TDMS Study 05019-04 Pathology Tables
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
Facility: Southern Research Institute
Chemical CAS #: 2425-85-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Cytologic Alterations | |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Granulomatous | |
Necrosis, Focal | 1 1 1 |
Necrosis, Multifocal | |
Kupffer Cell, Pigmentation | 2 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 1 2 3|
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Acute, Suppurative | 3 2|
Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Inflammation, Acute, Suppurative | 3 |
Inflammation, Chronic | |
Inflammation, Subacute | |
Acinus, Atrophy, Multifocal | 3 |
Acinus, Necrosis, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 2 2 |
Hyperplasia | 2 2 2 2 1 1 1 |
Hypertrophy | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | 2|
Hemorrhage | 2|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Diffuse | |
Hypertrophy, Focal | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
X-Zone, Degeneration, Fatty | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 1 2 3 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 2 2 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X|
Follicle, Cyst | 1 2|
Follicular Cell, Hyperplasia | 4 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multiple | 4 4|
Angiectasis | |
Cyst | 2 4 3 4 4 2 2|
Hemorrhage | 2 |
Hyperplasia, Cystic | 2 2 |
Inflammation, Chronic | 2 |
Pigmentation, Hemosiderin | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | |
Hydrometra | 2 |
Inflammation, Acute, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 1 3 3 3 4 3 2 4 4 3 3 1 3 3 3 2 3 4 4 3 3 4 4 4 1|
Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Lipocyte | 3 |
Myeloid Cell, Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Lymphoid | 4 |
Iliac, Hyperplasia, Lymphoid | 4 |
Mediastinal, Abscess | 2|
Mediastinal, Hyperplasia, Lymphoid | 4 2 3|
Mesenteric, Angiectasis | 1 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 1 4 2 4 2 2 2 2 3|
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 |
Hemorrhage | |
Mineralization, Multifocal | 1 2 2 1 1 1 1 2 2 2 2 1 1 2 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | |
Cortex, Fibrosis, Focal | |
Cortex, Metaplasia, Focal, Osseous | 2 |
Renal Tubule, Dilatation, Multifocal | 3 |
Renal Tubule, Necrosis, Multifocal | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|
| 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Cytologic Alterations | 1 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Granulomatous | 1 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 4 1 |
Kupffer Cell, Pigmentation | 2 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Acute, Suppurative | |
Inflammation, Chronic | 4|
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 4 |
Inflammation, Acute, Suppurative | |
Inflammation, Chronic | 4|
Inflammation, Subacute | 4 2 |
Acinus, Atrophy, Multifocal | 4 2 |
Acinus, Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 |
Hyperplasia | 2 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | |
Hemorrhage | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|
| 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia, Focal | 2|
Hyperplasia, Multifocal | |
Hypertrophy, Diffuse | 2 |
Hypertrophy, Focal | 1|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
X-Zone, Degeneration, Fatty | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicle, Cyst | 1 1 1 1 2|
Follicular Cell, Hyperplasia | 1 2 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multiple | |
Angiectasis | 2 |
Cyst | 3 3 2 2 2 2 3 X 3 2 4 |
Hemorrhage | |
Hyperplasia, Cystic | |
Inflammation, Chronic | 4|
Pigmentation, Hemosiderin | 2 |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|
| 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemorrhage | 3 |
Hydrometra | 3 2 2 2 |
Inflammation, Acute, Suppurative | 2 2 |
Endometrium, Hyperplasia, Cystic | 3 3 1 1 3 1 3 3 3 4 3 3 3 1 3 1 3 3 3 4 3 3|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Infiltration Cellular, Lipocyte | |
Myeloid Cell, Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | 2 1 3 |
Mesenteric, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3|
Hematopoietic Cell Proliferation | 3 4 3 4 2 1 3|
Thrombosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hemorrhage | 3 |
Mineralization, Multifocal | 2 2 2 2 2 1 2 2 1 1 2 2 1 2 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|
| 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Fibrosis | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 1 |
Cortex, Fibrosis, Focal | 2 1 |
Cortex, Metaplasia, Focal, Osseous | |
Renal Tubule, Dilatation, Multifocal | |
Renal Tubule, Necrosis, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 6| 9| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Cytologic Alterations | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Inflammation, Granulomatous | | 1 1.0|
Necrosis, Focal | | 4 1.0|
Necrosis, Multifocal | | 2 2.5|
Kupffer Cell, Pigmentation | | 2 2.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Inflammation, Acute, Suppurative | | 2 2.5|
Inflammation, Chronic | | 1 4.0|
Fat, Necrosis, Focal | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Cyst, Multiple | | 1 4.0|
Inflammation, Acute, Suppurative | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Subacute | | 2 3.0|
Acinus, Atrophy, Multifocal | | 3 3.0|
Acinus, Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Erosion | | 6 2.2|
Hyperplasia | | 11 1.7|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 6| 9| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion, Multiple | | 1 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Artery, Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Cyst | | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Diffuse | | 1 2.0|
Hypertrophy, Focal | | 2 1.5|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
X-Zone, Degeneration, Fatty | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Angiectasis | | 10 2.3|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 16 1.8|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Ultimobranchial Cyst | | 1 |
Follicle, Cyst | | 7 1.3|
Follicular Cell, Hyperplasia | | 11 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 6| 9| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Abscess, Multiple | | 2 4.0|
Angiectasis | | 1 2.0|
Cyst | | 18 2.8|
Hemorrhage | | 1 2.0|
Hyperplasia, Cystic | | 2 2.0|
Inflammation, Chronic | | 2 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Hemorrhage | | 1 3.0|
Hydrometra | | 5 2.2|
Inflammation, Acute, Suppurative | | 3 2.0|
Endometrium, Hyperplasia, Cystic | | 47 2.8|
Endometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Fibrosis | | 1 3.0|
Infiltration Cellular, Lipocyte | | 1 3.0|
Myeloid Cell, Hypercellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Deep Cervical, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Abscess | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 3.0|
Mesenteric, Angiectasis | | 5 1.8|
Mesenteric, Hyperplasia, Lymphoid | | 4 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis, Focal | | 2 3.0|
Hematopoietic Cell Proliferation | | 16 2.6|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 50 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 6| 9| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Duct, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 3 2.0|
Hemorrhage | | 1 3.0|
Mineralization, Multifocal | | 39 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy, Chronic | | 33 1.0|
Cortex, Cyst | | 1 1.0|
Cortex, Fibrosis, Focal | | 2 1.5|
Cortex, Metaplasia, Focal, Osseous | | 1 2.0|
Renal Tubule, Dilatation, Multifocal | | 1 3.0|
Renal Tubule, Necrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|
| 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 X |
Cytologic Alterations | 2 1 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 2 1 2 1 2 2 2 2 |
Inflammation, Granulomatous | 2 2 2 2 1 2 |
Mixed Cell Focus | X X |
Necrosis, Focal | 1 1 1 |
Necrosis, Multifocal | 1 1 2 |
Kupffer Cell, Pigmentation | 2 3 1 1 2 2 1 2 2 1 3|
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 3 2 2 1 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Acute, Suppurative | 2 2 2 |
Artery, Inflammation | 2 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Inflammation, Acute, Suppurative | 2 2 |
Inflammation, Subacute | 2 2 |
Acinus, Atrophy, Multifocal | 3 2 |
Acinus, Hyperplasia, Focal | 2 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | 2 2 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|
| 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Focal, Subacute | 1 |
Inflammation, Multifocal, Subacute | 2 |
Artery, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 2 |
Follicle, Cyst | 1 2 2 2 1 2 X 3 1 2 2 2|
Follicle, Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia | 1 1 2 1 2 2 2 1 2 1 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 3 |
Abscess, Multiple | 4 4 4 4 4 4 4 4 |
Cyst | 3 3 4 3 1 |
Cyst, Multiple | 3 X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Acute, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 3 2 2 2 3 2 3 2 3 2 3 2 3 3 3 2 2 1 2|
Serosa, Inflammation, Acute, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 3 2 3 1 2 3 3 3 2 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 4 4 4 3 3 4 4 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|
| 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia, Lymphoid | 2|
Inguinal, Infiltration Cellular, | |
Polymorphonuclear | 2|
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Lymphoid | 4 4 2 2 3 3 4 3 |
Mesenteric, Angiectasis | 2 1 |
Mesenteric, Hyperplasia, Lymphoid | 4 2 3 2 |
Mesenteric, Infiltration Cellular, | |
Polymorphonuclear | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 4 4 4 3 3 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 2 4 3 3 4 4 4 2 4 4 4 |
Pigmentation | 1 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosis, Focal | 4 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization, Multifocal | 1 1 2 2 1 1 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Histiocyte | 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|
| 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy, Chronic | 2 2 1 2 2 1 1 2 2 2 1 2 3 2 2 3 2 1 2 2 2 2 1|
Capsule, Inflammation, Subacute | |
Cortex, Cyst | 2 |
Cortex, Metaplasia, Focal, Osseous | |
Glomerulus, Inflammation | |
Renal Tubule, Degeneration, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Serosa, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytologic Alterations | X 2 2 3 2 2 2 2 2 3 2 2 1|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 2 3 2 |
Inflammation, Granulomatous | 1 2 2 3 2 |
Mixed Cell Focus | |
Necrosis, Focal | 1 2 1 |
Necrosis, Multifocal | 1 |
Kupffer Cell, Pigmentation | 1 1 3 1 2 2 3 2 1 2 1 2 2 3 1 2 2 1|
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute, Suppurative | |
Artery, Inflammation | |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Acute, Suppurative | |
Inflammation, Subacute | 3 |
Acinus, Atrophy, Multifocal | 2 |
Acinus, Hyperplasia, Focal | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 |
Hyperplasia | 2 2 1 2 2 2|
Ulcer | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Focal, Subacute | |
Inflammation, Multifocal, Subacute | 2 |
Artery, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Follicle, Cyst | 1 2 2 2 2 2 2 4 1|
Follicle, Hyperplasia, Cystic | 3 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 1 1 3 2 1 1 3 1 1 2 2 2 2 2 3 1 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 |
Abscess, Multiple | 4 4 |
Cyst | 2 3 2 3 3 2 4 X 4 2 4 |
Cyst, Multiple | 4 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Acute, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 2 4 3 3 3 3 3 2 3 2 2 2 3 2 2 3 3 2 3 3 3 4 2 |
Serosa, Inflammation, Acute, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 4 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 3 4 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Infiltration Cellular, | |
Polymorphonuclear | |
Mediastinal, Abscess | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 3 3 |
Mesenteric, Angiectasis | 1 2 2|
Mesenteric, Hyperplasia, Lymphoid | 2 3 |
Mesenteric, Infiltration Cellular, | |
Polymorphonuclear | 3 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 3 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 4 4 4 3 |
Pigmentation | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosis, Focal | 1 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization, Multifocal | 2 1 1 1 1 1 1 2 1 2 2 1 1 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 1 1 2 2 2 1 1 3 1 3 2 2 1 2 1 2 2 1 2 1 2|
Capsule, Inflammation, Subacute | 2 |
Cortex, Cyst | |
Cortex, Metaplasia, Focal, Osseous | 1 1 2 |
Glomerulus, Inflammation | 4 2 |
Renal Tubule, Degeneration, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Serosa, Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 9| 8| 9| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 2 3.0|
Cytologic Alterations | | 15 2.0|
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | | 15 1.9|
Inflammation, Granulomatous | | 11 1.9|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 6 1.2|
Necrosis, Multifocal | | 4 1.3|
Kupffer Cell, Pigmentation | | 29 1.8|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 18 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Inflammation, Acute, Suppurative | | 3 2.0|
Artery, Inflammation | | 1 2.0|
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Acute, Suppurative | | 2 2.0|
Inflammation, Subacute | | 3 2.3|
Acinus, Atrophy, Multifocal | | 3 2.3|
Acinus, Hyperplasia, Focal | | 1 2.0|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Erosion | | 4 2.0|
Hyperplasia | | 10 1.9|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 9| 8| 9| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Erosion, Multiple | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Focal, Subacute | | 1 1.0|
Inflammation, Multifocal, Subacute | | 2 2.0|
Artery, Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Hyperplasia | | 12 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Artery, Inflammation | | 1 2.0|
Follicle, Cyst | | 21 1.9|
Follicle, Hyperplasia, Cystic | | 1 3.0|
Follicular Cell, Hyperplasia | | 38 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Abscess | | 9 3.9|
Abscess, Multiple | | 10 4.0|
Cyst | | 16 2.9|
Cyst, Multiple | | 4 3.7|
__________________________________________________________________________|____________|
Uterus | | 50 |
Angiectasis | | 1 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 48 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 9| 8| 9| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Serosa, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Myeloid Cell, Hypercellularity | | 15 2.7|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Iliac, Hyperplasia, Lymphoid | | 9 3.7|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Mediastinal, Abscess | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 11 3.1|
Mesenteric, Angiectasis | | 5 1.6|
Mesenteric, Hyperplasia, Lymphoid | | 6 2.7|
Mesenteric, Infiltration Cellular, | | |
Polymorphonuclear | | 3 2.3|
Pancreatic, Hyperplasia, Lymphoid | | 2 3.0|
Renal, Hyperplasia, Lymphoid | | 12 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 21 3.5|
Pigmentation | | 10 1.1|
__________________________________________________________________________|____________|
Thymus | | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Inflammation, Subacute | | 1 2.0|
Duct, Cyst | | 3 2.3|
__________________________________________________________________________|____________|
Skin | | 50 |
Subcutaneous Tissue, Fibrosis, Focal | | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 9| 8| 9| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage | | 1 3.0|
Mineralization, Multifocal | | 30 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 2.0|
Nephropathy, Chronic | | 45 1.8|
Capsule, Inflammation, Subacute | | 1 2.0|
Cortex, Cyst | | 1 2.0|
Cortex, Metaplasia, Focal, Osseous | | 3 1.3|
Glomerulus, Inflammation | | 2 3.0|
Renal Tubule, Degeneration, | | |
Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Inflammation, Subacute | | 1 2.0|
Serosa, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|
| 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 1 2 |
Inflammation, Granulomatous | 1 1 |
Necrosis, Focal | 1 |
Kupffer Cell, Pigmentation | 1 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 2 2 1 2 2|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute, Suppurative | 2 2 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + +|
Inflammation, Acute, Suppurative | 4 |
Acinus, Atrophy, Multifocal | 3 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Inflammation, Focal, Subacute | 1 |
Inflammation, Multifocal, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|
| 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + +|
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 1 1 2 |
Follicle, Hyperplasia, Cystic | 1 |
Follicular Cell, Hyperplasia | 1 1 1 2 1 1 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 1 4|
Abscess, Multiple | 4 4 |
Cyst | 2 2 3 2 2 |
Cyst, Multiple | 3 3 |
Hemorrhage | 2 3 |
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 |
Inflammation, Acute, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 3 3 3 2 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 2 2|
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Angiectasis | 1 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 4 3 3 2 4 3|
Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|
| 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute, Suppurative | 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 1 1 1 1 1 3 1 1 1 1 2 1 1 1 1 1 1 1 1 3|
Papilla, Necrosis | 3 |
Pelvis, Inflammation, Acute, | |
Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|
| 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + A + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 2 3 1 |
Inflammation, Granulomatous | |
Necrosis, Focal | |
Kupffer Cell, Pigmentation | |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute, Suppurative | |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + +|
Inflammation, Acute, Suppurative | |
Acinus, Atrophy, Multifocal | 2 2 2 4 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + A + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + +|
Erosion | 2 2 2 2 |
Hyperplasia | 2 2 2 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
Inflammation, Focal, Subacute | |
Inflammation, Multifocal, Subacute | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|
| 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + A + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + A + +|
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Follicle, Cyst | 1 1 1 1 2 1 1 |
Follicle, Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 3 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 2 |
Abscess, Multiple | 4 4 3 2 |
Cyst | 3 X 3 4 2 4 2 4 |
Cyst, Multiple | 3 3 |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + A + + + + +|
Hydrometra | 2|
Inflammation, Acute, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 3 2 3 4 4 2 3 4 2 3 1 4 2 3 4 4 3 3 4 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Myeloid Cell, Hypercellularity | 3 4 4 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + A + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Abscess | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mesenteric, Angiectasis | |
Mesenteric, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + A + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 1 4 1 4 4 3 4 2 4 3 4 |
Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|
| 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + A + +|
Mineralization, Multifocal | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Nephropathy, Chronic | 2 2 1 1 1 1 1 1 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | |
Pelvis, Inflammation, Acute, | |
Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 8| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 18 |
__________________________________________________________________________|____________|
Gallbladder | | 17 |
__________________________________________________________________________|____________|
Intestine Large | | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 18 |
__________________________________________________________________________|____________|
Intestine Small | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 17 |
__________________________________________________________________________|____________|
Liver | | 49 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | | 7 1.9|
Inflammation, Granulomatous | | 2 1.0|
Necrosis, Focal | | 1 1.0|
Kupffer Cell, Pigmentation | | 1 1.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 10 1.9|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Acute, Suppurative | | 2 2.0|
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 19 |
Inflammation, Acute, Suppurative | | 1 4.0|
Acinus, Atrophy, Multifocal | | 5 2.6|
Duct, Dilatation | | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 18 |
__________________________________________________________________________|____________|
Stomach | | 24 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 24 |
Erosion | | 4 2.0|
Hyperplasia | | 5 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 18 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 19 |
Inflammation, Focal, Subacute | | 1 1.0|
Inflammation, Multifocal, Subacute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 8| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 18 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 18 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | | 17 |
Pars Distalis, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicle, Cyst | | 11 1.2|
Follicle, Hyperplasia, Cystic | | 1 1.0|
Follicular Cell, Hyperplasia | | 24 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Abscess | | 6 3.2|
Abscess, Multiple | | 6 3.5|
Cyst | | 13 2.8|
Cyst, Multiple | | 4 3.0|
Hemorrhage | | 2 2.5|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | | 43 |
Hydrometra | | 4 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 39 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myeloid Cell, Hypercellularity | | 11 3.2|
__________________________________________________________________________|____________|
Lymph Node | | 23 |
Iliac, Hyperplasia, Lymphoid | | 4 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Abscess | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 8| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Lymphoid | | 3 2.0|
Mesenteric, Angiectasis | | 2 1.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 18 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 18 3.2|
Pigmentation | | 4 1.0|
__________________________________________________________________________|____________|
Thymus | | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 19 |
__________________________________________________________________________|____________|
Skin | | 33 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 19 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 18 |
Mineralization, Multifocal | | 12 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 21 |
Hemorrhage | | 1 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 19 |
__________________________________________________________________________|____________|
Trachea | | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Nephropathy, Chronic | | 46 1.3|
Papilla, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 8| 9| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|
| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Cytologic Alterations | 2 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Necrosis, Focal | 1 1 |
Kupffer Cell, Pigmentation | |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 2|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute, Suppurative | 2 |
Fat, Necrosis, Focal | 4 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + +|
Acinus, Atrophy, Multifocal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + +|
Erosion | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Inflammation, Focal, Subacute | |
Inflammation, Multifocal, Subacute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|
| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 2 2 1 1 2 1 |
Follicular Cell, Hyperplasia | 3 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + A + + + + + + + + +|
Abscess | 4 4|
Cyst | 2 3 3 3 2 |
Cyst, Multiple | 2 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 3 3 4 3 3 3 3 3 3 1 4 3 3 3 3 4 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 3 2|
Mesenteric, Angiectasis | |
Mesenteric, Hyperplasia, Lymphoid | 2 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 3 1 4 2 2 2 2 4 2|
__________________________________________________________________________|
Thymus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|
| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Compression | X |
Mineralization, Multifocal | 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 2 1 2 1 1 1 1 2 1 1 2 2 1 1 3 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Cytologic Alterations | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | 2 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Kupffer Cell, Pigmentation | 1 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute, Suppurative | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Erosion | 2 2 2 2 |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Inflammation, Focal, Subacute | 1 |
Inflammation, Multifocal, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 1 1 1 1 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | 2 4 2 1 2 2 4 3 3|
Cyst, Multiple | 2 |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Hydrometra | 2 2 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 4 4 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | 3 |
Mesenteric, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 3 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Compression | |
Mineralization, Multifocal | 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
__________________________________________________________________________|
Nose | + + + + + |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 14 |
__________________________________________________________________________|____________|
Gallbladder | | 12 |
__________________________________________________________________________|____________|
Intestine Large | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 12 |
__________________________________________________________________________|____________|
Intestine Small | | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 13 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 13 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 |
Cytologic Alterations | | 1 2.0|
Eosinophilic Focus | | 3 |
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Granulomatous | | 2 1.5|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 3 1.3|
Kupffer Cell, Pigmentation | | 1 1.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Acute, Suppurative | | 1 2.0|
Fat, Necrosis, Focal | | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | | 12 |
Acinus, Atrophy, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 13 |
__________________________________________________________________________|____________|
Stomach | | 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 16 |
Erosion | | 5 2.0|
Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 13 |
Inflammation, Focal, Subacute | | 1 1.0|
Inflammation, Multifocal, Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 14 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | | 14 |
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 12 1.3|
Follicular Cell, Hyperplasia | | 11 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Abscess | | 2 4.0|
Cyst | | 14 2.6|
Cyst, Multiple | | 2 2.0|
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | | 38 |
Hydrometra | | 3 2.0|
Endometrium, Hyperplasia, Cystic | | 33 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Myeloid Cell, Hypercellularity | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 20 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Mesenteric, Angiectasis | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 15 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 14 2.5|
__________________________________________________________________________|____________|
Thymus | | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 14 |
__________________________________________________________________________|____________|
Skin | | 29 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 14 |
Compression | | 1 |
Mineralization, Multifocal | | 6 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 13 |
__________________________________________________________________________|____________|
Nose | | 13 |
__________________________________________________________________________|____________|
Trachea | | 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Nephropathy, Chronic | | 45 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + A + + M +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Multifocal, Subacute | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 4 1 |
Necrosis, Multifocal | |
Centrilobular, Necrosis | 1 |
Sinusoid, Amyloid Deposition | |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Acinus, Atrophy, Focal | 1 |
Acinus, Hyperplasia, Focal | |
Acinus, Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + |
Dysplasia | 1 1 2 1 2 2 2 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Fibrosis, Focal | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 2 |
Hypertrophy, Multifocal | 2 |
Mineralization, Focal | |
Necrosis | |
Pigmentation, Focal, Hematoidin | |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicle, Degeneration, Cystic | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Inflammation, Subacute | 2 3 4 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Subacute | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 4 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 3 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ectasia | |
Inguinal, Hyperplasia, Lymphoid | 4 4 4|
Mesenteric, Angiectasis | 2 2 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 4 3 3 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + + + + M + + + + + + +|
Atrophy | 3 |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 2 3 2 3|
Inflammation, Multifocal, Subacute | 3 2 |
Ulcer | 2 3 |
Epidermis, Hyperplasia, Focal | |
Epidermis, Hyperplasia, Multifocal | 2 2 |
Subcutaneous Tissue, Edema, Focal | 3 |
Subcutaneous Tissue, Fibrosis, Focal | 3 3 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 2 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 |
Subcutaneous Tissue, Mineralization, | |
Focal | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mineralization, Multifocal | 2 2 2 2 2 2 2 1 2 1 2 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Conjunctiva, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hydronephrosis | 4 |
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1|
Glomerulus, Amyloid Deposition | |
Papilla, Necrosis | |
Renal Tubule, Mineralization, | |
Multifocal | 3 |
Right, Atrophy | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Inflammation, Suppurative | |
Wall, Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|
| 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Multifocal, Subacute | 2 |
Mixed Cell Focus | X X|
Necrosis, Focal | 3 |
Necrosis, Multifocal | 3 |
Centrilobular, Necrosis | |
Sinusoid, Amyloid Deposition | 4 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 3 |
Acinus, Atrophy, Focal | |
Acinus, Hyperplasia, Focal | 1 |
Acinus, Necrosis | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + |
Dysplasia | 3 2 1 1 4 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|
| 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 |
Fibrosis, Focal | 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 3 2 2 |
Hypertrophy, Multifocal | |
Mineralization, Focal | 3 |
Necrosis | 2 |
Pigmentation, Focal, Hematoidin | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
Spindle Cell, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + M + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 1 |
Follicle, Degeneration, Cystic | |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Inflammation, Subacute | 3 4 3 3 4 4 |
Duct, Cyst | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Subacute | 2 4 4 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|
| 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 4 3 2 4 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inguinal, Ectasia | 2 |
Inguinal, Hyperplasia, Lymphoid | 3 4 2 |
Mesenteric, Angiectasis | 2 1 1 2 1 3 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + M + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 3 4 3 4 3 3 |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 2 2 |
Inflammation, Multifocal, Subacute | 1 |
Ulcer | 3 |
Epidermis, Hyperplasia, Focal | 2 1 2 2 1 |
Epidermis, Hyperplasia, Multifocal | 1 |
Subcutaneous Tissue, Edema, Focal | |
Subcutaneous Tissue, Fibrosis, Focal | 2 2 3 3 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 1 2 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | |
Subcutaneous Tissue, Mineralization, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization, Multifocal | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|
| 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 2|
Conjunctiva, Inflammation, Subacute | |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 4 |
Hydronephrosis | |
Inflammation, Suppurative | 4 1 |
Nephropathy, Chronic | 1 1 3 1 1 3 1 1 1 1 1 1 2 1 1 1 1|
Glomerulus, Amyloid Deposition | 2 |
Papilla, Necrosis | 2 |
Renal Tubule, Mineralization, | |
Multifocal | |
Right, Atrophy | 3 |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Inflammation, Suppurative | 2 |
Wall, Mineralization, Focal | 1|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
__________________________________________________________________________|____________|
Gallbladder | | 47 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 47 |
__________________________________________________________________________|____________|
Intestine Small | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 3 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Multifocal, Subacute | | 2 1.5|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 4 2.5|
Necrosis, Multifocal | | 1 3.0|
Centrilobular, Necrosis | | 1 1.0|
Sinusoid, Amyloid Deposition | | 1 4.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Acute, Suppurative | | 1 3.0|
Acinus, Atrophy, Focal | | 1 1.0|
Acinus, Hyperplasia, Focal | | 1 1.0|
Acinus, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
__________________________________________________________________________|____________|
Tooth | | 16 |
Dysplasia | | 15 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Angiectasis | | 1 3.0|
Cyst | | 1 1.0|
Fibrosis, Focal | | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 5 2.2|
Hypertrophy, Multifocal | | 1 2.0|
Mineralization, Focal | | 1 3.0|
Necrosis | | 1 2.0|
Pigmentation, Focal, Hematoidin | | 1 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 2.0|
Spindle Cell, Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | | 46 |
Pars Distalis, Cyst | | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 3 1.3|
Follicle, Degeneration, Cystic | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Inflammation, Subacute | | 3 2.7|
__________________________________________________________________________|____________|
Preputial Gland | | 16 |
Inflammation, Subacute | | 9 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Cyst | | 3 3.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hemorrhage | | 1 2.0|
Inflammation, Subacute | | 6 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Fibrosis | | 1 3.0|
Inflammation, Subacute | | 2 3.0|
__________________________________________________________________________|____________|
Testes | | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 4.0|
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Myeloid Cell, Hypercellularity | | 9 2.9|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Inguinal, Ectasia | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 6 3.5|
Mesenteric, Angiectasis | | 14 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 46 |
__________________________________________________________________________|____________|
Spleen | | 48 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | | 12 3.2|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 46 |
Atrophy | | 1 3.0|
Cyst | | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 49 |
Inflammation, Focal, Subacute | | 6 2.3|
Inflammation, Multifocal, Subacute | | 3 2.0|
Ulcer | | 3 2.7|
Epidermis, Hyperplasia, Focal | | 5 1.6|
Epidermis, Hyperplasia, Multifocal | | 3 1.7|
Subcutaneous Tissue, Edema, Focal | | 1 3.0|
Subcutaneous Tissue, Fibrosis, Focal | | 6 2.7|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 2.0|
Subcutaneous Tissue, Mineralization, | | |
Focal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage | | 1 2.0|
Mineralization, Multifocal | | 31 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 3.0|
Hemorrhage, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Conjunctiva, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Bacterium | | 1 4.0|
Hydronephrosis | | 1 4.0|
Inflammation, Suppurative | | 2 2.5|
Nephropathy, Chronic | | 34 1.2|
Glomerulus, Amyloid Deposition | | 1 2.0|
Papilla, Necrosis | | 1 2.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Right, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Inflammation, Subacute | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Wall, Mineralization, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|
DAY ON TEST | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|
| 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Cytologic Alterations | 2 3 1 3 3 3 3 3 3 1 3 3 2 3 3 3 3 3 3 2|
Eosinophilic Focus | 2 X |
Inflammation, Granulomatous | 3 1 3 2 3 2 2 3 1 3 3 2 3 3 3 2 3 2|
Mixed Cell Focus | X X |
Necrosis, Multifocal | 2 |
Kupffer Cell, Pigmentation | 2 3 1 3 3 3 3 3 4 1 4 3 2 3 3 3 4 3 3 2|
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization, Focal | 2 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Acinus, Inflammation, Focal, Subacute| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Dysplasia | 4 2 2 2 3 2 1 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|
DAY ON TEST | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|
| 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 1 1 3 2 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 1 1 2 2 2 2 1 2 2 1 1 1 1 2 1 1 2 1|
Follicular Cell, Hyperplasia | 1 3 2 2 1 3 3 2 2 3 3 2 1 3 2 3 1 3 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Subacute | 1 2 1 |
__________________________________________________________________________|
Penis | M |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Subacute | 4 3 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 2 2 4 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + |
Myeloid Cell, Hypercellularity | 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | 3|
Inguinal, Hyperplasia, Lymphoid | 4 3 2 2 2 |
Mesenteric, Angiectasis | 1 2 3 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|
DAY ON TEST | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|
| 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hyperplasia, Lymphoid | 3 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
Pigmentation | 1 2 1 1 2 1 1 1 1 2 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 4 |
Necrosis | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 2 |
Epidermis, Hyperplasia, Focal | 2 2 |
Subcutaneous Tissue, Fibrosis, Focal | 3 4 3 2 |
Subcutaneous Tissue, Hemorrhage | 4 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 3 3 |
Subcutaneous Tissue, Mineralization, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 2 2 1 2 2 2 2 2 2 1 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nephropathy, Chronic | 1 1 3 1 1 1 1 1 3 3 3 2 2 1 1 2 2 1 3 2 1 1 3|
Artery, Inflammation | |
Cortex, Cyst | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|
DAY ON TEST | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|
| 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Left, Fibrosis, Focal | |
Renal Tubule, Dilatation, Multifocal | |
Renal Tubule, Hyperplasia, Cystic | 1 |
Renal Tubule, Hyperplasia | 2 4 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 1 2 2 |
Renal Tubule, Epithelium, Cytomegaly | 3 2 3 3 1 2 3 3 4 4 4 2 3 3 3 3 3 3 3 1 1 3 3 3|
__________________________________________________________________________|
Urethra | |
Dilatation | |
Inflammation, Suppurative | |
Bulbourethral Gland, Cyst | |
Bulbourethral Gland, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|
| 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + A + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | |
Cytologic Alterations | 3 3 3 3 3 3 3 1 2 1 3 3 3 3 2 3 3 2 2 1 3 2 3|
Eosinophilic Focus | X |
Inflammation, Granulomatous | 2 3 3 2 2 2 2 2 2 2 2 3 3 3 3 2 2 3 2 2|
Mixed Cell Focus | |
Necrosis, Multifocal | |
Kupffer Cell, Pigmentation | 3 3 3 2 3 3 3 1 3 2 3 3 3 4 3 3 2 2 3 2 1|
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Mineralization, Focal | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Inflammation, Focal, Subacute| 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Dysplasia | 3 3 2 2 2 2 3 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|
| 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Spindle Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 1 2 2 1 2 1 2 2 2 2 2 2 1 2 1 2 2 1|
Follicular Cell, Hyperplasia | 3 2 2 2 2 1 3 3 2 1 2 2 3 2 3 2 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3|
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Subacute | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukocytosis | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 2 3 1 |
Mesenteric, Angiectasis | 2 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|
| 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
Pigmentation | 2 1 2 1 1 2 2 2 1 1 2 2 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Thymus | + + M + + + M + M M + + + + + + + + + + + + + + +|
Atrophy | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | |
Epidermis, Hyperplasia, Focal | 2 1 |
Subcutaneous Tissue, Fibrosis, Focal | 2 2 1 |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 1 |
Subcutaneous Tissue, Mineralization, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 2 2 1 1 2 1 1 2 2 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 2 1 3 2 1 3 1 1 1 2 1 3 3 1 1 1 3 2 2 2 3|
Artery, Inflammation | 3 |
Cortex, Cyst | 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|
| 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Left, Fibrosis, Focal | 4 |
Renal Tubule, Dilatation, Multifocal | 2 |
Renal Tubule, Hyperplasia, Cystic | 1 1 1 |
Renal Tubule, Hyperplasia | 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 2 |
Renal Tubule, Epithelium, Cytomegaly | 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2|
__________________________________________________________________________|
Urethra | + + |
Dilatation | 3 |
Inflammation, Suppurative | 3 |
Bulbourethral Gland, Cyst | 3 |
Bulbourethral Gland, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5| | |
| 4| 7| 7| 6| 6| 1| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
Mineralization, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 8 |
Clear Cell Focus | | 1 |
Cytologic Alterations | | 43 2.6|
Eosinophilic Focus | | 3 2.0|
Inflammation, Granulomatous | | 38 2.4|
Mixed Cell Focus | | 2 |
Necrosis, Multifocal | | 1 2.0|
Kupffer Cell, Pigmentation | | 41 2.7|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Mineralization, Focal | | 1 2.0|
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Inflammation, Focal, Subacute| | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 24 |
Dysplasia | | 24 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5| | |
| 4| 7| 7| 6| 6| 1| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Capsule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hypertrophy, Focal | | 8 1.6|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
Spindle Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 38 1.6|
Follicular Cell, Hyperplasia | | 41 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 2 3.0|
Inflammation, Subacute | | 4 1.3|
__________________________________________________________________________|____________|
Penis | | |
__________________________________________________________________________|____________|
Preputial Gland | | 4 |
Inflammation, Subacute | | 2 3.5|
Duct, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Inflammation, Subacute | | 8 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Inflammation, Subacute | | 2 4.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Degeneration | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5| | |
| 4| 7| 7| 6| 6| 1| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myeloid Cell, Hypercellularity | | 6 1.7|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 8 2.4|
Mesenteric, Angiectasis | | 14 1.6|
Mesenteric, Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
__________________________________________________________________________|____________|
Spleen | | 48 |
Hematopoietic Cell Proliferation | | 5 2.4|
Pigmentation | | 39 1.3|
__________________________________________________________________________|____________|
Thymus | | 45 |
Atrophy | | 2 3.5|
Necrosis | | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Focal, Subacute | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 4 1.8|
Subcutaneous Tissue, Fibrosis, Focal | | 7 2.4|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 3 2.3|
Subcutaneous Tissue, Mineralization, | | |
Focal | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Multifocal | | 36 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5| | |
| 4| 7| 7| 6| 6| 1| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Inflammation, Acute, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Suppurative | | 1 2.0|
Nephropathy, Chronic | | 45 1.8|
Artery, Inflammation | | 1 3.0|
Cortex, Cyst | | 9 1.7|
Left, Fibrosis, Focal | | 1 4.0|
Renal Tubule, Dilatation, Multifocal | | 1 2.0|
Renal Tubule, Hyperplasia, Cystic | | 4 1.0|
Renal Tubule, Hyperplasia | | 7 1.6|
Renal Tubule, Mineralization, | | |
Multifocal | | 4 1.8|
Renal Tubule, Epithelium, Cytomegaly | | 46 2.8|
__________________________________________________________________________|____________|
Urethra | | 2 |
Dilatation | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Bulbourethral Gland, Cyst | | 1 3.0|
Bulbourethral Gland, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|
| 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + A A + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + A A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cytologic Alterations | 2 2 1 1 1 1 1 2 3 2 1 1 2 1 1 2 1 2 2 2 2 1|
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | 1 1 2 2 1 1 1 1 |
Inflammation, Multifocal, Subacute | 2 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Kupffer Cell, Pigmentation | 2 1 2 2 1 1 2 1 1 2 1 2 2 1 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
Erosion | 2 |
Hyperplasia | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|
| 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 3 2 1 2 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 2 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + |
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Subacute | 3 3 3 |
Duct, Cyst | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Dilatation | |
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Hyperplasia, Histiocytic | 2 |
Myeloid Cell, Hypercellularity | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 2 |
Mesenteric, Angiectasis | 2 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 2 |
Hemorrhage | |
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|
| 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 2 2 4 |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 3 2 3 2 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Hemorrhage | 2 |
Mineralization, Multifocal | 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 1 1 1 1 1 3 1 2 1 1 1 1 1 1 1 1 1 2 2 1 1|
Cortex, Cyst | 2 1 1 |
Papilla, Necrosis | |
Renal Tubule, Hyperplasia | 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 2 |
Renal Tubule, Epithelium, Cytomegaly | 1 2 2 2 2 2 2 1 3 3 2 2 2 1 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Hemorrhage | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|
| 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cytologic Alterations | 1 1 1 2 1 1 1 2 1 1 2 1 1 2 1 2 2 2 2|
Hematopoietic Cell Proliferation | 2 2|
Inflammation, Granulomatous | 2 2 |
Inflammation, Multifocal, Subacute | |
Mixed Cell Focus | X |
Necrosis, Focal | 3 |
Kupffer Cell, Pigmentation | 2 1 2 1 1 2 1 3 1 1 2 1 1 2 1|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + A + + + + A + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + +|
Erosion | 2 2 |
Hyperplasia | 2 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + |
Dysplasia | 1 3 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + +|
Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + A + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|
| 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 1 2 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Subacute | 4 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + A + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + + +|
Dilatation | 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Myeloid Cell, Hypercellularity | 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | 3|
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Angiectasis | 3 2 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 4|
Hemorrhage | 3 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 2 3|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|
| 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Epidermis, Hyperplasia, Focal | 2 2 |
Subcutaneous Tissue, Fibrosis, Focal | 3 2 1 2 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 2 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
Hemorrhage | |
Mineralization, Multifocal | 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Chronic, Focal | |
Inflammation, Suppurative | 2 |
Nephropathy, Chronic | 2 3 1 1 1 1 3 1 1 2 1 1 3 2 1 2 1 3 1 1|
Cortex, Cyst | 2 |
Papilla, Necrosis | 2 |
Renal Tubule, Hyperplasia | 1 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 2 2 2 2 |
Renal Tubule, Epithelium, Cytomegaly | 2 2 3 1 2 2 1 3 1 2 2 1 2 3 2 1 2 2 2 3 2 2 2|
__________________________________________________________________________|
Urethra | + + |
Bulbourethral Gland, Hemorrhage | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + +|
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 6| 6| 6| 7| 6| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 19 |
__________________________________________________________________________|____________|
Gallbladder | | 15 |
__________________________________________________________________________|____________|
Intestine Large | | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 16 |
__________________________________________________________________________|____________|
Intestine Small | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 14 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 3 |
Cytologic Alterations | | 41 1.5|
Hematopoietic Cell Proliferation | | 2 2.0|
Inflammation, Granulomatous | | 10 1.4|
Inflammation, Multifocal, Subacute | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 2 2.5|
Kupffer Cell, Pigmentation | | 30 1.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | | 18 |
__________________________________________________________________________|____________|
Salivary Glands | | 19 |
__________________________________________________________________________|____________|
Stomach | | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 22 |
Erosion | | 3 2.0|
Hyperplasia | | 5 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 18 |
__________________________________________________________________________|____________|
Tooth | | 4 |
Dysplasia | | 4 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 19 |
Spindle Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 6| 6| 6| 7| 6| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 17 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 19 1.3|
Follicular Cell, Hyperplasia | | 24 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 19 |
Inflammation, Subacute | | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
Inflammation, Subacute | | 4 3.3|
Duct, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | | 19 |
Inflammation, Subacute | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 18 |
Dilatation | | 1 3.0|
Inflammation, Subacute | | 2 3.0|
__________________________________________________________________________|____________|
Testes | | 19 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | | 19 |
Hyperplasia, Histiocytic | | 1 2.0|
Myeloid Cell, Hypercellularity | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | | 26 |
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 3 2.0|
Mesenteric, Angiectasis | | 4 2.3|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 17 |
__________________________________________________________________________|____________|
Spleen | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 6| 6| 6| 7| 6| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 11 2.3|
Hemorrhage | | 1 3.0|
Pigmentation | | 23 1.0|
__________________________________________________________________________|____________|
Thymus | | 19 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | | 45 |
Inflammation, Focal, Subacute | | 5 2.4|
Ulcer | | 4 2.8|
Epidermis, Hyperplasia, Focal | | 3 2.0|
Subcutaneous Tissue, Fibrosis, Focal | | 8 2.3|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 19 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 19 |
Hemorrhage | | 1 2.0|
Mineralization, Multifocal | | 15 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 26 |
Alveolar Epithelium, Hyperplasia | | 4 2.8|
__________________________________________________________________________|____________|
Nose | | 20 |
__________________________________________________________________________|____________|
Trachea | | 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 6| 6| 6| 7| 6| 7| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Nephropathy, Chronic | | 42 1.4|
Cortex, Cyst | | 4 1.5|
Papilla, Necrosis | | 1 2.0|
Renal Tubule, Hyperplasia | | 7 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 5 2.0|
Renal Tubule, Epithelium, Cytomegaly | | 47 2.0|
__________________________________________________________________________|____________|
Urethra | | 3 |
Bulbourethral Gland, Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 18 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|
DAY ON TEST | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|
| 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M A + + + + A M M M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + A + + M|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis | 1 |
Basophilic Focus | X |
Cytologic Alterations | 1 1 1 1 1 1 1 2 1 1 1 1 |
Eosinophilic Focus | X X X |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
Centrilobular, Necrosis | |
Kupffer Cell, Pigmentation | 2 1 |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A +|
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + A +|
Hyperplasia | 2 |
Inflammation, Subacute | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + A +|
Erosion | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Abdominal, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|
DAY ON TEST | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|
| 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +|
Cyst | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Penis | + + + |
Developmental Malformation | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Inflammation, Subacute | 2 4 3 3 2 4 2 |
Duct, Cyst | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Subacute | 4 2 4 3 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + +|
Myeloid Cell, Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|
DAY ON TEST | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|
| 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + A|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 2 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + M +|
Atrophy | 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 3 2 2 3 2 |
Ulcer | 3 2 2 3 |
Epidermis, Hyperplasia, Focal | |
Epidermis, Hyperplasia | 1 |
Subcutaneous Tissue, Fibrosis, Focal | 3 3 3 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1|
Necrosis, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Inflammation, Suppurative | 3 |
Nephropathy, Chronic | 2 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|
DAY ON TEST | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|
| 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation | 2 |
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization, | |
Multifocal | 1 1 1 1 |
Renal Tubule, Epithelium, Cytomegaly | 1 1 2 2 1 1 1 1 2 2 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urethra | + |
Dilatation | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
Hemorrhage | 2 4 |
Inflammation, Subacute | 2 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|
| 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Cytologic Alterations | 1 1 1 1 1 1 1 1 2|
Eosinophilic Focus | X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X |
Necrosis, Focal | 2 3 |
Centrilobular, Necrosis | 1 |
Kupffer Cell, Pigmentation | 1 1 1|
__________________________________________________________________________|
Mesentery | + + |
Cyst | 3 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + |
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + |
Hyperplasia | |
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + |
Erosion | |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Abdominal, Inflammation, Subacute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Inflammation, Subacute | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|
| 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Cyst | |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Follicle, Cyst | 1 1 |
Follicular Cell, Hyperplasia | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
Developmental Malformation | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Subacute | 3 2 2 |
Duct, Cyst | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Hemorrhage | |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + A + + |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Myeloid Cell, Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mesenteric, Angiectasis | 2 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + M |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|
| 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy | 1 |
Hematopoietic Cell Proliferation | 4 3 1 2 2|
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Thymus | M + + + + + + M + + |
Atrophy | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 3 2 2|
Ulcer | 2 3 |
Epidermis, Hyperplasia, Focal | 2 2 2 2|
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Fibrosis, Focal | 3 2 2 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Mineralization, Multifocal | 1 1 1 1 1 |
Necrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Congestion | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 4 3 |
__________________________________________________________________________|
Nose | + + + + + + + A + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 1 1 1 2 1 2 1 2 2 2 1 1 2 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|
| 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation | |
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Mineralization, | |
Multifocal | 2 2 |
Renal Tubule, Epithelium, Cytomegaly | 1 1 1 1 2 1 1 1 2 2 2 2 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urethra | + |
Dilatation | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + |
Hemorrhage | |
Inflammation, Subacute | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 22 |
__________________________________________________________________________|____________|
Gallbladder | | 15 |
__________________________________________________________________________|____________|
Intestine Large | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 19 |
__________________________________________________________________________|____________|
Intestine Small | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 18 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 19 |
__________________________________________________________________________|____________|
Liver | | 48 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 2 |
Cytologic Alterations | | 21 1.1|
Eosinophilic Focus | | 4 |
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | | 3 |
Necrosis, Focal | | 3 2.0|
Centrilobular, Necrosis | | 1 1.0|
Kupffer Cell, Pigmentation | | 5 1.2|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Cyst | | 1 3.0|
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 20 |
Acinus, Atrophy, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 22 |
__________________________________________________________________________|____________|
Stomach | | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 21 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
Erosion | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Dysplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Abdominal, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Heart | | 22 |
Inflammation, Subacute | | 1 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 23 |
Cyst | | 1 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 22 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicle, Cyst | | 4 1.3|
Follicular Cell, Hyperplasia | | 10 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 22 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 3 |
Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 14 |
Inflammation, Subacute | | 10 2.7|
Duct, Cyst | | 6 2.0|
__________________________________________________________________________|____________|
Prostate | | 22 |
Hemorrhage | | 1 4.0|
Inflammation, Subacute | | 7 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 21 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 22 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 22 |
Myeloid Cell, Hypercellularity | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 27 |
Inguinal, Hyperplasia, Lymphoid | | 4 2.8|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mesenteric, Angiectasis | | 7 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 18 |
__________________________________________________________________________|____________|
Spleen | | 47 |
Atrophy | | 2 2.0|
Hematopoietic Cell Proliferation | | 9 2.3|
Pigmentation | | 6 1.0|
__________________________________________________________________________|____________|
Thymus | | 18 |
Atrophy | | 1 2.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 39 |
Inflammation, Focal, Subacute | | 8 2.4|
Ulcer | | 6 2.5|
Epidermis, Hyperplasia, Focal | | 4 2.0|
Epidermis, Hyperplasia | | 1 1.0|
Subcutaneous Tissue, Fibrosis, Focal | | 6 2.7|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 22 |
Mineralization, Multifocal | | 11 1.0|
Necrosis, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05019-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:26
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.25% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 2 3.5|
__________________________________________________________________________|____________|
Nose | | 21 |
__________________________________________________________________________|____________|
Trachea | | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy, Chronic | | 39 1.3|
Artery, Inflammation | | 1 2.0|
Cortex, Cyst | | 2 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 6 1.3|
Renal Tubule, Epithelium, Cytomegaly | | 40 1.3|
__________________________________________________________________________|____________|
Urethra | | 2 |
Dilatation | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 22 |
Hemorrhage | | 2 3.0|
Inflammation, Subacute | | 2 2.5|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
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