         (12)         (17)         (48)                                   
   Intestine Large, Rectum                            (48)         (12)         (18)         (49)                                   
      Wall, Fibrosarcoma, Metastatic, Skin             1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (13)         (19)         (48)                                   
   Intestine Small, Jejunum                           (49)         (13)         (17)         (48)                                   
   Liver                                              (50)         (50)         (49)         (50)                                   
      Fibrosarcoma, Multiple, Metastatic, Three,                                                                                    
           Skin                                        1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         4 (8%)       6 (12%)      2 (4%)       1 (2%)                                
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple, Two                       1 (2%)                                                          
      Hepatocellular Adenoma                           7 (14%)      8 (16%)      2 (4%)       7 (14%)                               
      Hepatocellular Adenoma, Multiple, Two                                                   1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       2 (4%)                                
      Mast Cell Tumor Malignant                                                               1 (2%)                                
   Mesentery                                          (8)          (4)          (4)          (6)                                    
      Fibrosarcoma, Multiple, Metastatic, Greater                                                                                   
          Than Five, Skin                              1 (13%)                                                                      
      Fibrous Histiocytoma, Multiple, Greater Than                                                                                  
          Five                                                                                1 (17%)                               
   Pancreas                                           (50)         (12)         (19)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
   Salivary Glands                                    (50)         (13)         (18)         (50)                                   
   Stomach, Forestomach                               (50)         (16)         (24)         (49)                                   
      Hemangioma                                                                              1 (2%)                                
      Squamous Cell Papilloma                                                    1 (4%)       1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (50)         (12)         (18)         (49)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (13)         (19)         (50)                                   
      Histiocytic Sarcoma                                                        1 (5%)                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland, Cortex                              (50)         (15)         (18)         (50)                                   
      Adenoma                                                       1 (7%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (14)         (18)         (50)                                   
      Pheochromocytoma Malignant                                    1 (7%)                                                          
      Pheochromocytoma Benign                          1 (2%)       1 (7%)                                                          
   Islets, Pancreatic                                 (50)         (12)         (18)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (49)         (14)         (17)         (50)                                   
      Pars Distalis, Adenoma                           8 (16%)      2 (14%)                   2 (4%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)                    3 (6%)                                
      Follicular Cell, Adenoma, Multiple               2 (4%)                                                                       
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Cystadenoma                                                   1 (2%)                                                          
      Cystadenoma, Papillary                                                                  1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Granulosa Cell, Adenoma                                                    1 (2%)       2 (4%)                                
   Uterus                                             (50)         (38)         (43)         (50)                                   
      Adenoma, Cystic                                                                         1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (3%)       1 (2%)                                             
      Polyp Stromal                                    2 (4%)       1 (3%)                                                          
      Sarcoma                                                       1 (3%)       1 (2%)       1 (2%)                                
      Cervix, Histiocytic Sarcoma                                   1 (3%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Mast Cell Tumor Malignant                                                               1 (2%)                                
   Lymph Node                                         (50)         (20)         (23)         (50)                                   
      Axillary, Fibrosarcoma, Metastatic, Skin                                   1 (4%)                                             
      Axillary, Histiocytic Sarcoma                                                           1 (2%)                                
      Deep Cervical, Histiocytic Sarcoma                                                      1 (2%)                                
      Iliac, Histiocytic Sarcoma                                                              2 (4%)                                
      Inguinal, Fibrosarcoma, Metastatic, Skin                                   1 (4%)       1 (2%)                                
      Inguinal, Histiocytic Sarcoma                                                           1 (2%)                                
      Mediastinal, Fibrosarcoma, Metastatic, Skin      1 (2%)                                                                       
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Mesentery                                                               1 (2%)                                
      Mesenteric, Histiocytic Sarcoma                                                         1 (2%)                                
      Renal, Histiocytic Sarcoma                                                              2 (4%)                                
   Lymph Node, Mandibular                             (50)         (15)         (18)         (49)                                   
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
      Hemangioma                                       1 (2%)                                 1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (4%)       2 (4%)                                             
      Histiocytic Sarcoma                                                                     2 (4%)                                
      Mast Cell Tumor Malignant                                                               1 (2%)                                
   Thymus                                             (50)         (13)         (19)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Mesentery                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (50)         (29)         (33)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (3%)                                             
      Subcutaneous Tissue, Fibroma                                                            1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    1 (3%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                             1 (2%)                                
      Subcutaneous Tissue, Hemangioma                               1 (3%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (3%)                                                          
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Multiple                                     1 (3%)                                             
      Subcutaneous Tissue, Schwannoma Benign                                     1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (50)         (13)         (19)         (50)                                   
      Osteosarcoma                                     1 (2%)                    1 (5%)                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (13)         (21)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)                                 3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (5%)                                             
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Greater Than Five, Liver                      1 (8%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (8%)                                                          
      Osteosarcoma, Multiple, Metastatic, Greater                                                                                   
          Than Five, Bone                              1 (2%)                    1 (5%)                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (3)          (2)          (1)          (1)                                    
      Adenoma                                          3 (100%)     1 (50%)      1 (100%)     1 (100%)                              
      Carcinoma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Mast Cell Tumor Malignant                                                               1 (2%)                                
      Osteosarcoma, Multiple, Metastatic, Two, Bone    1 (2%)                                                                       
   Urinary Bladder                                    (50)         (12)         (18)         (50)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       3 (6%)                                
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                        14 (28%)      9 (18%)      8 (16%)      6 (12%)                               
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            36          29          23          33                                       
     Total Primary Neoplasms                           58          44          27          43                                       
   Total Animals with Benign Neoplasms                 21          15           6          23                                       
     Total Benign Neoplasms                            30          17           6          25                                       
   Total Animals with Malignant Neoplasms              21          20          19          15                                       
     Total Malignant Neoplasms                         28          27          21          18                                       
   Total Animals with Metastatic Neoplasms              3           1           2           2                                       
     Total Metastatic Neoplasm                         10           1           3           7                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9            8                                     
  Early Deaths                                                                                                                      
    Moribund                                           8           13           10           10                                     
    Dead                                               8            9           10            9                                     
    Natural Death                                      1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           28           31           33                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Small, Duodenum                          (46)         (18)         (16)         (45)                                   
      Polyp Adenomatous                                                          1 (6%)                                             
   Intestine Small, Ileum                             (45)         (18)         (16)         (44)                                   
   Intestine Small, Jejunum                           (46)         (19)         (14)         (46)                                   
   Liver                                              (50)         (48)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                         4 (8%)       7 (15%)      8 (16%)      4 (8%)                                
      Hepatocellular Carcinoma, Multiple                            3 (6%)                                                          
      Hepatocellular Carcinoma, Multiple, Three        1 (2%)                                                                       
      Hepatocellular Adenoma                           6 (12%)     11 (23%)      9 (18%)     13 (27%)                               
      Hepatocellular Adenoma, Multiple                                           2 (4%)       2 (4%)                                
      Hepatocellular Adenoma, Multiple, Two            2 (4%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (49)         (21)         (22)         (50)                                   
      Squamous Cell Papilloma                                       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland, Cortex                              (50)         (23)         (19)         (50)                                   
   Adrenal Gland, Medulla                             (50)         (21)         (18)         (50)                                   
      Pheochromocytoma Malignant                                    1 (5%)                                                          
   Pituitary Gland                                    (46)         (20)         (18)         (49)                                   
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                                                   1 (2%)       5 (10%)                               
                                                             Page   8                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (50)         (22)         (19)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (5%)                                             
   Prostate                                           (50)         (22)         (19)         (50)                                   
   Testes                                             (50)         (22)         (19)         (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (22)         (19)         (49)                                   
   Lymph Node                                         (49)         (27)         (26)         (50)                                   
      Axillary, Fibrosarcoma, Metastatic, Skin                                   1 (4%)                                             
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (4%)                                                          
   Lymph Node, Mandibular                             (46)         (18)         (17)         (48)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Spleen                                             (48)         (47)         (49)         (48)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (46)         (18)         (19)         (45)                                   
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (49)         (39)         (45)         (50)                                   
      Subcutaneous Tissue, Fibroma                     4 (8%)       1 (3%)       3 (7%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma               11 (22%)      7 (18%)      8 (18%)      4 (8%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Neurofibroma                             1 (3%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma                                                  1 (2%)                                
      Subcutaneous Tissue, Rhabdomyosarcoma,                                                                                        
          Metastatic, Skeletal Muscle                                            1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     2 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                                              (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (22)         (19)         (50)                                   
      Histiocytic Sarcoma                                                        1 (5%)                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (25)         (26)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       5 (20%)      7 (27%)      5 (10%)                               
      Alveolar/Bronchiolar Carcinoma                                2 (8%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (4%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Greater Than Five, Liver         1 (2%)       1 (4%)                                                          
   Nose                                               (50)         (21)         (20)         (50)                                   
      Sarcoma                                                                    1 (5%)                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (2)          (3)          (1)          (1)                                    
      Adenoma                                          2 (100%)     2 (67%)      1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cortex, Adenoma                                                                         5 (10%)                               
      Cortex, Adenoma, Multiple                                                               1 (2%)                                
   Urethra                                            (1)          (2)          (3)          (2)                                    
      Transitional Epithelium, Carcinoma                                         1 (33%)                                            
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         2 (4%)       2 (4%)       6 (12%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05019-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 16:33:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            25          27          33          35                                       
     Total Primary Neoplasms                           37          47          53          51                                       
   Total Animals with Benign Neoplasms                 16          17          20          28                                       
     Total Benign Neoplasms                            18          22          24          34                                       
   Total Animals with Malignant Neoplasms              18          23          25          17                                       
     Total Malignant Neoplasms                         19          25          29          17                                       
   Total Animals with Metastatic Neoplasms              2           2           3                                                   
     Total Metastatic Neoplasm                          2           3           3                                                   
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
--multipart-boundary
Content-type: text/plain
Range: bytes 64862-64862/64862
--multipart-boundary--